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Expert Opinion on Therapeutic Targets Volume 10, 2006 - Issue 2
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Review

Adrenomedullin: a new and promising target for drug discovery

Mario A García Research Fellow, Universidad San Pablo CEU, Departamento de Química, Facultad de Farmacia, Urbanización Montepríncipe, 28668 Boadilla del Monte, Madrid, Spain
,
Sonsoles Martín-Santamaría Associate Professor, Universidad San Pablo CEU, Departamento de Química, Facultad de Farmacia, Urbanización Montepríncipe, 28668 Boadilla del Monte, Madrid, Spain
,
Beatriz de Pascual-Teresa Head of Department, Universidad San Pablo CEU, Departamento de Química, Facultad de Farmacia, Urbanización Montepríncipe, 28668 Boadilla del Monte, Madrid, Spain
,
Ana Ramos Professor, Universidad San Pablo CEU, Departamento de Química, Facultad de Farmacia, Urbanización Montepríncipe, 28668 Boadilla del Monte, Madrid, Spain
,
Miguel Julián Associate Professor, Universidad San Pablo CEU, Departamento de Química, Facultad de Farmacia, Urbanización Montepríncipe, 28668 Boadilla del Monte, Madrid, Spain
&
Alfredo Martínez Associate Professor, Instituto Cajal, CSIC, Departamento de Neuroanatomía y Biología Celular, 28002 Madrid, Spain. [email protected]
Pages 303-317 | Published online: 21 Mar 2006

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Jean-Laurent Deville, Sébastien Salas, Dominique Figarella-Branger, L'Houcine Ouafik & Laurent Daniel. (2010) Adrenomedullin as a therapeutic target in angiogenesis. Expert Opinion on Therapeutic Targets 14:10, pages 1059-1072.
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Articles from other publishers (17)

Zhi Yang, Hongchun Li, Pengfei Wu, Qingyan Li, ChunYan Yu, Denian Wang & Weimin Li. (2023) Multi-biological functions of intermedin in diseases. Frontiers in Physiology 14.
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Pang-Hu Zhou, Lei Shi, Wei Hu, Xiao-Bin Zhang, Wei Wang & Li-Jun Zhang. (2016) Changes of adrenomedullin and natriuretic peptides in patients with adrenal medullary hyperplasia prior to and following pharmacological therapy and adrenalectomy. Experimental and Therapeutic Medicine 12:2, pages 864-872.
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Gijs W.D. Landman, Peter R. van Dijk, Iefke Drion, Kornelis J.J. van Hateren, Joachim Struck, Klaas H. Groenier, Rijk O.B. Gans, Henk J.G. Bilo, Stephan J.L. Bakker & Nanne Kleefstra. (2014) Midregional Fragment of Proadrenomedullin, New-Onset Albuminuria, and Cardiovascular and All-Cause Mortality in Patients With Type 2 Diabetes (ZODIAC-30). Diabetes Care 37:3, pages 839-845.
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Talero Elena, Di Paola Rosanna, Mazzon Emanuela, Emanuela Esposito, Motilva Virginia & Cuzzocrea Salvatore. (2012) Anti-Inflammatory Effects of Adrenomedullin on Acute Lung Injury Induced by Carrageenan in Mice. Mediators of Inflammation 2012, pages 1-13.
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Ignacio M. Larrayoz, Laura Ochoa-Callejero, Josune García-Sanmartín, Carlos Vicario-Abejón & Alfredo Martínez. 2012. International Review of Cell and Molecular Biology Volume 297. International Review of Cell and Molecular Biology Volume 297 175 234 .
Javier Pérez-Castells, Sonsoles Martín-Santamaría, Lidia Nieto, Ana Ramos, Alfredo Martínez, Beatriz de Pascual-Teresa & Jesús Jiménez-Barbero. (2012) Structure of micelle-bound adrenomedullin: A first step toward the analysis of its interactions with receptors and small molecules. Biopolymers 97:1, pages 45-53.
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Rosanna Di Paola, Elena Talero, Maria Galuppo, Emanuela Mazzon, Placido Bramanti, Virginia Motilva & Salvatore Cuzzocrea. (2011) Adrenomedullin in inflammatory process associated with experimental pulmonary fibrosis. Respiratory Research 12:1.
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Bernard M Y Cheung, Kwok Leung Ong, Annette W K Tso, Raymond Y H Leung, Stacey S Cherny, Pak Chung Sham, Tai Hing Lam & Karen S L Lam. (2011) Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene. European Journal of Endocrinology 165:4, pages 571-577.
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E. Talero, S. Sánchez-Fidalgo, I. Villegas, Alarcón C. de la Lastra, M. Illanes & V. Motilva. (2011) Role of different inflammatory and tumor biomarkers in the development of ulcerative colitis-associated carcinogenesis. Inflammatory Bowel Diseases 17:3, pages 696-710.
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Emma Langella, Sébastien Pierre, Wadih Ghattas, Michel Giorgi, Marius Réglier, Michele Saviano, Luciana Esposito & Renaud Hardré. (2010) Probing the Peptidylglycine α-Hydroxylating Monooxygenase Active Site with Novel 4-Phenyl-3-butenoic Acid Based Inhibitors. ChemMedChem 5:9, pages 1568-1576.
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David S. Musson, Julia L. McLachlan, Alastair J. Sloan, Anthony J. Smith & Paul R. Cooper. (2012) Adrenomedullin is expressed during rodent dental tissue development and promotes cell growth and mineralization. Biology of the Cell 102:3, pages 145-157.
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Samuel D. Robinson, Jacqueline F. Aitken, Richard J. Bailey, David R. Poyner & Debbie L. Hay. (2009) Novel Peptide Antagonists of Adrenomedullin and Calcitonin Gene-Related Peptide Receptors: Identification, Pharmacological Characterization, and Interactions with Position 74 in Receptor Activity-Modifying Protein 1/3. Journal of Pharmacology and Experimental Therapeutics 331:2, pages 513-521.
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Michael Gröschl, Olaf Wendler, Hans-Georg Topf, Jörg Bohlender & Henrik Köhler. (2009) Significance of salivary adrenomedullin in the maintenance of oral health: Stimulation of oral cell proliferation and antibacterial properties. Regulatory Peptides 154:1-3, pages 16-22.
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Virginia Roldós, Sonsoles Martín-Santamaría, Miguel Julián, Alfredo Martínez, Laurence Choulier, Danièle Altschuh, Beatriz de Pascual-Teresa & Ana Ramos. (2008) Small-Molecule Negative Modulators of Adrenomedullin: Design, Synthesis, and 3D-QSAR Study. ChemMedChem, pages NA-NA.
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Alfredo Martínez, Jaqueline Arias, Jorge A. Bassuk, Heng Wu, Paul Kurlansky & Jose A. Adams. (2008) Adrenomedullin is increased by pulsatile shear stress on the vascular endothelium via periodic acceleration (pGz). Peptides 29:1, pages 73-78.
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Domenico Ribatti, Maria Teresa Conconi & Gastone G. Nussdorfer. (2007) Nonclassic Endogenous Novel Regulators of Angiogenesis. Pharmacological Reviews 59:2, pages 185-205.
Crossref
Chun Shui Pan, Shao Ju Jin, Chang Qi Cao, Jing Zhao, Jing Zhang, Xian Wang, Chao Shu Tang & Yong Fen Qi. (2007) The myocardial response to adrenomedullin involves increased cAMP generation as well as augmented Akt phosphorylation. Peptides 28:4, pages 900-909.
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