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Expert Opinion on Therapeutic Targets Volume 12, 2008 - Issue 7
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Original Research

The effects of pharmacological PAI-1 inhibition on thrombus formation and neointima formation after arterial injury

Jun-ichi Suzuki Tokyo Medical and Dental University, Graduate School of Medicine, Department of Cardiovascular Medicine, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan +81 03 5803 5951; +81 03 5803 0133; [email protected]
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Masahito Ogawa Tokyo Medical and Dental University, Graduate School of Medicine, Department of Cardiovascular Medicine, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan +81 03 5803 5951; +81 03 5803 0133; [email protected]
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Susumu Muto Institute of Medicinal Molecular Design, Tokyo, Japan
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Yoichi Yamaguchi Institute of Medicinal Molecular Design, Tokyo, Japan
,
Akiko Itai Institute of Medicinal Molecular Design, Tokyo, Japan
&
Mitsuaki Isobe Tokyo Medical and Dental University, Graduate School of Medicine, Department of Cardiovascular Medicine, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan +81 03 5803 5951; +81 03 5803 0133; [email protected]
Pages 783-794 | Published online: 13 Jun 2008

Citations (18)

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Read on this site (4)

Yolanda M Fortenberry. (2013) Plasminogen activator inhibitor-1 inhibitors: a patent review (2006 – present). Expert Opinion on Therapeutic Patents 23:7, pages 801-815.
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Jun-ichi Suzuki, Masahito Ogawa, Ryo Watanabe, Ryuichi Morishita, Yasunobu Hirata, Ryozo Nagai & Mitsuaki Isobe. (2011) Autoimmune giant cell myocarditis – clinical characteristics, experimental models and future treatments. Expert Opinion on Therapeutic Targets 15:10, pages 1163-1172.
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Jun-Ichi Suzuki, Masahito Ogawa, Susumu Muto, Akiko Itai, Yasunobu Hirata, Mitsuaki Isobe & Ryozo Nagai. (2011) Effects of specific chemical suppressors of plasminogen activator inhibitor-1 in cardiovascular diseases. Expert Opinion on Investigational Drugs 20:2, pages 255-264.
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Jun-ichi Suzuki, Masahito Ogawa, Susumu Muto, Akiko Itai & Mitsuaki Isobe. (2008) A specific inhibitor of plasminogen activator inhibitor-1 suppresses rat autoimmune myocarditis. Expert Opinion on Therapeutic Targets 12:11, pages 1313-1320.
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Articles from other publishers (14)

Machteld Sillen & Paul J. Declerck. (2020) Targeting PAI-1 in Cardiovascular Disease: Structural Insights Into PAI-1 Functionality and Inhibition. Frontiers in Cardiovascular Medicine 7.
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Hekmat B. Khoukaz, Yan Ji, Drew J. Braet, Manisha Vadali, Ahmed A. Abdelhamid, Cory D. EmalDaniel A. LawrenceWilliam P. Fay. (2020) Drug Targeting of Plasminogen Activator Inhibitor-1 Inhibits Metabolic Dysfunction and Atherosclerosis in a Murine Model of Metabolic Syndrome. Arteriosclerosis, Thrombosis, and Vascular Biology 40:6, pages 1479-1490.
Crossref
Takashi DAN, Wataru UCHIDA, Hideaki HIRATSUKA, Yoshiteru OSHIMA & Toshio MIYATA. (2018) New direction of PAI-1 inhibitor development: Clinical application to cancer treatmentPAI-1 阻害剤の新展開―がん治療への臨床応用―. Japanese Journal of Thrombosis and Hemostasis 29:5, pages 487-494.
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Naho Kobayashi, Jun-ichi Suzuki, Norio Aoyama, Hiroki Sato, Shouta Akimoto, Kouji Wakayama, Hidetoshi Kumagai, Yuichi Ikeda, Hiroshi Akazawa, Issei Komuro, Yuichi Izumi & Mitsuaki Isobe. (2016) Toll-like receptor 4 signaling has a critical role in Porphyromonas gingivalis-accelerated neointimal formation after arterial injury in mice. Hypertension Research 39:10, pages 717-722.
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Wei Zhao, Chengyan Wang, Ruixue Liu, Cuilei Wei, Juncang Duan, Kejian Liu, Shugang Li, Hong Zou, Jin Zhao, Lianghai Wang, Yan Qi, Weihua Liang, Jinfang Jiang, Wenjie Zhang, Lijuan Pang & Feng Li. (2016) Effect of TGF-β1 on the Migration and Recruitment of Mesenchymal Stem Cells after Vascular Balloon Injury: Involvement of Matrix Metalloproteinase-14. Scientific Reports 6:1.
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Tine Wyseure & Paul J. Declerck. (2014) Novel or expanding current targets in fibrinolysis. Drug Discovery Today 19:9, pages 1476-1482.
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Naho Kobayashi, Jun-ichi Suzuki, Masahito Ogawa, Norio Aoyama, Issei Komuro, Yuichi Izumi & Mitsuaki Isobe. (2013) Porphyromonas gingivalis promotes neointimal formation after arterial injury through toll-like receptor 2 signaling. Heart and Vessels 29:4, pages 542-549.
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Michael Schuliga, Glen Westall, Yuxiu Xia & Alastair G Stewart. (2013) The plasminogen activation system: new targets in lung inflammation and remodeling. Current Opinion in Pharmacology 13:3, pages 386-393.
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Ying‐Hong Xiao, Long‐Fei Yang, Xue‐Chao Feng, Hong Yang & Tong‐Hui Ma. (2012) Tanshinones Increase Fibrinolysis through Inhibition of Plasminogen Activator Inhibitor‐1. CNS Neuroscience & Therapeutics 18:5, pages 436-438.
Crossref
J. Wouter Jukema, Jeffrey J. W. Verschuren, Tarek A. N. Ahmed & Paul H. A. Quax. (2011) Restenosis after PCI. Part 1: pathophysiology and risk factors. Nature Reviews Cardiology 9:1, pages 53-62.
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Stephanie BrandalCharlene M. BlakeBruce A. SullengerYolanda M. Fortenberry. (2011) Effects of Plasminogen Activator Inhibitor-1–Specific RNA Aptamers on Cell Adhesion, Motility, and Tube Formation. Nucleic Acid Therapeutics 21:6, pages 373-381.
Crossref
Masahito Ogawa, Jun-ichi Suzuki, Yoichi Yamaguchi, Susumu Muto, Akiko Itai, Yasunobu Hirata, Mitsuaki Isobe & Ryozo Nagai. (2011) The Effects of Pharmacologic Plasminogen Activator Inhibitor-1 Inhibition in Acute and Chronic Rejection in Murine Cardiac Allografts. Transplantation 91:1, pages 21-26.
Crossref
Ryo Watanabe, Takuya Nakajima, Masahito Ogawa, Jun-ichi Suzuki, Susumu Muto, Akiko Itai, Yasunobu Hirata, Ryozo Nagai & Mitsuaki Isobe. (2011) Effects of Pharmacological Suppression of Plasminogen Activator Inhibitor-1 in Myocardial Remodeling After Ischemia Reperfusion Injury. International Heart Journal 52:6, pages 388-392.
Crossref
Elena Y. SenchenkovaJanice RussellLidiana D. Almeida-PaulaJoseph W. HardingD. Neil Granger. (2010) Angiotensin II–Mediated Microvascular Thrombosis. Hypertension 56:6, pages 1089-1095.
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