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The apelinergic system: a promising therapeutic target

, PhD, , MD & , MD PhD
Pages 633-645 | Published online: 29 Mar 2010

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Qian Liu, Shao-Bin Duan, Lin Wang, Xiao-Qin Luo, Hong-Shen Wang, Ying-Hao Deng, Xi Wu, Ting Wu, Ping Yan and & Yi-Xin Kang. (2023) Apelin-13 alleviates contrast-induced acute kidney injury by inhibiting endoplasmic reticulum stress. Renal Failure 45:1.
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Articles from other publishers (33)

Alessandro Troisi, Cecilia Dall’Aglio, Margherita Maranesi, Riccardo Orlandi, Chiara Suvieri, Sara Pastore, Marilena Bazzano, Marcelo Martínez-Barbitta & Angela Polisca. (2022) Presence and localization of apelin and its cognate receptor in canine testes using immunohistochemical and RT-PCR techniques. Veterinary Research Communications 47:2, pages 929-935.
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Yuki Enoki, Tomoya Nagai, Yuna Hamamura, Sumika Osa, Hideaki Nakamura, Kazuaki Taguchi, Hiroshi Watanabe, Toru Maruyama & Kazuaki Matsumoto. (2022) The G protein‐coupled receptor ligand apelin‐13 ameliorates skeletal muscle atrophy induced by chronic kidney disease. Journal of Cachexia, Sarcopenia and Muscle 14:1, pages 553-564.
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Mikael Sturny, Léa Anguenot, Fabiana P. Costa-Fraga, Maiia E. Bragina, Augusto Martins Lima, Rafaela F. da Silva, Rodrigo A. Fraga-Silva & Nikolaos Stergiopulos. (2021) Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced by High-Fat Diet in an MMP-Dependent Mechanism. The Journal of Sexual Medicine 18:5, pages 875-888.
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Patrícia G. Rodrigues, Daniela Miranda-Silva, Xidan Li, Cláudia Sousa-Mendes, Ricardo Martins-Ferreira, Zaher Elbeck, Adelino F. Leite-Moreira, Ralph Knöll & Inês Falcão-Pires. (2020) The Degree of Cardiac Remodelling before Overload Relief Triggers Different Transcriptome and miRome Signatures during Reverse Remodelling (RR)—Molecular Signature Differ with the Extent of RR. International Journal of Molecular Sciences 21:24, pages 9687.
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A. Troisi, C. Dall’Aglio, M. Maranesi, R. Orlandi, R. Speranza, M. Zerani & A. Polisca. (2020) Presence and expression of apelin and apelin receptor in bitch placenta. Theriogenology 147, pages 192-196.
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Patricia Leme Goto, Mathieu Cinato, Fadi Merachli, Bohdana Vons, Tony Jimenez, Dimitri Marsal, Nika Todua, Halyna Loi, Yohan Santin, Stéphanie Cassel, Muriel Blanzat, Helene Tronchere, Christophe Dejugnat, Oksana Kunduzova & Frederic Boal. (2020) In vitro and in vivo cardioprotective and metabolic efficacy of vitamin E TPGS/Apelin. Journal of Molecular and Cellular Cardiology 138, pages 165-174.
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Junxia Zhang, Xue Lin, Jinxiu Xu & Feng Tang. (2019) Apelin-13 reduces oxidative stress induced by uric acid via downregulation of renin-angiotensin system in adipose tissue. Toxicology Letters 305, pages 51-57.
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Alexandre Murza, Kien Trân, Laurent Bruneau-Cossette, Olivier Lesur, Mannix Auger-Messier, Pierre Lavigne, Philippe Sarret & Éric Marsault. (2019) Apelins, ELABELA, and their derivatives: Peptidic regulators of the cardiovascular system and beyond. Peptide Science 111:1, pages e24064.
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Elham Haghparast, Saeed Esmaeili-Mahani, Mehdi Abbasnejad & Vahid Sheibani. (2018) Apelin-13 ameliorates cognitive impairments in 6-hydroxydopamine-induced substantia nigra lesion in rats. Neuropeptides 68, pages 28-35.
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Alexandre Murza, Xavier Sainsily, Jérôme Côté, Laurent Bruneau-Cossette, Élie Besserer-Offroy, Jean-Michel Longpré, Richard Leduc, Robert Dumaine, Olivier Lesur, Mannix Auger-Messier, Philippe Sarret & Éric Marsault. (2017) Structure–activity relationship of novel macrocyclic biased apelin receptor agonists. Organic & Biomolecular Chemistry 15:2, pages 449-458.
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Daniel Moreira-Gonçalves, Rita Ferreira-Nogueira, Mário Santos, Ana Filipa Silva, Rita Ferreira, Adelino Leite-Moreira, José Alberto Duarte & Tiago Henriques-Coelho. 2017. Exercise for Cardiovascular Disease Prevention and Treatment. Exercise for Cardiovascular Disease Prevention and Treatment 307 324 .
Ke Wang, Ziyong Ju, Yue Yong, Tongyu Chen, Jiangang Song & Jia Zhou. (2016) The Effects of Electroacupuncture on the Apelin/APJ System in the Spinal Cord of Rats With Inflammatory Pain. Anesthesia & Analgesia 123:6, pages 1603-1610.
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Prashant Kumar, Anisha Ashokan & Gopala Krishna Aradhyam. (2016) Apelin binding to human APJ receptor leads to biased signaling. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1864:12, pages 1748-1756.
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Jinxin Li, Min Feng, Yanli Wang, Yaodong Li, Yanyi Zhang, Lei Li, Jian Xiong, Changzhu Lu, Bin Wang, Zuheng Cheng, Baopeng Tang & Wenquan Niu. (2014) The relationship between three X-linked genes and the risk for hypertension among northeastern Han Chinese. Journal of the Renin-Angiotensin-Aldosterone System 16:4, pages 1321-1328.
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Keqin Luo, Huibao Long, Bincan Xu & Yanling Luo. (2015) Apelin attenuates postburn sepsis via a phosphatidylinositol 3-kinase/protein kinase B dependent mechanism: A randomized animal study. International Journal of Surgery 21, pages 22-27.
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Yunfei Chi, Jiake Chai, Chengfeng Xu, Hongmin Luo & Qinxue Zhang. (2015) Apelin inhibits the activation of the nucleotide-binding domain and the leucine-rich, repeat-containing family, pyrin-containing 3 (NLRP3) inflammasome and ameliorates insulin resistance in severely burned rats. Surgery 157:6, pages 1142-1152.
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Alexandre Murza, Élie Besserer-Offroy, Jérôme Côté, Patrick Bérubé, Jean-Michel Longpré, Robert Dumaine, Olivier Lesur, Mannix Auger-Messier, Richard Leduc, Philippe Sarret & Éric Marsault. (2015) C-Terminal Modifications of Apelin-13 Significantly Change Ligand Binding, Receptor Signaling, and Hypotensive Action. Journal of Medicinal Chemistry 58:5, pages 2431-2440.
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Nádia Gonçalves, Inês Falcão-Pires & Adelino Ferreira Leite-Moreira. (2015) Adipokines and their receptors: potential new targets in cardiovascular diseases. Future Medicinal Chemistry 7:2, pages 139-157.
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Eman T. Mehanna, Dina M. Abo-Elmatty, Maivel H. Ghattas, Noha M. Mesbah & Samy M. Saleh. (2015) Apelin rs2235306 polymorphism is not related to metabolic syndrome in Egyptian women. Egyptian Journal of Medical Human Genetics 16:1, pages 35-40.
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Susan Walker, Mark H. D. Danton, Alexander D. Lang & Fiona Lyall. (2014) Apelin Receptor (APJ) Expression during Cardiopulmonary Bypass in Children Undergoing Surgical Repair. PLoS ONE 9:9, pages e106262.
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Yanyan Zhang, Rangan Maitra, Danni L. Harris, Suraj Dhungana, Rodney Snyder & Scott P. Runyon. (2014) Identifying structural determinants of potency for analogs of apelin-13: Integration of C-terminal truncation with structure–activity. Bioorganic & Medicinal Chemistry 22:11, pages 2992-2997.
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Gyula Telegdy & Miklós Jászberényi. (2014) Transmitter mediation of the anxiolytic action of apelin-13 in male mice. Behavioural Brain Research 263, pages 198-202.
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Ruoshan Liu, Hongye Zhao, Yuefei Wang, Yanli Wang, Changzhu Lu, Yu Xiao, Nan Jia, Bin Wang & Wenquan Niu. (2014) The Contributory Role of Angiotensin Receptor-Like 1 Gene Multiple Polymorphisms in Hypertension among Northeastern Han Chinese. PLoS ONE 9:1, pages e86095.
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Shigeyuki Obara, Sumio Akifusa, Wataru Ariyoshi, Toshinori Okinaga, Michihiko Usui, Keisuke Nakashima & Tatsuji Nishihara. (2014) Pyroglutamated Apelin-13 Inhibits Lipopolysaccharide-Induced Production of Pro-Inflammatory Cytokines in Murine Macrophage J774.1 Cells. Modern Research in Inflammation 03:02, pages 59-66.
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Robert T. Day, Rita C. Cavaglieri & Denis Feliers. (2013) Apelin retards the progression of diabetic nephropathy. American Journal of Physiology-Renal Physiology 304:6, pages F788-F800.
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Jiaojiao Chu, Hangxiang Zhang, Xiuqing Huang, Yajun Lin, Tao Shen, Beidong Chen, Yong Man, Shu Wang & Jian Li. (2013) Apelin Ameliorates TNF-α-Induced Reduction of Glycogen Synthesis in the Hepatocytes through G Protein-Coupled Receptor APJ. PLoS ONE 8:2, pages e57231.
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Changge Fang, Ingalill Avis, Caterina Bianco, Natalie Held, Jennifer Morris, Kris Ylaya, Stephen M. Hewitt, Alfred C. Aplin, Roberto F. Nicosia, Laura A. Fung, John D. Lewis, William G. Stetler-Stevenson, David S. Salomon & Frank Cuttitta. (2013) SCNH2 is a novel apelinergic family member acting as a potent mitogenic and chemotactic factor for both endothelial and epithelial cells. Open Journal of Clinical Diagnostics 03:02, pages 37-51.
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N. Aozasa, Y. Asano, K. Akamata, S. Noda, Y. Masui, D. Yamada, Z. Tamaki, Y. Tada, M. Sugaya, T. Kadono & S Sato. (2013) Serum apelin levels: clinical association with vascular involvements in patients with systemic sclerosis. Journal of the European Academy of Dermatology and Venereology 27:1, pages 37-42.
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Gyula Telegdy, Agnes Adamik & Miklós Jászberényi. (2013) Involvement of neurotransmitters in the action of apelin-13 on passive avoidance learning in mice. Peptides 39, pages 171-174.
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Frank Cuttitta & David S. Salomon. 2013. Handbook of Biologically Active Peptides. Handbook of Biologically Active Peptides 502 505 .
Dmitri Pchejetski, Camille Foussal, Chiara Alfarano, Olivier Lairez, Denis Calise, Celine Guilbeau-Frugier, Stéphane Schaak, Marie-Hélène Seguelas, Estelle Wanecq, Philippe Valet, Angelo Parini & Oksana Kunduzova. (2012) Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1. European Heart Journal 33:18, pages 2360-2369.
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Inês Falcão-Pires, Paulo Castro-Chaves, Daniela Miranda-Silva, André P. Lourenço & Adelino F. Leite-Moreira. (2012) Physiological, pathological and potential therapeutic roles of adipokines. Drug Discovery Today 17:15-16, pages 880-889.
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Toshihiro Yamamoto, Yugo Habata, Yoshio Matsumoto, Yoshitaka Yasuhara, Tadatoshi Hashimoto, Hitomi Hamajyo, Hisashi Anayama, Ryo Fujii, Hiromitsu Fuse, Yasushi Shintani & Masaaki Mori. (2011) Apelin-transgenic mice exhibit a resistance against diet-induced obesity by increasing vascular mass and mitochondrial biogenesis in skeletal muscle. Biochimica et Biophysica Acta (BBA) - General Subjects 1810:9, pages 853-862.
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