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Expert Opinion on Emerging Drugs Volume 12, 2007 - Issue 3
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Review

Advances in hemorrhagic stroke therapy: conventional and novel approaches

Paul A Lapchak University of California San Diego, Department of Neuroscience, MTF 316, 9500 Gilman Drive, La Jolla, CA 92093-0624, USA +1 858 822 1297; +1 858 822 4106; [email protected]
&
Dalia M Araujo University of California San Diego, Department of Neuroscience, MTF 316, 9500 Gilman Drive, La Jolla, CA 92093-0624, USA +1 858 822 1297; +1 858 822 4106; [email protected]
Pages 389-406 | Published online: 17 Sep 2007

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Paul A Lapchak. (2011) Neuroprotective and neurotrophic curcuminoids to treat stroke: a translational perspective. Expert Opinion on Investigational Drugs 20:1, pages 13-22.
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Paul A Lapchak. (2008) The many faces of erythropoietin: from erythropoiesis to a rational neuroprotective strategy – correspondence. Expert Opinion on Investigational Drugs 17:10, pages 1615-1616.
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Paul A Lapchak. (2008) Carbamylated erythropoietin to treat neuronal injury: new development strategies. Expert Opinion on Investigational Drugs 17:8, pages 1175-1186.
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Articles from other publishers (35)

Matyas Jelinek & Kamil Duris. (2023) Inflammatory response in sepsis and hemorrhagic stroke. Brain Hemorrhages 4:2, pages 96-107.
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Manisha Choudhary, Sayali Chaudhari, Tanisha Gupta, Dnyaneshwar Kalyane, Bhagwat Sirsat, Umesh Kathar, Pinaki Sengupta & Rakesh K. Tekade. (2023) Stimuli-Responsive Nanotherapeutics for Treatment and Diagnosis of Stroke. Pharmaceutics 15:4, pages 1036.
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Victoria L. M. Herrera, Christopher M. Gromisch, Julius L. Decano, Khristine Amber Pasion, Glaiza L. A. Tan, Ning Hua, Courtney E. Takahashi, David M. Greer & Nelson Ruiz-Opazo. (2023) Anti-DEspR antibody treatment improves survival and reduces neurologic deficits in a hypertensive, spontaneous intracerebral hemorrhage (hsICH) rat model. Scientific Reports 13:1.
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Biying Liu, Dan Huang, Yunlu Guo, Xiaoqiong Sun, Caiyang Chen, Xiaozhu Zhai, Xia Jin, Hui Zhu, Peiying Li & Weifeng Yu. (2021) Recent advances and perspectives of postoperative neurological disorders in the elderly surgical patients. CNS Neuroscience & Therapeutics 28:4, pages 470-483.
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Dhrumi Patel & Sarika Wairkar. (2021) Biotechnology-based therapeutics for management of cerebral stroke. European Journal of Pharmacology 913, pages 174638.
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Bei Huang & Xihong Li. (2021) The Role of Mfsd2a in Nervous System Diseases. Frontiers in Neuroscience 15.
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Hyunjun Ahn, Sang Yeon Lee, Won Ju Jung & Kye-Ho Lee. (2021) Treatment of acute ischemic stroke by minimally manipulated umbilical cord-derived mesenchymal stem cells transplantation: A case report. World Journal of Stem Cells 13:8, pages 1151-1159.
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Kajal Rajdev & Sidharth Mehan. (2019) Neuroprotective Methodologies of Co-Enzyme Q10 Mediated Brain Hemorrhagic Treatment: Clinical and Pre-Clinical Findings. CNS & Neurological Disorders - Drug Targets 18:6, pages 446-465.
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Paul A. Lapchak. 2017. Translational Research in Stroke. Translational Research in Stroke 3 27 .
Lulu Deng, Meaghan A O’Reilly, Ryan M Jones, Ran An & Kullervo Hynynen. (2016) A multi-frequency sparse hemispherical ultrasound phased array for microbubble-mediated transcranial therapy and simultaneous cavitation mapping. Physics in Medicine and Biology 61:24, pages 8476-8501.
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Andrés da Silva-Candal, Alba Vieites-Prado, María Gutiérrez-Fernández, Ramón I Rey, Bárbara Argibay, David Mirelman, Tomás Sobrino, Berta Rodríguez-Frutos, José Castillo & Francisco Campos. (2015) Blood Glutamate Grabbing Does Not Reduce the Hematoma in an Intracerebral Hemorrhage Model but it is a Safe Excitotoxic Treatment Modality. Journal of Cerebral Blood Flow & Metabolism 35:7, pages 1206-1212.
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Paul A. Lapchak, Jessica T. Daley & Paul D. Boitano. (2015) A blinded, randomized study of l-arginine in small clot embolized rabbits. Experimental Neurology 266, pages 143-146.
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Paul A. Lapchak. (2015) A Cost-Effective Rabbit Embolic Stroke Bioassay: Insight into the Development of Acute Ischemic Stroke Therapy. Translational Stroke Research 6:2, pages 99-103.
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Jun Iwanami, Masaki Mogi, Kana Tsukuda, Fei Jing, Kousei Ohshima, Xiao-Li Wang, Hirotomo Nakaoka, Harumi Kan-no, Toshiyuki Chisaka, Hui-Yu Bai, Li-Juan Min & Masatsugu Horiuchi. (2014) Possible synergistic effect of direct angiotensin II type 2 receptor stimulation by compound 21 with memantine on prevention of cognitive decline in type 2 diabetic mice. European Journal of Pharmacology 724, pages 9-15.
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Dwi Setyowati Karolina & Kandiah Jeyaseelan. 2014. Metabolism of Human Diseases. Metabolism of Human Diseases 267 271 .
Wendy C. Ziai. (2013) Hematology and Inflammatory Signaling of Intracerebral Hemorrhage. Stroke 44:6_suppl_1.
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Paul A. Lapchak. (2012) Drug-Like Property Profiling of Novel Neuroprotective Compounds to Treat Acute Ischemic Stroke: Guidelines to Develop Pleiotropic Molecules. Translational Stroke Research 4:3, pages 328-342.
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Sen Lin, Qing Yin, Qi Zhong, Feng-Lin Lv, Yu Zhou, Jing-Qi Li, Jing-Zhou Wang, Bing-yin Su & Qing-Wu Yang. (2012) Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage. Journal of Neuroinflammation 9:1.
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Axel MontagneMarie HébertAmandine JullienneFlavie LeseptAudrey Le BéhotMorgane LouessardMaxime GaubertiCyrille OrsetCarine AliVéronique AginEric MaubertDenis Vivien. (2012) Memantine Improves Safety of Thrombolysis for Stroke. Stroke 43:10, pages 2774-2781.
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Andrew S. Brunswick, Brian Y. Hwang, Geoffrey Appelboom, Richard Y. Hwang, Matthew A. Piazza & E. Sander ConnollyJr.Jr.. (2012) Serum biomarkers of spontaneous intracerebral hemorrhage induced secondary brain injury. Journal of the Neurological Sciences 321:1-2, pages 1-10.
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P.D. Schellinger & M. Köhrmann. (2012) Nah-Infrarot-Lasertherapie beim akuten SchlaganfallNear-infrared laser treatment of acute stroke. Der Nervenarzt 83:8, pages 966-974.
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Johannes Boltze, Uwe R. Schmidt, Doreen M. Reich, Alexander Kranz, Klaus G. Reymann, Maria Strassburger, Donald Lobsien, Daniel-Christoph Wagner, Annette Förschler & Wolf-Rüdiger Schäbitz. (2012) Determination of the Therapeutic Time Window for Human Umbilical Cord Blood Mononuclear Cell Transplantation following Experimental Stroke in Rats. Cell Transplantation 21:6, pages 1199-1211.
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Homajoun Maslehaty, Athanasios K. Petridis, Harald Barth, Alexandros Doukas & Hubertus Maximilian Mehdorn. (2012) Treatment of 817 Patients with Spontaneous Supratentorial Intracerebral Hemorrhage: Characteristics, Predictive Factors and Outcome. Clinics and Practice 2:3, pages e56.
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Donald J. AbrahamPhilippe G. Nantermet, Evan F. Shalen, Shankar Venkatraman, Hong Zhu & Robert J. Mark. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 447 828 .
Paul A. Lapchak. (2010) A new embolus injection method to evaluate intracerebral hemorrhage in New Zealand white rabbits. Brain Research 1349, pages 129-136.
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E. Steve Roach, Kerstin Bettermann & Jose Biller. 2013. Toole's Cerebrovascular Disorders. Toole's Cerebrovascular Disorders 217 233 .
Yu Zhou, Kun-Lin Xiong, Sen Lin, Qi Zhong, Feng-Lin Lu, Hong Liang, Jing-Cheng Li, Jing-Zhou Wang & Qing-Wu Yang. (2010) Elevation of High-Mobility Group Protein Box-1 in Serum Correlates with Severity of Acute Intracerebral Hemorrhage. Mediators of Inflammation 2010, pages 1-6.
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Paul A. Lapchak. (2010) Efficacy and safety profile of the carotenoid trans sodium crocetinate administered to rabbits following multiple infarct ischemic strokes: A combination therapy study with tissue plasminogen activator. Brain Research 1309, pages 136-145.
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Paul A. Lapchak. (2009) Effect of internal carotid artery reperfusion in combination with Tenecteplase on clinical scores and hemorrhage in a rabbit embolic stroke model. Brain Research 1294, pages 211-217.
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Adriano Meneghini, Celso Ferreira, Luiz Carlos de Abreu, Vitor E. Valenti, Marcelo Ferreira, Celso F. Filho & Neif Murad. (2009) Memantine Prevents Cardiomyocytes Nuclear Size Reduction in the Left Ventricle of Rats Exposed to Cold Stress. Clinics 64:9, pages 921-926.
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Paul A. LapchakMoon-Ku HanKarmen F. SalgadoJackson StreeterJustin A. Zivin. (2008) Safety Profile of Transcranial Near-Infrared Laser Therapy Administered in Combination With Thrombolytic Therapy to Embolized Rabbits. Stroke 39:11, pages 3073-3078.
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A. Bhalla & D. Hargroves. (2008) Does early medical intervention have a role in the management of intracerebral haemorrhage?. International Journal of Clinical Practice 62:4, pages 633-641.
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Robert H. Andres, Raphael GuzmanAngélique D. Ducray, Pasquale Mordasini, Atul GeraAlain Barth, Hans R. Widmer & Gary K. Steinberg. (2008) Cell replacement therapy for intracerebral hemorrhage. Neurosurgical Focus 24:3-4, pages E16.
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J. F. Clark, M. Loftspring, W. L. Wurster, S. Beiler, C. Beiler, K. R. Wagner & G. J. Pyne-Geithman. 2008. Cerebral Hemorrhage. Cerebral Hemorrhage 7 12 .
Paul A. Lapchak. (2007) Tumor necrosis factor-α is involved in thrombolytic-induced hemorrhage following embolic strokes in rabbits. Brain Research 1167, pages 123-128.
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