52
Views
58
CrossRef citations to date
0
Altmetric
Review

Emerging therapies for hepatitis C virus infection

Pages 13-42 | Published online: 24 Feb 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Srikanth Venkatraman & F George Njoroge. (2009) Macrocyclic inhibitors of HCV NS3 protease. Expert Opinion on Therapeutic Patents 19:9, pages 1277-1303.
Read now
Javed A Khan, Farhad Forouhar, Xiao Tao & Liang Tong. (2007) Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery. Expert Opinion on Therapeutic Targets 11:5, pages 695-705.
Read now
Byoung-Kwon Chun, Peiyuan Wang, Abdalla Hassan, Jinfa Du, PhillipM. Tharnish, Eisuke Murakami, Lieven Stuyver, MichaelJ. Otto, RaymondF. Schinazi & KyoichiA. Watanabe. (2007) Synthesis and Biological Activity of 5′,9-Anhydro-3-Purine-ISONucleosides as Potential Anti-Hepatitis C Virus Agents. Nucleosides, Nucleotides & Nucleic Acids 26:1, pages 83-97.
Read now
Minwan Wu, Yahya El-Kattan, Tsu-Hsing Lin, Ajit Ghosh, Satish Vadlakonda, PravinL. Kotian, YarlagaddaS. Babu & Pooran Chand. (2005) Synthesis of 9-[1-(Substituted)-3-(phosphonomethoxy)propyl]adenine Derivatives as Possible Antiviral Agents. Nucleosides, Nucleotides & Nucleic Acids 24:10-12, pages 1543-1568.
Read now
Per Hoffmann, Maria Quasdorff, Maria Á González-Carmona & Wolfgang H Caselmann. (2003) Recent patents on experimental therapy for hepatitis C virus infection (1999 – 2002). Expert Opinion on Therapeutic Patents 13:11, pages 1707-1723.
Read now
Yi Lu, Zhujun Zhang, Deyong He & Yufei Hu. (2003) Flow Injection Chemiluminescence Method for Determination of Ribavirin Based on Enhancement of Luminol-Persulfate Reaction. Analytical Letters 36:8, pages 1587-1595.
Read now

Articles from other publishers (52)

Larry Yet. 2018. Privileged Structures in Drug Discovery. Privileged Structures in Drug Discovery 321 355 .
G. R. JunaBeegum, Amjesh Revikumar, S. SuharaBeevy & Vetha Sundaram Sugunan. (2016) Identification of novel inhibitors of HCV NS3 protease genotype 3 subtype B through molecular docking studies of phytochemicals from Boerhavia diffusa L. Medicinal Chemistry Research 26:2, pages 327-334.
Crossref
Iou-Jiun Kang, Li-Wen Wang, Teng-Kuang Yeh, Chung-Chi Lee, Yen-Chun Lee, Sheng-Ju Hsu, Yen-Shian Wu, Jing-Chyi Wang, Yu-Sheng Chao, Andrew Yueh & Jyh-Haur Chern. (2010) Synthesis, activity, and pharmacokinetic properties of a series of conformationally-restricted thiourea analogs as novel hepatitis C virus inhibitors. Bioorganic & Medicinal Chemistry 18:17, pages 6414-6421.
Crossref
Latha G. Nair, Stephane Bogen, Frank Bennett, Kevin Chen, Bancha Vibulbhan, Yuhua Huang, Weing Yang, Ronald J. Doll, N.-Y. Shih & F. George Njoroge. (2010) Design and synthesis of novel fluoro amino acids: synthons for potent macrocyclic HCV NS3 protease inhibitors. Tetrahedron Letters 51:23, pages 3057-3061.
Crossref
Ashok Arasappan, Frank Bennett, Stephane L. Bogen, Srikanth Venkatraman, Melissa Blackman, Kevin X. Chen, Siska Hendrata, Yuhua Huang, Regina M. Huelgas, Latha Nair, Angela I. Padilla, Weidong Pan, Russell Pike, Patrick Pinto, Sumei Ruan, Mousumi Sannigrahi, Francisco Velazquez, Bancha Vibulbhan, Wanli Wu, Weiying Yang, Anil K. Saksena, Viyyoor Girijavallabhan, Neng-Yang Shih, Jianshe Kong, Tao Meng, Yan Jin, Jesse Wong, Paul McNamara, Andrew Prongay, Vincent Madison, John J. Piwinski, Kuo-Chi Cheng, Richard Morrison, Bruce Malcolm, Xiao Tong, Robert Ralston & F. George Njoroge. (2010) Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor. ACS Medicinal Chemistry Letters 1:2, pages 64-69.
Crossref
Frank Bennett, Yuhua Huang, Siska Hendrata, Raymond Lovey, Stephane L. Bogen, Weidong Pan, Zhuyan Guo, Andrew Prongay, Kevin X. Chen, Ashok Arasappan, Srikanth Venkatraman, Francisco Velazquez, Latha Nair, Mousumi Sannigrahi, Xiao Tong, John Pichardo, Kuo-Chi Cheng, Viyyoor M. Girijavallabhan, Anil K. Saksena & F. George Njoroge. (2010) The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir®: A change in direction in the search for a second generation HCV NS3 protease inhibitor. Bioorganic & Medicinal Chemistry Letters 20:8, pages 2617-2621.
Crossref
Latha G. Nair, Stephane Bogen, Sumei Ruan, Weidong Pan, Russel Pike, Xiao Tong, Kuo-Chi Cheng, Zhuyan Guo, Ronald J. Doll & F. George Njoroge. (2010) Towards the second generation of Boceprevir: Dithianes as an alternative P2 substituent for 2,2-dimethyl cycloproyl proline in HCV NS3 protease inhibitors. Bioorganic & Medicinal Chemistry Letters 20:5, pages 1689-1692.
Crossref
Stéphane L. Bogen, Ashok Arasappan, Francisco Velazquez, Melissa Blackman, Regina Huelgas, Weidong Pan, Elise Siegel, Latha G. Nair, Srikanth Venkatraman, Zhuyan Guo, Ronald Doll, Neng-Yang Shih & F. George Njoroge. (2010) Discovery of potent sulfonamide P4-capped ketoamide second generation inhibitors of hepatitis C virus NS3 serine protease with favorable pharmacokinetic profiles in preclinical species. Bioorganic & Medicinal Chemistry 18:5, pages 1854-1865.
Crossref
Latha G. Nair, Mousumi Sannigrahi, Stephane Bogen, Patrick Pinto, Kevin X. Chen, Andrew Prongay, Xiao Tong, K.-C. Cheng, Viyyoor Girijavallabhan & F. George Njoroge. (2010) P4 capped amides and lactams as HCV NS3 protease inhibitors with improved potency and DMPK profile. Bioorganic & Medicinal Chemistry Letters 20:2, pages 567-570.
Crossref
Iou-Jiun Kang, Li-Wen Wang, Sheng-Ju Hsu, Chung-Chi Lee, Yen-Chun Lee, Yen-Shian Wu, Andrew Yueh, Jing-Chyi Wang, Tsu-An Hsu, Yu-Sheng Chao & Jyh-Haur Chern. (2009) Design and efficient synthesis of novel arylthiourea derivatives as potent hepatitis C virus inhibitors. Bioorganic & Medicinal Chemistry Letters 19:21, pages 6063-6068.
Crossref
Srikanth Venkatraman, Wanli Wu, Neng-Yang Shih & F. George Njoroge. (2009) Potent aza-peptide derived inhibitors of HCV NS3 protease. Bioorganic & Medicinal Chemistry Letters 19:16, pages 4760-4763.
Crossref
Iou-Jiun Kang, Li-Wen Wang, Sheng-Ju Hsu, Chung-Chi Lee, Yen-Chun Lee, Yen-Shian Wu, Tsu-An Hsu, Andrew Yueh, Yu-Sheng Chao & Jyh-Haur Chern. (2009) Design and synthesis of indole, 2,3-dihydro-indole, and 3,4-dihydro-2H-quinoline-1-carbothioic acid amide derivatives as novel HCV inhibitors. Bioorganic & Medicinal Chemistry Letters 19:15, pages 4134-4138.
Crossref
Srikanth Venkatraman, Mellissa Blackman, Wanli Wu, Latha Nair, Ashok Arasappan, Angela Padilla, Stéphane Bogen, Frank Bennett, Kevin Chen, John Pichardo, Xiao Tong, Andrew Prongay, Kuo-Chi Cheng, Viyyoor Girijavallabhan & F. George Njoroge. (2009) Discovery of novel P3 sulfonamide-capped inhibitors of HCV NS3 protease. Inhibitors with improved cellular potencies. Bioorganic & Medicinal Chemistry 17:13, pages 4486-4495.
Crossref
Stéphane L. Bogen, Weidong Pan, Sumei Ruan, Latha G. Nair, Ashok Arasappan, Frank Bennett, Kevin X. Chen, Edwin Jao, Srikanth Venkatraman, Bancha Vibulbhan, Rong Liu, Kuo-Chi Cheng, Zhuyan Guo, Xiao Tong, Anil K. Saksena, Viyyoor Girijavallabhan & F. George Njoroge. (2009) Toward the Back-Up of Boceprevir (SCH 503034): Discovery of New Extended P 4 -Capped Ketoamide Inhibitors of Hepatitis C Virus NS3 Serine Protease with Improved Potency and Pharmacokinetic Profiles . Journal of Medicinal Chemistry 52:12, pages 3679-3688.
Crossref
Ashok Arasappan, Angela I. Padilla, Edwin Jao, Frank Bennett, Stephane L. Bogen, Kevin X. Chen, Russell E. Pike, Mousumi Sannigrahi, Joana Soares, Srikanth Venkatraman, Bancha Vibulbhan, Anil K. Saksena, Viyyoor Girijavallabhan, Xiao Tong, Kuo-Chi Cheng & F. George Njoroge. (2009) Toward Second Generation Hepatitis C Virus NS3 Serine Protease Inhibitors: Discovery of Novel P4 Modified Analogues with Improved Potency and Pharmacokinetic Profile. Journal of Medicinal Chemistry 52:9, pages 2806-2817.
Crossref
Iou-Jiun Kang, Li-Wen Wang, Chung-Chi Lee, Yen-Chun Lee, Yu-Sheng Chao, Tsu-An Hsu & Jyh-Haur Chern. (2009) Design, synthesis, and anti-HCV activity of thiourea compounds. Bioorganic & Medicinal Chemistry Letters 19:7, pages 1950-1955.
Crossref
Kevin X. Chen, Bancha Vibulbhan, Weiying Yang, Latha G. Nair, Xiao Tong, Kuo-Chi Cheng & F. George Njoroge. (2009) Novel potent inhibitors of hepatitis C virus (HCV) NS3 protease with cyclic sulfonyl P3 cappings. Bioorganic & Medicinal Chemistry Letters 19:4, pages 1105-1109.
Crossref
Ian Stansfield, Caterina Ercolani, Angela Mackay, Immacolata Conte, Marco Pompei, Uwe Koch, Nadia Gennari, Claudio Giuliano, Michael Rowley & Frank Narjes. (2009) Tetracyclic indole inhibitors of hepatitis C virus NS5B-polymerase. Bioorganic & Medicinal Chemistry Letters 19:3, pages 627-632.
Crossref
Srikanth Venkatraman, Francisco Velazquez, Wanli Wu, Melissa Blackman, Kevin X. Chen, Stephane Bogen, Latha Nair, Xiao Tong, Robert Chase, Andrea Hart, Sony Agrawal, John Pichardo, Andrew Prongay, Kuo-Chi Cheng, Viyyoor Girijavallabhan, John Piwinski, Neng-Yang Shih & F. George Njoroge. (2008) Discovery and Structure−Activity Relationship of P 1 −P 3 Ketoamide Derived Macrocyclic Inhibitors of Hepatitis C Virus NS3 Protease . Journal of Medicinal Chemistry 52:2, pages 336-346.
Crossref
Ian Stansfield, Marco Pompei, Immacolata Conte, Caterina Ercolani, Giovanni Migliaccio, Mark Jairaj, Claudio Giuliano, Michael Rowley & Frank Narjes. (2007) Development of carboxylic acid replacements in indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase. Bioorganic & Medicinal Chemistry Letters 17:18, pages 5143-5149.
Crossref
Srikanth Venkatraman, Stéphane L. Bogen, Ashok Arasappan, Frank Bennett, Kevin Chen, Edwin Jao, Yi-Tsung Liu, Raymond Lovey, Siska Hendrata, Yuhua Huang, Weidong Pan, Tejal Parekh, Patrick Pinto, Veljko Popov, Russel Pike, Sumei Ruan, Bama Santhanam, Bancha Vibulbhan, Wanli Wu, Weiying Yang, Jianshe Kong, Xiang Liang, Jesse Wong, Rong Liu, Nancy Butkiewicz, Robert Chase, Andrea Hart, Sony Agrawal, Paul Ingravallo, John Pichardo, Rong Kong, Bahige Baroudy, Bruce Malcolm, Zhuyan Guo, Andrew Prongay, Vincent Madison, Lisa Broske, Xiaoming Cui, Kuo-Chi Cheng, Yunsheng Hsieh, Jean-Marc Brisson, Danial Prelusky, Walter Korfmacher, Ronald White, Susan Bogdanowich-Knipp, Anastasia Pavlovsky, Prudence Bradley, Anil K. Saksena, Ashit Ganguly, John Piwinski, Viyyoor Girijavallabhan & F. George Njoroge. (2006) Discovery of (1 R ,5 S )- N -[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2( S )-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2( S )-carboxamide (SCH 503034), a Selective, Potent, Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor:  A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection . Journal of Medicinal Chemistry 49:20, pages 6074-6086.
Crossref
Ashok Arasappan, F. George Njoroge, Kevin X. Chen, Srikanth Venkatraman, Tejal N. Parekh, Haining Gu, John Pichardo, Nancy Butkiewicz, Andrew Prongay, Vincent Madison & Viyyoor Girijavallabhan. (2006) P2–P4 Macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease. Bioorganic & Medicinal Chemistry Letters 16:15, pages 3960-3965.
Crossref
Jesus M. Ontoria, Jose I. Martìn Hernando, Savina Malancona, Barbara Attenni, Ian Stansfield, Immacolata Conte, Caterina Ercolani, Jörg Habermann, Simona Ponzi, Marcello Di Filippo, Uwe Koch, Michael Rowley & Frank Narjes. (2006) Identification of thieno[3,2-b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase. Bioorganic & Medicinal Chemistry Letters 16:15, pages 4026-4030.
Crossref
Stéphane L. Bogen, Sumei Ruan, Rong Liu, Sony Agrawal, John Pichardo, Andrew Prongay, Bahige Baroudy, Anil K. Saksena, Viyyoor Girijavallabhan & F. George Njoroge. (2006) Depeptidization efforts on α-ketoamide inhibitors of HCV NS3-4A serine protease: Effect on HCV replicon activity. Bioorganic & Medicinal Chemistry Letters 16:6, pages 1621-1627.
Crossref
Kevin X. Chen, F. George Njoroge, Andrew Prongay, John Pichardo, Vincent Madison & Viyyoor Girijavallabhan. (2005) Synthesis and biological activity of macrocyclic inhibitors of hepatitis C virus (HCV) NS3 protease. Bioorganic & Medicinal Chemistry Letters 15:20, pages 4475-4478.
Crossref
S. Bogen, A.K. Saksena, A. Arasappan, H. Gu, F.G. Njoroge, V. Girijavallabhan, J. Pichardo, N. Butkiewicz, A. Prongay & V. Madison. (2005) Hepatitis C virus NS3-4A serine protease inhibitors: Use of a P2–P1 cyclopropyl alanine combination for improved potency. Bioorganic & Medicinal Chemistry Letters 15:20, pages 4515-4519.
Crossref
A. Arasappan, F.G. Njoroge, T.-Y. Chan, F. Bennett, S.L. Bogen, K. Chen, H. Gu, L. Hong, E. Jao, Y.-T. Liu, R.G. Lovey, T. Parekh, R.E. Pike, P. Pinto, B. Santhanam, S. Venkatraman, H. Vaccaro, H. Wang, X. Yang, Z. Zhu, B. Mckittrick, A.K. Saksena, V. Girijavallabhan, J. Pichardo, N. Butkiewicz, R. Ingram, B. Malcolm, A. Prongay, N. Yao, B. Marten, V. Madison, S. Kemp, O. Levy, M. Lim-Wilby, S. Tamura & A.K. Ganguly. (2005) Hepatitis C virus NS3-4A serine protease inhibitors: SAR of moiety with improved potency. Bioorganic & Medicinal Chemistry Letters 15:19, pages 4180-4184.
Crossref
Srikanth Venkatraman, F. George Njoroge, Viyyoor M. Girijavallabhan, Vincent S. Madison, Nanua H. Yao, Andrew J. Prongay, Nancy Butkiewicz & John Pichardo. (2005) Design and Synthesis of Depeptidized Macrocyclic Inhibitors of Hepatitis C NS3-4A Protease Using Structure-Based Drug Design. Journal of Medicinal Chemistry 48:16, pages 5088-5091.
Crossref
Steven Harper, Salvatore Avolio, Barbara Pacini, Marcello Di Filippo, Sergio Altamura, Licia Tomei, Giacomo Paonessa, Di Marco, Andrea Carfi, Claudio Giuliano, Julio Padron, Fabio Bonelli, Giovanni Migliaccio, Raffaele De Francesco, Ralph Laufer, Michael Rowley & Frank Narjes. (2005) Potent Inhibitors of Subgenomic Hepatitis C Virus RNA Replication through Optimization of Indole- N -Acetamide Allosteric Inhibitors of the Viral NS5B Polymerase . Journal of Medicinal Chemistry 48:14, pages 4547-4557.
Crossref
Steven Harper, Barbara Pacini, Salvatore Avolio, Marcello Di Filippo, Giovanni Migliaccio, Ralph Laufer, Raffaele De Francesco, Michael Rowley & Frank Narjes. (2005) Development and Preliminary Optimization of Indole- N -Acetamide Inhibitors of Hepatitis C Virus NS5B Polymerase . Journal of Medicinal Chemistry 48:5, pages 1314-1317.
Crossref
Yili Ding, Jean-Luc Girardet, Kenneth L. Smith, Gary Larson, Brett Prigaro, Vicky C.H. Lai, Weidong Zhong & Jim Z. Wu. (2005) Parallel synthesis of pteridine derivatives as potent inhibitors for hepatitis C virus NS5B RNA-dependent RNA polymerase. Bioorganic & Medicinal Chemistry Letters 15:3, pages 675-678.
Crossref
Jesus M. Ontoria, Stefania Di Marco, Immacolata Conte, M. Emilia Di Francesco, Cristina Gardelli, Uwe Koch, Victor G. Matassa, Marco Poma, Christian Steinkühler, Cinzia Volpari & Steven Harper. (2004) The Design and Enzyme-Bound Crystal Structure of Indoline Based Peptidomimetic Inhibitors of Hepatitis C Virus NS3 Protease. Journal of Medicinal Chemistry 47:26, pages 6443-6446.
Crossref
Ashok Arasappan, F. George Njoroge, Tejal N. Parekh, Xiaozheng Yang, John Pichardo, Nancy Butkiewicz, Andrew Prongay, Nanhua Yao & Viyyoor Girijavallabhan. (2004) Novel 2-oxoimidazolidine-4-carboxylic acid derivatives as Hepatitis C virus NS3-4A serine protease inhibitors: synthesis, activity, and X-ray crystal structure of an enzyme inhibitor complex. Bioorganic & Medicinal Chemistry Letters 14:23, pages 5751-5755.
Crossref
Vincenzo Summa, Alessia Petrocchi, Victor G. Matassa, Marina Taliani, Ralph Laufer, Raffaele De Francesco, Sergio Altamura & Paola Pace. (2004) HCV NS5b RNA-Dependent RNA Polymerase Inhibitors:  From α,γ-Diketoacids to 4,5-Dihydroxypyrimidine- or 3-Methyl-5- hydroxypyrimidinonecarboxylic Acids. Design and Synthesis. Journal of Medicinal Chemistry 47:22, pages 5336-5339.
Crossref
Yvonne Yip, Frantz Victor, Jason Lamar, Robert Johnson, Q. May Wang, John I. Glass, Nathan Yumibe, Mark Wakulchik, John Munroe & Shu-Hui Chen. (2004) P4 and P1′ optimization of bicycloproline P2 bearing tetrapeptidyl α-ketoamides as HCV protease inhibitors. Bioorganic & Medicinal Chemistry Letters 14:19, pages 5007-5011.
Crossref
David X Sun, Lifei Liu, Beverly Heinz, Alexander Kolykhalov, Jason Lamar, Robert B Johnson, Q.May Wang, Yvonne Yip & Shu-Hui Chen. (2004) P4 cap modified tetrapeptidyl α-ketoamides as potent HCV NS3 protease inhibitors. Bioorganic & Medicinal Chemistry Letters 14:16, pages 4333-4338.
Crossref
Paola Pace, Emanuela Nizi, Barbara Pacini, Silvia Pesci, Victor Matassa, Raffaele De Francesco, Sergio Altamura & Vincenzo Summa. (2004) The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase. Bioorganic & Medicinal Chemistry Letters 14:12, pages 3257-3261.
Crossref
Vincenzo Summa, Alessia Petrocchi, Paola Pace, Victor G. Matassa, Raffaele De Francesco, Sergio Altamura, Licia Tomei, Uwe Koch & Philippe Neuner. (2003) Discovery of α,γ-Diketo Acids as Potent Selective and Reversible Inhibitors of Hepatitis C Virus NS5b RNA-Dependent RNA Polymerase. Journal of Medicinal Chemistry 47:1, pages 14-17.
Crossref
Jason Lamar, Frantz Victor, Nancy Snyder, Robert B. Johnson, Q.May Wang, John I. Glass & Shu-Hui Chen. (2004) Novel P4 truncated tripeptidyl α-ketoamides as HCV protease inhibitors. Bioorganic & Medicinal Chemistry Letters 14:1, pages 263-266.
Crossref
Frantz Victor, Jason Lamar, Nancy Snyder, Yvonne Yip, Deqi Guo, Nathan Yumibe, Robert B. Johnson, Q.May Wang, John I. Glass & Shu-Hui Chen. (2004) P1 and P3 optimization of novel bicycloproline P2 bearing tetrapeptidyl α-ketoamide based HCV protease inhibitors. Bioorganic & Medicinal Chemistry Letters 14:1, pages 257-261.
Crossref
Yvonne Yip, Frantz Victor, Jason Lamar, Robert Johnson, Q.May Wang, Donna Barket, John Glass, Ling Jin, Lifei Liu, Daryl Venable, Mark Wakulchik, Congping Xie, Beverly Heinz, Elcira Villarreal, Joe Colacino, Nathan Yumibe, Mark Tebbe, John Munroe & Shu-Hui Chen. (2004) Discovery of a novel bicycloproline P2 bearing peptidyl α-ketoamide LY514962 as HCV protease inhibitor. Bioorganic & Medicinal Chemistry Letters 14:1, pages 251-256.
Crossref
T.Jagadeeswar Reddy, Laval Chan, Nathalie Turcotte, Melanie Proulx, Oswy Z. Pereira, Sanjoy K. Das, Arshad Siddiqui, Wuyi Wang, Carl Poisson, Constantin G. Yannopoulos, Darius Bilimoria, Lucille L'Heureux, Hicham M.A. Alaoui & Nghe Nguyen-Ba. (2003) Further SAR studies on novel small molecule inhibitors of the hepatitis C (HCV) NS5B polymerase. Bioorganic & Medicinal Chemistry Letters 13:19, pages 3341-3344.
Crossref
Karin Oscarsson, Anton Poliakov, Stefan Oscarson, U.Helena Danielson, Anders Hallberg & Bertil Samuelsson. (2003) Peptide-based inhibitors of hepatitis C virus full-length NS3 (protease-helicase/NTPase): model compounds towards small molecule inhibitors. Bioorganic & Medicinal Chemistry 11:13, pages 2955-2963.
Crossref
Anja Johansson, Anton Poliakov, Eva Åkerblom, Karin Wiklund, Gunnar Lindeberg, Susanne Winiwarter, U.Helena Danielson, Bertil Samuelsson & Anders Hallberg. (2003) Acyl sulfonamides as potent protease inhibitors of the hepatitis C virus full-Length NS3 (Protease-Helicase/NTPase): A comparative study of different C-terminals. Bioorganic & Medicinal Chemistry 11:12, pages 2551-2568.
Crossref
Laval Chan, T. Jagadeeswar Reddy, Mélanie Proulx, Sanjoy K. Das, Oswy Pereira, Wuyi Wang, Arshad Siddiqui, Constantin G. Yannopoulos, Carl Poisson, Nathalie Turcotte, Alexandre Drouin, M. Hicham Alaoui-Ismaili, Richard Bethell, Martine Hamel, Lucille L'Heureux, Darius Bilimoria & Nghe Nguyen-Ba. (2003) Identification of N,N -Disubstituted Phenylalanines as a Novel Class of Inhibitors of Hepatitis C NS5B Polymerase . Journal of Medicinal Chemistry 46:8, pages 1283-1285.
Crossref
Noel J.C Snell. (2003) Examining unmet needs in infectious disease. Drug Discovery Today 8:1, pages 22-30.
Crossref
Anja Johansson, Anton Poliakov, Eva Åkerblom, Gunnar Lindeberg, Susanne Winiwarter, Bertil Samuelsson, U.Helena Danielson & Anders Hallberg. (2002) Tetrapeptides as potent protease inhibitors of hepatitis C virus full-Length NS3 (Protease-Helicase/NTPase). Bioorganic & Medicinal Chemistry 10:12, pages 3915-3922.
Crossref
John G. McHutchison & Keyur Patel. (2002) Future therapy of hepatitis C. Hepatology 36:5B, pages s245-s252.
Crossref
David Sperandio, Anthony R. Gangloff, Joane Litvak, Richard Goldsmith, Jason M. Hataye, Vivian R. Wang, Emma J. Shelton, Kyle Elrod, James W. Janc, James M. Clark, Ken Rice, Steve Weinheimer, Kap-Sun Yeung, Nicholas A. Meanwell, Dennis Hernandez, Andrew J. Staab, Brian L. Venables & Jeffrey R. Spencer. (2002) Highly potent non-peptidic inhibitors of the HCV NS3/NS4A serine protease. Bioorganic & Medicinal Chemistry Letters 12:21, pages 3129-3133.
Crossref
John G. McHutchison & Keyur Patel. (2002) Future therapy of hepatitis C. Hepatology 36:S1, pages S245-S252.
Crossref
Rebekah Beevers, Maria G Carr, Philip S Jones, Steven Jordan, Paul B Kay, Robert C Lazell & Tony M Raynham. (2002) Solution and solid-Phase synthesis of potent inhibitors of hepatitis C Virus NS3 proteinase. Bioorganic & Medicinal Chemistry Letters 12:4, pages 641-643.
Crossref
Nicholas A Meanwell, John F Kadow & Paul M Scola. 2002. Annual Reports in Medicinal Chemistry Volume 37. Annual Reports in Medicinal Chemistry Volume 37 133 147 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.