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Expert Opinion on Therapeutic Targets Volume 11, 2007 - Issue 5
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Review

Targeting the PI3K and MAPK pathways to treat Kaposi’s sarcoma-associated herpes virus infection and pathogenesis

Phelps J Lambert Brody School of Medicine at East Carolina University, Department of Microbiology & Immunology, Greenville, NC 27834, USA. [email protected]
,
Aniqa Z Shahrier Brody School of Medicine at East Carolina University, Department of Microbiology & Immunology, Greenville, NC 27834, USA. [email protected]
,
Audy G Whitman Brody School of Medicine at East Carolina University, Department of Microbiology & Immunology, Greenville, NC 27834, USA. [email protected]
,
Ossie F Dyson Brody School of Medicine at East Carolina University, Department of Microbiology & Immunology, Greenville, NC 27834, USA. [email protected]
,
Adrian J Reber University of Georgia, Department of Large Animal Medicine, College of Veterinary Medicine, Athens, GA 30602, USA
,
James A McCubrey Brody School of Medicine at East Carolina University, Department of Microbiology & Immunology, Greenville, NC 27834, USA. [email protected]
&
Shaw M Akula Brody School of Medicine at East Carolina University, Department of Microbiology & Immunology, Greenville, NC 27834, USA. [email protected]
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Pages 589-599 | Published online: 27 Apr 2007

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Alma Chávez-Blanco, Rommel Chacón-Salinas, Guadalupe Dominguez-Gomez, Aurora Gonzalez-Fierro, Enrique Perez-Cardenas, Lucia Taja-Chayeb, Catalina Trejo-Becerril & Alfonso Duenas-Gonzalez. (2016) Viral inhibitors of NKG2D ligands for tumor surveillance. Expert Opinion on Therapeutic Targets 20:11, pages 1375-1387.
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Qinqin Sun, Fan Wang, Qingyang Chen, Ronit Sarid, Xiaojuan Li & Ersheng Kuang. (2022) Upregulation of ATF4-LAMP3 Axis by ORF45 Facilitates Lytic Replication of Kaposi’s Sarcoma-Associated Herpesvirus. Journal of Virology 96:23.
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Chunyuan Tang, Ying Zhou, Wen Sun, Haihong Hu, Yuxi Liu, Lu Chen, Fengting Ou, Su Zeng, Nengming Lin & Lushan Yu. (2022) Oncopeptide MBOP Encoded by LINC01234 Promotes Colorectal Cancer through MAPK Signaling Pathway. Cancers 14:9, pages 2338.
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Mengtian Yang, Lu Huang, Xiaojuan Li & Ersheng Kuang. (2016) Chloroquine inhibits lytic replication of Kaposi's sarcoma-associated herpesvirus by disrupting mTOR and p38-MAPK activation. Antiviral Research 133, pages 223-233.
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Lia R. Walker, Anshul V. Subramanya, Zeal T. Akula & Shaw M. Akula. 2015. Human Emerging and Re‐emerging Infections. Human Emerging and Re‐emerging Infections 265 279 .
Sugalesini Subramaniam, John Johnston, Likit Preeyanon, C. Titus Brown, Hsing-Jien Kung & Hans H. Cheng. (2013) Integrated Analyses of Genome-Wide DNA Occupancy and Expression Profiling Identify Key Genes and Pathways Involved in Cellular Transformation by a Marek's Disease Virus Oncoprotein, Meq. Journal of Virology 87:16, pages 9016-9029.
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Joseph W CarlJrJr, Joanne Trgovcich & Sridhar Hannenhalli. (2013) Widespread evidence of viral miRNAs targeting host pathways. BMC Bioinformatics 14:S2.
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Jader Nones, Ana Paula Costa, Rodrigo Bainy Leal, Flávia Carvalho Alcantara Gomes & Andréa Gonçalves Trentin. (2012) The flavonoids hesperidin and rutin promote neural crest cell survival. Cell and Tissue Research 350:2, pages 305-315.
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Sabrina Marozin, Jennifer Altomonte, Sibylle Apfel, Phat X. Dinh, Enrico N. De Toni, Antonia Rizzani, Andreas Nüssler, Nobuyuki Kato, Roland M. Schmid, Asit K. Pattnaik & Oliver Ebert. (2012) Posttranslational Modification of Vesicular Stomatitis Virus Glycoprotein, but Not JNK Inhibition, Is the Antiviral Mechanism of SP600125. Journal of Virology 86:9, pages 4844-4855.
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Kai Liu, Wei Rao, Hardik Parikh, Qianbin Li, Tai L. Guo, Steven Grant, Glen E. Kellogg & Shijun Zhang. (2012) 3,5-Disubstituted-thiazolidine-2,4-dione analogs as anticancer agents: Design, synthesis and biological characterization. European Journal of Medicinal Chemistry 47, pages 125-137.
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Ersheng Kuang, Bishi Fu, Qiming Liang, Jinjong Myoung & Fanxiu Zhu. (2011) Phosphorylation of Eukaryotic Translation Initiation Factor 4B (EIF4B) by Open Reading Frame 45/p90 Ribosomal S6 Kinase (ORF45/RSK) Signaling Axis Facilitates Protein Translation during Kaposi Sarcoma-associated Herpesvirus (KSHV) Lytic Replication. Journal of Biological Chemistry 286:48, pages 41171-41182.
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Jader Nones, Tania Cristina Leite de Sampaio e Spohr & Flávia Carvalho Alcantara Gomes. (2011) Hesperidin, a Flavone Glycoside, as Mediator of Neuronal Survival. Neurochemical Research 36:10, pages 1776-1784.
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Gianluca Baldanzi, Stefano Pietronave, Deborah Locarno, Simone Merlin, Paolo Porporato, Federica Chianale, Nicoletta Filigheddu, Anna Rita Cantelmo, Adriana Albini, Andrea Graziani & Maria Prat. (2011) Diacylglycerol kinases are essential for hepatocyte growth factor‐dependent proliferation and motility of Kaposi’s sarcoma cells. Cancer Science 102:7, pages 1329-1336.
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Christopher M Traylen, Hersh R Patel, Wylder Fondaw, Sheran Mahatme, John F Williams, Lia R Walker, Ossie F Dyson, Sergio Arce & Shaw M Akula. (2011) Virus reactivation: a panoramic view in human infections. Future Virology 6:4, pages 451-463.
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Qianbin Li, Jingde Wu, Hui Zheng, Kai Liu, Tai L. Guo, Yuying Liu, Scott T. Eblen, Steven Grant & Shijun Zhang. (2010) Discovery of 3-(2-aminoethyl)-5-(3-phenyl-propylidene)-thiazolidine-2,4-dione as a dual inhibitor of the Raf/MEK/ERK and the PI3K/Akt signaling pathways. Bioorganic & Medicinal Chemistry Letters 20:15, pages 4526-4530.
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Harilaos Filippakis, Demetrios A. Spandidos & George Sourvinos. (2010) Herpesviruses: Hijacking the Ras signaling pathway. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1803:7, pages 777-785.
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RICHARD N. MITCHELL & FREDERICK J. SCHOEN. 2010. Robbins and Cotran Pathologic Basis of Disease. Robbins and Cotran Pathologic Basis of Disease 487 528 .
Mohamed RahmaniAnh AndersonJoseph Reza HabibiTimothy Ryan CrabtreeMandy MayoHisashi HaradaAndrea Ferreira-GonzalezPaul Dent & Steven Grant. (2009) The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways. Blood 114:20, pages 4507-4516.
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Ningjie Hu, Richard Yu, Cecilia Shikuma, Bruce Shiramizu, Mario A. Ostrwoski & Qigui Yu. (2009) Role of cell signaling in poxvirus-mediated foreign gene expression in mammalian cells. Vaccine 27:22, pages 2994-3006.
Crossref
Ravit Arav-Boger. (2009) Treatment for Kaposi sarcoma herpesvirus: great challenges with promising accomplishments. Virus Genes 38:2, pages 195-203.
Crossref

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