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Myxoma virus and oncolytic virotherapy: a new biologic weapon in the war against cancer

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Pages 1415-1425 | Published online: 29 Aug 2007

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Jovian J Tsang & Harold L Atkins. (2015) The ex vivo purge of cancer cells using oncolytic viruses: recent advances and clinical implications. Oncolytic Virotherapy 4, pages 13-23.
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Jonathan G Pol, Julien Rességuier & Brian D Lichty. (2012) Oncolytic viruses: a step into cancer immunotherapy. Virus Adaptation and Treatment 4, pages 1-21.
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Mário Sousa-Pimenta, Ângelo Martins & Vera Machado. 2023. Viral Vectors in Cancer Immunotherapy. Viral Vectors in Cancer Immunotherapy 189 219 .
Masmudur M. Rahman, Grant McFadden, Gordon Ruthel, De’Broski.R. Herbert, Bruce D. Freedman, Robert M. Greenberg & Swarna Bais. (2022) Oncolytic Myxoma virus infects and damages the tegument of the human parasitic flatworm Schistosoma mansoni. Experimental Parasitology 239, pages 108263.
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Yaomei Tian, Daoyuan Xie & Li Yang. (2022) Engineering strategies to enhance oncolytic viruses in cancer immunotherapy. Signal Transduction and Targeted Therapy 7:1.
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Victor A. Naumenko, Aleksei A. Stepanenko, Anastasiia V. Lipatova, Daniil A. Vishnevskiy & Vladimir P. Chekhonin. (2022) Infection of non-cancer cells: A barrier or support for oncolytic virotherapy?. Molecular Therapy - Oncolytics 24, pages 663-682.
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Zhilong Yang, Mark Gray & Lake Winter. (2021) Why do poxviruses still matter?. Cell & Bioscience 11:1.
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Fan Guo & Li Xing. (2021) RNA helicase A as co-factor for DNA viruses during replication. Virus Research 291, pages 198206.
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Yvonne Cornejo, Min Li, Thanh H. Dellinger, Rachael Mooney, Masmudur M. Rahman, Grant McFadden, Karen S. Aboody & Mohamed Hammad. (2020) NSCs are permissive to oncolytic Myxoma virus and provide a delivery method for targeted ovarian cancer therapy . Oncotarget 11:51, pages 4693-4698.
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Joanna Jazowiecka-Rakus, Aleksander Sochanik, Aleksandra Rusin, Agata Hadryś, Wojciech Fidyk, Nancy Villa, Masmudur M. Rahman, Ewa Chmielik, Lina S. Franco & Grant McFadden. (2020) Myxoma Virus-Loaded Mesenchymal Stem Cells in Experimental Oncolytic Therapy of Murine Pulmonary Melanoma. Molecular Therapy - Oncolytics 18, pages 335-350.
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Nancy.Y. Villa, Masmudur M. Rahman, Joseph. Mamola, Julia D’Isabella, Elizabeth Goras, Jacquelyn Kilbourne, Kenneth Lowe, Juliane Daggett-Vondras, Lino Torres, John Christie, Nicole Appel, Anna L. Cox, Jae B. Kim & Grant McFadden. (2020) Autologous Transplantation Using Donor Leukocytes Loaded Ex Vivo with Oncolytic Myxoma Virus Can Eliminate Residual Multiple Myeloma. Molecular Therapy - Oncolytics 18, pages 171-188.
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Raela B. Ridley, Brianna M. Young, Jieun Lee, Erin Walsh, Chulbul M. Ahmed, Alfred S. Lewin & Cristhian J. Ildefonso. (2019) AAV Mediated Delivery of Myxoma Virus M013 Gene Protects the Retina against Autoimmune Uveitis. Journal of Clinical Medicine 8:12, pages 2082.
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Nancy Y. Villa & Grant McFadden. (2018) Virotherapy as Potential Adjunct Therapy for Graft-Vs-Host Disease. Current Pathobiology Reports 6:4, pages 247-263.
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Marine Ricordel, Johann Foloppe, Christelle Pichon, Annie Findeli, Caroline Tosch, Pascale Cordier, Sandrine Cochin, Eric Quémeneur, Christelle Camus-Bouclainville, Stéphane Bertagnoli & Philippe Erbs. (2018) Oncolytic properties of non-vaccinia poxviruses. Oncotarget 9:89, pages 35891-35906.
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Daniel E. Meyers, Satbir Thakur, Chandini M. Thirukkumaran & Don G. Morris. (2017) Oncolytic virotherapy as an immunotherapeutic strategy for multiple myeloma. Blood Cancer Journal 7:12.
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Marine Ricordel, Johann Foloppe, Christelle Pichon, Nathalie Sfrontato, Delphine Antoine, Caroline Tosch, Sandrine Cochin, Pascale Cordier, Eric Quemeneur, Christelle Camus-Bouclainville, Stéphane Bertagnoli & Philippe Erbs. (2017) Cowpox Virus: A New and Armed Oncolytic Poxvirus. Molecular Therapy - Oncolytics 7, pages 1-11.
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Qiu‑Sheng Zhang, Meng Zhang, Xian‑Jian Huang, Xiao‑Jia Liu & Wei‑Ping Li. (2017) Apoptosis-inducing effect of myxoma virus on human neuroglioma cell lines. Experimental and Therapeutic Medicine.
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Cameron L. Lilly, Nancy Y. Villa, Ana Lemos de Matos, Haider M. Ali, Jess-Karan S. Dhillon, Tom Hofland, Masmudur M. Rahman, Winnie Chan, Bjarne Bogen, Christopher Cogle & Grant McFadden. (2017) Ex Vivo Oncolytic Virotherapy with Myxoma Virus Arms Multiple Allogeneic Bone Marrow Transplant Leukocytes to Enhance Graft versus Tumor. Molecular Therapy - Oncolytics 4, pages 31-40.
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Chad Smithson, Nick Tang, Scott Sammons, Mike Frace, Dhwani Batra, Yu Li, Ginny L. Emerson, Darin S. Carroll & Chris Upton. (2016) The genomes of three North American orthopoxviruses. Virus Genes 53:1, pages 21-34.
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Alexandra Pisklakova, Brienne McKenzie, Franz Zemp, Xueqing Lun, Rajappa S. Kenchappa, Arnold B. Etame, Masmudur M. Rahman, Karlyne Reilly, Shari Pilon-Thomas, Grant McFadden, Ebba Kurz & Peter A. Forsyth. (2016) M011L-deficient oncolytic myxoma virus induces apoptosis in brain tumor-initiating cells and enhances survival in a novel immunocompetent mouse model of glioblastoma. Neuro-Oncology 18:8, pages 1088-1098.
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Nancy Villa, Masmudur Rahman, Grant McFadden & Christopher Cogle. (2016) Therapeutics for Graft-versus-Host Disease: From Conventional Therapies to Novel Virotherapeutic Strategies. Viruses 8:3, pages 85.
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Song Hee Choi, Byoung Kwon Park, Keun-Wook Lee, Jun Chang, Younghee Lee & Hyung-Joo Kwon. (2015) Effect of respiratory syncytial virus on the growth of hepatocellular carcinoma cell-lines. BMB Reports 48:10, pages 565-570.
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Wilson Poon, Xuan Zhang, Devesh Bekah, Jose G Teodoro & Jay L Nadeau. (2015) Targeting B16 tumors in vivo with peptide-conjugated gold nanoparticles . Nanotechnology 26:28, pages 285101.
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Jay Nadeau, Wilson Poon & Xuan Zhang. Mechanisms of cell penetration and cytotoxicity of ultrasmall Au nanoparticles conjugated to doxorubicin and/or targeting peptides. Mechanisms of cell penetration and cytotoxicity of ultrasmall Au nanoparticles conjugated to doxorubicin and/or targeting peptides.
Winnie M. ChanGrant McFadden. (2014) Oncolytic Poxviruses. Annual Review of Virology 1:1, pages 191-214.
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Vaishali Patil & Satya Gupta. 2014. Cancer-Causing Viruses and Their Inhibitors. Cancer-Causing Viruses and Their Inhibitors 437 466 .
Carolina S. Ilkow, Stephanie L. Swift, John C. Bell & Jean-Simon Diallo. (2014) From Scourge to Cure: Tumour-Selective Viral Pathogenesis as a New Strategy against Cancer. PLoS Pathogens 10:1, pages e1003836.
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Winnie M. Chan, Masmudur M. Rahman & Grant McFadden. (2013) Oncolytic myxoma virus: The path to clinic. Vaccine 31:39, pages 4252-4258.
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Winnie M. Chan, Eric C. Bartee, Jan S. Moreb, Ken Dower, John H. Connor & Grant McFadden. (2013) Myxoma and Vaccinia Viruses Bind Differentially to Human Leukocytes. Journal of Virology 87:8, pages 4445-4460.
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Craig N. Jenne, Connie H.Y. Wong, Franz J. Zemp, Braedon McDonald, Masmudur M. Rahman, Peter A. Forsyth, Grant McFadden & Paul Kubes. (2013) Neutrophils Recruited to Sites of Infection Protect from Virus Challenge by Releasing Neutrophil Extracellular Traps. Cell Host & Microbe 13:2, pages 169-180.
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Nahlah M Almansour, Elena Pirogova, Peter J Coloe, Irena Cosic & Taghrid S Istivan. (2012) A bioactive peptide analogue for myxoma virus protein with a targeted cytotoxicity for human skin cancer in vitro. Journal of Biomedical Science 19:1.
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Eric Bartee, Winnie M. Chan, Jan S. Moreb, Christopher R. Cogle & Grant McFadden. (2012) Selective Purging of Human Multiple Myeloma Cells from Autologous Stem Cell Transplantation Grafts using Oncolytic Myxoma Virus. Biology of Blood and Marrow Transplantation 18:10, pages 1540-1551.
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Nahlah M Almansour, Elena Pirogova, Peter J Coloe, Irena Cosic & Taghrid S Istivan. (2012) Investigation of cytotoxicity of negative control peptides versus bioactive peptides on skin cancer and normal cells: a comparative study. Future Medicinal Chemistry 4:12, pages 1553-1565.
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Rohann J.M. Correa, Monica Komar, Jessica G.K. Tong, Milani Sivapragasam, Masmudur M. Rahman, Grant McFadden, Gabriel E. DiMattia & Trevor G. Shepherd. (2012) Myxoma virus-mediated oncolysis of ascites-derived human ovarian cancer cells and spheroids is impacted by differential AKT activity. Gynecologic Oncology 125:2, pages 441-450.
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Sonia Tusell Wennier, Jia Liu, Shoudong Li, Masmudur M. Rahman, Mahmoud Mona & Grant McFadden. (2012) Myxoma Virus Sensitizes Cancer Cells to Gemcitabine and Is an Effective Oncolytic Virotherapeutic in Models of Disseminated Pancreatic Cancer. Molecular Therapy 20:4, pages 759-768.
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Ibtissam Echchgadda, Te-Hung Chang, Ahmed Sabbah, Imad Bakri, Yuji Ikeno, Gene B Hubbard, Bandana Chatterjee & Santanu Bose. (2011) Oncolytic targeting of androgen-sensitive prostate tumor by the respiratory syncytial virus (RSV): consequences of deficient interferon-dependent antiviral defense. BMC Cancer 11:1.
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Danijela Koppers‐Lalic & Rob C. Hoeben. (2011) Non‐human viruses developed as therapeutic agent for use in humans. Reviews in Medical Virology 21:4, pages 227-239.
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Sourav RoyChoudhury, Archana Pan & Debaprasad Mukherjee. (2011) Genus specific evolution of codon usage and nucleotide compositional traits of poxviruses. Virus Genes 42:2, pages 189-199.
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Bart Spiesschaert, Grant McFadden, Katleen Hermans, Hans Nauwynck & Gerlinde R Van de Walle. (2011) The current status and future directions of myxoma virus, a master in immune evasion. Veterinary Research 42:1, pages 76.
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Phonphimon Wongthida, Rosa M Diaz, Feorillo Galivo, Timothy Kottke, Jill Thompson, Alan Melcher & Richard Vile. (2011) VSV Oncolytic Virotherapy in the B16 Model Depends Upon Intact MyD88 Signaling. Molecular Therapy 19:1, pages 150-158.
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Peter J. Kerr & Grant McFadden. 2011. The Springer Index of Viruses. The Springer Index of Viruses 1469 1478 .
Jia Liu, Sonia Wennier & Grant McFadden. (2010) The immunoregulatory properties of oncolytic myxoma virus and their implications in therapeutics. Microbes and Infection 12:14-15, pages 1144-1152.
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Lila Farrington, Gabriela O'Neill & Ann B. Hill. 2010. The Immune Response to Infection. The Immune Response to Infection 391 401 .
Don B. Gammon, Branawan Gowrishankar, Sophie Duraffour, Graciela Andrei, Chris Upton & David H. Evans. (2010) Vaccinia Virus–Encoded Ribonucleotide Reductase Subunits Are Differentially Required for Replication and Pathogenesis. PLoS Pathogens 6:7, pages e1000984.
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M Kim, C T Williamson, J Prudhomme, D G Bebb, K Riabowol, P W K Lee, S P Lees-Miller, Y Mori, M M Rahman, G McFadden & R N Johnston. (2010) The viral tropism of two distinct oncolytic viruses, reovirus and myxoma virus, is modulated by cellular tumor suppressor gene status. Oncogene 29:27, pages 3990-3996.
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Phonphimon Wongthida, Rosa Maria Diaz, Feorillo Galivo, Timothy Kottke, Jill Thompson, Jose Pulido, Kevin Pavelko, Larry Pease, Alan Melcher & Richard Vile. (2010) Type III IFN Interleukin-28 Mediates the Antitumor Efficacy of Oncolytic Virus VSV in Immune-Competent Mouse Models of Cancer. Cancer Research 70:11, pages 4539-4549.
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Nancy Y. Villa, Eric Bartee, Mohamed R. Mohamed, Masmudur M. Rahman, John W. Barrett & Grant McFadden. (2010) Myxoma and vaccinia viruses exploit different mechanisms to enter and infect human cancer cells. Virology 401:2, pages 266-279.
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Laura Evgin, Markus Vähä-Koskela, Julia Rintoul, Theresa Falls, Fabrice Le Boeuf, John W Barrett, John C Bell & Marianne M Stanford. (2010) Potent Oncolytic Activity of Raccoonpox Virus in the Absence of Natural Pathogenicity. Molecular Therapy 18:5, pages 896-902.
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Sherin E. Smallwood, Masmudur M. Rahman, Dorothy W. Smith & Grant McFadden. (2010) Myxoma Virus: Propagation, Purification, Quantification, and Storage. Current Protocols in Microbiology 17:1, pages 14A.1.1-14A.1.20.
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M Kim, G J Madlambayan, M M Rahman, S E Smallwood, A M Meacham, K Hosaka, E W Scott, C R Cogle & G McFadden. (2009) Myxoma virus targets primary human leukemic stem and progenitor cells while sparing normal hematopoietic stem and progenitor cells. Leukemia 23:12, pages 2313-2317.
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I Echchgadda, S Kota, I DeLa Cruz, A Sabbah, T Chang, R Harnack, V Mgbemena, B Chatterjee & S Bose. (2009) Anticancer oncolytic activity of respiratory syncytial virus. Cancer Gene Therapy 16:12, pages 923-935.
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Masmudur M. Rahman, Mohamed R. Mohamed, Manbok Kim, Sherin Smallwood & Grant McFadden. (2009) Co-Regulation of NF-κB and Inflammasome-Mediated Inflammatory Responses by Myxoma Virus Pyrin Domain-Containing Protein M013. PLoS Pathogens 5:10, pages e1000635.
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Timothy P Cripe, Pin-Yi Wang, Paola Marcato, Yonatan Y Mahller & Patrick WK Lee. (2009) Targeting Cancer-initiating Cells With Oncolytic Viruses. Molecular Therapy 17:10, pages 1677-1682.
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Leiliang Zhang, Marianne Stanford, Jia Liu, Catherine Barrett, Lei Jiang, A. Neil Barclay & Grant McFadden. (2009) Inhibition of Macrophage Activation by the Myxoma Virus M141 Protein (vCD200). Journal of Virology 83:18, pages 9602-9607.
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Eric Bartee & Grant McFadden. (2009) Human cancer cells have specifically lost the ability to induce the synergistic state caused by tumor necrosis factor plus interferon-β. Cytokine 47:3, pages 199-205.
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Jia Liu, Sonia Wennier, Mary Reinhard, Edward Roy, Amy MacNeill & Grant McFadden. (2009) Myxoma Virus Expressing Interleukin-15 Fails To Cause Lethal Myxomatosis in European Rabbits. Journal of Virology 83:11, pages 5933-5938.
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Eric Bartee, Mohamed R. Mohamed, M. Cecilia Lopez, Henry V. Baker & Grant McFadden. (2009) The Addition of Tumor Necrosis Factor plus Beta Interferon Induces a Novel Synergistic Antiviral State against Poxviruses in Primary Human Fibroblasts. Journal of Virology 83:2, pages 498-511.
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M. Bazan-PeregrinoR.C. CarlisleR. Hernandez-AlcocebaR. IggoK. HomicskoK.D. FisherG. HalldénV. MautnerY. ShenL.W. Seymour. (2008) Comparison of Molecular Strategies for Breast Cancer Virotherapy Using Oncolytic Adenovirus. Human Gene Therapy 19:9, pages 873-886.
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Cheng-Yen Huang, Tsai-Yi Lu, Chi-Horng Bair, Yuan-Shau Chang, Jeng-Kuan Jwo & Wen Chang. (2008) A Novel Cellular Protein, VPEF, Facilitates Vaccinia Virus Penetration into HeLa Cells through Fluid Phase Endocytosis. Journal of Virology 82:16, pages 7988-7999.
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Z. Sheng Guo, Stephen H. Thorne & David L. Bartlett. (2008) Oncolytic virotherapy: Molecular targets in tumor-selective replication and carrier cell-mediated delivery of oncolytic viruses. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1785:2, pages 217-231.
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