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Edgardo Cortes-Justo, Sergio H Garfias-Ramírez & Alonso Vilches-Flores. (2023) The function of the endocannabinoid system in the pancreatic islet and its implications on metabolic syndrome and diabetes. Islets 15:1, pages 1-11.
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George Amato, Nayaab S Khan & Rangan Maitra. (2019) A patent update on cannabinoid receptor 1 antagonists (2015-2018). Expert Opinion on Therapeutic Patents 29:4, pages 261-269.
Read now
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David R. Janero & Ganesh A. Thakur. (2016) Leveraging allostery to improve G protein-coupled receptor (GPCR)-directed therapeutics: cannabinoid receptor 1 as discovery target. Expert Opinion on Drug Discovery 11:12, pages 1223-1237.
Read now
Read now
Giuseppe Derosa & Pamela Maffioli. (2012) Anti-obesity drugs: a review about their effects and their safety. Expert Opinion on Drug Safety 11:3, pages 459-471.
Read now
Read now
David R. Janero. (2012) Cannabinoid-1 receptor (CB1R) blockers as medicines: beyond obesity and cardiometabolic disorders to substance abuse/drug addiction with CB1R neutral antagonists. Expert Opinion on Emerging Drugs 17:1, pages 17-29.
Read now
Read now
David R Janero, Loren Lindsley, Venkata Kiran Vemuri & Alexandros Makriyannis. (2011) Cannabinoid 1 G protein-coupled receptor (periphero-)neutral antagonists: emerging therapeutics for treating obesity-driven metabolic disease and reducing cardiovascular risk. Expert Opinion on Drug Discovery 6:10, pages 995-1025.
Read now
Read now
Giulio Marchesini, Simona Moscatiello, Federica Agostini, Nicola Villanova & Davide Festi. (2011) Treatment of non-alcoholic fatty liver disease with focus on emerging drugs. Expert Opinion on Emerging Drugs 16:1, pages 121-136.
Read now
Read now
M-T Van der Merwe. (2009) Cannabinoid antagonist in obesity treatment. Journal of Endocrinology, Metabolism and Diabetes of South Africa 14:2, pages 112-113.
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Articles from other publishers (134)
Thomas Högberg, Jean-Marie Receveur, Anthony Murray, Jean-Michel Linget, Pia K. Nørregaard, Paul B. Little & Martin Cooper. (2024) Optimizing and characterizing 4-methyl substituted pyrazol-3-carboxamides leading to the peripheral cannabinoid 1 receptor inverse agonist TM38837. Bioorganic & Medicinal Chemistry Letters 98, pages 129572.
Crossref
Crossref
Jimit Girish Raghav, Hritik Kumar, Lipin Ji, Kiran Vemuri, Alexandros Makriyannis, Junghyup Suh, Michael Z Leonard, Vivi Dang, Chelsea Ty, Stephen Marandola, Natalie Kane, Annika S Witt, Samar Shaqour & Klaus A. Miczek. (2023) The neutral CB1 antagonist AM6527 reduces ethanol seeking, binge-like consumption, reinforcing, and withdrawal effects in male and female mice. Psychopharmacology.
Crossref
Crossref
Szabolcs Dvorácskó, Alexa Herrerias, Anna Oliverio, Pinaki Bhattacharjee, Lenny Pommerolle, Ziyi Liu, Dechun Feng, Yong-Sok Lee, Sergio A. Hassan, Grzegorz Godlewski, Resat Cinar & Malliga R. Iyer. (2023) Cannabinoformins: Designing Biguanide-Embedded, Orally Available, Peripherally Selective Cannabinoid-1 Receptor Antagonists for Metabolic Syndrome Disorders. Journal of Medicinal Chemistry 66:17, pages 11985-12004.
Crossref
Crossref
Alexandru Vasincu, Răzvan-Nicolae Rusu, Daniela-Carmen Ababei, Monica Neamțu, Oana Dana Arcan, Ioana Macadan, Sorin Beșchea Chiriac, Walther Bild & Veronica Bild. (2023) Exploring the Therapeutic Potential of Cannabinoid Receptor Antagonists in Inflammation, Diabetes Mellitus, and Obesity. Biomedicines 11:6, pages 1667.
Crossref
Crossref
Malliga R. Iyer. 2023. Cannabis Use, Neurobiology, Psychology, and Treatment. Cannabis Use, Neurobiology, Psychology, and Treatment
237
250
.
Oscar Díaz, Pedro Renault & Jesús Giraldo. (2022)
Evaluating Allosteric Perturbations in Cannabinoid Receptor 1 by
In Silico
Single-Point Mutation
. ACS Omega 7:42, pages 37873-37884.
Crossref
Crossref
Tianyu Hu, Xiaolin Yang, Fengjiang Liu, Shan Sun, Zhiqi Xiong, Jingxi Liang, Xiaobao Yang, Haofeng Wang, Xiuna Yang, Luke W. Guddat, Haitao Yang, Zihe Rao & Bing Zhang. (2022) Structure-based design of anti-mycobacterial drug leads that target the mycolic acid transporter MmpL3. Structure 30:10, pages 1395-1402.e4.
Crossref
Crossref
Yue Sun, Zuguang Yang, Shu-Ning Lu, Zhengkai Chen & Xiao-Feng Wu. (2022)
Formal [4+1] Annulation of Azoalkenes with CF
3
-Imidoyl Sulfoxonium Ylides and Dual Double Bond Isomerization Cascade: Synthesis of Trifluoromethyl-Containing Pyrazole Derivatives
. Organic Letters 24:37, pages 6822-6827.
Crossref
Crossref
Tania Muller, Laurent Demizieux, Stéphanie Troy-Fioramonti, Chloé Buch, Julia Leemput, Christine Belloir, Jean-Paul Pais de Barros, Tony Jourdan, Patricia Passilly-Degrace, Xavier Fioramonti, Anne-Marie Le Bon, Bruno Vergès, Jean-Michel Robert & Pascal Degrace. (2022) Chemical Synthesis, Pharmacokinetic Properties and Biological Effects of JM-00266, a Putative Non-Brain Penetrant Cannabinoid Receptor 1 Inverse Agonist. International Journal of Molecular Sciences 23:6, pages 2923.
Crossref
Crossref
Malliga R. Iyer, Resat Cinar, Casey M. Wood, Charles N. Zawatsky, Nathan J. Coffey, Kyu Ah Kim, Ziyi Liu, Alexis Katz, Jasmina Abdalla, Sergio A. Hassan & Yong-Sok Lee. (2022)
Synthesis, Biological Evaluation, and Molecular Modeling Studies of 3,4-Diarylpyrazoline Series of Compounds as Potent, Nonbrain Penetrant Antagonists of Cannabinoid-1 (CB
1
R) Receptor with Reduced Lipophilicity
. Journal of Medicinal Chemistry 65:3, pages 2374-2387.
Crossref
Crossref
Gerwyn Morris, Ken Walder, Stefan Kloiber, Paul Amminger, Michael Berk, Chiara C. Bortolasci, Michael Maes, Basant K. Puri & Andre F. Carvalho. (2021) The endocannabinoidome in neuropsychiatry: Opportunities and potential risks. Pharmacological Research 170, pages 105729.
Crossref
Crossref
Theodor Dingermann. (2021) Grundlagen der Pharmakologie von Cannabinoiden. Schmerzmedizin 37:S1, pages 8-13.
Crossref
Crossref
Shan Jiang, Christos Iliopoulos-Tsoutsouvas, Fei Tong, Christina A. Brust, Catherine M. Keenan, Jimit Girish Raghav, Tian Hua, Simiao Wu, Jo-Hao Ho, Yiran Wu, Travis W. Grim, Nikolai Zvonok, Ganesh A. Thakur, Zhi-Jie Liu, Keith A. Sharkey, Laura M. Bohn, Spyros P. Nikas & Alexandros Makriyannis. (2021) Novel Functionalized Cannabinoid Receptor Probes: Development of Exceptionally Potent Agonists. Journal of Medicinal Chemistry 64:7, pages 3870-3884.
Crossref
Crossref
Marieka V. DeVuonoKelly M. HreljaGavin N. PetrieCheryl L. LimebeerErin M. RockMatthew N. HillLinda A. Parker. (2020) Nausea-Induced Conditioned Gaping Reactions in Rats Produced by High-Dose Synthetic Cannabinoid, JWH-018. Cannabis and Cannabinoid Research 5:4, pages 298-304.
Crossref
Crossref
Pedro González-Naranjo, Concepción Pérez, Rocío Girón, Eva M. Sánchez-Robles, María I. Martín-Fontelles, Natalia Carrillo-López, Julia Martín-Vírgala, Manuel Naves, Nuria E. Campillo & Juan A. Páez. (2020) New cannabinoid receptor antagonists as pharmacological tool. Bioorganic & Medicinal Chemistry 28:19, pages 115672.
Crossref
Crossref
Dongchen An, Steve Peigneur, Louise Antonia Hendrickx & Jan Tytgat. (2020) Targeting Cannabinoid Receptors: Current Status and Prospects of Natural Products. International Journal of Molecular Sciences 21:14, pages 5064.
Crossref
Crossref
Marieka V. DeVuonoLinda A. Parker. (2020) Cannabinoid Hyperemesis Syndrome: A Review of Potential Mechanisms. Cannabis and Cannabinoid Research 5:2, pages 132-144.
Crossref
Crossref
Marco Colizzi, Mirella Ruggeri & Sagnik Bhattacharyya. (2020) Unraveling the Intoxicating and Therapeutic Effects of Cannabis Ingredients on Psychosis and Cognition. Frontiers in Psychology 11.
Crossref
Crossref
Phil Skolnick & Roger Crystal. (2019) Cannabinoid1 (CB-1) receptor antagonists: a molecular approach to treating acute cannabinoid overdose. Journal of Neural Transmission 127:2, pages 279-286.
Crossref
Crossref
Tingting Guo, Tomohiro Tanaka, Mami Matsumoto, Kentaro Kaneko, Tomo Unzai, Yohei Ogino, Daisuke Aotani, Toru Kusakabe, Hiroshi Iwakura, Takashi Miyazawa, Kazunobu Sawamoto, Yasuhiko Minokoshi, Hiroaki Masuzaki, Nobuya Inagaki & Kazuwa Nakao. (2020) A combination of dietary fat intake and nicotine exposure enhances CB1 endocannabinoid receptor expression in hypothalamic nuclei in male mice. Neuroscience Letters 714, pages 134550.
Crossref
Crossref
Han Zhou, Xingrong Peng, Tao Hou, Nan Zhao, Minghua Qiu, Xiuli Zhang & Xinmiao Liang. (2020) Identification of novel phytocannabinoids from Ganoderma by label-free dynamic mass redistribution assay. Journal of Ethnopharmacology 246, pages 112218.
Crossref
Crossref
Andrei A. Bunaciu, Hassan Y. Aboul-Enein & Vu Dang Hoang. 2020. Vibrational Spectroscopy Applications in Biomedical, Pharmaceutical and Food Sciences. Vibrational Spectroscopy Applications in Biomedical, Pharmaceutical and Food Sciences
97
135
.
Pratishtha Singh, Anjali Ganjiwale, Allyn C. Howlett & Sudha M. Cowsik. (2019)
Molecular Interaction between Distal C-Terminal Domain of the CB
1
Cannabinoid Receptor and Cannabinoid Receptor Interacting Proteins (CRIP1a/CRIP1b)
. Journal of Chemical Information and Modeling 59:12, pages 5294-5303.
Crossref
Crossref
Robert B. Laprairie, Kiran Vemuri, Edward L. Stahl, Anisha Korde, Jo-Hao Ho, Travis W. Grim, Tian Hua, Yiran Wu, Raymond C. Stevens, Zhi-Jie Liu, Alexandros Makriyannis & Laura M. Bohn. (2019)
Probing the CB
1
Cannabinoid Receptor Binding Pocket with AM6538, a High-Affinity Irreversible Antagonist
. Molecular Pharmacology 96:5, pages 619-628.
Crossref
Crossref
Dimmito, Stefanucci, Pieretti, Minosi, Dvorácskó, Tömböly, Zengin & Mollica. (2019) Discovery of Orexant and Anorexant Agents with Indazole Scaffold Endowed with Peripheral Antiedema Activity. Biomolecules 9:9, pages 492.
Crossref
Crossref
Serena Montanari, Ali Mokhtar Mahmoud, Letizia Pruccoli, Alessandro Rabbito, Marina Naldi, Sabrina Petralla, Ignacio Moraleda, Manuela Bartolini, Barbara Monti, Isabel Iriepa, Federica Belluti, Silvia Gobbi, Vincenzo Di Marzo, Alessandra Bisi, Andrea Tarozzi, Alessia Ligresti & Angela Rampa. (2019) Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment. European Journal of Medicinal Chemistry 178, pages 243-258.
Crossref
Crossref
George Amato, Amruta Manke, Robert Wiethe, Vineetha Vasukuttan, Rodney Snyder, Yun Lan Yueh, Ann Decker, Scott Runyon & Rangan Maitra. (2019) Functionalized 6-(Piperidin-1-yl)-8,9-Diphenyl Purines as Peripherally Restricted Inverse Agonists of the CB1 Receptor. Journal of Medicinal Chemistry 62:13, pages 6330-6345.
Crossref
Crossref
Silvana Russo & Walter Filgueira De Azevedo. (2019) Advances in the Understanding of the Cannabinoid Receptor 1 – Focusing on the Inverse Agonists Interactions. Current Medicinal Chemistry 26:10, pages 1908-1919.
Crossref
Crossref
Óscar Díaz, James A. R. Dalton & Jesús Giraldo. (2019) Revealing the Mechanism of Agonist-Mediated Cannabinoid Receptor 1 (CB1) Activation and Phospholipid-Mediated Allosteric Modulation. Journal of Medicinal Chemistry 62:11, pages 5638-5654.
Crossref
Crossref
Theresa Mallick-Searle & Barbara St. Marie. (2019) Cannabinoids in Pain Treatment: An Overview. Pain Management Nursing 20:2, pages 107-112.
Crossref
Crossref
Dai Lu, Sri Sujana Immadi, Zhixing Wu & Debra A. Kendall. (2018) Translational potential of allosteric modulators targeting the cannabinoid CB1 receptor. Acta Pharmacologica Sinica 40:3, pages 324-335.
Crossref
Crossref
Bing Zhang, Jun Li, Xiaolin Yang, Lijie Wu, Jia Zhang, Yang Yang, Yao Zhao, Lu Zhang, Xiuna Yang, Xiaobao Yang, Xi Cheng, Zhijie Liu, Biao Jiang, Hualiang Jiang, Luke W. Guddat, Haitao Yang & Zihe Rao. (2019) Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target. Cell 176:3, pages 636-648.e13.
Crossref
Crossref
Xiaoting Li, Tian Hua, Kiran Vemuri, Jo-Hao Ho, Yiran Wu, Lijie Wu, Petr Popov, Othman Benchama, Nikolai Zvonok, K’ara Locke, Lu Qu, Gye Won Han, Malliga R. Iyer, Resat Cinar, Nathan J. Coffey, Jingjing Wang, Meng Wu, Vsevolod Katritch, Suwen Zhao, George Kunos, Laura M. Bohn, Alexandros Makriyannis, Raymond C. Stevens & Zhi-Jie Liu. (2019) Crystal Structure of the Human Cannabinoid Receptor CB2. Cell 176:3, pages 459-467.e13.
Crossref
Crossref
David R. Janero, V. Kiran Vemuri & Alexandros Makriyannis. 2019. Cannabis Use Disorders. Cannabis Use Disorders
43
54
.
Duck-Pil Ok, Kangeun Ko & Ju Yong Bae. (2018) Exercise without dietary changes alleviates nonalcoholic fatty liver disease without weight loss benefits. Lipids in Health and Disease 17:1.
Crossref
Crossref
Marieka V. DeVuono, Kelly M. Hrelja, Lauren Sabaziotis, Alex Rajna, Erin M. Rock, Cheryl L. Limebeer, David M. Mutch & Linda A. Parker. (2018) Conditioned gaping produced by high dose Δ9-tetrahydracannabinol: Dysregulation of the hypothalamic endocannabinoid system. Neuropharmacology 141, pages 272-282.
Crossref
Crossref
Cheng Liu, Congmin Yuan, Pinwen Wu, Chen Zhu, Hao Fang, Lili Wang & Wei Fu. (2018) Computational investigation on the binding modes of Rimonabant analogs with CB1 and CB2. Chemical Biology & Drug Design 92:3, pages 1699-1707.
Crossref
Crossref
Anna Gorzkiewicz & Janusz Szemraj. (2018) Brain endocannabinoid signaling exhibits remarkable complexity. Brain Research Bulletin 142, pages 33-46.
Crossref
Crossref
George S. Amato, Amruta Manke, Vineetha Vasukuttan, Robert W. Wiethe, Rodney W. Snyder, Scott P. Runyon & Rangan Maitra. (2018) Synthesis and pharmacological characterization of functionalized 6-piperazin-1-yl-purines as cannabinoid receptor 1 (CB1) inverse agonists. Bioorganic & Medicinal Chemistry 26:15, pages 4518-4531.
Crossref
Crossref
Malliga R. Iyer, Resat Cinar, Nathan J. Coffey & George Kunos. (2018)
Synthesis of
13
C
6
-labeled, dual-target inhibitor of cannabinoid-1 receptor (CB
1
R) and inducible nitric oxide synthase (iNOS)
. Journal of Labelled Compounds and Radiopharmaceuticals 61:10, pages 773-779.
Crossref
Crossref
E. Haijen, M. Farre, R. de la Torre, A. Pastor, E. Olesti, N. Pizarro, J. G. Ramaekers & K. P. C. Kuypers. (2017) Peripheral endocannabinoid concentrations are not associated with verbal memory impairment during MDMA intoxication. Psychopharmacology 235:3, pages 709-717.
Crossref
Crossref
Yoonji Lee, Shaherin Basith & Sun Choi. (2017) Recent Advances in Structure-Based Drug Design Targeting Class A G Protein-Coupled Receptors Utilizing Crystal Structures and Computational Simulations. Journal of Medicinal Chemistry 61:1, pages 1-46.
Crossref
Crossref
Hideyo Takahashi, Koji Araki, Kosho Makino, Hidetsugu Tabata, Hiroshi Nakayama, Kei Zaitsu, Tetsuta Oshitari & Hideaki Natsugari. (2018) Synthesis of 3-Aroylindoles as Intermediates of Cannabimimetics and Elucidation of Their Physicochemical Properties. HETEROCYCLES 96:5, pages 910.
Crossref
Crossref
Matthias V. Westphal, Michael A. Schafroth, Roman C. Sarott, Michael A. Imhof, Christian P. Bold, Philipp Leippe, Amey Dhopeshwarkar, Jessica M. Grandner, Vsevolod Katritch, Ken Mackie, Dirk Trauner, Erick M. Carreira & James A. Frank. (2017)
Synthesis of Photoswitchable Δ
9
-Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling
. Journal of the American Chemical Society 139:50, pages 18206-18212.
Crossref
Crossref
Shao-Hua Su, Yi-Fang Wu, Qi Lin & Jian Hai. (2017) Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 ameliorate neuroinflammatory responses in chronic cerebral hypoperfusion model by blocking NF-κB pathways. Naunyn-Schmiedeberg's Archives of Pharmacology 390:12, pages 1189-1200.
Crossref
Crossref
Gareth Pryce & David Baker. (2017)
Antidote to cannabinoid intoxication: the CB
1
receptor inverse agonist, AM251, reverses hypothermic effects of the CB
1
receptor agonist, CB‐13, in mice
. British Journal of Pharmacology 174:21, pages 3790-3794.
Crossref
Crossref
Wei Chen, Fengchun Shui, Cheng Liu, Xinbo Zhou, Wei Li, Zhibing Zheng, Wei Fu & Lili Wang. (2017) Novel Peripherally Restricted Cannabinoid 1 Receptor Selective Antagonist TXX-522 with Prominent Weight-Loss Efficacy in Diet Induced Obese Mice. Frontiers in Pharmacology 8.
Crossref
Crossref
Ying Shi, Yan-Hui Duan, Yue-Yang Ji, Zhi-Long Wang, Yan-Ran Wu, Hendra Gunosewoyo, Xiao-Yu Xie, Jian-Zhong Chen, Fan Yang, Jing Li, Jie Tang, Xin Xie & Li-Fang Yu. (2017) Amidoalkylindoles as Potent and Selective Cannabinoid Type 2 Receptor Agonists with in Vivo Efficacy in a Mouse Model of Multiple Sclerosis. Journal of Medicinal Chemistry 60:16, pages 7067-7083.
Crossref
Crossref
Balázs Varga, Ferenc Kassai, György Szabó, Péter Kovács, János Fischer & István Gyertyán. (2017) Pharmacological comparison of traditional and non-traditional cannabinoid receptor 1 blockers in rodent models in vivo. Pharmacology Biochemistry and Behavior 159, pages 24-35.
Crossref
Crossref
Chisayo Kozuka, Tadashi Kaname, Chigusa Shimizu-Okabe, Chitoshi Takayama, Masato Tsutsui, Masayuki Matsushita, Keiko Abe & Hiroaki Masuzaki. (2017) Impact of brown rice-specific γ-oryzanol on epigenetic modulation of dopamine D2 receptors in brain striatum in high-fat-diet-induced obesity in mice. Diabetologia 60:8, pages 1502-1511.
Crossref
Crossref
Malliga R. Iyer, Resat Cinar, Alexis Katz, Michael Gao, Katalin Erdelyi, Tony Jourdan, Nathan J. Coffey, Pal Pacher & George Kunos. (2017)
Design, Synthesis, and Biological Evaluation of Novel, Non-Brain-Penetrant, Hybrid Cannabinoid CB
1
R Inverse Agonist/Inducible Nitric Oxide Synthase (iNOS) Inhibitors for the Treatment of Liver Fibrosis
. Journal of Medicinal Chemistry 60:3, pages 1126-1141.
Crossref
Crossref
Giulio Ragusa, María Gómez-Cañas, Paula Morales, Carmen Rodríguez-Cueto, María R. Pazos, Battistina Asproni, Elena Cichero, Paola Fossa, Gerard A. Pinna, Nadine Jagerovic, Javier Fernández-Ruiz & Gabriele Murineddu. (2017) New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking. European Journal of Medicinal Chemistry 127, pages 398-412.
Crossref
Crossref
David R. Janero, Anisha Korde & Alexandros Makriyannis. 2017. Cannabinoids and Their Receptors. Cannabinoids and Their Receptors
217
235
.
S. Deiana. 2017. Handbook of Cannabis and Related Pathologies. Handbook of Cannabis and Related Pathologies
958
967
.
Yoshiro Ishimaru, Chisayo Kozuka, Kenichiro Nakajima & Tsutomu Sasaki. (2016) Expanding frontiers in weight-control research explored by young investigators. The Journal of Physiological Sciences 67:1, pages 83-95.
Crossref
Crossref
Meghan R. Johnston, Alexandros Makriyannis, Kyle M. Whitten, Olivia C. Drew & Fiona A. Best. (2016) Biocatalyzed Regioselective Synthesis in Undergraduate Organic Laboratories: Multistep Synthesis of 2-Arachidonoylglycerol. Journal of Chemical Education 93:12, pages 2080-2083.
Crossref
Crossref
Aliou B. Gueye, Yaroslaw Pryslawsky, Jose M. Trigo, Nafsika Poulia, Foteini Delis, Katerina Antoniou, Michael Loureiro, Steve R. Laviolette, Kiran Vemuri, Alexandros Makriyannis & Bernard Le Foll. (2016)
The CB
1
Neutral Antagonist AM4113 Retains the Therapeutic Efficacy of the Inverse Agonist Rimonabant for Nicotine Dependence and Weight Loss with Better Psychiatric Tolerability
. International Journal of Neuropsychopharmacology 19:12, pages pyw068.
Crossref
Crossref
Zhenhua Shao, Jie Yin, Karen Chapman, Magdalena Grzemska, Lindsay Clark, Junmei Wang & Daniel M. Rosenbaum. (2016) High-resolution crystal structure of the human CB1 cannabinoid receptor. Nature 540:7634, pages 602-606.
Crossref
Crossref
Rachelle Abouchedid, James H. Ho, Simon Hudson, Alison Dines, John R. H. Archer, David M. Wood & Paul I. Dargan. (2016) Acute Toxicity Associated with Use of 5F-Derivations of Synthetic Cannabinoid Receptor Agonists with Analytical Confirmation. Journal of Medical Toxicology 12:4, pages 396-401.
Crossref
Crossref
Bin Zhu, Jay M. Matthews, Mingde Xia, Shawn Black, Cailin Chen, Cuifen Hou, Yin Liang, Yuting Tang & Mark J. Macielag. (2016) Tetrahydropyrazolo[4,3-c]pyridine derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists. Bioorganic & Medicinal Chemistry Letters 26:22, pages 5597-5601.
Crossref
Crossref
Tian Hua, Kiran Vemuri, Mengchen Pu, Lu Qu, Gye Won Han, Yiran Wu, Suwen Zhao, Wenqing Shui, Shanshan Li, Anisha Korde, Robert B. Laprairie, Edward L. Stahl, Jo-Hao Ho, Nikolai Zvonok, Han Zhou, Irina Kufareva, Beili Wu, Qiang Zhao, Michael A. Hanson, Laura M. Bohn, Alexandros Makriyannis, Raymond C. Stevens & Zhi-Jie Liu. (2016) Crystal Structure of the Human Cannabinoid Receptor CB1. Cell 167:3, pages 750-762.e14.
Crossref
Crossref
Charles W Schindler, Godfrey H Redhi, Kiran Vemuri, Alexandros Makriyannis, Bernard Le Foll, Jack Bergman, Steven R Goldberg & Zuzana Justinova. (2016) Blockade of Nicotine and Cannabinoid Reinforcement and Relapse by a Cannabinoid CB1-Receptor Neutral Antagonist AM4113 and Inverse Agonist Rimonabant in Squirrel Monkeys. Neuropsychopharmacology 41:9, pages 2283-2293.
Crossref
Crossref
M. G?mez-Ca?as, P. Morales, L. Garc?a-Toscano, C. Navarrete, E. Mu?oz, N. Jagerovic, J. Fern?ndez-Ruiz, M. Garc?a-Arencibia & M.R. Pazos. (2016) Biological characterization of PM226, a chromenoisoxazole, as a selective CB 2 receptor agonist with neuroprotective profile. Pharmacological Research 110, pages 205-215.
Crossref
Crossref
Maria Scherma, Anna Lisa Muntoni, Miriam Melis, Liana Fattore, Paola Fadda, Walter Fratta & Marco Pistis. (2016) Interactions between the endocannabinoid and nicotinic cholinergic systems: preclinical evidence and therapeutic perspectives. Psychopharmacology 233:10, pages 1765-1777.
Crossref
Crossref
Valeria Deiana, María Gómez-Cañas, M. Ruth Pazos, Javier Fernández-Ruiz, Battistina Asproni, Elena Cichero, Paola Fossa, Eduardo Muñoz, Francesco Deligia, Gabriele Murineddu, Moisés García-Arencibia & Gerard A. Pinna. (2016) Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties. European Journal of Medicinal Chemistry 112, pages 66-80.
Crossref
Crossref
Chaowei Ma, Ping Wen, Jihui Li, Xu Han, Zhaoyang Wu & Guosheng Huang. (2016) Palladium and Copper Cocatalyzed Intermolecular Cyclization Reaction: Synthesis of 5-Aminopyrazole Derivatives. Advanced Synthesis & Catalysis 358:7, pages 1073-1077.
Crossref
Crossref
Alan Fulp, Yanan Zhang, Katherine Bortoff, Herbert Seltzman, Rodney Snyder, Robert Wiethe, George Amato & Rangan Maitra. (2016) Pyrazole antagonists of the CB1 receptor with reduced brain penetration. Bioorganic & Medicinal Chemistry 24:5, pages 1063-1070.
Crossref
Crossref
L.V. Panlilio, Z. Justinova, J.M. Trigo & B. Le Foll. 2016. Animal Models for Medications Screening to Treat Addiction. Animal Models for Medications Screening to Treat Addiction
87
120
.
Dai Lu, Rachel Dopart & Debra A. Kendall. (2015) Controlled downregulation of the cannabinoid CB1 receptor provides a promising approach for the treatment of obesity and obesity-derived type 2 diabetes. Cell Stress and Chaperones 21:1, pages 1-7.
Crossref
Crossref
James S. Brodie, Vincenzo Di Marzo & Geoffrey W. Guy. (2015) Polypharmacology Shakes Hands with Complex Aetiopathology. Trends in Pharmacological Sciences 36:12, pages 802-821.
Crossref
Crossref
S.-H. Su, Y.-F. Wu, Q. Lin, F. Yu & J. Hai. (2015) Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 suppress chronic cerebral hypoperfusion-induced neuronal apoptosis by inhibiting c-Jun N-terminal kinase signaling. Neuroscience 301, pages 563-575.
Crossref
Crossref
Elisabetta Esposito, Laura Ravani, Markus Drechsler, Paolo Mariani, Catia Contado, Janne Ruokolainen, Patrizia Ratano, Patrizia Campolongo, Viviana Trezza, Claudio Nastruzzi & Rita Cortesi. (2015) Cannabinoid antagonist in nanostructured lipid carriers (NLCs): design, characterization and in vivo study. Materials Science and Engineering: C 48, pages 328-336.
Crossref
Crossref
M. M. Mahmoud, T. Olszewska, H. Liu, D. M. Shore, D. P. Hurst, P. H. Reggio, D. Lu & D. A. Kendall. (2014) (4-(Bis(4-Fluorophenyl)Methyl)Piperazin-1-yl)(Cyclohexyl)Methanone Hydrochloride (LDK1229): A New Cannabinoid CB1 Receptor Inverse Agonist from the Class of Benzhydryl Piperazine Analogs. Molecular Pharmacology 87:2, pages 197-206.
Crossref
Crossref
A.C. Pascual, A.M. Martín-Moreno, N.M. Giusto, M.L. de Ceballos & S.J. Pasquaré. (2014) Normal aging in rats and pathological aging in human Alzheimer’s disease decrease FAAH activity: Modulation by cannabinoid agonists. Experimental Gerontology 60, pages 92-99.
Crossref
Crossref
Lesley D. O?Brien, Martin A. Sticht, Krista A. Mitchnick, Cheryl L. Limebeer, Linda A. Parker & Boyer D. Winters. (2014) CB1 receptor antagonism in the granular insular cortex or somatosensory area facilitates consolidation of object recognition memory. Neuroscience Letters 578, pages 192-196.
Crossref
Crossref
Javier Fernández‐Ruiz, Mariluz Hernández & Yolanda García‐Movellán. 2014. Cannabinoids. Cannabinoids
175
218
.
Mukesh C. Sharma. (2013) Discovery of new lead pyrimidines derivatives as potential cannabinoid CB1 receptor antagonistic through molecular modeling and pharmacophore approach. Medicinal Chemistry Research 23:5, pages 2287-2311.
Crossref
Crossref
Stephan Röver, Mirjana Andjelkovic, Agnès Bénardeau, Evelyne Chaput, Wolfgang Guba, Paul Hebeisen, Susanne Mohr, Matthias Nettekoven, Ulrike Obst, Wolfgang F. Richter, Christoph Ullmer, Pius Waldmeier & Matthew B. Wright. (2013) 6-Alkoxy-5-aryl-3-pyridinecarboxamides, a New Series of Bioavailable Cannabinoid Receptor Type 1 (CB1) Antagonists Including Peripherally Selective Compounds. Journal of Medicinal Chemistry 56:24, pages 9874-9896.
Crossref
Crossref
Alan Fulp, Katherine Bortoff, Yanan Zhang, Rodney Snyder, Tim Fennell, Julie A. Marusich, Jenny L. Wiley, Herbert Seltzman & Rangan Maitra. (2013) Peripherally Selective Diphenyl Purine Antagonist of the CB1 Receptor. Journal of Medicinal Chemistry 56:20, pages 8066-8072.
Crossref
Crossref
Robert J. Chorvat. (2013) Peripherally restricted CB1 receptor blockers. Bioorganic & Medicinal Chemistry Letters 23:17, pages 4751-4760.
Crossref
Crossref
Samuel D. Banister, Shane M. Wilkinson, Mitchell Longworth, Jordyn Stuart, Nadine Apetz, Katrina English, Lance Brooker, Catrin Goebel, David E. Hibbs, Michelle Glass, Mark Connor, Iain S. McGregor & Michael Kassiou. (2013) The Synthesis and Pharmacological Evaluation of Adamantane-Derived Indoles: Cannabimimetic Drugs of Abuse. ACS Chemical Neuroscience 4:7, pages 1081-1092.
Crossref
Crossref
Tamara Vasiljevik, Lirit N. Franks, Benjamin M. Ford, Justin T. Douglas, Paul L. Prather, William E. Fantegrossi & Thomas E. Prisinzano. (2013) Design, Synthesis, and Biological Evaluation of Aminoalkylindole Derivatives as Cannabinoid Receptor Ligands with Potential for Treatment of Alcohol Abuse. Journal of Medicinal Chemistry 56:11, pages 4537-4550.
Crossref
Crossref
Stephanie C. Tucker & Kenneth V. Honn. (2013) Emerging targets in lipid-based therapy. Biochemical Pharmacology 85:5, pages 673-688.
Crossref
Crossref
Lesley D. O'Brien, Kiri L. Wills, Blair Segsworth, Brittany Dashney, Erin M. Rock, Cheryl L. Limebeer & Linda A. Parker. (2013) Effect of chronic exposure to rimonabant and phytocannabinoids on anxiety-like behavior and saccharin palatability. Pharmacology Biochemistry and Behavior 103:3, pages 597-602.
Crossref
Crossref
Ana Franky Carvalho & Elisabeth J. Van Bockstaele. 2013. Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders. Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders
135
156
.
Bal?zs Varga, Ferenc Kassai & Istv?n Gyerty?n. (2012) Interactions of CB1 and mGlu5 receptor antagonists in food intake, anxiety and memory models in rats. Pharmacology Biochemistry and Behavior 103:2, pages 425-430.
Crossref
Crossref
Alan Fulp, Katherine Bortoff, Yanan Zhang, Herbert Seltzman, James Mathews, Rodney Snyder, Tim Fennell & Rangan Maitra. (2012) Diphenyl Purine Derivatives as Peripherally Selective Cannabinoid Receptor 1 Antagonists. Journal of Medicinal Chemistry 55:22, pages 10022-10032.
Crossref
Crossref
CL Limebeer, EM Rock, R Mechoulam & LA Parker. (2012)
The anti-nausea effects of CB
1
agonists are mediated by an action at the visceral insular cortex
. British Journal of Pharmacology 167:5, pages 1126-1136.
Crossref
Crossref
Elisabeth J. Van Bockstaele. (2012) Cannabinoid receptor signaling and modulation of monoamines: Implications for psychiatric and neurological disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry 38:1, pages 1-3.
Crossref
Crossref
R. B. Raffa & S. J. Ward. (2012) CB1-independent mechanisms of ?9-THCV, AM251 and SR141716 (rimonabant). Journal of Clinical Pharmacy and Therapeutics 37:3, pages 260-265.
Crossref
Crossref
Alan Fulp, Katherine Bortoff, Herbert Seltzman, Yanan Zhang, James Mathews, Rodney Snyder, Tim Fennell & Rangan Maitra. (2012) Design and Synthesis of Cannabinoid Receptor 1 Antagonists for Peripheral Selectivity. Journal of Medicinal Chemistry 55:6, pages 2820-2834.
Crossref
Crossref
Hideki Fujii & Norifumi Kawada. (2012) Inflammation and fibrogenesis in steatohepatitis. Journal of Gastroenterology 47:3, pages 215-225.
Crossref
Crossref
Antonia Serrano & Loren H. Parsons. (2011) Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors. Pharmacology & Therapeutics 132:3, pages 215-241.
Crossref
Crossref
Laura H. Jacobson, S. Renee Commerford, Sarah P. Gerber, Yu Alice Chen, Beatriz Dardik, Frederique Chaperon, Chad Schwartzkopf, Van Nguyen-Tran, Thomas Hollenbeck, Peter McNamara, Xiaohui He, Hong Liu, H. Martin Seidel, Anne-Liese Jaton, Jesper Gromada & Sandra Teixeira. (2011) Characterization of a novel, brain-penetrating CB1 receptor inverse agonist: metabolic profile in diet-induced obese models and aspects of central activity. Naunyn-Schmiedeberg's Archives of Pharmacology 384:6, pages 565-581.
Crossref
Crossref
Linghuan Gao, Min Li, Tao Meng, Hongli Peng, Xin Xie, Yongliang Zhang, Yu Jin, Xin Wang, Libo Zou & Jingkang Shen. (2011) Asymmetric synthesis and biological evaluation of N-cyclohexyl-4-[1-(2,4-dichlorophenyl)-1-(p-tolyl)methyl]piperazine-1-carboxamide as hCB1 receptor antagonists. European Journal of Medicinal Chemistry 46:11, pages 5310-5316.
Crossref
Crossref
Leslie Iversen. 2011. Marijuana and Madness. Marijuana and Madness
1
16
.
Dennis W. Szymanski, Malvina Papanastasiou, Katja Melchior, Nikolai Zvonok, Richard W. Mercier, David R. Janero, Ganesh A. Thakur, Sangwon Cha, Billy Wu, Barry Karger & Alexandros Makriyannis. (2011) Mass Spectrometry-based Proteomics of Human Cannabinoid Receptor 2: Covalent Cysteine 6.47(257)-Ligand Interaction Affording Megagonist Receptor Activation. Journal of Proteome Research 10:10, pages 4789-4798.
Crossref
Crossref
David A. Gorelick, Robert S. Goodwin, Eugene Schwilke, David M. Schwope, William D. Darwin, Deanna L. Kelly, Robert P. McMahon, Fang Liu, Catherine Ortemann-Renon, Denis Bonnet & Marilyn A. Huestis. (2011) Antagonist-Elicited Cannabis Withdrawal in Humans. Journal of Clinical Psychopharmacology 31:5, pages 603-612.
Crossref
Crossref
Alan Fulp, Katherine Bortoff, Yanan Zhang, Herbert Seltzman, Rodney Snyder & Rangan Maitra. (2011) Towards rational design of cannabinoid receptor 1 (CB1) antagonists for peripheral selectivity. Bioorganic & Medicinal Chemistry Letters 21:19, pages 5711-5714.
Crossref
Crossref
Wei Chen, Cheng Xu, Hong-ying Liu, Long Long, Wei Zhang, Zhi-bing Zheng, Yun-de Xie, Li-li Wang & Song Li. (2011) Novel selective cannabinoid CB1 receptor antagonist MJ08 with potent in vivo bioactivity and inverse agonistic effects. Acta Pharmacologica Sinica 32:9, pages 1148-1158.
Crossref
Crossref
Javier Fernández‐Ruiz, Miguel Moreno‐Martet, Carmen Rodríguez‐Cueto, Cristina Palomo‐Garo, María Gómez‐Cañas, Sara Valdeolivas, Carmen Guaza, Julián Romero, Manuel Guzmán, Raphael Mechoulam & José A Ramos. (2011) Prospects for cannabinoid therapies in basal ganglia disorders. British Journal of Pharmacology 163:7, pages 1365-1378.
Crossref
Crossref
Chia-Shan Wu, Christopher P Jew & Hui-Chen Lu. (2011) Lasting impacts of prenatal cannabis exposure and the role of endogenous cannabinoids in the developing brain. Future Neurology 6:4, pages 459-480.
Crossref
Crossref
Jos H.M. Lange, Stefan Verhoog, Hans J. Sanders, Arnold van Loevezijn & Chris G. Kruse. (2011) A novel atom-efficient, one-pot synthesis of sulfonylguanidines and sulfamoylguanidines. Tetrahedron Letters 52:25, pages 3198-3200.
Crossref
Crossref
Mariko Kitajima, Masumi Iwai, Ruri Kikura-Hanajiri, Yukihiro Goda, Mitsuru Iida, Hisatoshi Yabushita & Hiromitsu Takayama. (2011) Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity. Bioorganic & Medicinal Chemistry Letters 21:7, pages 1962-1964.
Crossref
Crossref
Elvis K. Tiburu, Sergiy Tyukhtenko, Han Zhou, David R. Janero, Jochem Struppe & Alexandros Makriyannis. (2011) Human Cannabinoid 1 GPCR C-Terminal Domain Interacts with Bilayer Phospholipids to Modulate the Structure of its Membrane Environment. The AAPS Journal 13:1, pages 92-98.
Crossref
Crossref
Jos H.M. Lange, Hans J. Sanders & Jeroen van Rheenen. (2011) An expedient atom-efficient synthesis of the cannabinoid CB1 receptor inverse agonist ibipinabant. Tetrahedron Letters 52:12, pages 1303-1305.
Crossref
Crossref
Changyu Pan, Hyung Joon Yoo & Low-Tone Ho. (2011) Perspectives of CB1 Antagonist in Treatment of Obesity: Experience of RIO-Asia. Journal of Obesity 2011, pages 1-11.
Crossref
Crossref
Raphael Rozenfeld. (2010) Type I Cannabinoid Receptor Trafficking: All Roads Lead to Lysosome. Traffic 12:1, pages 12-18.
Crossref
Crossref
B.J. Venhuis, M.V. Vredenbregt, N. Kaun, J.K. Maurin, Z. Fijałek & D. de Kaste. (2011) The identification of rimonabant polymorphs, sibutramine and analogues of both in counterfeit Acomplia bought on the internet. Journal of Pharmaceutical and Biomedical Analysis 54:1, pages 21-26.
Crossref
Crossref
Alexander C. Bertalovitz, Kwang H. Ahn & Debra A. Kendall. (2010) Ligand binding sensitivity of the extracellular loop two of the cannabinoid receptor 1. Drug Development Research 71:7, pages 404-411.
Crossref
Crossref
Lenka Milfortová. (2010) Kanabinoidy. Kontakt 12:3, pages 343-351.
Crossref
Crossref
NL Cluny, VK Vemuri, AP Chambers, CL Limebeer, H Bedard, JT Wood, B Lutz, A Zimmer, LA Parker, A Makriyannis & KA Sharkey. (2010) A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents. British Journal of Pharmacology 161:3, pages 629-642.
Crossref
Crossref
Richard W. Mercier, Ying Pei, Lakshmipathi Pandarinathan, David R. Janero, Jing Zhang & Alexandros Makriyannis. (2010) hCB2 Ligand-Interaction Landscape: Cysteine Residues Critical to Biarylpyrazole Antagonist Binding Motif and Receptor Modulation. Chemistry & Biology 17:10, pages 1132-1142.
Crossref
Crossref
Ming-Shiu Hung, Chun-Ping Chang, Ting-Chieh Li, Teng-Kuang Yeh, Jen-Shin Song, Yinchiu Lin, Chien-Huang Wu, Po-Chu Kuo, Prashanth K. Amancha, Ying-Chieh Wong, Wen-Chi Hsiao, Yu-Sheng Chao & Kak-Shan Shia. (2010) Discovery of 1-(2,4-Dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a Potential Peripheral Cannabinoid-1 Receptor Inverse Agonist. ChemMedChem 5:9, pages 1439-1443.
Crossref
Crossref
CL Limebeer, VK Vemuri, H Bedard, ST Lang, KP Ossenkopp, A Makriyannis & LA Parker. (2010) Inverse agonism of cannabinoid CB1 receptors potentiates LiCl-induced nausea in the conditioned gaping model in rats. British Journal of Pharmacology 161:2, pages 336-349.
Crossref
Crossref
Chad E. Beyer, Jason M. Dwyer, Michael J. Piesla, Brian J. Platt, Ru Shen, Zia Rahman, Karen Chan, Melissa T. Manners, Tarek A. Samad, Jeffrey D. Kennedy, Brendan Bingham & Garth T. Whiteside. (2010) Depression-like phenotype following chronic CB1 receptor antagonism. Neurobiology of Disease 39:2, pages 148-155.
Crossref
Crossref
Ihor E. Kopka, Linus S. Lin, James P. Jewell, Thomas J. Lanza, Tung M. Fong, Chun-Pyn Shen, Zhege J. Lao, Sookhee Ha, Laurie G. Castonguay, Lex Van der Ploeg, Mark T. Goulet & William K. Hagmann. (2010) Synthesis and cannabinoid-1 receptor binding affinity of conformationally constrained analogs of taranabant. Bioorganic & Medicinal Chemistry Letters 20:16, pages 4757-4761.
Crossref
Crossref
Wei Chen, Huoling Tang, Hongying Liu, Long Long, Zehui Gong, Jianquan Zheng, Mugen Chi, Yunde Xie, Zhibing Zheng, Song Li & Lili Wang. (2010) Novel selective antagonist of the cannabinoid CB1 receptor, MJ15, with prominent anti-obesity effect in rodent models. European Journal of Pharmacology 637:1-3, pages 178-185.
Crossref
Crossref
JodiAnne T. Wood, John S. Williams, Lakshmipathi Pandarinathan, David R. Janero, Carol J. Lammi-Keefe & Alexandros Makriyannis. (2010) Dietary docosahexaenoic acid supplementation alters select physiological endocannabinoid-system metabolites in brain and plasma. Journal of Lipid Research 51:6, pages 1416-1423.
Crossref
Crossref
Tricia H Smith, Laura J Sim‐Selley & Dana E Selley. (2010)
Cannabinoid CB
1
receptor‐interacting proteins: novel targets for central nervous system drug discovery?
. British Journal of Pharmacology 160:3, pages 454-466.
Crossref
Crossref
Nikolai Zvonok, Wei Xu, John Williams, David R. Janero, Srinivasan C. Krishnan & Alexandros Makriyannis. (2010) Mass Spectrometry-Based GPCR Proteomics: Comprehensive Characterization of the Human Cannabinoid 1 Receptor. Journal of Proteome Research 9:4, pages 1746-1753.
Crossref
Crossref
Angelo A. Izzo & Keith A. Sharkey. (2010) Cannabinoids and the gut: New developments and emerging concepts. Pharmacology & Therapeutics 126:1, pages 21-38.
Crossref
Crossref
Jeannie Hwang, Crista Adamson, David Butler, David R. Janero, Alexandros Makriyannis & Ben A. Bahr. (2010) Enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: A neuroprotective therapeutic modality. Life Sciences 86:15-16, pages 615-623.
Crossref
Crossref
M-H Son, H D Kim, Y N Chae, M-K Kim, C Y Shin, G J Ahn, S-h Choi, E K Yang, K-J Park, H W Chae, H-S Moon, S-H Kim, Y-G Shin & S-H Yoon. (2009) Peripherally acting CB1-receptor antagonist: the relative importance of central and peripheral CB1 receptors in adiposity control. International Journal of Obesity 34:3, pages 547-556.
Crossref
Crossref
Tao Meng, Jue Wang, Hongli Peng, Guanghua Fang, Min Li, Bing Xiong, Xin Xie, Yongliang Zhang, Xin Wang & Jingkang Shen. (2010) Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach. European Journal of Medicinal Chemistry 45:3, pages 1133-1139.
Crossref
Crossref
Abishek Iyer, David P. Fairlie, Johannes B. Prins, Bruce D. Hammock & Lindsay Brown. (2010) Inflammatory lipid mediators in adipocyte function and obesity. Nature Reviews Endocrinology 6:2, pages 71-82.
Crossref
Crossref
Jean-Marie Receveur, Anthony Murray, Jean-Michel Linget, Pia K. Nørregaard, Martin Cooper, Emelie Bjurling, Peter Aadal Nielsen & Thomas Högberg. (2010) Conversion of 4-cyanomethyl-pyrazole-3-carboxamides into CB1 antagonists with lowered propensity to pass the blood–brain-barrier. Bioorganic & Medicinal Chemistry Letters 20:2, pages 453-457.
Crossref
Crossref
Martin Cooper, Jean-Marie Receveur, Emelie Bjurling, Pia K. N?rregaard, Peter Aadal Nielsen, Niklas Sk?ld & Thomas H?gberg. (2010) Exploring SAR features in diverse library of 4-cyanomethyl-pyrazole-3-carboxamides suitable for further elaborations as CB1 antagonists. Bioorganic & Medicinal Chemistry Letters 20:1, pages 26-30.
Crossref
Crossref
Vincent J. Aloyo, Kelly A. Berg, William P. Clarke, Umberto Spampinato & John A. Harvey. 2010. Membrane Proteins as Drug Targets. Membrane Proteins as Drug Targets
1
40
.
Sergiy Tyukhtenko, Elvis K. Tiburu, Lalit Deshmukh, Olga Vinogradova, David R. Janero & Alexandros Makriyannis. (2009) NMR solution structure of human cannabinoid receptor-1 helix 7/8 peptide: Candidate electrostatic interactions and microdomain formation. Biochemical and Biophysical Research Communications 390:3, pages 441-446.
Crossref
Crossref
Lance L. Stein, Mamie H. Dong & Rohit Loomba. (2009) Insulin sensitizers in nonalcoholic fatty liver disease and steatohepatitis: Current status. Advances in Therapy 26:10, pages 893-907.
Crossref
Crossref
Chien-Huang Wu, Ming-Shiu Hung, Jen-Shin Song, Teng-Kuang Yeh, Ming-Chen Chou, Cheng-Ming Chu, Jiing-Jyh Jan, Min-Tsang Hsieh, Shi-Liang Tseng, Chun-Ping Chang, Wan-Ping Hsieh, Yinchiu Lin, Yen-Nan Yeh, Wan-Ling Chung, Chun-Wei Kuo, Chin-Yu Lin, Horng-Shing Shy, Yu-Sheng Chao & Kak-Shan Shia. (2009)
Discovery of 2-[5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1
H
-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an Active Metabolite. A Novel, Potent and Selective Cannabinoid-1 Receptor Inverse Agonist with High Antiobesity Efficacy in DIO Mice
. Journal of Medicinal Chemistry 52:14, pages 4496-4510.
Crossref
Crossref
Elvis K. Tiburu, Stefano V. Gulla, Mark Tiburu, David R. Janero, David E. Budil & Alexandros Makriyannis. (2009) Dynamic Conformational Responses of a Human Cannabinoid Receptor-1 Helix Domain to Its Membrane Environment. Biochemistry 48:22, pages 4895-4904.
Crossref
Crossref
Stefania Petrosino, Alessia Ligresti & Vincenzo Di Marzo. (2009) Endocannabinoid chemical biology: a tool for the development of novel therapies. Current Opinion in Chemical Biology 13:3, pages 309-320.
Crossref
Crossref