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Review

Emerging Flt3 kinase inhibitors in the treatment of leukaemia

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Pages 153-165 | Published online: 27 Feb 2006

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Jack W Singer, Suliman Al-Fayoumi, Haiching Ma, Rami S Komrokji, Ruben Mesa & Srdan Verstovsek. (2016) Comprehensive kinase profile of pacritinib, a nonmyelosuppressive Janus kinase 2 inhibitor. Journal of Experimental Pharmacology 8, pages 11-19.
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Joana M. O. Santos, Alexandra C. Costa, Tânia R. Dias, Setareh Satari, Maria Paula Costa e Silva, Rui M. Gil da Costa & Rui Medeiros. (2021) Towards Drug Repurposing in Cancer Cachexia: Potential Targets and Candidates. Pharmaceuticals 14:11, pages 1084.
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Manoj Garg, Yasunobu NagataDeepika KanojiaAnand MayakondaKenichi YoshidaSreya Haridas KelothZhi Jiang ZangYusuke OkunoYuichi Shiraishi, Kenichi Chiba, Hiroko TanakaSatoru MiyanoLing-Wen DingTamara AlpermannQiao-Yang SunDe-Chen LinWenwen ChienVikas MadanLi-Zhen LiuKar-Tong TanAbhishek SampathSubhashree VenkatesanKoiti InokuchiSatoshi WakitaHiroki YamaguchiWee Joo ChngShirley-Kow Yin KhamAllen Eng-Juh YeohMasashi SanadaJoanna SchillerKarl-Anton KreuzerSteven M. KornblauHagop M. KantarjianTorsten HaferlachMichael LillMing-Chung KuoLee-Yung ShihIgor-Wolfgang Blau, Olga Blau, Henry YangSeishi OgawaH. Phillip Koeffler. (2015) Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse. Blood 126:22, pages 2491-2501.
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K C Goh, V Novotny-Diermayr, S Hart, L C Ong, Y K Loh, A Cheong, Y C Tan, C Hu, R Jayaraman, A D William, E T Sun, B W Dymock, K H Ong, K Ethirajulu, F Burrows & J M Wood. (2011) TG02, a novel oral multi-kinase inhibitor of CDKs, JAK2 and FLT3 with potent anti-leukemic properties. Leukemia 26:2, pages 236-243.
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S Hart, K C Goh, V Novotny-Diermayr, C Y Hu, H Hentze, Y C Tan, B Madan, C Amalini, Y K Loh, L C Ong, A D William, A Lee, A Poulsen, R Jayaraman, K H Ong, K Ethirajulu, B W Dymock & J W Wood. (2011) SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies. Leukemia 25:11, pages 1751-1759.
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Mathias Rhein, Adrian Schwarzer, Min Yang, Volkhard Kaever, Martijn Brugman, Johann Meyer, Arnold Ganser, Christopher Baum & Zhixiong Li. (2010) Leukemias induced by altered TRK-signaling are sensitive to mTOR inhibitors in preclinical models. Annals of Hematology 90:3, pages 283-292.
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Paul S. Gaynon & Theresa M. Harned. 2011. New Agents for the Treatment of Acute Lymphoblastic Leukemia. New Agents for the Treatment of Acute Lymphoblastic Leukemia 311 327 .
Susanne C. Miller, Ruili Huang, Srilatha Sakamuru, Sunita J. Shukla, Matias S. Attene-Ramos, Paul Shinn, Danielle Van Leer, William Leister, Christopher P. Austin & Menghang Xia. (2010) Identification of known drugs that act as inhibitors of NF-κB signaling and their mechanism of action. Biochemical Pharmacology 79:9, pages 1272-1280.
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E Voisset, S Lopez, A Chaix, C Georges, K Hanssens, T Prébet, P Dubreuil & P De Sepulveda. (2010) FES kinases are required for oncogenic FLT3 signaling. Leukemia 24:4, pages 721-728.
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Zhixiong Li, Gernot Beutel, Mathias Rhein, Johann Meyer, Christian Koenecke, Thomas Neumann, Min Yang, Jürgen Krauter, Nils von Neuhoff, Michael Heuser, Helmut Diedrich, Gudrun Göhring, Ludwig Wilkens, Brigitte Schlegelberger, Arnold Ganser & Christopher Baum. (2009) High-affinity neurotrophin receptors and ligands promote leukemogenesis. Blood 113:9, pages 2028-2037.
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S. Haihua Chu & Donald Small. (2009) Mechanisms of resistance to FLT3 inhibitors. Drug Resistance Updates 12:1-2, pages 8-16.
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Frank-D. Böhmer & Andrea Uecker. (2009) A substrate peptide for the FLT3 receptor tyrosine kinase. British Journal of Haematology 144:1, pages 127-130.
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Wen-Chung ShiehJoe McKennaJoseph A. SclafaniSong XueMichael GirgisJames ViveloBranko RadetichKapa Prasad. (2008) Syntheses of a Triad of Flt3 Kinase Inhibitors: From Bench to Pilot Plant. Organic Process Research & Development 12:6, pages 1146-1155.
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Felicetto Ferrara, Salvatore Palmieri & Franco Leoni. (2008) Clinically useful prognostic factors in acute myeloid leukemia. Critical Reviews in Oncology/Hematology 66:3, pages 181-193.
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Ulrike Bacher, Claudia Haferlach, Wolfgang Kern, Torsten Haferlach & Susanne Schnittger. (2008) Prognostic relevance of FLT3-TKD mutations in AML: the combination matters—an analysis of 3082 patients. Blood 111:5, pages 2527-2537.
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Siavosh Mahboobi, Andrea Uecker, Christophe Cénac, Andreas Sellmer, Emerich Eichhorn, Sigurd Elz, Frank-D. Böhmer & Stefan Dove. (2007) Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones. Bioorganic & Medicinal Chemistry 15:5, pages 2187-2197.
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Zhuan-Hua Wang, Li Gao, Yu-Ying Li, Zheng Zhang, Jing-Ming Yuan, Hong-Wei Wang, Li Zhang & Lei Zhu. (2007) Induction of Apoptosis by Buckwheat Trypsin Inhibitor in Chronic Myeloid Leukemia K562 Cells. Biological and Pharmaceutical Bulletin 30:4, pages 783-786.
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Francis J. Giles. (2006) FLT3 inhibitor KRN383 on xenografted human leukemic cells harboring FLT3-activating mutations. Leukemia Research 30:12, pages 1469-1470.
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