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Galanin receptor subtypes 1 and 2 as therapeutic targets in head and neck squamous cell carcinoma

, MD PhD, , MD PhD & , PhD
Pages 289-302 | Published online: 12 Feb 2010

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Takeharu Kanazawa, Kiyoshi Misawa, Kazuya Shinmura, Yuki Misawa, Gen Kusaka, Mikiko Maruta, Toru Sasaki, Yusuke Watanabe & Thomas E. Carey. (2019) Promoter methylation of galanin receptors as epigenetic biomarkers for head and neck squamous cell carcinomas. Expert Review of Molecular Diagnostics 19:2, pages 137-148.
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Sankar Jagadeeshan, Ofra Z. Novoplansky, Oded Cohen, Ina Kurth, Jochen Hess, Ari J. Rosenberg, Jennifer R. Grandis & Moshe Elkabets. (2023) New insights into RAS in head and neck cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1878:6, pages 188963.
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Manuel Lisardo Sánchez & Rafael Coveñas. (2022) The Galaninergic System: A Target for Cancer Treatment. Cancers 14:15, pages 3755.
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Kiyoshi Misawa, Masato Mima, Yamada Satoshi, Yuki Misawa, Atsushi Imai, Daiki Mochizuki, Takuya Nakagawa, Tomoya Kurokawa, Miki Oguro, Ryuji Ishikawa, Yuki Yamaguchi, Shiori Endo, Hideya Kawasaki, Takeharu Kanazawa & Hiroyuki Mineta. (2020) Neuropeptide receptor genes GHSR and NMUR1 are candidate epigenetic biomarkers and predictors for surgically treated patients with oropharyngeal cancer. Scientific Reports 10:1.
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Daniela Russo, Francesco Merolla, Silvia Varricchio, Giovanni Salzano, Giovanni Zarrilli, Massimo Mascolo, Viviana Strazzullo, Rosa� Di Crescenzo, Angela Celetti & Gennaro Ilardi. (2018) Epigenetics of oral and oropharyngeal cancers (Review). Biomedical Reports.
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Iulia Solomon, Vlad Mihai Voiculescu, Constantin Caruntu, Mihai Lupu, Alexandra Popa, Mihaela Adriana Ilie, Radu Albulescu, Ana Caruntu, Cristiana Tanase, Carolina Constantin, Monica Neagu & Daniel Boda. (2018) Neuroendocrine Factors and Head and Neck Squamous Cell Carcinoma: An Affair to Remember. Disease Markers 2018, pages 1-12.
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Zhenhui Liu, Linfang Li & Min Zhang. 2018. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1996 2003 .
Kiyoshi Misawa, Atsushi Imai, Daiki Mochizuki, Yuki Misawa, Shiori Endo, Seiji Hosokawa, Ryuji Ishikawa, Masato Mima, Kazuya Shinmura, Takeharu Kanazawa & Hiroyuki Mineta. (2017) Genes encoding neuropeptide receptors are epigenetic markers in patients with head and neck cancer: a site-specific analysis. Oncotarget 8:44, pages 76318-76328.
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Kiyoshi Misawa, Daiki Mochizuki, Shiori Endo, Masato Mima, Yuki Misawa, Atsushi Imai, Kazuya Shinmura, Takeharu Kanazawa, Thomas E. Carey & Hiroyuki Mineta. (2017) Site-specific methylation patterns of the GAL and GALR1/2 genes in head and neck cancer: Potential utility as biomarkers for prognosis . Molecular Carcinogenesis 56:3, pages 1107-1116.
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Kiyoshi Misawa, Yuki Misawa, Takeharu Kanazawa, Daiki Mochizuki, Atsushi Imai, Shiori Endo, Thomas E. Carey & Hiroyuki Mineta. (2015) Epigenetic inactivation of galanin and GALR1/2 is associated with early recurrence in head and neck cancer. Clinical & Experimental Metastasis 33:2, pages 187-195.
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Takeharu Kanazawa, Kiyoshi Misawa, Yuki Misawa, Takayuki Uehara, Hirofumi Fukushima, Gen Kusaka, Mikiko Maruta & Thomas Carey. (2015) G-Protein-Coupled Receptors: Next Generation Therapeutic Targets in Head and Neck Cancer?. Toxins 7:8, pages 2959-2984.
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Kiyoshi Misawa, Yuki Misawa, Haruki Kondo, Daiki Mochizuki, Atsushi Imai, Hirofumi Fukushima, Takayuki Uehara, Takeharu Kanazawa & Hiroyuki Mineta. (2015) Aberrant Methylation Inactivates Somatostatin and Somatostatin Receptor Type 1 in Head and Neck Squamous Cell Carcinoma. PLOS ONE 10:3, pages e0118588.
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TAKEHARU KANAZAWA, KIYOSHI MISAWA, YUKI MISAWA, MIKIKO MARUTA, TAKAYUKI UEHARA, KAZUMI KAWADA, TAKAFUMI NAGATOMO & KEIICHI ICHIMURA. (2014) Galanin receptor 2 utilizes distinct signaling pathways to suppress cell proliferation and induce apoptosis in HNSCC. Molecular Medicine Reports 10:3, pages 1289-1294.
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Takayuki Uehara, Takeharu Kanazawa, Hiroaki Mizukami, Ryosuke Uchibori, Tomonori Tsukahara, Masashi Urabe, Akihiro Kume, Kiyoshi Misawa, Thomas E. Carey, Mikio Suzuki, Keiichi Ichimura & Keiya Ozawa. (2014) Novel anti-tumor mechanism of galanin receptor type 2 in head and neck squamous cell carcinoma cells. Cancer Science 105:1, pages 72-80.
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Roberto A. Lleras, Richard V. Smith, Leslie R. Adrien, Nicolas F. Schlecht, Robert D. Burk, Thomas M. Harris, Geoffrey Childs, Michael B. Prystowsky & Thomas J. Belbin. (2013) Unique DNA Methylation Loci Distinguish Anatomic Site and HPV Status in Head and Neck Squamous Cell Carcinoma. Clinical Cancer Research 19:19, pages 5444-5455.
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Kiyoshi Misawa, Takeharu Kanazawa, Yuki Misawa, Takayuki Uehara, Atsushi Imai, Goro Takahashi, Satoru Takebayashi, Andrew Cole, Thomas E Carey & Hiroyuki Mineta. (2013) Galanin Has Tumor Suppressor Activity and Is Frequently Inactivated by Aberrant Promoter Methylation in Head and Neck Cancer. Translational Oncology 6:3, pages 338-346.
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Kiyoshi Misawa, Takeharu Kanazawa, Yuki Misawa, Atsushi Imai, Takayuki Uehara, Daiki Mochizuki, Shiori Endo, Goro Takahashi & Hiroyuki Mineta. (2013) Frequent promoter hypermethylation of tachykinin-1 and tachykinin receptor type 1 is a potential biomarker for head and neck cancer. Journal of Cancer Research and Clinical Oncology 139:5, pages 879-889.
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Hiroyuki Yamamoto, Rina Okada, Kazuaki Iguchi, Satoshi Ohno, Takashi Yokogawa, Kazuya Nishikawa, Keiko Unno, Minoru Hoshino & Atsushi Takeda. (2013) Involvement of plasmin-mediated extracellular activation of progalanin in angiogenesis. Biochemical and Biophysical Research Communications 430:3, pages 999-1004.
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Roshan Tofighi, Swapnali Barde, Miklos Palkovits, Anders Höög, Tomas Hökfelt, Sandra Ceccatelli & Anna-Lena Hulting. (2012) Galanin and its three receptors in human pituitary adenoma. Neuropeptides 46:5, pages 195-201.
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Zhenhui Liu, Linfang Li & Min Zhang. 2012. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 750 756 .
Jin C. Kim, Han C. Lee, Dong H. Cho, Eun Y. Choi, Yoon K. Cho, Ye J. Ha, Pyong W. Choi, Seon A. Roh, Seon Y. Kim & Yong S. Kim. (2011) Genome-wide identification of possible methylation markers chemosensitive to targeted regimens in colorectal cancers. Journal of Cancer Research and Clinical Oncology 137:10, pages 1571-1580.
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