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Targeting the IGF1 axis in cancer proliferation

, MD, , MSc & , PhD
Pages 1179-1192 | Published online: 10 Aug 2009

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Ilan Bruchim & Haim Werner. (2013) Targeting IGF-1 signaling pathways in gynecologic malignancies. Expert Opinion on Therapeutic Targets 17:3, pages 307-320.
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Piotr J Wysocki & Bogna Wierusz-Wysocka. (2010) Obesity, hyperinsulinemia and breast cancer: novel targets and a novel role for metformin. Expert Review of Molecular Diagnostics 10:4, pages 509-519.
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Fatemeh Meshkini, Nahid Ramezani‐Jolfaie, Saman Sargazi, Cain C.T. Clark & Sepideh Soltani. (2022) The effects of lycopene supplementation on insulin‐like growth factor‐1 and insulin‐like growth factor binding proteins: A systematic review of randomized controlled trials . Phytotherapy Research 36:4, pages 1633-1643.
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Yi Fang, Chi Yang, Yao Lu, Lihui Wei, Jinyan Zhao, Lisha Lu & Jiumao Lin. (2022) Based on the Network Pharmacology to Investigate the Mechanism of Qingjie Fuzheng Granules against Colorectal Cancer. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-14.
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Anna Ianza, Marianna Sirico, Ottavia Bernocchi & Daniele Generali. (2021) Role of the IGF-1 Axis in Overcoming Resistance in Breast Cancer. Frontiers in Cell and Developmental Biology 9.
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Tali Sinai-Livne, Metsada Pasmanik-Chor, Zoya Cohen, Ilan Tsarfaty, Haim Werner & Raanan Berger. (2020) Proteomic analysis of combined IGF1 receptor targeted therapy and chemotherapy identifies signatures associated with survival in breast cancer patients. Oncotarget 11:17, pages 1515-1530.
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Guo‐shu Xu, Zi‐wei Li, Zhi‐Ping Huang, F. Charles Brunicardi, Fu Jia, Chao Song, Hai‐jian Zou & Rui‐fen Sun. (2019) Retracted: MiR‐497‐5p inhibits cell proliferation and metastasis in hepatocellular carcinoma by targeting insulin‐like growth factor 1 . Molecular Genetics & Genomic Medicine 7:10.
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Xia Wu, Lu Gao, Xiaopeng Guo, Qiang Wang, Zihao Wang, Wei Lian, Wei Liu, Jian Sun & Bing Xing. (2018) GH, IGF-1, and Age Are Important Contributors to Thyroid Abnormalities in Patients with Acromegaly. International Journal of Endocrinology 2018, pages 1-8.
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Jaime Guevara-Aguirre, Alexandra Guevara, Iván Palacios, Mónica Pérez, Patricio Prócel & Enrique Terán. (2017) GH and GHR signaling in human disease. Growth Hormone & IGF Research.
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Tali Cohen-Sinai, Zoya Cohen, Haim Werner & Raanan Berger. (2017) Identification of BRCA1 As a Potential Biomarker for Insulin-Like Growth Factor-1 Receptor Targeted Therapy in Breast Cancer. Frontiers in Endocrinology 8.
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Katherine C. Gates, Lindsey N. Goetzmann, Jeremy D. Cantlon, Kimberly M. Jeckel & Russell V. Anthony. (2017) Effect of proline rich 15-deficiency on trophoblast viability and survival. PLOS ONE 12:4, pages e0174976.
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N. I. Solovyeva, T. A. Gureeva, O. S. Timoshenko, T. A. Moskvitina & E. V. Kugaevskaya. (2017) Furin as proprotein convertase and its role in normal and pathological biological processes. Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry 11:2, pages 87-100.
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Doerte Poburski, Christiane Leovsky, Josefine Barbara Boerner, Luisa Szimmtenings, Michael Ristow, Michael Glei & René Thierbach. (2016) Insulin-IGF signaling affects cell transformation in the BALB/c 3T3 cell model. Scientific Reports 6:1.
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N.I. Solovyeva, T.A. Gureeva, O.S. Timoshenko, T.A. Moskvitina & E.V. Kugaevskaya. (2016) Furin as proprotein convertase and its role in normal and pathological biological processes. Biomeditsinskaya Khimiya 62:6, pages 609-621.
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Haim Werner, Rive Sarfstein, Derek LeRoith & Ilan Bruchim. (2016) Insulin-like Growth Factor 1 Signaling Axis Meets p53 Genome Protection Pathways. Frontiers in Oncology 6.
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Xuefeng Jing, Takashi Sonoki, Masayasu Miyajima, Takahiro Sawada, Nanako Terada, Shigeki Takemura & Kazushige Sakaguchi. (2016) EphA4‐deleted microenvironment regulates cancer development and leukemoid reaction of the isografted 4T1 murine breast cancer via reduction of an IGF 1 signal . Cancer Medicine 5:6, pages 1214-1227.
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Hao Hong, Tapas R. Nayak, Sixiang Shi, Stephen A. Graves, Brianne C. Fliss, Todd E. Barnhart & Weibo Cai. (2014) Generation and Screening of Monoclonal Antibodies for ImmunoPET Imaging of IGF1R in Prostate Cancer. Molecular Pharmaceutics 11:10, pages 3624-3630.
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Connie Bitelman, Rive Sarfstein, Menahem Sarig, Zohar Attias-Geva, Ami Fishman, Haim Werner & Ilan Bruchim. (2013) IGF1R-directed targeted therapy enhances the cytotoxic effect of chemotherapy in endometrial cancer. Cancer Letters 335:1, pages 153-159.
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Rive Sarfstein, Yael Friedman, Zohar Attias-Geva, Ami Fishman, Ilan Bruchim & Haim Werner. (2013) Metformin Downregulates the Insulin/IGF-I Signaling Pathway and Inhibits Different Uterine Serous Carcinoma (USC) Cells Proliferation and Migration in p53-Dependent or -Independent Manners. PLoS ONE 8:4, pages e61537.
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Anna Orlova, Camilla Hofstr?m, Joanna Strand, Zohreh Varasteh, Mattias Sandstrom, Karl Andersson, Vladimir Tolmachev & Torbj?rn Gr?slund. (2012) [99mTc(CO)3]+-(HE)3-ZIGF1R:4551, a new Affibody conjugate for visualization of insulin-like growth factor-1 receptor expression in malignant tumours. European Journal of Nuclear Medicine and Molecular Imaging 40:3, pages 439-449.
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Haim Werner & Ilan Bruchim. (2012) IGF-1 and BRCA1 signalling pathways in familial cancer. The Lancet Oncology 13:12, pages e537-e544.
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H Werner. (2011) Tumor suppressors govern insulin-like growth factor signaling pathways: implications in metabolism and cancer. Oncogene 31:22, pages 2703-2714.
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Maria Catherine Pietanza & Charles M. Rudin. (2012) Novel Therapeutic Approaches for Small Cell Lung Cancer: The Future has Arrived. Current Problems in Cancer 36:3, pages 156-173.
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H. Christian Reinhardt & Bj?rn Schumacher. (2012) The p53 network: cellular and systemic DNA damage responses in aging and cancer. Trends in Genetics 28:3, pages 128-136.
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Sheref E. Hassan, Mikhail Bekarev, Mimi Y. Kim, Juan Lin, Sajida Piperdi, Richard Gorlick & David S. Geller. (2011) Cell surface receptor expression patterns in osteosarcoma. Cancer 118:3, pages 740-749.
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Rive Sarfstein, Metsada Pasmanik-Chor, Adva Yeheskel, Liat Edry, Noam Shomron, Naama Warman, Efrat Wertheimer, Sharon Maor, Lea Shochat & Haim Werner. (2012) Insulin-like Growth Factor-I Receptor (IGF-IR) Translocates to Nucleus and Autoregulates IGF-IR Gene Expression in Breast Cancer Cells. Journal of Biological Chemistry 287:4, pages 2766-2776.
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Jilong Yang, Antti Ylipää, Yan Sun, Hong Zheng, Kexin Chen, Matti Nykter, Jonathan Trent, Nancy Ratner, Dina C. Lev & Wei Zhang. (2011) Genomic and Molecular Characterization of Malignant Peripheral Nerve Sheath Tumor Identifies the IGF1R Pathway as a Primary Target for Treatment. Clinical Cancer Research 17:24, pages 7563-7573.
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Takayuki Okano, Shouhong Xuan & Matthew W. Kelley. (2011) Insulin-Like Growth Factor Signaling Regulates the Timing of Sensory Cell Differentiation in the Mouse Cochlea. The Journal of Neuroscience 31:49, pages 18104-18118.
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Chi-Ming Wu, Te-Mao Li, Sheng-Feng Hsu, Yi-Chang Su, Shung-Te Kao, Yi-Chin Fong & Chih-Hsin Tang. (2011) IGF-I enhances ?5?1 integrin expression and cell motility in human chondrosarcoma cells. Journal of Cellular Physiology 226:12, pages 3270-3277.
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Zohar Attias-Geva, Itay Bentov, Dale L. Ludwig, Ami Fishman, Ilan Bruchim & Haim Werner. (2011) Insulin-like growth factor-I receptor (IGF-IR) targeting with monoclonal antibody cixutumumab (IMC-A12) inhibits IGF-I action in endometrial cancer cells. European Journal of Cancer 47:11, pages 1717-1726.
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Zohar Attias-Geva, Itay Bentov, Ami Fishman, Haim Werner & Ilan Bruchim. (2011) Insulin-like growth factor-I receptor inhibition by specific tyrosine kinase inhibitor NVP-AEW541 in endometrioid and serous papillary endometrial cancer cell lines. Gynecologic Oncology 121:2, pages 383-389.
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Ioannis Ilias, Thomas Paparrigopoulos, Elias Tzavellas, Dimitris Karaiskos, Panagiotis Kontoleon & Ioannis Liappas. (2011) IGF-I and IGFBP-3 before and after inpatient alcohol detoxification in alcohol-dependent subjects. Medical Science Monitor 17:10, pages CR547-CR551.
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Ettore Capoluongo. (2011) Insulin-Like Growth Factor System and Sporadic Malignant Melanoma. The American Journal of Pathology 178:1, pages 26-31.
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William Engen, Terrence E. O’Brien, Brendan Kelly, Jacinda Do, Liezel Rillera, Lance K. Stapleton, Jack F. Youngren & Marc O. Anderson. (2010) Synthesis of aryl-heteroaryl ureas (AHUs) based on 4-aminoquinoline and their evaluation against the insulin-like growth factor receptor (IGF-1R). Bioorganic & Medicinal Chemistry 18:16, pages 5995-6005.
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