Advanced search
Publication Cover
Expert Opinion on Therapeutic Targets Volume 11, 2007 - Issue 5
Submit an article Journal homepage
367
Views
38
CrossRef citations to date
0
Altmetric
Review

Towards the discovery of novel T-type calcium channel blockers

Philippe Lory Institut de Génomique Fonctionnelle (IGF), Département de Physiologie, CNRS UMR 5203 – INSERM U661 – IFR3 – Universités de Montpellier I and II, 141 rue de la Cardonille, 34094 Montpellier cedex 05, France. [email protected]
&
Jean Chemin Institut de Génomique Fonctionnelle (IGF), Département de Physiologie, CNRS UMR 5203 – INSERM U661 – IFR3 – Universités de Montpellier I and II, 141 rue de la Cardonille, 34094 Montpellier cedex 05, France. [email protected]
Pages 717-722 | Published online: 27 Apr 2007

Citations (38)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Wayne E Childers, Adam M Gilbert, Jeffrey D Kennedy & Garth T Whiteside. (2008) Advances in the development of novel analgesics. Expert Opinion on Therapeutic Patents 18:9, pages 1027-1067.
Read now

Articles from other publishers (37)

Jun Yang, Kejun Ye, Rui Zhang, Xinrong Fan, Rui Xiong, Shiyu Zhang, Qiming Liu, Miao Lin, Bin Wang, Xiaoqiu Tan, Qiang Wen & Xianhong Ou. (2023) The characteristics and molecular targets of antiarrhythmic natural products. Biomedicine & Pharmacotherapy 168, pages 115762.
Crossref
Maricruz Rangel-Galván, Violeta Rangel-Galván & Alejandro Rangel-Huerta. (2023) T-type calcium channel modulation by hydrogen sulfide in neuropathic pain conditions. Frontiers in Pharmacology 14.
Crossref
Anton V. Il’in, Arthur F. Gubaev, Daut R. Islamov, Karim R. Islamov & Vladimir I. Galkin. (2021) Highly efficient phosphine-catalyzed routes to α-imidoacrylates and 2,3-diimidopropanoates. Chemistry of Heterocyclic Compounds 57:2, pages 175-180.
Crossref
Philippe Lory, Sophie Nicole & Arnaud Monteil. (2020) Neuronal Cav3 channelopathies: recent progress and perspectives. Pflügers Archiv - European Journal of Physiology 472:7, pages 831-844.
Crossref
Chaymae El Alaoui, Jean Chemin, Taoufiq Fechtali & Philippe Lory. (2017) Modulation of T-type Ca2+ channels by Lavender and Rosemary extracts. PLOS ONE 12:10, pages e0186864.
Crossref
Lennart Brewitz, Naoya Kumagai & Masakatsu Shibasaki. (2017) Catalytic asymmetric synthesis of 2,3,3,3-tetrafluoro-2-methyl-1-arylpropan-1-amines as useful building blocks for SAR-studies. Journal of Fluorine Chemistry 194, pages 1-7.
Crossref
P. Beswick. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 65 130 .
Adriana Galvan, Annaelle Devergnas, Damien Pittard, Gunasingh Masilamoni, Jocelyn Vuong, J. Scott Daniels, Ryan D. Morrison, Craig W. Lindsley & Thomas Wichmann. (2016) Lack of Antiparkinsonian Effects of Systemic Injections of the Specific T-Type Calcium Channel Blocker ML218 in MPTP-Treated Monkeys. ACS Chemical Neuroscience 7:11, pages 1543-1551.
Crossref
Yangmi Kim & Kyung-Ah Kim. (2016) Cell proliferation inhibition effects of epigallocatechin-3-gallate in TREK2-channel overexpressing cell line. Journal of the Korea Academia-Industrial cooperation Society 17:3, pages 127-135.
Crossref
Rebecca Kulbida, Yipeng Wang, Eva-Maria Mandelkow, Susanne Schoch, Albert J. Becker & Karen M. J. van Loo. (2014) Molecular imaging reveals epileptogenic Ca2+-channel promoter activation in hippocampi of living mice. Brain Structure and Function 220:5, pages 3067-3073.
Crossref
Chris Bladen, Jawed Hamid, Ivana A Souza & Gerald W Zamponi. (2014) Block of T-type calcium channels by protoxins I and II. Molecular Brain 7:1.
Crossref
Kim L. Powell, Stuart M. Cain, Terrance P. Snutch & Terence J. O'Brien. (2014) Low threshold T-type calcium channels as targets for novel epilepsy treatments. British Journal of Clinical Pharmacology 77:5, pages 729-739.
Crossref
Magali Cazade, Cindy E. Nuss, Isabelle Bidaud, John J. Renger, Victor N. Uebele, Philippe Lory & Jean Chemin. (2014) Cross-Modulation and Molecular Interaction at the Ca v 3.3 Protein between the Endogenous Lipids and the T-Type Calcium Channel Antagonist TTA-A2. . Molecular Pharmacology 85:2, pages 218-225.
Crossref
Jin Yeong Park, Heung Woo Choi, Doo Li Choi, Sun Jeong Jang, Je Hak Kim, Joo Han Lee, Dong Joon Choo, Jungahn Kim, Kyung-Tae Lee & Jae Yeol Lee. (2013) Evaluation of T-Type Calcium Channel Blockers against Human Pancreatic MIA PaCa-2 Carcinoma Xenografts. Bulletin of the Korean Chemical Society 34:2, pages 482-488.
Crossref
Chul Won Lee, Chanhyung Bae, Jaeho Lee, Jae Ha Ryu, Ha Hyung Kim, Toshiyuki Kohno, Kenton J. Swartz & Jae Il Kim. (2012) Solution Structure of Kurtoxin: A Gating Modifier Selective for Cav3 Voltage-Gated Ca 2+ Channels . Biochemistry 51:9, pages 1862-1873.
Crossref
WonJoo Choe, Richard B. Messinger, Emily Leach, Veit-Simon Eckle, Aleksandar Obradovic, Reza Salajegheh, Vesna Jevtovic-Todorovic & Slobodan M. Todorovic. (2011) TTA-P2 Is a Potent and Selective Blocker of T-Type Calcium Channels in Rat Sensory Neurons and a Novel Antinociceptive Agent. Molecular Pharmacology 80:5, pages 900-910.
Crossref
Hideto Miwa & Tomoyoshi Kondo. (2011) T-Type Calcium Channel as a New Therapeutic Target for Tremor. The Cerebellum 10:3, pages 563-569.
Crossref
Slobodan M Todorovic & Vesna Jevtovic-Todorovic. (2011) T-type voltage-gated calcium channels as targets for the development of novel pain therapies. British Journal of Pharmacology 163:3, pages 484-495.
Crossref
Arnulfo Quesada, Peter H. Bui, Gregg E. Homanics, Oliver Hankinson & Adrian Handforth. (2011) Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor. European Journal of Pharmacology 659:1, pages 30-36.
Crossref
Thomas S. Reger, Zhi-Qiang Yang, Kelly-Ann S. Schlegel, Youheng Shu, Christa Mattern, Rowena Cube, Kenneth E. Rittle, Georgia B. McGaughey, George D. Hartman, Cuyue Tang, Jeanine Ballard, Yuhsin Kuo, Thomayant Prueksaritanont, Cindy E. Nuss, Scott M. Doran, Steven V. Fox, Susan L. Garson, Yuxing Li, Richard L. Kraus, Victor N. Uebele, John J. Renger & James C. Barrow. (2011) Pyridyl amides as potent inhibitors of T-type calcium channels. Bioorganic & Medicinal Chemistry Letters 21:6, pages 1692-1696.
Crossref
Hideto Miwa, Jinsoo Koh, Yoshinori Kajimoto & Tomoyoshi Kondo. (2011) Effects of T-type calcium channel blockers on a parkinsonian tremor model in rats. Pharmacology Biochemistry and Behavior 97:4, pages 656-659.
Crossref
Hang-Ah Park, Soo-Yeon Jung, So-Hyung Lee, Han-Byul Kang, Min-Sik Min, Jung-Ahn Kim, Dong-Joon Choo, Chun-Rim Oh, Young-Deuk Kim, Kyung-Tae Lee & Jae-Yeol Lee. (2010) Anti-Cancer Activity of T-Type Calcium Channel Blocker In Vivo. Bulletin of the Korean Chemical Society 31:11, pages 3353-3358.
Crossref
Soo Yeon Jung, So Hyung Lee, Han Byul Kang, Hang Ah Park, Sun Ki Chang, Jungahn Kim, Dong Joon Choo, Chun Rim Oh, Young Deuk Kim, Ji Hyung Seo, Kyung-Tae Lee & Jae Yeol Lee. (2010) Antitumor activity of 3,4-dihydroquinazoline dihydrochloride in A549 xenograft nude mice. Bioorganic & Medicinal Chemistry Letters 20:22, pages 6633-6636.
Crossref
Jason M. Uslaner, Joshua D. Vardigan, Jason M. Drott, Victor N. Uebele, John J. Renger, Ariel Lee, Zhaoxia Li, A.D. Lê & Pete H. Hutson. (2010) T-Type Calcium Channel Antagonism Decreases Motivation for Nicotine and Blocks Nicotine- and Cue-Induced Reinstatement for a Response Previously Reinforced with Nicotine. Biological Psychiatry 68:8, pages 712-718.
Crossref
Hyung Lee, Soo-Yeon Jung, Hang-Ah Park, Han-Byul Kang, Jung-Ahn Kim, Dong-Joon Choo, Adrian Handforth & Jae-Yeol Lee. (2010) Multi-Functional 3,4-Dihydroquinazoline Derivative as T-Type Calcium Channel Blocker: Pharmacokinetics and Anti-Tremor Activity. Bulletin of the Korean Chemical Society 31:9, pages 2451-2452.
Crossref
Viktor Pastukh, Hairu Chen, Songwei Wu, Chian Ju JongMikhail Alexeyev & Stephen W. Schaffer. (2010) Effect of hypernatremia on injury caused by energy deficiency: role of T-type Ca 2+ channel . American Journal of Physiology-Cell Physiology 299:2, pages C289-C297.
Crossref
Minsoo Han, Kee Dal Nam, Dongyun Shin, Nakcheol Jeong & Hoh-Gyu Hahn. (2010) Exploration of Novel 2-Alkylimino-1,3-thiazolines: T-Type Calcium Channel Inhibitory Activity. Journal of Combinatorial Chemistry 12:4, pages 518-530.
Crossref
Jie Eun Lee, Hun Yeong Koh, Seon Hee Seo, Yi Yeon Baek, Hyewhon Rhim, Yong Seo Cho, Hyunah Choo & Ae Nim Pae. (2010) Synthesis and biological evaluation of oxazole derivatives as T-type calcium channel blockers. Bioorganic & Medicinal Chemistry Letters 20:14, pages 4219-4222.
Crossref
Jon-Paul Bingham, Erin Mitsunaga & Zachary L. Bergeron. (2010) Drugs from slugs—Past, present and future perspectives of ω-conotoxin research. Chemico-Biological Interactions 183:1, pages 1-18.
Crossref
Victor N. Uebele, Cindy E. Nuss, Steven V. Fox, Susan L. Garson, Razvan Cristescu, Scott M. Doran, Richard L. Kraus, Vincent P. Santarelli, Yuxing Li, James C. Barrow, Zhi-Qiang Yang, Kelly-Ann S. Schlegel, Kenneth E. Rittle, Thomas S. Reger, Rodney A. Bednar, Wei Lemaire, Faith A. Mullen, Jeanine E. Ballard, Cuyue Tang, Ge Dai, Owen B. McManus, Kenneth S. Koblan & John J. Renger. (2009) Positive Allosteric Interaction of Structurally Diverse T-Type Calcium Channel Antagonists. Cell Biochemistry and Biophysics 55:2, pages 81-93.
Crossref
Taiji Furukawa, Toshihide Nukada, Yoshiko Namiki, Yoriko Miyashita, Kento Hatsuno, Yasunari Ueno, Takeshi Yamakawa & Takaaki Isshiki. (2009) Five different profiles of dihydropyridines in blocking T-type Ca2+ channel subtypes (Cav3.1 (α1G), Cav3.2 (α1H), and Cav3.3 (α1I)) expressed in Xenopus oocytes. European Journal of Pharmacology 613:1-3, pages 100-107.
Crossref
Sylvaine Huc, Arnaud Monteil, Isabelle Bidaud, Guillaume Barbara, Jean Chemin & Philippe Lory. (2009) Regulation of T-type calcium channels: Signalling pathways and functional implications. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1793:6, pages 947-952.
Crossref
Pedro Emilio Bermejo & Rodolfo Dorado. (2009) Zonisamide for Migraine Prophylaxis in Patients Refractory to Topiramate. Clinical Neuropharmacology 32:2, pages 103-106.
Crossref
Zhi-Qiang Yang, James C. Barrow, William D. Shipe, Kelly-Ann S. Schlegel, Youheng Shu, F. Vivien Yang, Craig W. Lindsley, Kenneth E. Rittle, Mark G. Bock, George D. Hartman, Victor N. Uebele, Cindy E. Nuss, Steve V. Fox, Richard L. Kraus, Scott M. Doran, Thomas M. Connolly, Cuyue Tang, Jeanine E. Ballard, Yuhsin Kuo, Emily D. Adarayan, Thomayant Prueksaritanont, Matthew M. Zrada, Michael J. Marino, Valerie Kuzmick Graufelds, Anthony G. DiLella, Ian J. Reynolds, Hugo M. Vargas, Patricia B. Bunting, Richard F. Woltmann, Michael M. Magee, Kenneth S. Koblan & John J. Renger. (2008) Discovery of 1,4-Substituted Piperidines as Potent and Selective Inhibitors of T-Type Calcium Channels. Journal of Medicinal Chemistry 51:20, pages 6471-6477.
Crossref
Yves Landry & Jean-Pierre Gies. (2008) Drugs and their molecular targets: an updated overview. Fundamental & Clinical Pharmacology 22:1, pages 1-18.
Crossref
James T Taylor, Xiang-Bin Zeng, Jonathan E Pottle, Kevin Lee, Alun R Wang, Stephenie G Yi, Jennifer A S Scruggs, Suresh S Sikka & Ming Li. (2008) Calcium signaling and T-type calcium channels in cancer cell cycling. World Journal of Gastroenterology 14:32, pages 4984.
Crossref
Jean-Pierre Gies & Yves Landry. 2008. The Practice of Medicinal Chemistry. The Practice of Medicinal Chemistry 85 105 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.