255
Views
32
CrossRef citations to date
0
Altmetric
Review

Lysine-specific demethylase 1 as a potential therapeutic target

&
Pages 809-820 | Published online: 15 May 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Yuji Tanaka, Hirohisa Yano, Sachiko Ogasawara, Sho-ichi Yoshioka, Hiromi Imamura, Kengo Okamoto & Makoto Tsuneoka. (2015) Mild Glucose Starvation Induces KDM2A-Mediated H3K36me2 Demethylation through AMPK To Reduce rRNA Transcription and Cell Proliferation. Molecular and Cellular Biology 35:24, pages 4170-4184.
Read now
Brian R Keppler & Trevor K Archer. (2008) Chromatin-modifying enzymes as therapeutic targets – Part 1. Expert Opinion on Therapeutic Targets 12:10, pages 1301-1312.
Read now

Articles from other publishers (30)

Rashmi Srivastava, Rubi Singh, Shaurya Jauhari, Niraj Lodhi & Rakesh Srivastava. (2023) Histone Demethylase Modulation: Epigenetic Strategy to Combat Cancer Progression. Epigenomes 7:2, pages 10.
Crossref
Zhongze Wang, Huarui Cai, Erhu Zhao & Hongjuan Cui. (2022) The Diverse Roles of Histone Demethylase KDM4B in Normal and Cancer Development and Progression. Frontiers in Cell and Developmental Biology 9.
Crossref
Yue Yang, Jiangwei Hu, Hao Fang, Xuben Hou, Zhun Hou, Lihong Sang & Xinying Yang. (2020) Enantioseparation of lysine derivatives on amylose tris (3, 5-dimethylphenylcarbamate) as chiral stationary phase with high separation factor. Journal of Chromatography A 1632, pages 461598.
Crossref
Samir Mehndiratta & Jing-Ping Liou. (2020) Histone lysine specific demethylase 1 inhibitors. RSC Medicinal Chemistry 11:9, pages 969-981.
Crossref
Pedro de Sena M. Pinheiro, Daniel A. Rodrigues, Rodolfo do Couto Maia, Sreekanth Thota & Carlos A.M. Fraga. (2019) The Use of Conformational Restriction in Medicinal Chemistry. Current Topics in Medicinal Chemistry 19:19, pages 1712-1733.
Crossref
Nam Hoang, Xuan Zhang, Chunxiao Zhang, Van Vo, Feng Leng, Lovely Saxena, Feng Yin, Fei Lu, Guangrong Zheng, Pradip Bhowmik & Hui Zhang. (2018) New histone demethylase LSD1 inhibitor selectively targets teratocarcinoma and embryonic carcinoma cells. Bioorganic & Medicinal Chemistry 26:8, pages 1523-1537.
Crossref
Waleed A. Zalloum & Hiba M. Zalloum. (2017) Exploring the Active Center of the LSD1/CoREST Complex by Molecular Dynamics Simulation Utilizing Its Co-crystallized Co-factor Tetrahydrofolate as a Probe. Journal of Chemical Information and Modeling 57:12, pages 3022-3031.
Crossref
Qiu Xie, Caihua Li, Xiaozhen Song, Lihua Wu, Qian Jiang, Zhiyong Qiu, Haiyan Cao, Kaihui Yu, Chunlei Wan, Jianting Li, Feng Yang, Zebing Huang, Bo niu, Zhengwen Jiang & Ting Zhang. (2017) Folate deficiency facilitates recruitment of upstream binding factor to hot spots of DNA double-strand breaks of rRNA genes and promotes its transcription. Nucleic Acids Research 45:5, pages 2472-2489.
Crossref
P.M. Woster. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 297 328 .
Hong-Jie Yan, Shu-Yan Zhou, Yang Li, Hui Zhang, Chun-Yan Deng, Hui Qi & Fu-Rong Li. (2016) The effects of LSD1 inhibition on self-renewal and differentiation of human induced pluripotent stem cells. Experimental Cell Research 340:2, pages 227-237.
Crossref
Fei Lu & Hui Zhang. 2015. Epigenetics for Drug Discovery. Epigenetics for Drug Discovery 168 191 .
Minoru Tanaka, Justin M Roberts, Jun Qi & James E Bradner. (2015) Inhibitors of emerging epigenetic targets for cancer therapy: a patent review (2010–2014). Pharmaceutical Patent Analyst 4:4, pages 261-284.
Crossref
Jonathan M. Burg, Jennifer E. Link, Brittany S. Morgan, Frederick J. Heller, Amanda E. Hargrove & Dewey G. McCafferty. (2015) KDM1 class flavin-dependent protein lysine demethylases. Biopolymers 104:4, pages 213-246.
Crossref
Craig J. Kutz, Steven L. Holshouser, Ethan A. Marrow & Patrick M. Woster. (2014) 3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors. MedChemComm 5:12, pages 1863-1870.
Crossref
Isuru R. Kumarasinghe & Patrick M. Woster. (2013) Synthesis and Evaluation of Novel Cyclic Peptide Inhibitors of Lysine-Specific Demethylase 1. ACS Medicinal Chemistry Letters 5:1, pages 29-33.
Crossref
Yuji Tanaka, Toshiyuki Umata, Kengo Okamoto, Chikashi Obuse & Makoto Tsuneoka. (2014) CxxC-ZF Domain Is Needed for KDM2A to Demethylate Histone in rDNA Promoter in Response to Starvation. Cell Structure and Function 39:1, pages 79-92.
Crossref
Boobalan Pachaiyappan & Patrick M. Woster. (2014) Design of small molecule epigenetic modulators. Bioorganic & Medicinal Chemistry Letters 24:1, pages 21-32.
Crossref
Rui Fang, Fei Chen, Zhenghong Dong, Di Hu, Andrew?J. Barbera, Erin?A. Clark, Jian Fang, Ying Yang, Pinchao Mei, Michael Rutenberg, Ze Li, Ying Zhang, Youwei Xu, Huirong Yang, Ping Wang, Matthew?D. Simon, Qiongjie Zhou, Jing Li, Mark?P. Marynick, Xiaotian Li, Haojie Lu, Ursula?B. Kaiser, Robert?E. Kingston, Yanhui Xu & Yujiang?Geno Shi. (2013) LSD2/KDM1B and Its Cofactor NPAC/GLYR1 Endow a Structural and Molecular Model for Regulation of H3K4 Demethylation. Molecular Cell 49:3, pages 558-570.
Crossref
Stuart Hazeldine, Boobalan Pachaiyappan, Nora Steinbergs, Shannon Nowotarski, Allison S. Hanson, Robert A. CaseroJr.Jr. & Patrick M. Woster. (2012) Low Molecular Weight Amidoximes that Act as Potent Inhibitors of Lysine-Specific Demethylase 1. Journal of Medicinal Chemistry 55:17, pages 7378-7391.
Crossref
Shiv K. Sharma, Stuart Hazeldine, Michael L. Crowley, Allison Hanson, Ross Beattie, Sheeba Varghese, Thulani M. D. Senanayake, Aiko Hirata, Fusao Hirata, Yi Huang, Yu Wu, Nora Steinbergs, Tracey Murray-Stewart, Ian Bytheway, Robert A. Casero & Patrick M. Woster. (2012) Polyamine-based small molecule epigenetic modulators. MedChemComm 3:1, pages 14-21.
Crossref
Jing Wang, Fei Lu, Qi Ren, Hong Sun, Zhengshuang Xu, Rongfeng Lan, Yuqing Liu, David Ward, Junmin Quan, Tao Ye & Hui Zhang. (2011) Novel Histone Demethylase LSD1 Inhibitors Selectively Target Cancer Cells with Pluripotent Stem Cell Properties. Cancer Research 71:23, pages 7238-7249.
Crossref
Patrick M. Woster & Robert A. Casero, Jr. 2011. Polyamine Drug Discovery. Polyamine Drug Discovery 104 134 .
Shiv K. Sharma, Yu Wu, Nora Steinbergs, Michael L. Crowley, Allison S. Hanson, Robert A. CaseroJr.Jr. & Patrick M. Woster. (2010) (Bis)urea and (Bis)thiourea Inhibitors of Lysine-Specific Demethylase 1 as Epigenetic Modulators. Journal of Medicinal Chemistry 53:14, pages 5197-5212.
Crossref
Yuji Tanaka, Kengo Okamoto, Kwesi Teye, Toshiyuki Umata, Noriyuki Yamagiwa, Yutaka Suto, Yi Zhang & Makoto Tsuneoka. (2010) JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation. The EMBO Journal 29:9, pages 1510-1522.
Crossref
Patrick M. Woster. 2010. 245 260 .
Yi HuangLaurence J. MartonPatrick M. WosterRobert A. CaseroJrJr. (2009) Polyamine analogues targeting epigenetic gene regulation. Essays in Biochemistry 46, pages 95-110.
Crossref
Robert A. CaseroJr.Jr. & Patrick M. Woster. (2009) Recent Advances in the Development of Polyamine Analogues as Antitumor Agents. Journal of Medicinal Chemistry 52:15, pages 4551-4573.
Crossref
Johannes H. Schulte, Soyoung Lim, Alexander Schramm, Nicolaus Friedrichs, Jan Koster, Rogier Versteeg, Ingrid Ora, Kristian Pajtler, Ludger Klein-Hitpass, Steffi Kuhfittig-Kulle, Eric Metzger, Roland Schüle, Angelika Eggert, Reinhard Buettner & Jutta Kirfel. (2009) Lysine-Specific Demethylase 1 Is Strongly Expressed in Poorly Differentiated Neuroblastoma: Implications for Therapy. Cancer Research 69:5, pages 2065-2071.
Crossref
Pete Stavropoulos, Vivien Nagy, Günter Blobel & André Hoelz. (2008) Molecular basis for the autoregulation of the protein acetyl transferase Rtt109. Proceedings of the National Academy of Sciences 105:34, pages 12236-12241.
Crossref
Siming Shen & Patrizia Casaccia-Bonnefil. (2007) Post-Translational Modifications of Nucleosomal Histones in Oligodendrocyte Lineage Cells in Development and Disease. Journal of Molecular Neuroscience 35:1, pages 13-22.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.