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Expert Opinion on Therapeutic Targets Volume 12, 2008 - Issue 3
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Reviews

Anti-infectives Targeting the isoprenoid pathway of Toxoplasma gondii

Silvia NJ Moreno University of Georgia, Department of Cellular Biology and Center for Tropical and Emerging Global Diseases, 500 D. W. Brooks Dr, Athens, Georgia 30602, USA +1 706 542 4736; +1 706 542 9493; [email protected]
&
Zhu-Hong Li University of Georgia, Department of Cellular Biology and Center for Tropical and Emerging Global Diseases, 500 D. W. Brooks Dr, Athens, Georgia 30602, USA +1 706 542 4736; +1 706 542 9493; [email protected]
Pages 253-263 | Published online: 13 Feb 2008

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Lakshmipuram Seshadri Swapna & John Parkinson. (2017) Genomics of apicomplexan parasites. Critical Reviews in Biochemistry and Molecular Biology 52:3, pages 254-273.
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Sandhya Kortagere. (2012) Screening for small molecule inhibitors of Toxoplasma gondii . Expert Opinion on Drug Discovery 7:12, pages 1193-1206.
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Juan Bautista Rodriguez & Sergio Hernán Szajnman. (2012) New antibacterials for the treatment of toxoplasmosis; a patent review. Expert Opinion on Therapeutic Patents 22:3, pages 311-333.
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Shuting Sun & Charles E McKenna. (2011) Farnesyl pyrophosphate synthase modulators: a patent review (2006 – 2010). Expert Opinion on Therapeutic Patents 21:9, pages 1433-1451.
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Articles from other publishers (30)

Juan B. Rodriguez & Sergio H. Szajnman. (2023) An updated review of chemical compounds with anti-Toxoplasma gondii activity. European Journal of Medicinal Chemistry 262, pages 115885.
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Joice Castelo Branco Santos, Jonathas Alves de Melo, Sweta Maheshwari, Wendy Marina Toscano Queiroz de Medeiros, Johny Wysllas de Freitas Oliveira, Cláudia Jassica Moreno, L. Mario Amzel, Sandra B. Gabelli & Marcelo Sousa Silva. (2020) Bisphosphonate-Based Molecules as Potential New Antiparasitic Drugs. Molecules 25:11, pages 2602.
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Zhixiao Xu, Na Li, Yaqiong Guo, Yaoyu Feng & Lihua Xiao. (2020) Comparative genomic analysis of three intestinal species reveals reductions in secreted pathogenesis determinants in bovine-specific and non-pathogenic Cryptosporidium species. Microbial Genomics 6:6.
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Tamila Galaka, Bruno N. Falcone, Catherine Li, Sergio H. Szajnman, Silvia N.J. Moreno, Roberto Docampo & Juan B. Rodriguez. (2019) Synthesis and biological evaluation of 1-alkylaminomethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii. Bioorganic & Medicinal Chemistry 27:16, pages 3663-3673.
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María N. Chao, Melissa Storey, Catherine Li, Maricel G. Rodríguez, Florencia Di Salvo, Sergio H. Szajnman, Silvia N.J. Moreno, Roberto Docampo & Juan B. Rodriguez. (2017) Selenium-containing analogues of WC-9 are extremely potent inhibitors of Trypanosoma cruzi proliferation. Bioorganic & Medicinal Chemistry 25:24, pages 6435-6449.
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Sergio H. Szajnman, Tamila Galaka, Zhu-Hong Li, Catherine Li, Nathan M. Howell, María N. Chao, Boris Striepen, Vasant Muralidharan, Silvia N. J. Moreno & Juan B. Rodriguez. (2017) In Vitro and In Vivo Activities of Sulfur-Containing Linear Bisphosphonates against Apicomplexan Parasites . Antimicrobial Agents and Chemotherapy 61:2.
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Tamila Galaka, Mariana Ferrer Casal, Melissa Storey, Catherine Li, María Chao, Sergio Szajnman, Roberto Docampo, Silvia Moreno & Juan Rodriguez. (2017) Antiparasitic Activity of Sulfur- and Fluorine-Containing Bisphosphonates against Trypanosomatids and Apicomplexan Parasites. Molecules 22:1, pages 82.
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Michael Holmes, Vaunell Itaas & Sirinart Ananvoranich. (2014) Sustained translational repression of lactate dehydrogenase 1 in Toxoplasma gondii bradyzoites is conferred by a small regulatory RNA hairpin . FEBS Journal 281:22, pages 5077-5091.
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Isabelle Coppens. (2014) Exploitation of auxotrophies and metabolic defects in Toxoplasma as therapeutic approaches. International Journal for Parasitology 44:2, pages 109-120.
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Mariana Ferrer-Casal, Catherine Li, Melina Galizzi, Carlos A. Stortz, Sergio H. Szajnman, Roberto Docampo, Silvia N.J. Moreno & Juan B. Rodriguez. (2014) New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase. Bioorganic & Medicinal Chemistry 22:1, pages 398-405.
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Peter D. Ziniel, Janish Desai, Cynthia L. Cass, Craig Gatto, Eric Oldfield & David L. Williams. (2013) Characterization of Potential Drug Targets Farnesyl Diphosphate Synthase and Geranylgeranyl Diphosphate Synthase in Schistosoma mansoni. Antimicrobial Agents and Chemotherapy 57:12, pages 5969-5976.
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Isabelle Coppens. (2013) Targeting lipid biosynthesis and salvage in apicomplexan parasites for improved chemotherapies. Nature Reviews Microbiology 11:12, pages 823-835.
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Pablo D. Elicio, María N. Chao, Melina Galizzi, Catherine Li, Sergio H. Szajnman, Roberto Docampo, Silvia N.J. Moreno & Juan B. Rodriguez. (2013) Design, synthesis and biological evaluation of WC-9 analogs as antiparasitic agents. European Journal of Medicinal Chemistry 69, pages 480-489.
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J. Kipchirchir Bitok & Caren Freel Meyers. (2013) Synthesis and evaluation of stable substrate analogs as potential modulators of cyclodiphosphate synthase IspF. MedChemComm 4:1, pages 130-134.
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Carl Song, Melissa A Chiasson, Nirvana Nursimulu, Stacy S Hung, James Wasmuth, Michael E Grigg & John Parkinson. (2013) Metabolic reconstruction identifies strain‐specific regulation of virulence in Toxoplasma gondii . Molecular Systems Biology 9:1.
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J. Kipchirchir Bitok & Caren Freel Meyers. (2012) 2 C -Methyl- d -erythritol 4-Phosphate Enhances and Sustains Cyclodiphosphate Synthase IspF Activity . ACS Chemical Biology 7:10, pages 1702-1710.
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Sergio H. Szajnman, Valeria S. Rosso, Leena Malayil, Alyssa Smith, Silvia N. J. Moreno, Roberto Docampo & Juan B. Rodriguez. (2012) 1-(Fluoroalkylidene)-1,1-bisphosphonic acids are potent and selective inhibitors of the enzymatic activity of Toxoplasma gondii farnesyl pyrophosphate synthase. Organic & Biomolecular Chemistry 10:7, pages 1424.
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T. Matthew Payne, Amanda J. Payne & Laura J. Knoll. (2011) A Toxoplasma gondii mutant highlights the importance of translational regulation in the apicoplast during animal infection. Molecular Microbiology 82:5, pages 1204-1216.
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Sethu C. Nair & Boris Striepen. (2011) What Do Human Parasites Do with a Chloroplast Anyway?. PLoS Biology 9:8, pages e1001137.
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Sethu C. Nair, Carrie F. Brooks, Christopher D. Goodman, Angelika Strurm, Geoffrey I. McFadden, Sandeep Sundriyal, Justin L. Anglin, Yongcheng Song, Silvia N.J. Moreno & Boris Striepen. (2011) Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii . Journal of Experimental Medicine 208:7, pages 1547-1559.
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Stacy S. Hung & John Parkinson. (2011) Post-genomics resources and tools for studying apicomplexan metabolism. Trends in Parasitology 27:3, pages 131-140.
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Sandeep J Joseph, José A Fernández-Robledo, Malcolm J Gardner, Najib M El-Sayed, Chih-Horng Kuo, Eric J Schott, Haiming Wang, Jessica C Kissinger & Gerardo R Vasta. (2010) The Alveolate Perkinsus marinus: Biological Insights from EST Gene Discovery. BMC Genomics 11:1.
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Tobias Fleige, Julien Limenitakis & Dominique Soldati-Favre. (2010) Apicoplast: keep it or leave it. Microbes and Infection 12:4, pages 253-262.
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Frank Seeber & Dominique Soldati-Favre. 2010. 161 228 .
Michel Rohmer. 2010. Comprehensive Natural Products II. Comprehensive Natural Products II 517 555 .
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Swati Agrawal, Sethu Nair, Lilach Sheiner & Boris Striepen. 2010. Structures and Organelles in Pathogenic Protists. Structures and Organelles in Pathogenic Protists 253 283 .
U Kastenbauer, E Wolf, C Kollan, O Hamouda & JR Bogner. (2009) Impaired CD4-cell immune reconstitution upon HIV therapy in patients with toxoplasmic encephalitis compared to patients with pneumocystis pneumonia as AIDS indicating disease. European Journal of Medical Research 14:6.
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Frank Seeber. 2009. Antiparasitic and Antibacterial Drug Discovery. Antiparasitic and Antibacterial Drug Discovery 277 298 .
Erika Cortez, Ana Carolina Stumbo, Mariana Oliveira, Helene S. Barbosa & Lais Carvalho. (2009) Statins inhibit Toxoplasma gondii multiplication in macrophages in vitro. International Journal of Antimicrobial Agents 33:2, pages 185-186.
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