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Type 4 phosphodiesterase inhibitors and their potential in the treatment of inflammatory disease

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Pages 249-268 | Published online: 24 Feb 2005

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William M Brown. (2007) Treating COPD with PDE 4 inhibitors. International Journal of Chronic Obstructive Pulmonary Disease 2:4, pages 517-533.
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Sharon L Wolda. (2000) PDE4 inhibitors and chronic obstructive pulmonary disease. Emerging Drugs 5:3, pages 309-319.
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Yun-Deng Wu, Xiao-Lei Zhang, Xiao-Hong Liu, Jian Xu, Mei Zhang, Kun Shen, Si-Han Zhang, Yong-Mei He, Yan Ma & Ai-Hua Zhang. (2017) The preparation, characterization, structure and dissolution analysis of apremilast solvatomorphs. Acta Crystallographica Section C Structural Chemistry 73:4, pages 305-313.
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Morgan E. Lawrenz, E. A. Salter, Andrzej Wierzbicki & W. J. Thompson. (2005) Molecular modeling study of binding to the catalytic site of PDE4 enzymes by a novel class of inhibitors. International Journal of Quantum Chemistry 105:4, pages 410-415.
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Yaseen A. Al-Soud, Mohammad N. Al-Dweri & Najim A. Al-Masoudi. (2004) Synthesis, antitumor and antiviral properties of some 1,2,4-triazole derivatives. Il Farmaco 59:10, pages 775-783.
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Junghee Han, Ho-Chul Shin, Jong-Choon Kim & Byungbae Kim. (2004) Subacute toxicity and toxicokinetics of CJ-10882, a type IV phosphodiesterase inhibitor, after 4-week repeated oral administration in dogs. Food and Chemical Toxicology 42:3, pages 373-380.
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Tatsuzo Ukita, Masakatsu Sugahara, Yoshihiro Terakawa, Tooru Kuroda, Kazuteru Wada, Aya Nakata, Hideo Kikkawa, Katsuo Ikezawa & Kazuaki Naito. (2003) Synthesis and biological activities of 1-pyridylisoquinoline and 1-pyridyldihydroisoquinoline derivatives as PDE4 inhibitors. Bioorganic & Medicinal Chemistry Letters 13:14, pages 2347-2350.
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George M. Buckley, Nicola Cooper, Hazel J. Dyke, Fiona P. Galleway, Lewis Gowers, Alan F. Haughan, Hannah J. Kendall, Christopher Lowe, Robert Maxey, John G. Montana, Robert Naylor, Janet Oxford, Joanna C. Peake, C.Louise Picken, Karen A. Runcie, Verity Sabin, Andrew Sharpe & Julie B.H. Warneck. (2002) 8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma. Bioorganic & Medicinal Chemistry Letters 12:12, pages 1613-1615.
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George M Buckley, Nicola Cooper, Richard J Davenport, Hazel J Dyke, Fiona P Galleway, Lewis Gowers, Alan F Haughan, Hannah J Kendall, Christopher Lowe, John G Montana, Janet Oxford, Joanna C Peake, C.Louise Picken, Marianna D Richard, Verity Sabin, Andrew Sharpe & Julie B.H Warneck. (2002) 7-Methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 Inhibitors: A Potential Treatment for Asthma. Bioorganic & Medicinal Chemistry Letters 12:3, pages 509-512.
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George Buckley, Nicola Cooper, Hazel J Dyke, Fiona Galleway, Lewis Gowers, Joanna C Gregory, Duncan R Hannah, Alan F Haughan, Paul G Hellewell, Hannah J Kendall, Christopher Lowe, Robert Maxey, John G Montana, Robert Naylor, C.Louise Picken, Karen A Runcie, Verity Sabin, Bishwa R Tuladhar & Julie B.H Warneck. (2000) 7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma. Bioorganic & Medicinal Chemistry Letters 10:18, pages 2137-2140.
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John E. Souness, David Aldous & Carol Sargent. (2000) Immunosuppressive and anti-inflammatory effects of cyclic AMP phosphodiesterase (PDE) type 4 inhibitors. Immunopharmacology 47:2-3, pages 127-162.
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Keith D Laemont, Caralee J Schaefer, Paul L Juneau & Denis J Schrier. (1999) Effects of the phosphodiesterase inhibitor rolipram on streptococcal cell wall-induced arthritis in rats. International Journal of Immunopharmacology 21:11, pages 711-725.
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Annette M Doherty. (1999) Phosphodiesterase 4 inhibitors as novel anti-inflammatory agents. Current Opinion in Chemical Biology 3:4, pages 466-473.
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Laura G. Corral, Patrick A. J. Haslett, George W. Muller, Roger Chen, Lu-Min Wong, Christopher J. Ocampo, Rebecca T. Patterson, David I. Stirling & Gilla Kaplan. (1999) Differential Cytokine Modulation and T Cell Activation by Two Distinct Classes of Thalidomide Analogues That Are Potent Inhibitors of TNF-α. The Journal of Immunology 163:1, pages 380-386.
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D.G McGarry, J.R Regan, F.A Volz, C Hulme, K.J Moriarty, S.W Djuric, J.E Souness, B.E Miller, J.J Travis & D.M Sweeney. (1999) Benzofuran based PDE4 inhibitors. Bioorganic & Medicinal Chemistry 7:6, pages 1131-1139.
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Robert D. Groneberg, Christopher J. Burns, Matthew M. Morrissette, John W. Ullrich, Robert L. Morris, Shelley Darnbrough, Stevan W. Djuric, Stephen M. Condon, Gerard M. McGeehan, Richard Labaudiniere, Kent Neuenschwander, Anthony C. Scotese & Jane A. Kline. (1999) Dual Inhibition of Phosphodiesterase 4 and Matrix Metalloproteinases by an (Arylsulfonyl)hydroxamic Acid Template. Journal of Medicinal Chemistry 42:4, pages 541-544.
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John Regan, Joseph Bruno, Daniel McGarry, Gregory Poli, Barbara Hanney, Shelly Bower, Jeffrey Travis, Dennis Sweeney, Bruce Miller, John Souness & Stevan Djuric. (1998) 2-Substituted-4-methoxybenzimidazole-based PDE4 inhibitors. Bioorganic & Medicinal Chemistry Letters 8:19, pages 2737-2742.
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Steven C. Beasley, Nicola Cooper, Lewis Gowers, Joanna P. Gregory, Alan F Haughan, Paul G. Hellewell, David Macari, Jadwiga Miotla, John G. Montana, Trevor Morgan, Robert Naylor, Karen A. Runcie, Bishwa Tuladhar & Julie B.H. Warneck. (1998) Synthesis and evaluation of a novel series of phosphodiesterase IV inhibitors. A potential treatment for asthma. Bioorganic & Medicinal Chemistry Letters 8:19, pages 2629-2634.
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John E. Souness, Clare Houghton, Nughat Sardar & Michael T. Withnall. (2009) Evidence that cyclic AMP phosphodiesterase inhibitors suppress interleukin‐2 release from murine splenocytes by interacting with a ‘low‐affinity’ phosphodiesterase 4 conformer. British Journal of Pharmacology 121:4, pages 743-750.
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