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Review

Emerging therapies for multiple myeloma

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Pages 99-127 | Published online: 27 Feb 2009

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Antonio Palumbo, Massimo Offidani, Francesca Patriarca, Maria Teresa Petrucci & Michele Cavo. (2015) Bendamustine for the treatment of multiple myeloma in first-line and relapsed–refractory settings: a review of clinical trial data. Leukemia & Lymphoma 56:3, pages 559-567.
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Articles from other publishers (39)

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Chuansheng Yang, Zhikai Mai, Can Liu, Shuanghong Yin, Yantao Cai & Chenglai Xia. (2022) Natural Products in Preventing Tumor Drug Resistance and Related Signaling Pathways. Molecules 27:11, pages 3513.
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Mahdieh Mehrpouri. (2022) The contributory roles of the CXCL12/CXCR4/CXCR7 axis in normal and malignant hematopoiesis: A possible therapeutic target in hematologic malignancies. European Journal of Pharmacology 920, pages 174831.
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Syed Hassan Mehdi, Sana Nafees, Syed Jafar Mehdi, Carol A. Morris, Ladan Mashouri & Donghoon Yoon. (2021) Animal Models of Multiple Myeloma Bone Disease. Frontiers in Genetics 12.
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Jinsha Liu, Priyanka Pandya & Sepideh Afshar. (2021) Therapeutic Advances in Oncology. International Journal of Molecular Sciences 22:4, pages 2008.
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Gordon Cook & Curly T. C. M. Morris. (2020) Evolution or revolution in multiple myeloma therapy and the role of the UK. British Journal of Haematology 191:4, pages 542-551.
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Crystal Loke, Peter Mollee, Ian McPherson, Euan Walpole, Mimi Yue, Howard Mutsando, Phillip Wong, Helen Weston, Ross Tomlinson & Samantha Hollingworth. (2020) Bortezomib use and outcomes for the treatment of multiple myeloma. Internal Medicine Journal 50:9, pages 1059-1066.
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A. A. Philchenkov. (2019) Bone marrow adipocytes and multiple myeloma. Oncohematology 14:1, pages 60-75.
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Laurie Besson, Emily Charrier, Lionel Karlin, Omran Allatif, Antoine Marçais, Paul Rouzaire, Lucie Belmont, Michel Attal, Christine Lombard, Gilles Salles, Thierry Walzer & Sébastien Viel. (2018) One-Year Follow-Up of Natural Killer Cell Activity in Multiple Myeloma Patients Treated With Adjuvant Lenalidomide Therapy. Frontiers in Immunology 9.
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Shang-Yi Huang, Cheng-Shyong Chang, Ta-Chih Liu, Po-Nan Wang, Su-Peng Yeh, Ching-Liang Ho, Ming-Chung Kuo, Hsuan-Yu Lin, Jan de Jong, Jia-Yi Chen & Ya-Wen Yang. (2018) Pharmacokinetic study of bortezomib administered intravenously in Taiwanese patients with multiple myeloma. Hematological Oncology 36:1, pages 238-244.
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Michelle M. McDonald, Heather Fairfield, Carolyne Falank & Michaela R. Reagan. (2016) Adipose, Bone, and Myeloma: Contributions from the Microenvironment. Calcified Tissue International 100:5, pages 433-448.
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Katia Beider, Evgenia Rosenberg, Hanna Bitner, Avichai Shimoni, Merav Leiba, Maya Koren-Michowitz, Elena Ribakovsky, Shiri Klein, Devorah Olam, Lola Weiss, Hanna Wald, Michal Abraham, Eithan Galun, Amnon Peled & Arnon Nagler. (2017) The Sphingosine-1-Phosphate Modulator FTY720 Targets Multiple Myeloma via the CXCR4/CXCL12 Pathway. Clinical Cancer Research 23:7, pages 1733-1747.
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J Ramachandran, L Santo, K T Siu, C Panaroni & N Raje. (2016) Pim2 is important for regulating DNA damage response in multiple myeloma cells. Blood Cancer Journal 6:8, pages e462-e462.
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M Rabie Al-Turkmani. (2016) The Role of Serum Free Light Chain and M-Protein Measurements in Determining Recurrent Disease in Multiple Myeloma After Stem Cell Transplantation. International Clinical Pathology Journal 2:1.
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Raymond Boon Tar Lim, En Yun Loy, Gek Hsiang Lim, Huili Zheng, Khuan Yew Chow & Soon Thye Lim. (2015) Gender and ethnic differences in incidence and survival of lymphoid neoplasm subtypes in an Asian population: Secular trends of a population-based cancer registry from 1998 to 2012. International Journal of Cancer 137:11, pages 2674-2687.
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Parisa Asvadi, Andrew Cuddihy, Rosanne D. Dunn, Vivien Jiang, Mae X. Wong, Darren R. Jones, Tiffany Khong & Andrew Spencer. (2015) MDX-1097 induces antibody-dependent cellular cytotoxicity against kappa multiple myeloma cells and its activity is augmented by lenalidomide. British Journal of Haematology 169:3, pages 333-343.
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David Jackson & Sherine Elsawa. (2015) Factors Regulating Immunoglobulin Production by Normal and Disease-Associated Plasma Cells. Biomolecules 5:1, pages 20-40.
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Arianna Ferrucci, Michele Moschetta, Maria Antonia Frassanito, Simona Berardi, Ivana Catacchio, Roberto Ria, Vito Racanelli, Antonella Caivano, Antonio Giovanni Solimando, Daniele Vergara, Michele Maffia, Dominga Latorre, Antonia Rizzello, Alfredo Zito, Paolo Ditonno, Eugenio Maiorano, Domenico Ribatti & Angelo Vacca. (2014) A HGF/cMET Autocrine Loop Is Operative in Multiple Myeloma Bone Marrow Endothelial Cells and May Represent a Novel Therapeutic Target. Clinical Cancer Research 20:22, pages 5796-5807.
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Gordan Srkalovic, Mohamad A. Hussein, Antje Hoering, Jeffrey A. Zonder, Leslie L. Popplewell, Harsha Trivedi, Sandy Mazzoni, Rachel Sexton, Robert Z. Orlowski & Bart Barlogie. (2014) A phase II trial of BAY 43‐9006 (sorafenib) ( NSC ‐724772) in patients with relapsing and resistant multiple myeloma: SWOG S0434 . Cancer Medicine 3:5, pages 1275-1283.
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E Bolaños, B Iñigo, C Benavente & R Martínez. (2014) Management of multiple myeloma in older people. Reviews in Clinical Gerontology 24:3, pages 173-181.
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Kodappully Sivaraman Siveen, Nurulhuda Mustafa, Feng Li, Radhamani Kannaiyan, Kwang Seok Ahn, Alan Prem Kumar, Wee-Joo Chng & Gautam Sethi. (2013) Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model. Oncotarget 5:3, pages 634-648.
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Jing Su, Le Zhang, Wen Zhang, Dong Song Choi, Jianguo Wen, Beini Jiang, Chung-Che Chang & Xiaobo Zhou. (2014) Targeting the Biophysical Properties of the Myeloma Initiating Cell Niches: A Pharmaceutical Synergism Analysis Using Multi-Scale Agent-Based Modeling. PLoS ONE 9:1, pages e85059.
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Yu-Tzu Tai & Kenneth C. Anderson. 2013. Myeloma. Myeloma 110 120 .
Rajesh N. Gacche & Rohan J. Meshram. (2013) Targeting tumor micro-environment for design and development of novel anti-angiogenic agents arresting tumor growth. Progress in Biophysics and Molecular Biology 113:2, pages 333-354.
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Ivetta Danylesko, Avichai Shimoni & Arnon Nagler. (2013) Allogeneic Stem Cell Transplantation and Targeted Immunotherapy for Multiple Myeloma. Clinical Lymphoma Myeloma and Leukemia 13, pages S330-S348.
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Surinder S. Sahota, Natalia Savelyeva, Debora Joseph-Pietras, Niklas Zojer & Jason Rice. 2013. Advances in Biology and Therapy of Multiple Myeloma. Advances in Biology and Therapy of Multiple Myeloma 73 110 .
Antonio Basile, Michele Moschetta, Paolo Ditonno, Roberto Ria, Ilaria Marech, Annunziata De Luisi, Simona Berardi, Maria Antonia Frassanito, Emanuele Angelucci, Daniele Derudas, Giorgina Specchia, Paola Curci, Vincenzo Pavone, Bernardo Rossini, Domenico Ribatti, Barbara Bottazzi, Alberto Mantovani, Marco Presta, Franco Dammacco & Angelo Vacca. (2012) Pentraxin 3 (PTX3) inhibits plasma cell/stromal cell cross‐talk in the bone marrow of multiple myeloma patients. The Journal of Pathology 229:1, pages 87-98.
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Li-jing Yang, Yan Chen, Jing He, Sha Yi, Lu Wen, Jie Zhao, Ben-ping Zhang & Guo-hui Cui. (2012) Betulinic acid inhibits autophagic flux and induces apoptosis in human multiple myeloma cells in vitro. Acta Pharmacologica Sinica 33:12, pages 1542-1548.
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Ivetta Danylesko, Katia Beider, Avichai Shimoni & Arnon Nagler. (2012) Monoclonal antibody-based immunotherapy for multiple myeloma. Immunotherapy 4:9, pages 919-938.
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Johanna Atamaniuk, Andreas Gleiss, Edit Porpaczy, Birgit Kainz, Thomas W. Grunt, Markus Raderer, Bernadette Hilgarth, Johannes Drach, Heinz Ludwig, Heinz Gisslinger, Ulrich Jaeger & Alexander Gaiger. (2012) Overexpression of G protein‐coupled receptor 5D in the bone marrow is associated with poor prognosis in patients with multiple myeloma. European Journal of Clinical Investigation 42:9, pages 953-960.
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Jaehyup Kim, Ryan A. Denu, Bridget A. Dollar, Leah E. Escalante, Justin P. Kuether, Natalie S. Callander, Fotis Asimakopoulos & Peiman Hematti. (2012) Macrophages and mesenchymal stromal cells support survival and proliferation of multiple myeloma cells. British Journal of Haematology 158:3, pages 336-346.
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Ivetta Danylesko, Katia Beider, Avichai Shimoni & Arnon Nagler. (2012) Novel Strategies for Immunotherapy in Multiple Myeloma: Previous Experience and Future Directions. Clinical and Developmental Immunology 2012, pages 1-28.
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Leonardo Mirandola, Yuefei Yu, Marjorie R Jenkins, Raffaella Chiaramonte, Everardo Cobos, Constance M John & Maurizio Chiriva-Internati. (2011) Tracking human multiple myeloma xenografts in NOD-Rag-1/IL-2 receptor gamma chain-null mice with the novel biomarker AKAP-4. BMC Cancer 11:1.
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Sagar Lonial, Constantine S. Mitsiades & Paul G. Richardson. (2011) Treatment Options for Relapsed and Refractory Multiple Myeloma. Clinical Cancer Research 17:6, pages 1264-1277.
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Giuseppe Petralia, Nicola Fazio, Luke Bonello, Gabriele D'Andrea, Davide Radice & Massimo Bellomi. (2011) Perfusion Computed Tomography in Patients With Hepatocellular Carcinoma Treated With Thalidomide. Journal of Computer Assisted Tomography 35:2, pages 195-201.
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Michel de Weers, Yu-Tzu Tai, Michael S. van der Veer, Joost M. Bakker, Tom Vink, Daniëlle C. H. Jacobs, Lukas A. Oomen, Matthias Peipp, Thomas Valerius, Jerry W. Slootstra, Tuna Mutis, Wim K. Bleeker, Kenneth C. Anderson, Henk M. Lokhorst, Jan G. J. van de Winkel & Paul W. H. I. Parren. (2011) Daratumumab, a Novel Therapeutic Human CD38 Monoclonal Antibody, Induces Killing of Multiple Myeloma and Other Hematological Tumors. The Journal of Immunology 186:3, pages 1840-1848.
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Gwenny M. Fuhler, Mirjam Baanstra, Daniel Chesik, Rajesh Somasundaram, Anja Seckinger, Dirk Hose, Maikel P. Peppelenbosch & Nico A. Bos. (2010) Bone marrow stromal cell interaction reduces Syndecan-1 expression and induces kinomic changes in myeloma cells. Experimental Cell Research 316:11, pages 1816-1828.
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