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Review

Novel drugs targeting the cell cycle

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Pages 45-59 | Published online: 24 Feb 2005

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Sandra E Wilkinson & William Harris. (2000) Selective tyrosine kinase inhibitors. Emerging Drugs 5:3, pages 287-297.
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Abeer M. El-Naggar, Maher A. El-Hashash & Eslam B. Elkaeed. (2021) Eco-friendly sequential one-pot synthesis, molecular docking, and anticancer evaluation of arylidene-hydrazinyl-thiazole derivatives as CDK2 inhibitors. Bioorganic Chemistry 108, pages 104615.
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XI-NAN SHI, HONGJIAN LI, HONG YAO, XU LIU, LING LI, KWONG-SAK LEUNG, HSIANG-FU KUNG & MARIE CHIA-MI LIN. (2015) Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinoma. Molecular Medicine Reports 12:5, pages 6501-6508.
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Diaa A. Ibrahim & Nasser S.M. Ismail. (2011) Design, synthesis and biological study of novel pyrido[2,3-d]pyrimidine as anti-proliferative CDK2 inhibitors. European Journal of Medicinal Chemistry 46:12, pages 5825-5832.
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C. Flader Lavey, D. Hesk, D. Koharski, V. Truong & P. McNamara. (2011) Synthesis of 3H-, 13C3-, and 14C-labeled Sch 727965. Journal of Labelled Compounds and Radiopharmaceuticals 54:4, pages 196-201.
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Kamil Paruch, Michael P. Dwyer, Carmen Alvarez, Courtney Brown, Tin-Yau Chan, Ronald J. Doll, Kerry Keertikar, Chad Knutson, Brian McKittrick, Jocelyn Rivera, Randall Rossman, Greg Tucker, Thierry Fischmann, Alan Hruza, Vincent Madison, Amin A. Nomeir, Yaolin Wang, Paul Kirschmeier, Emma Lees, David Parry, Nicole Sgambellone, Wolfgang Seghezzi, Lesley Schultz, Frances Shanahan, Derek Wiswell, Xiaoying Xu, Quiao Zhou, Ray A. James, Vidyadhar M. Paradkar, Haengsoon Park, Laura R. Rokosz, Tara M. Stauffer & Timothy J. Guzi. (2010) Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases. ACS Medicinal Chemistry Letters 1:5, pages 204-208.
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Shayne Cox GadKeykavous Parang & Gongqin Sun. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
Aurélie Bourderioux, Paméla Kassis, Jean-Yves Mérour & Sylvain Routier. (2008) Synthesis of new fused and substituted benzo and pyrido carbazoles via C-2 (het)arylindoles. Tetrahedron 64:49, pages 11012-11019.
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Michael P. Dwyer, Kamil Paruch, Carmen Alvarez, Ronald J. Doll, Kerry Keertikar, Jose Duca, Thierry O. Fischmann, Alan Hruza, Vincent Madison, Emma Lees, David Parry, Wolfgang Seghezzi, Nicole Sgambellone, Frances Shanahan, Derek Wiswell & Timothy J. Guzi. (2007) Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors. Bioorganic & Medicinal Chemistry Letters 17:22, pages 6216-6219.
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Kamil Paruch, Michael P. Dwyer, Carmen Alvarez, Courtney Brown, Tin-Yau Chan, Ronald J. Doll, Kerry Keertikar, Chad Knutson, Brian McKittrick, Jocelyn Rivera, Randall Rossman, Greg Tucker, Thierry O. Fischmann, Alan Hruza, Vincent Madison, Amin A. Nomeir, Yaolin Wang, Emma Lees, David Parry, Nicole Sgambellone, Wolfgang Seghezzi, Lesley Schultz, Fran Shanahan, Derek Wiswell, Xiaoying Xu, Quiao Zhou, Ray A. James, Vidyadhar M. Paradkar, Haengsoon Park, Laura R. Rokosz, Tara M. Stauffer & Timothy J. Guzi. (2007) Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2. Bioorganic & Medicinal Chemistry Letters 17:22, pages 6220-6223.
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Yadagiri Bathini, Inderjit Singh, Patricia J. Harvey, Paul R. Keller, Rajeshwar Singh, Ronald G. Micetich, David W. Fry, Ellen M. Dobrusin & Peter L. Toogood. (2005) 2-Aminoquinazoline inhibitors of cyclin-dependent kinases. Bioorganic & Medicinal Chemistry Letters 15:17, pages 3881-3885.
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Scott N. VanderWel, Patricia J. Harvey, Dennis J. McNamara, Joseph T. Repine, Paul R. Keller, John Quin, R. John Booth, William L. Elliott, Ellen M. Dobrusin, David W. Fry & Peter L. Toogood. (2005) Pyrido[2,3- d ]pyrimidin-7-ones as Specific Inhibitors of Cyclin-Dependent Kinase 4 . Journal of Medicinal Chemistry 48:7, pages 2371-2387.
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Peter L. Toogood, Patricia J. Harvey, Joseph T. Repine, Derek J. Sheehan, Scott N. VanderWel, Hairong Zhou, Paul R. Keller, Dennis J. McNamara, Debra Sherry, Tong Zhu, Joanne Brodfuehrer, Chung Choi, Mark R. Barvian & David W. Fry. (2005) Discovery of a Potent and Selective Inhibitor of Cyclin-Dependent Kinase 4/6. Journal of Medicinal Chemistry 48:7, pages 2388-2406.
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Sharad Verma, Dhanapalan Nagarathnam, Jianxing Shao, Lei Zhang, Jin Zhao, Yamin Wang, Tindy Li, Eric Mull, Istvan Enyedy, Chunguang Wang, Qingming Zhu, Martha Altieri, Jerold Jordan, Thu-Thi-Anh Dang & Sanjeeva Reddy. (2005) Substituted aminobenzimidazole pyrimidines as cyclin-dependent kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 15:8, pages 1973-1977.
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Shudong Wang, Gavin Wood, Christopher Meades, Gary Griffiths, Carol Midgley, Iain McNae, Campbell McInnes, Sian Anderson, Wayne Jackson, Mokdad Mezna, Rhoda Yuill, Malcolm Walkinshaw & Peter M Fischer. (2004) Synthesis and biological activity of 2-anilino-4-(1H-pyrrol-3-yl) pyrimidine CDK inhibitors. Bioorganic & Medicinal Chemistry Letters 14:16, pages 4237-4240.
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Raj N. Misra, Hai-yun Xiao, David K. Williams, Kyoung S. Kim, Songfeng Lu, Kristen A. Keller, Janet G. Mulheron, Roberta Batorsky, John S. Tokarski, John S. Sack, S.David Kimball, Francis Y. Lee & Kevin R. Webster. (2004) Synthesis and biological activity of N-aryl-2-aminothiazoles: potent pan inhibitors of cyclin-dependent kinases. Bioorganic & Medicinal Chemistry Letters 14:11, pages 2973-2977.
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Concha Sanchez-Martinez, Chuan Shih, Margaret M. Faul, Guoxin Zhu, Michael Paal, Carmen Somoza, Tiechao Li, Christine A. Kumrich, Leonard L. Winneroski, Zhou Xun, Harold B. Brooks, Bharvin K.R. Patel, Richard M. Schultz, Tammy B. DeHahn, Charles D. Spencer, Scott A. Watkins, Eileen Considine, Jack A. Dempsey, Catherine A. Ogg, Robert M. Campbell, Bryan A. Anderson & Jill Wagner. (2003) Aryl[ a ]pyrrolo[3,4- c ]carbazoles as selective cyclin D1-CDK4 inhibitors. Bioorganic & Medicinal Chemistry Letters 13:21, pages 3835-3839.
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Malcolm Anderson, John F. Beattie, Gloria A. Breault, Jason Breed, Kate F. Byth, Janet D. Culshaw, Rebecca P.A. Ellston, Stephen Green, Claire A. Minshull, Richard A. Norman, Richard A. Pauptit, Judith Stanway, Andrew P. Thomas & Philip J. Jewsbury. (2003) Imidazo[1,2-a]pyridines: A potent and selective class of cyclin-Dependent kinase inhibitors identified through structure-Based hybridisation. Bioorganic & Medicinal Chemistry Letters 13:18, pages 3021-3026.
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John F. Beattie, Gloria A. Breault, Rebecca P.A. Ellston, Stephen Green, Philip J. Jewsbury, Catherine J. Midgley, Russell T. Naven, Claire A. Minshull, Richard A. Pauptit, Julie A. Tucker & J.Elizabeth Pease. (2003) Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: identification and optimisation of substituted 4,6-Bis anilino pyrimidines. Bioorganic & Medicinal Chemistry Letters 13:18, pages 2955-2960.
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Jin-Jun Liu, Apostolos Dermatakis, Christine Lukacs, Fred Konzelmann, Yi Chen, Ursula Kammlott, Wanda Depinto, Hong Yang, Xuefeng Yin, Yingsi Chen, Andy Schutt, Mary Ellen Simcox & Kin-Chun Luk. (2003) 3,5,6-Trisubstituted naphthostyrils as CDK2 inhibitors. Bioorganic & Medicinal Chemistry Letters 13:15, pages 2465-2468.
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Raj N. Misra, Hai-yun Xiao, David B. Rawlins, Weifang Shan, Kristen A. Kellar, Janet G. Mulheron, John S. Sack, John S. Tokarski, S.David Kimball & Kevin R. Webster. (2003) 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues. Bioorganic & Medicinal Chemistry Letters 13:14, pages 2405-2408.
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Apos Dermatakis, Kin-Chun Luk & Wanda DePinto. (2003) Synthesis of Potent Oxindole CDK2 Inhibitors. Bioorganic & Medicinal Chemistry 11:8, pages 1873-1881.
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Guoxin Zhu, Scott Conner, Xun Zhou, Chuan Shih, Harold B. Brooks, Eileen Considine, Jack A. Dempsey, Cathy Ogg, Bharvin Patel, Richard M. Schultz, Charles D. Spencer, Beverly Teicher & Scott A. Watkins. (2003) Synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin D1/CDK4 inhibitors. Bioorganic & Medicinal Chemistry Letters 13:7, pages 1231-1235.
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Raj N. Misra, David B. Rawlins, Hai-yun Xiao, Weifang Shan, Isia Bursuker, Kristin A. Kellar, Janet G. Mulheron, John S. Sack, John S. Tokarski, S.David Kimball & Kevin R. Webster. (2003) 1H-Pyrazolo[3,4-b]pyridine Inhibitors of Cyclin-Dependent Kinases. Bioorganic & Medicinal Chemistry Letters 13:6, pages 1133-1136.
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Peter L Toogood. (2002) Progress toward the development of agents to modulate the cell cycle. Current Opinion in Chemical Biology 6:4, pages 472-478.
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Peter L. Toogood. (2001) Cyclin-dependent kinase inhibitors for treating cancer. Medicinal Research Reviews 21:6, pages 487-498.
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Mark Barvian, Diane H. Boschelli, Jennifer Cossrow, Ellen Dobrusin, Ali Fattaey, Alex Fritsch, David Fry, Patricia Harvey, Paul Keller, Michelle Garrett, Frances La, Wilbur Leopold, Dennis McNamara, Maire Quin, Susanne Trumpp-Kallmeyer, Peter Toogood, Zhipei Wu & Erli Zhang. (2000) Pyrido[2,3- d ]pyrimidin-7-one Inhibitors of Cyclin-Dependent Kinases . Journal of Medicinal Chemistry 43:24, pages 4606-4616.
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Kevin R. Webster. (2000) Therapeutic Potential of Targeting the Cell Cycle. Chemical Research in Toxicology 13:10, pages 940-943.
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