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Review

Eag1 as a cancer target

, MD PhD & , PhD
Pages 837-843 | Published online: 13 Jun 2008

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Neil A Castle. (2010) Pharmacological modulation of voltage-gated potassium channels as a therapeutic strategy. Expert Opinion on Therapeutic Patents 20:11, pages 1471-1503.
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Xinqiu Liu, Yuying Wu & Yi Zhou. (2010) Intracellular linkers are involved in Mg2+-dependent modulation of the Eag potassium channel. Channels 4:4, pages 311-318.
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Lorenza Díaz, Samantha V. Bernadez-Vallejo, Rafael Vargas-Castro, Euclides Avila, Karla A. Gómez-Ceja, Rocío García-Becerra, Mariana Segovia-Mendoza, Heriberto Prado-Garcia, Galia Lara-Sotelo, Javier Camacho, Fernando Larrea & Janice García-Quiroz. (2023) The Phytochemical α-Mangostin Inhibits Cervical Cancer Cell Proliferation and Tumor Growth by Downregulating E6/E7-HPV Oncogenes and KCNH1 Gene Expression. International Journal of Molecular Sciences 24:3, pages 3055.
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Magdalena Alvarez-Ramirez, Lauro Figueroa-Valverde, Francisco Diaz-Cedillo, Marcela Rosas-Nexticapa, Maria Lopez-Ramos, Virginia Mateu-Armand & Lopez-Gutierrez Tomas. (2023) Theoretical Evaluation of Furanone and its Derivatives for the Treatment of Cancer Through Eag-1 Inhibition. Clinical Cancer Investigation Journal 12:4, pages 4-9.
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Pareesa Kamgar-Dayhoff & Tinatin I. Brelidze. (2021) Multifaceted effect of chlorpromazine in cancer: implications for cancer treatment. Oncotarget 12:14, pages 1406-1426.
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Yang Shi, Xiaohua Yang, Xiaofeng Xue, Ding Sun, Peng Cai, Qingwei Song, Bin Zhang & Lei Qin. (2019) HANR promotes lymphangiogenesis of hepatocellular carcinoma via secreting miR‐296 exosome and regulating EAG1/VEGFA signaling in HDLEC cells. Journal of Cellular Biochemistry 120:10, pages 17699-17708.
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Lien Moreels, Steve Peigneur, Diogo Galan, Edwin De Pauw, Lászlo Béress, Etienne Waelkens, Luis Pardo, Loïc Quinton & Jan Tytgat. (2017) APETx4, a Novel Sea Anemone Toxin and a Modulator of the Cancer-Relevant Potassium Channel KV10.1. Marine Drugs 15:9, pages 287.
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Xue Tang, Juan Shao & Xiaohong Qin. (2016) Crystal structure of the PAS domain of the hEAG potassium channel. Acta Crystallographica Section F Structural Biology Communications 72:8, pages 578-585.
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Min Seok Song, Seon Young Choi, Pan Dong Ryu & So Yeong Lee. (2016) Voltage-Gated K+ Channel, Kv3.3 Is Involved in Hemin-Induced K562 Differentiation. PLOS ONE 11:2, pages e0148633.
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Nuria Comes, Antonio Serrano-Albarrás, Jesusa Capera, Clara Serrano-Novillo, Enric Condom, Santiago Ramón y Cajal, Joan Carles Ferreres & Antonio Felipe. (2015) Involvement of potassium channels in the progression of cancer to a more malignant phenotype. Biochimica et Biophysica Acta (BBA) - Biomembranes 1848:10, pages 2477-2492.
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Maria Zeniou, Marie Fève, Samir Mameri, Jihu Dong, Christophe Salomé, Wanyin Chen, Elias A. El-Habr, Fanny Bousson, Mohamadou Sy, Julie Obszynski, Alexandre Boh, Pascal Villa, Suzana Assad Kahn, Bruno Didier, Dominique Bagnard, Marie-Pierre Junier, Hervé Chneiweiss, Jacques Haiech, Marcel Hibert & Marie-Claude Kilhoffer. (2015) Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells. PLOS ONE 10:8, pages e0134793.
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Janice García-Quiroz, Rocío García-Becerra, Nancy Santos-Martínez, David Barrera, David Ordaz-Rosado, Euclides Avila, Ali Halhali, Octavio Villanueva, Maŕa J Ibarra-Sánchez, José Esparza-López, Armando Gamboa-Domínguez, Javier Camacho, Fernando Larrea & Lorenza Díaz. (2014) In vivo dual targeting of the oncogenic Ether-à-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors. BMC Cancer 14:1.
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Nancy Santos-Martínez, Lorenza Díaz, David Ordaz-Rosado, Janice García-Quiroz, David Barrera, Euclides Avila, Ali Halhali, Heriberto Medina-Franco, María J Ibarra-Sánchez, José Esparza-López, Javier Camacho, Fernando Larrea & Rocío García-Becerra. (2014) Calcitriol restores antiestrogen responsiveness in estrogen receptor negative breast cancer cells: A potential new therapeutic approach. BMC Cancer 14:1.
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Chai Ann Ng, Kevin Phan, Adam P. Hill, Jamie I. Vandenberg & Matthew D. Perry. (2014) Multiple Interactions between Cytoplasmic Domains Regulate Slow Deactivation of Kv11.1 Channels. Journal of Biological Chemistry 289:37, pages 25822-25832.
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Nirakar SahooToshinori HoshiStefan H. Heinemann. (2014) Oxidative Modulation of Voltage-Gated Potassium Channels. Antioxidants & Redox Signaling 21:6, pages 933-952.
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Jin Wu, Daixing Zhong, Xijin Fu, Qingjun Liu, Liangqi Kang & Zhenqi Ding. (2014) Silencing of Ether à Go-Go 1 by shRNA Inhibits Osteosarcoma Growth and Cell Cycle Progression. International Journal of Molecular Sciences 15:4, pages 5570-5581.
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Chai Ann Ng, Ying Ke, Matthew D. Perry, Peter S. Tan, Adam P. Hill & Jamie I. Vandenberg. (2013) C-Terminal β9-Strand of the Cyclic Nucleotide-Binding Homology Domain Stabilizes Activated States of Kv11.1 Channels. PLoS ONE 8:10, pages e77032.
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Albert Vallejo-Gracia, Joanna Bielanska, Javier Hernández-Losa, Josep Castellví, M Carmen Ruiz-Marcellan, Santiago Ramón y Cajal, Enric Condom, Joan Manils, Concepció Soler, Núria Comes, Joan Carles Ferreres & Antonio Felipe. (2013) Emerging role for the voltage-dependent K+ channel Kv1.5 in B-lymphocyte physiology: expression associated with human lymphoma malignancy. Journal of Leukocyte Biology 94:4, pages 779-789.
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Florian Gackière, Marine Warnier, Maria Katsogiannou, Sandra Derouiche, Philippe Delcourt, Etienne Dewailly, Christian Slomianny, Sandrine Humez, Natalia Prevarskaya, Morad Roudbaraki & Pascal Mariot. (2013) Functional coupling between large-conductance potassium channels and Cav3.2 voltage-dependent calcium channels participates in prostate cancer cell growth. Biology Open 2:9, pages 941-951.
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Roser Ufartes, Tomasz Schneider, Lena Sünke Mortensen, Camino de Juan Romero, Klaus Hentrich, Hendrik Knoetgen, Vadim Beilinson, Wiebke Moebius, Victor Tarabykin, Frauke Alves, Luis A. Pardo, J. Nicholas P. Rawlins & Walter Stuehmer. (2013) Behavioural and functional characterization of Kv10.1 (Eag1) knockout mice. Human Molecular Genetics 22:11, pages 2247-2262.
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Ricardo Adaixo, Carol A. Harley, Artur F. Castro-Rodrigues & João H. Morais-Cabral. (2013) Structural Properties of PAS Domains from the KCNH Potassium Channels. PLoS ONE 8:3, pages e59265.
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Maria J. Marques-Carvalho, Nirakar Sahoo, Frederick W. Muskett, Ricardo S. Vieira-Pires, Guillaume Gabant, Martine Cadene, Roland Schönherr & João H. Morais-Cabral. (2012) Structural, Biochemical, and Functional Characterization of the Cyclic Nucleotide Binding Homology Domain from the Mouse EAG1 Potassium Channel. Journal of Molecular Biology 423:1, pages 34-46.
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Vivek Garg, Frank B. Sachse & Michael C. Sanguinetti. (2012) Tuning of EAG K+ channel inactivation: Molecular determinants of amplification by mutations and a small molecule. Journal of General Physiology 140:3, pages 307-324.
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Carlos González, David Baez‐Nieto, Ignacio Valencia, Ingrid Oyarzún, Patricio Rojas, David Naranjo & Ramón Latorre. 2011. Comprehensive Physiology. Comprehensive Physiology 2087 2149 .
Jesús Adrián Rodríguez-Rasgado, Isabel Acuña-Macías & Javier Camacho. (2012) Eag1 Channels as Potential Cancer Biomarkers. Sensors 12:5, pages 5986-5995.
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Maria João Marques-Carvalho & João Henrique Morais-Cabral. (2012) Crystallization and preliminary X-ray crystallographic characterization of a cyclic nucleotide-binding homology domain from the mouse EAG potassium channel. Acta Crystallographica Section F Structural Biology and Crystallization Communications 68:3, pages 337-339.
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Anne-Sophie Borowiec, Frédéric Hague, Valérie Gouilleux-Gruart, Kaiss Lassoued & Halima Ouadid-Ahidouch. (2011) Regulation of IGF-1-dependent cyclin D1 and E expression by hEag1 channels in MCF-7 cells: The critical role of hEag1 channels in G1 phase progression. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813:5, pages 723-730.
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Soo Hwa JangPan Dong RyuSo Yeong Lee. (2011) Dendrotoxin-κ suppresses tumor growth induced by human lung adenocarcinoma A549 cells in nude mice. Journal of Veterinary Science 12:1, pages 35.
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Viren Asher, Averil Warren, Robert Shaw, Heidi Sowter, Anish Bali & Raheela Khan. (2011) The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line. Cancer Cell International 11:1, pages 6.
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Sofía Tirados Menéndez, Juan P Rodrigo, Eva Allonca, Darío García‐Carracedo, Gustavo Álvarez‐Alija, Sara Casado‐Zapico, Manuel F Fresno, Carmen Rodríguez, Carlos Suárez & Juana M García‐Pedrero. (2010) Expression and clinical significance of the Kv3.4 potassium channel subunit in the development and progression of head and neck squamous cell carcinomas. The Journal of Pathology 221:4, pages 402-410.
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Rocío García-Becerra, Lorenza Díaz, Javier Camacho, David Barrera, David Ordaz-Rosado, Angélica Morales, Cindy Sharon Ortiz, Euclides Avila, Enrique Bargallo, Myrna Arrecillas, Ali Halhali & Fernando Larrea. (2010) Calcitriol inhibits Ether-à go-go potassium channel expression and cell proliferation in human breast cancer cells. Experimental Cell Research 316:3, pages 433-442.
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Rustem Onkal & Mustafa B.A. Djamgoz. (2009) Molecular pharmacology of voltage-gated sodium channel expression in metastatic disease: Clinical potential of neonatal Nav1.5 in breast cancer. European Journal of Pharmacology 625:1-3, pages 206-219.
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