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Review

Emerging drugs for schizophrenia

, MD, , MBBS PhD FRCPC & , MD PhD FRCPC
Pages 479-495 | Published online: 02 Sep 2008

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Gary Remington, Ofer Agid & George Foussias. (2011) Schizophrenia as a disorder of too little dopamine: implications for symptoms and treatment. Expert Review of Neurotherapeutics 11:4, pages 589-607.
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Ofer Agid, George Foussias & Gary Remington. (2010) Long-acting injectable antipsychotics in the treatment of schizophrenia: their role in relapse prevention. Expert Opinion on Pharmacotherapy 11:14, pages 2301-2317.
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Robin Emsley. (2009) Drugs in development for the treatment of schizophrenia. Expert Opinion on Investigational Drugs 18:8, pages 1103-1118.
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Masato Nakashima, Haruka Imada, Eri Shiraishi, Yuki Ito, Noriko Suzuki, Maki Miyamoto, Takahiko Taniguchi & Hiroki Iwashita. (2018) Phosphodiesterase 2A Inhibitor TAK-915 Ameliorates Cognitive Impairments and Social Withdrawal in N -Methyl-d-Aspartate Receptor Antagonist–Induced Rat Models of Schizophrenia . Journal of Pharmacology and Experimental Therapeutics 365:1, pages 179-188.
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Carlos Forray & Raimund Buller. (2017) Challenges and opportunities for the development of new antipsychotic drugs. Biochemical Pharmacology 143, pages 10-24.
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Fabiana Maria das Gra?as Corsi-Zuelli, Fernanda Brognara, Gustavo Fernando da Silva Quirino, Carlos Hiroji Hiroki, Rafael Sobrano Fais, Cristina Marta Del-Ben, Luis Ulloa, Helio Cesar Salgado, Alexandre Kanashiro & Camila Marcelino Loureiro. (2017) Neuroimmune Interactions in Schizophrenia: Focus on Vagus Nerve Stimulation and Activation of the Alpha-7 Nicotinic Acetylcholine Receptor. Frontiers in Immunology 8.
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Juliana S. Cassoli, Paul C. Guest, Aline G. Santana & Daniel Martins-de-Souza. (2016) Employing proteomics to unravel the molecular effects of antipsychotics and their role in schizophrenia. PROTEOMICS - Clinical Applications 10:4, pages 442-455.
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Carmen Klein Herenbrink, David A. Sykes, Prashant Donthamsetti, Meritxell Canals, Thomas Coudrat, Jeremy Shonberg, Peter J. Scammells, Ben Capuano, Patrick M. Sexton, Steven J. Charlton, Jonathan A. Javitch, Arthur Christopoulos & J. Robert Lane. (2016) The role of kinetic context in apparent biased agonism at GPCRs. Nature Communications 7:1.
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Naren P. Rao & Ganesan Venkatasubramanian. 2015. Obsessive-Compulsive Symptoms in Schizophrenia. Obsessive-Compulsive Symptoms in Schizophrenia 135 146 .
Todd S. Woodward, Kwanghee Jung, Geoffrey N. Smith, Heungsun Hwang, Alasdair M. Barr, Ric M. Procyshyn, Sean W. Flynn, Mark van der Gaag & William G. Honer. (2013) Symptom changes in five dimensions of the Positive and Negative Syndrome Scale in refractory psychosis. European Archives of Psychiatry and Clinical Neuroscience 264:8, pages 673-682.
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Michael De Santis, Bo Pan, Jiamei Lian, Xu-Feng Huang & Chao Deng. (2014) Different effects of Bifeprunox, Aripiprazole, and Haloperidol on body weight gain, food and water intake, and locomotor activity in rats. Pharmacology Biochemistry and Behavior 124, pages 167-173.
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Anton A. H. P. Megens, Herman M. R. Hendrickx, Michel M. A. Mahieu, Annemie L. Y. Wellens, Peter Boer & Greet Vanhoof. (2014) PDE 10A inhibitors stimulate or suppress motor behavior dependent on the relative activation state of the direct and indirect striatal output pathways . Pharmacology Research & Perspectives 2:4.
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H.-J. Möller, F. Seemüller, R. Schennach-Wolff, S. Stübner, E. Rüther & R. Grohmann. (2013) History, background, concepts and current use of comedication and polypharmacy in psychiatry. The International Journal of Neuropsychopharmacology 17:07, pages 983-996.
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Jodi E. Gresack, Patricia A. Seymour, Christopher J. Schmidt & Victoria B. Risbrough. (2013) Inhibition of phosphodiesterase 10A has differential effects on dopamine D1 and D2 receptor modulation of sensorimotor gating. Psychopharmacology 231:10, pages 2189-2197.
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Pawel ZajdelAnna Partyka, Krzysztof Marciniec, Andrzej J Bojarski, Maciej Pawlowski & Anna Wesolowska. (2014) Quinoline- and isoquinoline-sulfonamide analogs of aripiprazole: novel antipsychotic agents?. Future Medicinal Chemistry 6:1, pages 57-75.
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S. Farooq, O. Agid, G. Foussias & G. Remington. (2013) Using Treatment Response to Subtype Schizophrenia: Proposal for a New Paradigm in Classification. Schizophrenia Bulletin 39:6, pages 1169-1172.
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Brian V. Broberg, Kristoffer H. Madsen, Niels Plath, Christina K. Olsen, Birte Y. Glenthøj, Olaf B. Paulson, Börje Bjelke & Lise V. Søgaard. (2013) A schizophrenia rat model induced by early postnatal phencyclidine treatment and characterized by Magnetic Resonance Imaging. Behavioural Brain Research 250, pages 1-8.
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Seiya Miyamoto. 2010. Encyclopedia of Psychopharmacology. Encyclopedia of Psychopharmacology 1 5 .
Ross J. BaldessariniRoss J. Baldessarini. 2013. Chemotherapy in Psychiatry. Chemotherapy in Psychiatry 31 88 .
S Miyamoto, N Miyake, L F Jarskog, W W Fleischhacker & J A Lieberman. (2012) Pharmacological treatment of schizophrenia: a critical review of the pharmacology and clinical effects of current and future therapeutic agents. Molecular Psychiatry 17:12, pages 1206-1227.
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Zeynep Yilmaz, Clement C. Zai, Rudi Hwang, Steve Mann, Tamara Arenovich, Gary Remington & Zafiris J. Daskalakis. (2012) Antipsychotics, dopamine D2 receptor occupancy and clinical improvement in schizophrenia: A meta-analysis. Schizophrenia Research 140:1-3, pages 214-220.
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H. A. Tejeda, T. S. Shippenberg & R. Henriksson. (2011) The dynorphin/κ-opioid receptor system and its role in psychiatric disorders. Cellular and Molecular Life Sciences 69:6, pages 857-896.
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Cara R. Rabin & Steven J. Siegel. 2012. Current Antipsychotics. Current Antipsychotics 267 298 .
Sridhar Natesan, Greg E. Reckless, Karen B. L. Barlow, José N. Nobrega & Shitij Kapur. (2010) Partial agonists in schizophrenia – why some work and others do not: insights from preclinical animal models. The International Journal of Neuropsychopharmacology 14:09, pages 1165-1178.
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Katherine Seto, Jane Dumontet & Mary H H Ensom. (2011) Risperidone in Schizophrenia: Is There a Role for Therapeutic Drug Monitoring?. Therapeutic Drug Monitoring 33:3, pages 275-283.
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Francisco López-Muñoz & Cecilio Álamo. (2011) Neurobiological Background for the Development of New Drugs in Schizophrenia. Clinical Neuropharmacology 34:3, pages 111-126.
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Jean-Martin Beaulieu & Raul R. Gainetdinov. (2011) The Physiology, Signaling, and Pharmacology of Dopamine Receptors. Pharmacological Reviews 63:1, pages 182-217.
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Lin Pei, Shupeng Li, Min Wang, Mustansir Diwan, Hymie Anisman, Paul J Fletcher, José N Nobrega & Fang Liu. (2010) Uncoupling the dopamine D1-D2 receptor complex exerts antidepressant-like effects. Nature Medicine 16:12, pages 1393-1395.
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Charles S. Elmore, Peter N. Dorff & J. Richard Heys. (2010) Syntheses of the tricyclic cores of clozapine, dibenzo[b,f][1,4]thiazepin‐11(10H)‐one, and dibenzo[b,f][1,4]oxazepin‐11(10H)‐one in C‐14 labeled form by [ 14 C]carbonylation . Journal of Labelled Compounds and Radiopharmaceuticals 53:13, pages 787-792.
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Seyed-Hesameddin Abbasi, Haleh Behpournia, Aboulfazl Ghoreshi, Bahman Salehi, Maedeh Raznahan, Shams-Ali Rezazadeh, Farzin Rezaei & Shahin Akhondzadeh. (2010) The effect of mirtazapine add on therapy to risperidone in the treatment of schizophrenia: A double-blind randomized placebo-controlled trial. Schizophrenia Research 116:2-3, pages 101-106.
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Laura Musazzi, Marco Milanese, Pasqualina Farisello, Simona Zappettini, Daniela Tardito, Valentina S. Barbiero, Tiziana Bonifacino, Alessandra Mallei, Pietro Baldelli, Giorgio Racagni, Maurizio Raiteri, Fabio Benfenati, Giambattista Bonanno & Maurizio Popoli. (2010) Acute Stress Increases Depolarization-Evoked Glutamate Release in the Rat Prefrontal/Frontal Cortex: The Dampening Action of Antidepressants. PLoS ONE 5:1, pages e8566.
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Gary Remington, George Foussias & Ofer Agid. (2010) Progress in Defining Optimal Treatment Outcome in Schizophrenia. CNS Drugs 24:1, pages 9-20.
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Marie-Noëlle Vacheron-Trystram, Françoise Cornic & Raphaël Gourevitch. 2010. La prise en charge des états réputés dangereux. La prise en charge des états réputés dangereux 97 152 .
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Jim van Os & Shitij Kapur. (2009) Schizophrenia. The Lancet 374:9690, pages 635-645.
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Fa?za Benaliouad, Shitij Kapur, Sridhar Natesan & Pierre-Paul Rompr?. (2009) Effects of the dopamine stabilizer, OSU-6162, on brain stimulation reward and on quinpirole-induced changes in reward and locomotion. European Neuropsychopharmacology 19:6, pages 416-430.
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Falko Biedermann & W Wolfgang Fleischhacker. (2009) Antipsychotics in the early stage of development. Current Opinion in Psychiatry 22:3, pages 326-330.
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