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Expert Opinion on Therapeutic Targets Volume 12, 2008 - Issue 7
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Review

Molecular targeting of E3 ligases – a therapeutic approach for cancer

Manikandan Lakshmanan Ranbaxy Laboratories Ltd, New Drug Discovery Research, R&D-III, Sector-18, Plot No. 20, Gurgaon-122015, India +91 124 2342001 10, ext. 5348; +91 124 2343544; [email protected]
,
Usha Bughani Ranbaxy Laboratories Ltd, New Drug Discovery Research, R&D-III, Sector-18, Plot No. 20, Gurgaon-122015, India +91 124 2342001 10, ext. 5348; +91 124 2343544; [email protected]
,
Senthil Duraisamy Ranbaxy Laboratories Ltd, New Drug Discovery Research, R&D-III, Sector-18, Plot No. 20, Gurgaon-122015, India +91 124 2342001 10, ext. 5348; +91 124 2343544; [email protected]
,
Manish Diwan Ranbaxy Laboratories Ltd, New Drug Discovery Research, R&D-III, Sector-18, Plot No. 20, Gurgaon-122015, India +91 124 2342001 10, ext. 5348; +91 124 2343544; [email protected]
,
Sunanda Dastidar Ranbaxy Laboratories Ltd, New Drug Discovery Research, R&D-III, Sector-18, Plot No. 20, Gurgaon-122015, India +91 124 2342001 10, ext. 5348; +91 124 2343544; [email protected]
&
Abhijit Ray Ranbaxy Laboratories Ltd, New Drug Discovery Research, R&D-III, Sector-18, Plot No. 20, Gurgaon-122015, India +91 124 2342001 10, ext. 5348; +91 124 2343544; [email protected]
Pages 855-870 | Published online: 13 Jun 2008

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Lyuben Tsvetkov, Meera Nanjundan, Maria Domino & Kenyon G Daniel. (2010) The ubiquitin–proteasome system and assays to determine responses to inhibitors. Expert Opinion on Drug Discovery 5:12, pages 1221-1236.
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Barrington G. Burnett, Eric Muñoz, Animesh Tandon, Deborah Y. Kwon, Charlotte J. Sumner & Kenneth H. Fischbeck. (2009) Regulation of SMN Protein Stability. Molecular and Cellular Biology 29:5, pages 1107-1115.
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Maria Birkou, Vasilios Raptis, Konstantinos D. Marousis, Athanasios Tsevis, Kyriakos Bourikas, Detlef Bentrop, Vasso Episkopou & Georgios A. Spyroulias. (2022) Impact of a Single Nucleotide Polymorphism on the 3D Protein Structure and Ubiquitination Activity of E3 Ubiquitin Ligase Arkadia. Frontiers in Molecular Biosciences 9.
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Le Shi, Jing Liu, Yunhua Peng, Jinfang Zhang, Xiangpeng Dai, Shuangxi Zhang, Yongyao Wang, Jiankang Liu & Jiangang Long. (2020) Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission. Molecular Oncology 14:12, pages 3169-3183.
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Ali Flores-Pérez, Laurence A. Marchat, Sergio Rodríguez-Cuevas, Verónica Piña Bautista, Lizeth Fuentes-Mera, Diana Romero-Zamora, Anabel Maciel-Dominguez, Olga Hernández de la Cruz, Miguel Fonseca-Sánchez, Erika Ruíz-García, Horacio Astudillo-de la Vega & César López-Camarillo. (2016) Suppression of cell migration is promoted by miR-944 through targeting of SIAH1 and PTP4A1 in breast cancer cells. BMC Cancer 16:1.
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Bo Wu, Bomin Guo, Jie Kang, Xianzhao Deng, Youben Fan, Xiaoping Zhang & Kaixing Ai. (2016) Downregulation of Smurf2 ubiquitin ligase in pancreatic cancer cells reversed TGF-β-induced tumor formation. Tumor Biology 37:12, pages 16077-16091.
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Christina S.F. Wong & Andreas Möller. (2013) Siah: A Promising Anticancer Target. Cancer Research 73:8, pages 2400-2406.
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ZHE LONG LIANG, MEERAN KIM, SONG MEI HUANG, HYO JIN LEE & JIN-MAN KIM. (2013) Expression of carboxyl terminus of Hsp70-interacting protein (CHIP) indicates poor prognosis in human gallbladder carcinoma. Oncology Letters 5:3, pages 813-818.
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Diana David, S. Asha Nair & M. Radhakrishna Pillai. (2013) Smurf E3 ubiquitin ligases at the cross roads of oncogenesis and tumor suppression. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1835:1, pages 119-128.
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LEI GAN, DONG-BO LIU, HAI-FENG LU, GUO-XIAN LONG, QI MEI, GUANG-YUAN HU, HONG QIU & GUO-QING HU. (2012) Decreased expression of the carboxyl terminus of heat shock cognate 70 interacting protein in human gastric cancer and its clinical significance. Oncology Reports 28:4, pages 1392-1398.
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Michael J. Eddins, Jeffrey G. Marblestone, K. G. Suresh Kumar, Craig A. Leach, David E. Sterner, Michael R. Mattern & Benjamin Nicholson. (2011) Targeting the Ubiquitin E3 Ligase MuRF1 to Inhibit Muscle Atrophy. Cell Biochemistry and Biophysics 60:1-2, pages 113-118.
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Tao Xu, Quan Zhou, Jingxu Zhou, Yan Huang, Yong Yan, Weiqing Li, Chunlin Wang, Guohan Hu, Yicheng Lu & Juxiang Chen. (2011) Carboxyl terminus of Hsp70-interacting protein (CHIP) contributes to human glioma oncogenesis. Cancer Science 102:5, pages 959-966.
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Donald J. AbrahamMarie Wehenkel & Kyung Bo Kim. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 175 190 .
Christos T. Chasapis, Ariadni K. Loutsidou, Malvina G. Orkoula & Georgios A. Spyroulias. (2010) Zinc Binding Properties of Engineered RING Finger Domain of Arkadia E3 Ubiquitin Ligase. Bioinorganic Chemistry and Applications 2010, pages 1-7.
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Tomas Kirchhoff, Zhang-qun Chen, Bert Gold, Prodipto Pal, Mia M. Gaudet, Kristi Kosarin, Douglas A. Levine, Peter Gregersen, Sara Spencer, Megan Harlan, Mark Robson, Robert J. Klein, Clifford A. Hudis, Larry Norton, Michael Dean & Kenneth Offit. (2009) The 6q22.33 Locus and Breast Cancer Susceptibility. Cancer Epidemiology, Biomarkers & Prevention 18:9, pages 2468-2475.
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David F. RestucciaBrian A. Hemmings. (2009) Blocking Akt-ivity. Science 325:5944, pages 1083-1084.
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