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Manipulation of indoleamine 2,3 dioxygenase; a novel therapeutic target for treatment of diseases

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Pages 987-1012 | Published online: 17 Jun 2009

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Arina Kozlova & Raphaël Frédérick. (2019) Current state on tryptophan 2,3-dioxygenase inhibitors: a patent review. Expert Opinion on Therapeutic Patents 29:1, pages 11-23.
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Tiziana Di Pucchio, Silvio Danese, Raimondo De Cristofaro & Sergio Rutella. (2010) Inhibitors of indoleamine 2,3-dioxygenase: a review of novel patented lead compounds. Expert Opinion on Therapeutic Patents 20:2, pages 229-250.
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Joerg C. Schefold, Jan-Philip Zeden, Rene Pschowski, Ben Hammoud, Christina Fotopoulou, Dietrich Hasper, Gerhard Fusch, Stephan Von Haehling, Hans-Dieter Volk, Christian Meisel, Christine Schütt & Petra Reinke. (2010) Treatment with granulocyte–macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock. Scandinavian Journal of Infectious Diseases 42:3, pages 164-171.
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M. Maes, B.E. Leonard, A.M. Myint, M. Kubera & R. Verkerk. (2011) The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry 35:3, pages 702-721.
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Nady BraidyGilles J. GuilleminRoss Grant. (2011) Effects of Kynurenine Pathway Inhibition on NAD + Metabolism and Cell Viability in Human Primary Astrocytes and Neurons . International Journal of Tryptophan Research 4, pages IJTR.S7052.
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Korrapati V. Sathyasaikumar, Erin K. Stachowski, Laura Amori, Paolo Guidetti, Paul J. Muchowski & Robert Schwarcz. (2010) Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington’s disease. Journal of Neurochemistry.
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I. Wonodi & R. Schwarcz. (2010) Cortical Kynurenine Pathway Metabolism: A Novel Target for Cognitive Enhancement in Schizophrenia. Schizophrenia Bulletin 36:2, pages 211-218.
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