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Review

Development of novel therapeutic strategies that target HIF-1

Pages 267-280 | Published online: 21 Mar 2006

Keep up to date with the latest research on this topic with citation updates for this article.

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Hyun Seung Ban, Yoshikazu Uto & Hiroyuki Nakamura. (2021) Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2016–2020). Expert Opinion on Therapeutic Patents 31:5, pages 387-397.
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Hyun Seung Ban, Yoshikazu Uto, Misun Won & Hiroyuki Nakamura. (2016) Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015). Expert Opinion on Therapeutic Patents 26:3, pages 309-322.
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Barbara Salani, Silvia Ravera, Adriana Amaro, Annalisa Salis, Mario Passalacqua, Enrico Millo, Gianluca Damonte, Cecilia Marini, Ulrich Pfeffer, Gianmario Sambuceti, Renzo Cordera & Davide Maggi. (2015) IGF1 regulates PKM2 function through Akt phosphorylation. Cell Cycle 14:10, pages 1559-1567.
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Darren Hargrave. (2009) Paediatric high and low grade glioma: the impact of tumour biology on current and future therapy. British Journal of Neurosurgery 23:4, pages 351-363.
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Rachida S Bel Aiba, Elitsa Y Dimova, Agnes Görlach & Thomas Kietzmann. (2006) The role of hypoxia inducible factor-1 in cell metabolism – a possible target in cancer therapy. Expert Opinion on Therapeutic Targets 10:4, pages 583-599.
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
Tadhg P. BegleyFlashman Emily, Loenarz Christoph & Christopher J. Schofield. 2007. Wiley Encyclopedia of Chemical Biology. Wiley Encyclopedia of Chemical Biology.
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
Cormac T. Taylor. (2007) Mitochondria and cellular oxygen sensing in the HIF pathway. Biochemical Journal 409:1, pages 19-26.
Crossref
Kristina M. Cook & Christopher J. Schofield. 2008. Angiogenesis. Angiogenesis 359 373 .
Philip J. S. Charlesworth & Adrian L. Harris. 2008. Angiogenesis. Angiogenesis 169 179 .
Rachida S. BelAiba, Steve Bonello, Christian Zähringer, Stefanie Schmidt, John Hess, Thomas Kietzmann & Agnes Görlach. (2007) Hypoxia Up-Regulates Hypoxia-Inducible Factor-1α Transcription by Involving Phosphatidylinositol 3-Kinase and Nuclear Factor κB in Pulmonary Artery Smooth Muscle Cells. Molecular Biology of the Cell 18:12, pages 4691-4697.
Crossref
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Crossref
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Crossref
Annelies S. Zinkernagel, Randall S. Johnson & Victor Nizet. (2007) Hypoxia inducible factor (HIF) function in innate immunity and infection. Journal of Molecular Medicine 85:12, pages 1339-1346.
Crossref
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Crossref
Ramon Bartrons & Jaime Caro. (2007) Hypoxia, glucose metabolism and the Warburg’s effect. Journal of Bioenergetics and Biomembranes 39:3, pages 223-229.
Crossref
A Rapisarda & G Melillo. (2007) UVC inhibits HIF-1α protein translation by a DNA damage- and topoisomerase I-independent pathway. Oncogene 26:48, pages 6875-6884.
Crossref
Gregg L. Semenza. (2007) Evaluation of HIF-1 inhibitors as anticancer agents. Drug Discovery Today 12:19-20, pages 853-859.
Crossref
Jingqiu Dai, Yang Liu, Hong Jia, Yu-Dong Zhou & Dale G. Nagle. (2007) Benzochromenones from the Marine Crinoid Comantheria rotula Inhibit Hypoxia-Inducible Factor-1 (HIF-1) in Cell-Based Reporter Assays and Differentially Suppress the Growth of Certain Tumor Cell Lines. Journal of Natural Products 70:9, pages 1462-1466.
Crossref
Miguel López-Lázaro. (2007) Dual role of hydrogen peroxide in cancer: Possible relevance to cancer chemoprevention and therapy. Cancer Letters 252:1, pages 1-8.
Crossref
Jarmila D.W. van der Bilt, Marije E. Soeters, Annique M.M.J. Duyverman, Maarten W. Nijkamp, Petronella O. Witteveen, Paul J. van Diest, Onno Kranenburg & Inne H.M. Borel Rinkes. (2007) Perinecrotic Hypoxia Contributes to Ischemia/Reperfusion-Accelerated Outgrowth of Colorectal Micrometastases. The American Journal of Pathology 170:4, pages 1379-1388.
Crossref
Miguel López-Lázaro. (2007) Excessive superoxide anion generation plays a key role in carcinogenesis. International Journal of Cancer 120:6, pages 1378-1380.
Crossref
Miguel López-Lázaro. (2006) Hypoxia-Inducible Factor 1 as a Possible Target for Cancer Chemoprevention. Cancer Epidemiology, Biomarkers & Prevention 15:12, pages 2332-2335.
Crossref
Gregg L. Semenza. (2006) Baffled by Bafilomycin: An Anticancer Agent That Induces Hypoxia-Inducible Factor-1α Expression: Fig. 1.. Molecular Pharmacology 70:6, pages 1841-1843.
Crossref
Jingqiu Dai, James A. Fishback, Yu-Dong Zhou & Dale G. Nagle. (2006) Sodwanone and Yardenone Triterpenes from a South African Species of the Marine Sponge Axinella Inhibit Hypoxia-Inducible Factor-1 (HIF-1) Activation in Both Breast and Prostate Tumor Cells . Journal of Natural Products 69:12, pages 1715-1720.
Crossref
Claudine KiedaRuth Greferath, Claire Crola Da SilvaKonstantina C. Fylaktakidou, Jean-Marie Lehn & Claude Nicolau. (2006) Suppression of hypoxia-induced HIF-1α and of angiogenesis in endothelial cells by myo -inositol trispyrophosphate-treated erythrocytes . Proceedings of the National Academy of Sciences 103:42, pages 15576-15581.
Crossref
Giovanni Melillo. (2006) Inhibiting Hypoxia-Inducible Factor 1 for Cancer Therapy. Molecular Cancer Research 4:9, pages 601-605.
Crossref
Gregg L. Semenza. (2006) Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia-inducible factor 1. Experimental Physiology 91:5, pages 803-806.
Crossref
Gregg L Semenza. (2006) Hypoxia pathway linked to kidney failure. Nature Medicine 12:9, pages 996-997.
Crossref
Philip I. Aaronson. (2006) TRPC Channel Upregulation in Chronically Hypoxic Pulmonary Arteries. Circulation Research 98:12, pages 1465-1467.
Crossref

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