744
Views
74
CrossRef citations to date
0
Altmetric
Reviews

Emerging medication for the treatment of male hypogonadism

, , &
Pages 239-259 | Published online: 21 May 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Giulia Rastrelli, Mauro Dicuio, Yacov Reismann, Alessandra Sforza, Mario Maggi & Giovanni Corona. (2018) Cardiovascular impact of testosterone therapy for hypogonadism. Expert Review of Cardiovascular Therapy 16:9, pages 617-625.
Read now
Giulia Rastrelli, Mario Maggi & Giovanni Corona. (2018) Pharmacological management of late-onset hypogonadism. Expert Review of Clinical Pharmacology 11:4, pages 439-458.
Read now
G. Corona, G. Rastrelli, Y. Reisman, A. Sforza & M. Maggi. (2018) The safety of available treatments of male hypogonadism in organic and functional hypogonadism. Expert Opinion on Drug Safety 17:3, pages 277-292.
Read now
Aydogan Aydogdu & Ronald S. Swerdloff. (2016) Emerging medication for the treatment of male hypogonadism. Expert Opinion on Emerging Drugs 21:3, pages 255-266.
Read now
Giovanni Corona, Giulia Ratrelli & Mario Maggi. (2015) The pharmacotherapy of male hypogonadism besides androgens. Expert Opinion on Pharmacotherapy 16:3, pages 369-387.
Read now
Emeka Udedibia & Jed Kaminetsky. (2014) Phase II drugs currently being investigated for the treatment of hypogonadism. Expert Opinion on Investigational Drugs 23:12, pages 1605-1618.
Read now
Giovanni Corona, Elisa Maseroli, Giulia Rastrelli, Andrea M Isidori, Alessandra Sforza, Edoardo Mannucci & Mario Maggi. (2014) Cardiovascular risk associated with testosterone-boosting medications: a systematic review and meta-analysis. Expert Opinion on Drug Safety 13:10, pages 1327-1351.
Read now
Giovanni Corona, Elisa Maseroli & Mario Maggi. (2014) Injectable testosterone undecanoate for the treatment of hypogonadism. Expert Opinion on Pharmacotherapy 15:13, pages 1903-1926.
Read now

Articles from other publishers (66)

George A. Kanakis, Riccardo Pofi, Dimitrios G. Goulis, Andrea M. Isidori, Eleni Armeni, C. Tamer Erel, Ivan Fistonić, Timothy Hillard, Angelica-Lindén Hirschberg, Blazej Meczekalski, Nicolás Mendoza, Alfred O. Mueck, Tommaso Simoncini, Petra Stute, Dorenda van Dijken, Margaret Rees & Irene Lambrinoudaki. (2023) EMAS position statement: Testosterone replacement therapy in older men. Maturitas 178, pages 107854.
Crossref
V. Zamponi, J. Haxhi, G. Pugliese, A. Faggiano & R. Mazzilli. (2023) Diabetes technology and sexual health: which role?. Journal of Endocrinological Investigation.
Crossref
T Hugh Jones, Adrian S Dobs, Harpal Randeva, William Moore & Jacqueline M Parkin. (2023) Leflutrozole in male obesity-associated hypogonadotropic hypogonadism: Ph 2b double-blind randomised controlled trial. European Journal of Endocrinology 189:3, pages 297-308.
Crossref
Giovanni Corona, Giulia Rastrelli, Simona Ferri, Alessandra Sforza & Mario Maggi. 2023. Testosterone. Testosterone 349 362 .
Shaimaa E.A. Elish, Fatma A. Sanad, Mostafa H. Baky, Noha A.E. Yasin, Abeer Temraz & Walid H. El-Tantawy. (2022) Ficus natalensis extract alleviates Cadmium chloride-induced testicular disruptions in albino rats. Journal of Trace Elements in Medicine and Biology 70, pages 126924.
Crossref
Alexander W. Pastuszak, Marc Gittelman, James P. Tursi, Jonathan S. Jaffe, David Schofield & Martin M. Miner. (2021) Pharmacokinetics of testosterone therapies in relation to diurnal variation of serum testosterone levels as men age. Andrology 10:2, pages 209-222.
Crossref
Aurelia S. Elz, Natalie L. Trevaskis, Christopher J.H. Porter, Joanne M. Bowen & Clive A. Prestidge. (2022) Smart design approaches for orally administered lipophilic prodrugs to promote lymphatic transport. Journal of Controlled Release 341, pages 676-701.
Crossref
Alexandre Hohl & Marcelo Fernando Ronsoni. 2022. Endocrinology and Diabetes. Endocrinology and Diabetes 139 155 .
Min Ho Lee, Yu Seob Shin & Sung Chul Kam. (2021) Correlation Between Testosterone Replacement Treatment and Lower Urinary Tract Symptoms. International Neurourology Journal 25:1, pages 12-22.
Crossref
Jan Tauchen, Michal Jurášek, Lukáš Huml & Silvie Rimpelová. (2021) Medicinal Use of Testosterone and Related Steroids Revisited. Molecules 26:4, pages 1032.
Crossref
Flavio Cadegiani, Erica M Lin, Andy Goren & Carlos G Wambier. (2021) Expression of concern: potential risk for developing severe COVID-19 disease among anabolic steroid users. BMJ Case Reports 14:2, pages e241572.
Crossref
Giuseppe Grande, Domenico Milardi, Silvia Baroni, Andrea Urbani & Alfredo Pontecorvi. (2020) Why Do We Need New Markers for Male Hypogonadism and How Seminal Proteomics Might Solve the Problem?. Protein & Peptide Letters 27:12, pages 1186-1191.
Crossref
Daniele Santi, Pascale Crépieux, Eric Reiter, Giorgia Spaggiari, Giulia Brigante, Livio Casarini, Vincenzo Rochira & Manuela Simoni. (2020) Follicle-Stimulating Hormone (FSH) Action on Spermatogenesis: A Focus on Physiological and Therapeutic Roles. Journal of Clinical Medicine 9:4, pages 1014.
Crossref
Giuseppe Grande, Federica Vincenzoni, Francesca Mancini, Ferran Barrachina, Antonella Giampietro, Massimo Castagnola, Andrea Urbani, Rafael Oliva, Domenico Milardi & Alfredo Pontecorvi. (2019) Quantitative Analysis of the Seminal Plasma Proteome in Secondary Hypogonadism. Journal of Clinical Medicine 8:12, pages 2128.
Crossref
Giulia Rastrelli, Federica Guaraldi, Yacov Reismann, Alessandra Sforza, Andrea M. Isidori, Mario Maggi & Giovanni Corona. (2019) Testosterone Replacement Therapy for Sexual Symptoms. Sexual Medicine Reviews 7:3, pages 464-475.
Crossref
Martin Miner, Sharon J. Parish, Kevin L. Billups, Mark Paulos, Mark Sigman & Michael J. Blaha. (2019) Erectile Dysfunction and Subclinical Cardiovascular Disease. Sexual Medicine Reviews 7:3, pages 455-463.
Crossref
Andrea Salonia, Giulia Rastrelli, Geoffrey Hackett, Stephanie B. Seminara, Ilpo T. Huhtaniemi, Rodolfo A. Rey, Wayne J. G. Hellstrom, Mark R. Palmert, Giovanni Corona, Gert R. Dohle, Mohit Khera, Yee-Ming Chan & Mario Maggi. (2019) Paediatric and adult-onset male hypogonadism. Nature Reviews Disease Primers 5:1.
Crossref
G. Rastrelli, Y. Reisman, S. Ferri, O. Prontera, A. Sforza, M. Maggi & G. Corona. 2019. Sexual Medicine. Sexual Medicine 79 93 .
F. Coluzzi, D. Billeci, M. Maggi & G. Corona. (2018) Testosterone deficiency in non-cancer opioid-treated patients. Journal of Endocrinological Investigation 41:12, pages 1377-1388.
Crossref
Christina Dimopoulou, Dimitrios G. Goulis, Giovanni Corona & Mario Maggi. (2018) The complex association between metabolic syndrome and male hypogonadism. Metabolism 86, pages 61-68.
Crossref
Giovanni Corona, Giulia Rastrelli, Giuseppe Di Pasquale, Alessandra Sforza, Edoardo Mannucci & Mario Maggi. (2018) Endogenous Testosterone Levels and Cardiovascular Risk: Meta-Analysis of Observational Studies. The Journal of Sexual Medicine 15:9, pages 1260-1271.
Crossref
Turky H. Almigbal & Peter Schattner. (2018) The willingness of Saudi men with type 2 diabetes to discuss erectile dysfunction with their physicians and the factors that influence this. PLOS ONE 13:7, pages e0201105.
Crossref
Giovanni Corona, Giulia Rastrelli, Giuseppe Di Pasquale, Alessandra Sforza, Edoardo Mannucci & Mario Maggi. (2018) Testosterone and Cardiovascular Risk: Meta-Analysis of Interventional Studies. The Journal of Sexual Medicine 15:6, pages 820-838.
Crossref
Giovanni Corona & Mario Maggi. (2018) Deciding Which Testosterone Therapy to Prescribe. The Journal of Sexual Medicine 15:5, pages 619-621.
Crossref
W K B A Owiredu, H Alidu, N Amidu, C Obirikorang, C K Gyasi-Sarpong, A T Bawah, P P M Dapare & A T Luuse. (2017) Sexual dysfunction among diabetics and its impact on the SQoL of their partners. International Journal of Impotence Research 29:6, pages 250-257.
Crossref
Giulia Rastrelli, Giovanni Corona, Edoardo Mannucci & Mario Maggi. (2017) Reply to Eugenio Ventimiglia, Paolo Capogrosso, Walter Cazzaniga, Francesco Montorsi, and Andrea Salonia's Letter to the Editor re: Giovanni Corona, Giulia Rastrelli, Abraham Morgentaler, Alessandra Sforza, Edoardo Mannucci, Mario Maggi. Meta-analysis of Results of Testosterone Therapy on Sexual Function Based on International Index of Erectile Function Scores. Eur Urol 2017;72:1000–11. European Urology 72:6, pages e162-e163.
Crossref
Giovanni Corona, Giulia Rastrelli, Abraham Morgentaler, Alessandra Sforza, Edoardo Mannucci & Mario Maggi. (2017) Meta-analysis of Results of Testosterone Therapy on Sexual Function Based on International Index of Erectile Function Scores. European Urology 72:6, pages 1000-1011.
Crossref
Syed Ghulam Musharraf, Qamar ul Arfeen, Arslan Ali, Fareeha Siddiqi, Malik Shoaib Ahmad, Ghazanfar Sultan, M. Iqbal Choudhary & Atta-ur-Rahman. (2017) Fungi as a source of marker compounds for the control of illicit use of drugs: mesterolone as a case study. Metabolomics 13:12.
Crossref
Michael Polet, Wim Van Gansbeke, Lore Geldof, Koen Deventer & Peter Van Eenoo. (2017) Identification and characterization of novel long‐term metabolites of oxymesterone and mesterolone in human urine by application of selected reaction monitoring GC‐CI‐MS/MS. Drug Testing and Analysis 9:11-12, pages 1673-1684.
Crossref
G Corona, M Dicuio, G Rastrelli, E Maseroli, F Lotti, A Sforza & M Maggi. (2023) Testosterone Treatment and Cardiovascular and Venous Thromboembolism Risk: What is ‘New’?. Journal of Investigative Medicine 65:6, pages 964-973.
Crossref
Faysal A. Yafi, Nora M. Haney, James Anaissie, Kenneth J. DeLay, Landon Trost, Mohit Khera & Wayne J.G. Hellstrom. (2017) Practice Patterns in the Diagnosis and Management of Hypogonadism: A Survey of Sexual Medicine Society of North America Members. Urology 106, pages 87-95.
Crossref
B Cangiano, C Cacciatore, L Persani & M Bonomi. (2017) Switch to restoration therapy in a testosterone treated central hypogonadism with erythrocytosis. Endocrinology, Diabetes & Metabolism Case Reports 2017.
Crossref
G. Corona, G. Tirabassi, D. Santi, E. Maseroli, M. Gacci, M. Dicuio, A. Sforza, E. Mannucci & M. Maggi. (2017) Sexual dysfunction in subjects treated with inhibitors of 5α-reductase for benign prostatic hyperplasia: a comprehensive review and meta-analysis. Andrology 5:4, pages 671-678.
Crossref
Giovanni Corona, Linda Vignozzi & Mario Maggi. 2017. Male Sexual Dysfunction. Male Sexual Dysfunction 79 90 .
Giovanni CoronaAlessandra SforzaMario Maggi. (2017) Testosterone Replacement Therapy: Long-Term Safety and Efficacy. The World Journal of Men's Health 35:2, pages 65.
Crossref
Giovanni Corona, Giulia Rastrelli, Simona Ferri, Alessandra Sforza & Mario Maggi. 2017. Testosterone. Testosterone 271 284 .
Daniele Santi & Giovanni Corona. 2017. Endocrinology of the Testis and Male Reproduction. Endocrinology of the Testis and Male Reproduction 687 747 .
Daniele Santi & Giovanni Corona. 2017. Thyroid Diseases. Thyroid Diseases 1 62 .
Malik Shoaib Ahmad, Rabia Farooq, Nusrat Hussain, Atia-tul-Wahab, Atta-ur-Rahman & M. Iqbal Choudhary. (2016) Three new analogues of androgenic drug mesterolone through biotransformation with Cunninghamella blakseleeana. Journal of Molecular Catalysis B: Enzymatic 133, pages S395-S399.
Crossref
Giovanni Corona, Carlo B. Giorda, Domenico Cucinotta, Piero Guida & Elisa Nada. (2016) Sexual Dysfunction in Type 2 Diabetes at Diagnosis: Progression over Time and Drug and Non-Drug Correlated Factors. PLOS ONE 11:10, pages e0157915.
Crossref
Giovanni Corona, Sarah Cipriani, Giulia Rastrelli, Alessandra Sforza, Edoardo Mannucci & Mario Maggi. (2016) High Triglycerides Predicts Arteriogenic Erectile Dysfunction and Major Adverse Cardiovascular Events in Subjects With Sexual Dysfunction. The Journal of Sexual Medicine 13:9, pages 1347-1358.
Crossref
G. Corona, V. A. Giagulli, E. Maseroli, L. Vignozzi, A. Aversa, M. Zitzmann, F. Saad, E. Mannucci & M. Maggi. (2016) Testosterone supplementation and body composition: results from a meta-analysis of observational studies. Journal of Endocrinological Investigation 39:9, pages 967-981.
Crossref
Richard Sundberg. 2016. The Chemical Century. The Chemical Century 543 564 .
Giacomo Tirabassi, Giovanni Corona, Sara Falzetti, Nicola delli Muti, Mario Maggi & Giancarlo Balercia. (2016) Influence of Androgen Receptor Gene CAG and GGC Polymorphisms on Male Sexual Function: A Cross-Sectional Study. International Journal of Endocrinology 2016, pages 1-7.
Crossref
G. Corona, L. Vignozzi, A. Sforza, E. Mannucci & M. Maggi. (2015) Obesity and late-onset hypogonadism. Molecular and Cellular Endocrinology 418, pages 120-133.
Crossref
John D. Dean, Chris G. McMahon, Andre T. Guay, Abraham Morgentaler, Stanley E. Althof, Edgardo F. Becher, Trinity J. Bivalacqua, Arthur L. Burnett, Jacques Buvat, Amr El Meliegy, Wayne J.G. Hellstrom, Emmanuele A. Jannini, Mario Maggi, Andrew McCullough, Luiz Otavio Torres & Michael Zitzmann. (2015) The International Society for Sexual Medicine's Process of Care for the Assessment and Management of Testosterone Deficiency in Adult Men. The Journal of Sexual Medicine 12:8, pages 1660-1686.
Crossref
Elisa Maseroli, Giovanni Corona, Giulia Rastrelli, Francesco Lotti, Sarah Cipriani, Gianni Forti, Edoardo Mannucci & Mario Maggi. (2015) Prevalence of Endocrine and Metabolic Disorders in Subjects with Erectile Dysfunction: A Comparative Study. The Journal of Sexual Medicine 12:4, pages 956-965.
Crossref
Giovanni Corona GGiulia RastrelliElisa MaseroliAlessandra SforzaMario Maggi. (2015) Testosterone Replacement Therapy and Cardiovascular Risk: A Review. The World Journal of Men's Health 33:3, pages 130.
Crossref
Michaela Luconi, Giovanni Corona, Enrico Facchiano, Marcello Lucchese & Mario Maggi. 2015. Handbook of Fertility. Handbook of Fertility 109 117 .
Mario Maggi, Annamaria Morelli, Micaela Luconi, Francesco Lotti, Marcello Lucchese, Enrico Facchiano & Giovanni Corona. 2015. Minimally Invasive Bariatric and Metabolic Surgery. Minimally Invasive Bariatric and Metabolic Surgery 35 42 .
Jianghai Lu, Mar?a Fern?ndez-?lvarez, Sheng Yang, Genye He, Youxuan Xu & Rodigo Aguilera. (2015) New potential biomarkers for mesterolone misuse in human urine by liquid chromatography quadrupole time-of-flight mass spectrometry. Journal of Mass Spectrometry 50:1, pages 153-159.
Crossref
Linda Vignozzi, Sandra Filippi, Paolo Comeglio, Ilaria Cellai, Annamaria Morelli, Matilde Marchetta & Mario Maggi. (2014) Estrogen Mediates Metabolic Syndrome?Induced Erectile Dysfunction: A Study in the Rabbit. The Journal of Sexual Medicine 11:12, pages 2890-2902.
Crossref
G. Rastrelli, G. Corona, E. Mannucci & M. Maggi. (2014) Factors affecting spermatogenesis upon gonadotropin‐replacement therapy: a meta‐analytic study. Andrology 2:6, pages 794-808.
Crossref
Thomas Ullrich, Sanjita Sasmal, Venkatesham Boorgu, Srinivasu Pasagadi, Srisailam Cheera, Sujatha Rajagopalan, Archana Bhumireddy, Dhanya Shashikumar, Shekar Chelur, Charamanna Belliappa, Chetan Pandit, Narasimharao Krishnamurthy, Subhendu Mukherjee, Anuradha Ramanathan, Chakshusmathi Ghadiyaram, Murali Ramachandra, Paulo G. Santos, Bharat Lagu, Mark G. Bock, Mark H. Perrone, Sven Weiler & Hansjoerg Keller. (2014) 3-Alkoxy-pyrrolo[1,2- b ]pyrazolines as Selective Androgen Receptor Modulators with Ideal Physicochemical Properties for Transdermal Administration . Journal of Medicinal Chemistry 57:17, pages 7396-7411.
Crossref
Clarisse R. Mazzola, Darren J. Katz, Nina Loghmanieh, Christian J. Nelson & John P. Mulhall. (2014) Predicting Biochemical Response to Clomiphene Citrate in Men with Hypogonadism. The Journal of Sexual Medicine 11:9, pages 2302-2307.
Crossref
Craig Donatucci, Zhanglin Cui, Yun Fang & David Muram. (2014) Long‐Term Treatment Patterns of Testosterone Replacement Medications. The Journal of Sexual Medicine 11:8, pages 2092-2099.
Crossref
Giovanni Corona, Andrea M. Isidori, Jaques Buvat, Antonio Aversa, Giulia Rastrelli, Geoff Hackett, Vincenzo Rochira, Alessandra Sforza, Andrea Lenzi, Edoardo Mannucci & Mario Maggi. (2014) Testosterone Supplementation and Sexual Function: A Meta-Analysis Study. The Journal of Sexual Medicine 11:6, pages 1577-1592.
Crossref
Malik Shoaib Ahmad, Salman Zafar, Marium Bibi, Saira Bano, Atia-tul-Wahab, Atta-ur-Rahman & M. Iqbal Choudhary. (2014) Biotransformation of androgenic steroid mesterolone with Cunninghamella blakesleeana and Macrophomina phaseolina. Steroids 82, pages 53-59.
Crossref
Jason R. Kovac, Saneal Rajanahally, Ryan P. Smith, Robert M. Coward, Dolores J. Lamb & Larry I. Lipshultz. (2014) Patient Satisfaction with Testosterone Replacement Therapies: The Reasons Behind the Choices. The Journal of Sexual Medicine 11:2, pages 553-562.
Crossref
Alexandre Hohl, Marcelo Fernando Ronsoni, Simone van de Sande-Lee, Fábio Cavalcanti de Faria Vieira, Marcelo Libório Schwarzbold, Alexandre Paim Diaz & Roger Walz. (2014) Androgens, Male Hypogonadism and Traumatic Brain Injury. Open Journal of Endocrine and Metabolic Diseases 04:01, pages 13-23.
Crossref
Alexandre Hohl & Marcelo Fernando Ronsoni. 2014. Endocrinology and Diabetes. Endocrinology and Diabetes 173 192 .
G. Corona, G. Rastrelli & M. Maggi. (2013) Diagnosis and treatment of late-onset hypogonadism: Systematic review and meta-analysis of TRT outcomes. Best Practice & Research Clinical Endocrinology & Metabolism 27:4, pages 557-579.
Crossref
Jyothis T. George, Johannes D. Veldhuis, Manuel Tena‐Sempere, Robert P. Millar & Richard A. Anderson. (2013) Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: Kisspeptin‐10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism . Clinical Endocrinology 79:1, pages 100-104.
Crossref
Giovanni Corona, Giulia Rastrelli, Matteo Monami, Farid Saad, Michaela Luconi, Marcello Lucchese, Enrico Facchiano, Alessandra Sforza, Gianni Forti, Edoardo Mannucci & Mario Maggi. (2013) Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a systematic review and meta-analysis. European Journal of Endocrinology 168:6, pages 829-843.
Crossref
Giovanni CoronaLinda VignozziAlessandra SforzaMario Maggi. (2013) Risks and Benefits of Late Onset Hypogonadism Treatment: An Expert Opinion. The World Journal of Men's Health 31:2, pages 103.
Crossref
Peter T. K. Chan. 2013. Biennial Review of Infertility. Biennial Review of Infertility 31 48 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.