Citations (33)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (2)
David R. Janero & Ganesh A. Thakur. (2016) Leveraging allostery to improve G protein-coupled receptor (GPCR)-directed therapeutics: cannabinoid receptor 1 as discovery target. Expert Opinion on Drug Discovery 11:12, pages 1223-1237.
Read now
Read now
David R Janero. (2014) Medications development for substance-use disorders: contextual influences (dis)incentivizing pharmaceutical-industry positioning. Expert Opinion on Drug Discovery 9:11, pages 1265-1279.
Read now
Read now
Articles from other publishers (31)
Michał Wiciński, Anna Fajkiel-Madajczyk, Zuzanna Kurant, Karol Gryczka, Dominik Kurant, Monika Szambelan, Bartosz Malinowski, Michal Falkowski, Jan Zabrzyński & Maciej Słupski. (2023) The Use of Cannabidiol in Metabolic Syndrome—An Opportunity to Improve the Patient’s Health or Much Ado about Nothing?. Journal of Clinical Medicine 12:14, pages 4620.
Crossref
Crossref
Rafael Rivas-Santisteban, Jaume Lillo, Iu Raïch, Ana Muñoz, Alejandro Lillo, Ana I. Rodríguez-Pérez, José L. Labandeira-García, Gemma Navarro & Rafael Franco. (2023) The cannabinoid CB1 receptor interacts with the angiotensin AT2 receptor. Overexpression of AT2-CB1 receptor heteromers in the striatum of 6-hydroxydopamine hemilesioned rats. Experimental Neurology 362, pages 114319.
Crossref
Crossref
Kayvan Ali Gharbi, Yvonne Ann Bonomo & Christine Mary Hallinan. (2023) Evidence from Human Studies for Utilising Cannabinoids for the Treatment of Substance-Use Disorders: A Scoping Review with a Systematic Approach. International Journal of Environmental Research and Public Health 20:5, pages 4087.
Crossref
Crossref
Sumanta Garai, Peter C. Schaffer, Robert B. Laprairie, David R. Janero, Roger G. Pertwee, Alex Straiker & Ganesh A. Thakur. (2021) Design, synthesis, and pharmacological profiling of cannabinoid 1 receptor allosteric modulators: Preclinical efficacy of C2-group GAT211 congeners for reducing intraocular pressure. Bioorganic & Medicinal Chemistry 50, pages 116421.
Crossref
Crossref
Sumanta Garai, Luciana M. Leo, Anna-Maria Szczesniak, Dow P. Hurst, Peter C. Schaffer, Ayat Zagzoog, Tallan Black, Jeffrey R. Deschamps, Elke Miess, Stefan Schulz, David R. Janero, Alex Straiker, Roger G. Pertwee, Mary E. Abood, Melanie E. M. Kelly, Patricia H. Reggio, Robert B. Laprairie & Ganesh A. Thakur. (2021) Discovery of a Biased Allosteric Modulator for Cannabinoid 1 Receptor: Preclinical Anti-Glaucoma Efficacy. Journal of Medicinal Chemistry 64:12, pages 8104-8126.
Crossref
Crossref
Piotr Schulz, Szymon Hryhorowicz, Anna Maria Rychter, Agnieszka Zawada, Ryszard Słomski, Agnieszka Dobrowolska & Iwona Krela-Kaźmierczak. (2021) What Role Does the Endocannabinoid System Play in the Pathogenesis of Obesity?. Nutrients 13:2, pages 373.
Crossref
Crossref
Javier Fernández-Ruiz, Ismael Galve-Roperh, Onintza Sagredo & Manuel Guzmán. (2020) Possible therapeutic applications of cannabis in the neuropsychopharmacology field. European Neuropsychopharmacology 36, pages 217-234.
Crossref
Crossref
Sumanta Garai, Pushkar M. Kulkarni, Peter C. Schaffer, Luciana M. Leo, Asher L. Brandt, Ayat Zagzoog, Tallan Black, Xiaoyan Lin, Dow P. Hurst, David R. Janero, Mary E. Abood, Anaelle Zimmowitch, Alex Straiker, Roger G. PertweeMelanie Kelly, Anna-Maria Szczesniak, Eileen M. Denovan-Wright, Ken Mackie, Andrea G. Hohmann, Patricia H. Reggio, Robert B. Laprairie & Ganesh A. Thakur. (2019) Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators. Journal of Medicinal Chemistry 63:2, pages 542-568.
Crossref
Crossref
Andrea Locci & Graziano Pinna. (2019) Stimulation of Peroxisome Proliferator-Activated Receptor-α by N-Palmitoylethanolamine Engages Allopregnanolone Biosynthesis to Modulate Emotional Behavior. Biological Psychiatry 85:12, pages 1036-1045.
Crossref
Crossref
David R. Janero, V. Kiran Vemuri & Alexandros Makriyannis. 2019. Cannabis Use Disorders. Cannabis Use Disorders
43
54
.
Haiming Ma, Guina Zhang, Chunrong Mou, Xiujuan Fu & Yadan Chen. (2018) Peripheral CB1 Receptor Neutral Antagonist, AM6545, Ameliorates Hypometabolic Obesity and Improves Adipokine Secretion in Monosodium Glutamate Induced Obese Mice. Frontiers in Pharmacology 9.
Crossref
Crossref
Noureldin Saleh, Oliver Hucke, Gert Kramer, Esther Schmidt, Florian Montel, Radoslaw Lipinski, Boris Ferger, Timothy Clark, Peter W. Hildebrand & Christofer S. Tautermann. (2018) Multiple Binding Sites Contribute to the Mechanism of Mixed Agonistic and Positive Allosteric Modulators of the Cannabinoid CB1 Receptor. Angewandte Chemie International Edition 57:10, pages 2580-2585.
Crossref
Crossref
Noureldin Saleh, Oliver Hucke, Gert Kramer, Esther Schmidt, Florian Montel, Radoslaw Lipinski, Boris Ferger, Timothy Clark, Peter W. Hildebrand & Christofer S. Tautermann. (2018) Multiple Binding Sites Contribute to the Mechanism of Mixed Agonistic and Positive Allosteric Modulators of the Cannabinoid CB1 Receptor. Angewandte Chemie 130:10, pages 2610-2615.
Crossref
Crossref
Hideyo Takahashi, Koji Araki, Kosho Makino, Hidetsugu Tabata, Hiroshi Nakayama, Kei Zaitsu, Tetsuta Oshitari & Hideaki Natsugari. (2018) Synthesis of 3-Aroylindoles as Intermediates of Cannabimimetics and Elucidation of Their Physicochemical Properties. HETEROCYCLES 96:5, pages 910.
Crossref
Crossref
Simone Bertini, Andrea Chicca, Francesca Gado, Chiara Arena, Daniela Nieri, Maria Digiacomo, Giuseppe Saccomanni, Pingwei Zhao, Mary E. Abood, Marco Macchia, Jürg Gertsch & Clementina Manera. (2017) Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor. Bioorganic & Medicinal Chemistry 25:24, pages 6427-6434.
Crossref
Crossref
Ying Shi, Yan-Hui Duan, Yue-Yang Ji, Zhi-Long Wang, Yan-Ran Wu, Hendra Gunosewoyo, Xiao-Yu Xie, Jian-Zhong Chen, Fan Yang, Jing Li, Jie Tang, Xin Xie & Li-Fang Yu. (2017) Amidoalkylindoles as Potent and Selective Cannabinoid Type 2 Receptor Agonists with in Vivo Efficacy in a Mouse Model of Multiple Sclerosis. Journal of Medicinal Chemistry 60:16, pages 7067-7083.
Crossref
Crossref
Robert B. Laprairie, Pushkar M. Kulkarni, Jeffrey R. Deschamps, Melanie E. M. Kelly, David R. Janero, Maria G. CascioLesley A. StevensonRoger G. PertweeTerrence P. Kenakin, Eileen M. Denovan-Wright & Ganesh A. Thakur. (2017) Enantiospecific Allosteric Modulation of Cannabinoid 1 Receptor. ACS Chemical Neuroscience 8:6, pages 1188-1203.
Crossref
Crossref
Jürg Gertsch. (2017) Cannabimimetic phytochemicals in the diet - an evolutionary link to food selection and metabolic stress adaptation?. British Journal of Pharmacology 174:11, pages 1464-1483.
Crossref
Crossref
Srikrishnan Mallipeddi, David R. Janero, Nikolai Zvonok & Alexandros Makriyannis. (2017) Functional selectivity at G-protein coupled receptors: Advancing cannabinoid receptors as drug targets. Biochemical Pharmacology 128, pages 1-11.
Crossref
Crossref
David R. Janero, Anisha Korde & Alexandros Makriyannis. 2017. Cannabinoids and Their Receptors. Cannabinoids and Their Receptors
217
235
.
Robert B. Laprairie, Abhijit R. Kulkarni, Pushkar M. Kulkarni, Dow P. Hurst, Diane Lynch, Patricia H. Reggio, David R. Janero, Roger G. Pertwee, Lesley A. Stevenson, Melanie E. M. Kelly, Eileen M. Denovan-Wright & Ganesh A. Thakur. (2016) Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe. ACS Chemical Neuroscience 7:6, pages 776-798.
Crossref
Crossref
Pushkar M. Kulkarni, Abhijit R. Kulkarni, Anisha Korde, Ritesh B. Tichkule, Robert B. Laprairie, Eileen M. Denovan-Wright, Han Zhou, David R. Janero, Nikolai Zvonok, Alexandros Makriyannis, Maria G. Cascio, Roger G. Pertwee & Ganesh A. Thakur. (2015) Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s). Journal of Medicinal Chemistry 59:1, pages 44-60.
Crossref
Crossref
Arnau Busquets Garcia, Edgar Soria-Gomez, Luigi Bellocchio & Giovanni Marsicano. (2016) Cannabinoid receptor type-1: breaking the dogmas. F1000Research 5, pages 990.
Crossref
Crossref
M. M. Mahmoud, T. Olszewska, H. Liu, D. M. Shore, D. P. Hurst, P. H. Reggio, D. Lu & D. A. Kendall. (2014) (4-(Bis(4-Fluorophenyl)Methyl)Piperazin-1-yl)(Cyclohexyl)Methanone Hydrochloride (LDK1229): A New Cannabinoid CB1 Receptor Inverse Agonist from the Class of Benzhydryl Piperazine Analogs. Molecular Pharmacology 87:2, pages 197-206.
Crossref
Crossref
Lirit N. Franks, Benjamin M. Ford, Nikhil R. Madadi, Narsimha R. Penthala, Peter A. Crooks & Paul L. Prather. (2014) Characterization of the intrinsic activity for a novel class of cannabinoid receptor ligands: Indole quinuclidine analogs. European Journal of Pharmacology 737, pages 140-148.
Crossref
Crossref
Javier Fernández‐Ruiz, Mariluz Hernández & Yolanda García‐Movellán. 2014. Cannabinoids. Cannabinoids
175
218
.
Luigia Cristino, Thorsten Becker & Vincenzo Di Marzo. (2014) Endocannabinoids and energy homeostasis: An update. BioFactors 40:4, pages 389-397.
Crossref
Crossref
L Cristino, L Palomba & V Di Marzo. (2014) New horizons on the role of cannabinoid CB1 receptors in palatable food intake, obesity and related dysmetabolism. International Journal of Obesity Supplements 4:S1, pages S26-S30.
Crossref
Crossref
Robert J. Chorvat. (2013) Peripherally restricted CB1 receptor blockers. Bioorganic & Medicinal Chemistry Letters 23:17, pages 4751-4760.
Crossref
Crossref
Tamara Vasiljevik, Lirit N. Franks, Benjamin M. Ford, Justin T. Douglas, Paul L. Prather, William E. Fantegrossi & Thomas E. Prisinzano. (2013) Design, Synthesis, and Biological Evaluation of Aminoalkylindole Derivatives as Cannabinoid Receptor Ligands with Potential for Treatment of Alcohol Abuse. Journal of Medicinal Chemistry 56:11, pages 4537-4550.
Crossref
Crossref
Tiziana Bisogno, Anu Mahadevan, Roberto Coccurello, Jae Won Chang, Marco Allarà, Yugang Chen, Giacomo Giacovazzo, Aron Lichtman, Benjamin Cravatt, Anna Moles & Vincenzo Di Marzo. (2013) A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2‐arachidonoylglycerol with potential anti‐obesity effects. British Journal of Pharmacology 169:4, pages 784-793.
Crossref
Crossref