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Review

Is YKL-40 a new therapeutic target in cancer?

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Pages 219-234 | Published online: 17 Jan 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Hailong Hao, Huiqing Chen, Liwu Xie & Hongyu Liu. (2021) YKL-40 promotes invasion and metastasis of bladder cancer by regulating epithelial mesenchymal transition. Annals of Medicine 53:1, pages 1171-1179.
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Filippo Baldacci, Simone Lista, Enrica Cavedo, Ubaldo Bonuccelli & Harald Hampel. (2017) Diagnostic function of the neuroinflammatory biomarker YKL-40 in Alzheimer’s disease and other neurodegenerative diseases. Expert Review of Proteomics 14:4, pages 285-299.
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Anne K. Mylin, Niels Abildgaard, Julia S. Johansen, Lene Heickendorff, Svend Kreiner, Anders Waage, Ingemar Turesson & Peter Gimsing. (2015) Serum YKL-40: a new independent prognostic marker for skeletal complications in patients with multiple myeloma. Leukemia & Lymphoma 56:9, pages 2650-2659.
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Pan Jo Kim, Dae Gy Hong, Ji Young Park, Young Lae Cho, Il Soo Park & Yoon Soon Lee. (2010) Immunohistochemical expression of YKL-40 in peritoneal endometriosis. Gynecological Endocrinology 26:1, pages 58-62.
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Ferdinando Mannello, Virginia Medda & Gaetana A Tonti. (2009) Protein profile ana lysis of the breast microenvironment to differentiate healthy women from breast cancer patients. Expert Review of Proteomics 6:1, pages 43-60.
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Anne Roslind, Eva Balslev, Hanne Kruse, Bente Stærgaard & Thomas Horn. (2008) Subcellular Localization of YKL-40 in Normal and Malignant Epithelial Cells of the Breast. Ultrastructural Pathology 32:3, pages 101-106.
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Articles from other publishers (37)

Shuang Shi, Jiacheng Zhong, Wen Peng, Haoyang Yin, Dong Zhong, Hongjuan Cui & Xiaochuan Sun. (2023) System analysis based on the migration- and invasion-related gene sets identifies the infiltration-related genes of glioma. Frontiers in Oncology 13.
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Mariangela De Robertis, Maria Raffaella Greco, Rosa Angela Cardone, Tommaso Mazza, Flaviana Marzano, Nikolay Mehterov, Maria Kazakova, Nikolay Belev, Apollonia Tullo, Graziano Pesole, Victoria Sarafian & Emanuela Signori. (2022) Upregulation of YKL-40 Promotes Metastatic Phenotype and Correlates with Poor Prognosis and Therapy Response in Patients with Colorectal Cancer. Cells 11:22, pages 3568.
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Dorota Nadbrzeżna-Barczyk, Dariusz Waniczek, Elżbieta Świętochowska, Ewa Nowakowska-Zajdel, Angelika Copija, Aleksandra Raźnikiewicz, Monika Rykaczewska-Czerwińska & Zbigniew Lorenc. (2021) Assessment of importance of YKL-40 protein as biomarker in colorectal cancer and its relation to selected clinical and pathological parameters. Annales Academiae Medicae Silesiensis 75, pages 136-146.
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Hong‐Yan Chen, Zhao‐Yu Zhou, Yan‐Lu Luo, Qin Luo & Jiang‐Tao Fan. (2021) Knockdown of YKL‐40 inhibits angiogenesis through regulation of VEGF/VEGFR2 and ERK1/2 signaling in endometrial cancer . Cell Biology International 45:12, pages 2557-2566.
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Il Hwan Oh, Jung-Soo Pyo & Byoung Kwan Son. (2021) Prognostic Impact of YKL-40 Immunohistochemical Expression in Patients with Colorectal Cancer. Current Oncology 28:4, pages 3139-3149.
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Ting Zhao, Zhongping Su, Yingchang Li, Xiaoren Zhang & Qiang You. (2020) Chitinase-3 like-protein-1 function and its role in diseases. Signal Transduction and Targeted Therapy 5:1.
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Hideko Suzuki, Hikari Boki, Hiroaki Kamijo, Rina Nakajima, Tomonori Oka, Naomi Shishido-Takahashi, Hiraku Suga, Makoto Sugaya, Shinichi Sato & Tomomitsu Miyagaki. (2020) YKL-40 Promotes Proliferation of Cutaneous T-Cell Lymphoma Tumor Cells through Extracellular Signal–Regulated Kinase Pathways. Journal of Investigative Dermatology 140:4, pages 860-868.e3.
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Biao Geng, Jinshun Pan, Ting Zhao, Jie Ji, Chen Zhang, Ying Che, Jing Yang, Hui Shi, Juan Li, Hong Zhou, Xianmin Mu, Che Xu, Chao Wang, Yue Xu, Zheng Liu, Hao Wen & Qiang You. (2018) Chitinase 3-like 1-CD44 interaction promotes metastasis and epithelial-to-mesenchymal transition through β-catenin/Erk/Akt signaling in gastric cancer. Journal of Experimental & Clinical Cancer Research 37:1.
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Guoxing Wan, Longchao Xiang, Xue Sun, Xuanbin Wang, Hongliang Li, Wei Ge & Fengjun Cao. (2016) Elevated YKL-40 expression is associated with a poor prognosis in breast cancer patients. Oncotarget 8:3, pages 5382-5391.
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W. Chaocharoen, A. Schulte & W. Suginta. (2017) hYKL-40 cancer biomarker electroanalysis in serum samples and model cell lysates: capacitive immunosensing compared with enzyme label immunosorbent assays (ELISA). The Analyst 142:3, pages 503-510.
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XiaoYan Long, Hui Hu, Shuyu Li, Mingna Chen, Jizhang Cai & Bingxin Song. (2016) Hippocampal YKL-40 expression in rats after status epilepticus. Epilepsy Research 125, pages 52-57.
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Ying-Cheng Chiang, Han-Wei Lin, Chi-Fang Chang, Ming-Cheng Chang, Chi-Feng Fu, Tsung-Ching Chen, Shu-Feng Hsieh, Chi-An Chen & Wen-Fang Cheng. (2015) Overexpression of CHI3L1 is associated with chemoresistance and poor outcome of epithelial ovarian carcinoma. Oncotarget 6:37, pages 39740-39755.
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Kumar Natesh, Dipali Bhosale, Aarti Desai, Goparaju Chandrika, Radha Pujari, Jayashree Jagtap, Ashish Chugh, Deepak Ranade & Padma Shastry. (2015) Oncostatin-M Differentially Regulates Mesenchymal and Proneural Signature Genes in Gliomas via STAT3 Signaling. Neoplasia 17:2, pages 225-237.
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Mads Emil Bjørn, Christen Lykkegaard Andersen, Morten Krogh Jensen & Hans C. Hasselbalch. (2014) Circulating YKL-40 in myelofibrosis a potential novel biomarker of disease activity and the inflammatory state. European Journal of Haematology 93:3, pages 224-228.
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Stephan Tschirdewahn, Henning Reis, Christian Niedworok, Peter Nyirady, Attila Szendröi, Kurt W. Schmid, Shahrokh F. Shariat, Gero Kramer, Frank vom Dorp, Herbert Rübben & Tibor Szarvas. (2014) Prognostic effect of serum and tissue YKL-40 levels in bladder cancer. Urologic Oncology: Seminars and Original Investigations 32:5, pages 663-669.
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Mansi Prakash, Manish Bodas, Divya Prakash, Neelu Nawani, Madhukar Khetmalas, Abul Mandal & Cecilia Eriksson. (2013) Diverse pathological implications of YKL-40: Answers may lie in ‘outside-in’ signaling. Cellular Signalling 25:7, pages 1567-1573.
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Ming Yang, Rakesh K Kumar, Philip M Hansbro & Paul S Foster. (2012) Emerging roles of pulmonary macrophages in driving the development of severe asthma. Journal of Leukocyte Biology 91:4, pages 557-569.
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Eleni Tsitsiou, Andrew E. Williams, Sterghios A. Moschos, Ketan Patel, Christos Rossios, Xiaoying Jiang, Oona-Delpuech Adams, Patricia Macedo, Richard Booton, David Gibeon, Kian Fan Chung & Mark A. Lindsay. (2012) Transcriptome analysis shows activation of circulating CD8+ T cells in patients with severe asthma. Journal of Allergy and Clinical Immunology 129:1, pages 95-103.
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Angel Díaz-Lagares, Estíbaliz Alegre, Ainhoa Arroyo, María González-Cao, Maria E. Zudaire, Santiago Viteri, Salvador Martín-Algarra & Alvaro González. (2011) Evaluation of multiple serum markers in advanced melanoma. Tumor Biology 32:6, pages 1155-1161.
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Andreas Hector, Michael S. D. Kormann, Ines Mack, Philipp Latzin, Carmen Casaulta, Elisabeth Kieninger, Zhe Zhou, Ali Ö. Yildirim, Alexander Bohla, Nikolaus Rieber, Matthias Kappler, Barbara Koller, Ernst Eber, Olaf Eickmeier, Stefan Zielen, Oliver Eickelberg, Matthias Griese, Marcus A. Mall & Dominik Hartl. (2011) The Chitinase-Like Protein YKL-40 Modulates Cystic Fibrosis Lung Disease. PLoS ONE 6:9, pages e24399.
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Ju Dong Yang, Eugene Kim, Rachel A. Pedersen, W. Ray Kim, Surakit Pungpapong & Lewis R. Roberts. (2010) Utility of Serum YKL-40 as a Tumor-Specific Marker of Hepatobiliary Malignancies. Gut and Liver 4:4, pages 537-542.
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Ina Thöm, Birte Andritzky, Gunter Schuch, Iris Burkholder, Lutz Edler, Julia S. Johansen, Carsten Bokemeyer, Udo Schumacher & Eckart Laack. (2010) Elevated pretreatment serum concentration of YKL‐40—An independent prognostic biomarker for poor survival in patients with metastatic nonsmall cell lung cancer. Cancer 116:17, pages 4114-4121.
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Nicolai A. Schultz & Julia S. Johansen. (2010) YKL-40—A Protein in the Field of Translational Medicine: A Role as a Biomarker in Cancer Patients?. Cancers 2:3, pages 1453-1491.
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Chun Geun LeeJack A Elias. (2010) Role of breast regression protein-39/YKL-40 in asthma and allergic responses. Allergy, Asthma and Immunology Research 2:1, pages 20.
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Stephanie T Chang, Jacob M Zahn, Joe Horecka, Pamela L Kunz, James M Ford, George A Fisher, Quynh T Le, Daniel T Chang, Hanlee Ji & Albert C Koong. (2009) Identification of a biomarker panel using a multiplex proximity ligation assay improves accuracy of pancreatic cancer diagnosis. Journal of Translational Medicine 7:1.
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Takeo Iwata, Masamichi Kuwajima, Akiko Sukeno, Naozumi Ishimaru, Yoshio Hayashi, Martin Wabitsch, Noriko Mizusawa, Mitsuo Itakura & Katsuhiko Yoshimoto. (2009) YKL-40 secreted from adipose tissue inhibits degradation of type I collagen. Biochemical and Biophysical Research Communications 388:3, pages 511-516.
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Julia S JohansenNicolai A Schultz & Benny V Jensen. (2009) Plasma YKL-40: a potential new cancer biomarker?. Future Oncology 5:7, pages 1065-1082.
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Chun Geun Lee, Dominik Hartl, Gap Ryol Lee, Barbara Koller, Hiroshi Matsuura, Carla A. Da Silva, Myung Hyun Sohn, Lauren Cohn, Robert J. Homer, Alexander A. Kozhich, Alison Humbles, Jennifer Kearley, Anthony Coyle, Geoffrey Chupp, Jennifer Reed, Richard A. Flavell & Jack A. Elias. (2009) Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13–induced tissue responses and apoptosis. Journal of Experimental Medicine 206:5, pages 1149-1166.
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Maciej M. Mrugala, James L. Rubenstein, Maurilio Ponzoni & Tracy T. Batchelor. (2008) Insights into the biology of primary central nervous system lymphoma. Current Oncology Reports 11:1, pages 73-80.
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Anne Roslind & Julia S. Johansen. 2009. Inflammation and Cancer. Inflammation and Cancer 159 184 .
V Rand, E Prebble, L Ridley, M Howard, W Wei, M-A Brundler, B E Fee, G J Riggins, B Coyle & R G Grundy. (2008) Investigation of chromosome 1q reveals differential expression of members of the S100 family in clinical subgroups of intracranial paediatric ependymoma. British Journal of Cancer 99:7, pages 1136-1143.
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Miquel Navasa & Xavier Forns. (2008) How accurately and how early can we predict rapid fibrosis progression in hepatitis C virus-infected patients after liver transplantation?. Liver Transplantation 14:9, pages 1237-1239.
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Andrea L Russo, Deborah Citrin & Kevin Camphausen. (2008) Biomarkers in radiation oncology. Biomarkers in Medicine 2:2, pages 155-163.
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Han W. TunDavid PersonettKaren A. BaskervilleDavid M. MenkeKurt A. Jaeckle, Pamela KreinestBrandy EdenfieldAbba C. ZubairBrian P. O'Neill, Weil R. Lai, Peter J. Park & Michael McKinney. (2008) Pathway analysis of primary central nervous system lymphoma. Blood 111:6, pages 3200-3210.
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Anne Roslind, Julia S. Johansen, Ib J. Christensen, Katalin Kiss, Eva Balslev, Dorte L. Nielsen, Jens Bentzen, Paul A. Price & Elo Andersen. (2008) High serum levels of YKL-40 in patients with squamous cell carcinoma of the head and neck are associated with short survival. International Journal of Cancer 122:4, pages 857-863.
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