Advanced search
Publication Cover
Expert Opinion on Therapeutic Targets Volume 12, 2008 - Issue 7
Submit an article Journal homepage
660
Views
40
CrossRef citations to date
0
Altmetric
Review

Kinase inhibitors as drugs for chronic inflammatory and immunological diseases: progress and challenges

Laura L Rokosz Pharmacopeia, Inc., PO Box 5350, Princeton, NJ 08543-5350, USA +1 609 452 3600; +1 609 655 4187; [email protected]
,
James R Beasley Pharmacopeia, Inc., PO Box 5350, Princeton, NJ 08543-5350, USA +1 609 452 3600; +1 609 655 4187; [email protected]
,
Carolyn DiIanni Carroll Pharmacopeia, Inc., PO Box 5350, Princeton, NJ 08543-5350, USA +1 609 452 3600; +1 609 655 4187; [email protected]
,
Tsung Lin Pharmacopeia, Inc., PO Box 5350, Princeton, NJ 08543-5350, USA +1 609 452 3600; +1 609 655 4187; [email protected]
,
Jiuqiao Zhao Pharmacopeia, Inc., PO Box 5350, Princeton, NJ 08543-5350, USA +1 609 452 3600; +1 609 655 4187; [email protected]
,
Kenneth C Appell Pharmacopeia, Inc., PO Box 5350, Princeton, NJ 08543-5350, USA +1 609 452 3600; +1 609 655 4187; [email protected]
&
Maria L Webb Pharmacopeia, Inc., PO Box 5350, Princeton, NJ 08543-5350, USA +1 609 452 3600; +1 609 655 4187; [email protected]
 show all
Pages 883-903 | Published online: 13 Jun 2008

Citations (40)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (7)

Hui Jiang, Kefeng Cao, Chang Fan, Xiaoya Cui, Yanzhen Ma & Jian Liu. (2021) Transcriptome-Wide High-Throughput m6A Sequencing of Differential m6A Methylation Patterns in the Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes Cell Line MH7A. Journal of Inflammation Research 14, pages 575-586.
Read now
David Gordon, Edward T Hellriegel, Heidi Rath Hope, David Burt & Joseph B Monahan. (2021) Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the MK2 Inhibitor ATI-450 in Healthy Subjects: A Placebo-Controlled, Randomized Phase 1 Study. Clinical Pharmacology: Advances and Applications 13, pages 123-134.
Read now
Maliha Khan, Jamie L Gibbons & Alessandra Ferrajoli. (2017) Spotlight on ibrutinib and its potential in frontline treatment of chronic lymphocytic leukemia. OncoTargets and Therapy 10, pages 1909-1914.
Read now
Rina Barouch-Bentov & Karsten Sauer. (2011) Mechanisms of drug resistance in kinases. Expert Opinion on Investigational Drugs 20:2, pages 153-208.
Read now
Lawrence J Wilson. (2010) Recent patents in the discovery of small molecule inhibitors of JAK3. Expert Opinion on Therapeutic Patents 20:5, pages 609-623.
Read now
Percy H Carter & Qihong Zhao. (2010) Clinically validated approaches to the treatment of autoimmune diseases. Expert Opinion on Investigational Drugs 19:2, pages 195-213.
Read now
Florian Nigsch, NJ Maximilan Macaluso, John BO Mitchell & Donatas Zmuidinavicius. (2009) Computational toxicology: an overview of the sources of data and of modelling methods. Expert Opinion on Drug Metabolism & Toxicology 5:1, pages 1-14.
Read now

Articles from other publishers (33)

V. Pratap Reddy Gajulapalli. (2023) Development of Kinase‐Centric Drugs: A Computational Perspective. ChemMedChem 18:19.
Crossref
Jingyu Zhu, Jingyu Sun, Lei Jia, Lei Xu, Yanfei Cai, Yun Chen & Jian Jin. (2023) Machine Learning‐Enabled Virtual Screening with Multiple Protein Structures toward the Discovery of Novel JAK3 Inhibitors: Integration of Molecular Docking, Pharmacophore, and Naïve Bayesian Classification. Advanced Theory and Simulations 6:7.
Crossref
Andrew A. Bieberich & Christopher R. M. Asquith. (2023) Utilization of Supervised Machine Learning to Understand Kinase Inhibitor Toxophore Profiles. International Journal of Molecular Sciences 24:6, pages 5088.
Crossref
Dimitris Korovesis, Hester A. Beard, Christel Mérillat & Steven H. L. Verhelst. (2021) Probes for Photoaffinity Labelling of Kinases. ChemBioChem 22:13, pages 2206-2218.
Crossref
Adriana Coricello, Francesco Mesiti, Antonio Lupia, Annalisa Maruca & Stefano Alcaro. (2020) Inside Perspective of the Synthetic and Computational Toolbox of JAK Inhibitors: Recent Updates. Molecules 25:15, pages 3321.
Crossref
Reihane Ziadlou, Andrea Barbero, Ivan Martin, Xinluan Wang, Ling Qin, Mauro Alini & Sibylle Grad. (2020) Anti-Inflammatory and Chondroprotective Effects of Vanillic Acid and Epimedin C in Human Osteoarthritic Chondrocytes. Biomolecules 10:6, pages 932.
Crossref
Christopher R. M. Asquith, Tuomo Laitinen, James M. Bennett, Carrow I. Wells, Jonathan M. Elkins, William J. Zuercher, Graham J. Tizzard & Antti Poso. (2019) Design and Analysis of the 4‐Anilinoquin(az)oline Kinase Inhibition Profiles of GAK/SLK/STK10 Using Quantitative Structure‐Activity Relationships. ChemMedChem 15:1, pages 26-49.
Crossref
Marian C. Bryan, Joy Drobnick, Alberto Gobbi, Aleksandr Kolesnikov, Yongsheng Chen, Naomi Rajapaksa, Chudi Ndubaku, Jianwen Feng, Willy Chang, Ross Francis, Christine Yu, Edna F. Choo, Kevin DeMent, Yingqing Ran, Le An, Claire Emson, Zhiyu Huang, Swathi Sujatha-Bhaskar, Hans Brightbill, Antonio DiPasquale, Jonathan Maher, John Wai, Brent S. McKenzie, Patrick J. Lupardus, Ali A. Zarrin & James R. Kiefer. (2019) Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors. Journal of Medicinal Chemistry 62:13, pages 6223-6240.
Crossref
Marian C. Bryan & Naomi S. Rajapaksa. (2018) Kinase Inhibitors for the Treatment of Immunological Disorders: Recent Advances. Journal of Medicinal Chemistry 61:20, pages 9030-9058.
Crossref
Haneesh Jasuja, Navriti Chadha, Pankaj Kumar Singh, Maninder Kaur, Malkeet Singh Bahia & Om Silakari. (2018) Putative dual inhibitors of Janus kinase 1 and 3 (JAK1/3): Pharmacophore based hierarchical virtual screening. Computational Biology and Chemistry 76, pages 109-117.
Crossref
Daniela Fiore, Robert N. Judson, Marcela Low, Sunny Lee, Erica Zhang, Claudia Hopkins, Peter Xu, Andrea Lenzi, Fabio M.V. Rossi & Dario R. Lemos. (2016) Pharmacological blockage of fibro/adipogenic progenitor expansion and suppression of regenerative fibrogenesis is associated with impaired skeletal muscle regeneration. Stem Cell Research 17:1, pages 161-169.
Crossref
Yi Zou, Jianhu Xiao, Zhengchao Tu, Yingyi Zhang, Kun Yao, Minghao Luo, Ke Ding, Yihua Zhang & Yisheng Lai. (2016) Structure-based discovery of novel 4,5,6-trisubstituted pyrimidines as potent covalent Bruton’s tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 26:13, pages 3052-3059.
Crossref
Qingjie Liu, Douglas G. Batt, Jonathan S. Lippy, Neha Surti, Andrew J. Tebben, Jodi K. Muckelbauer, Lin Chen, Yongmi An, Chiehying Chang, Matt Pokross, Zheng Yang, Haiqing Wang, James R. Burke, Percy H. Carter & Joseph A. Tino. (2015) Design and synthesis of carbazole carboxamides as promising inhibitors of Bruton’s tyrosine kinase (BTK) and Janus kinase 2 (JAK2). Bioorganic & Medicinal Chemistry Letters 25:19, pages 4265-4269.
Crossref
Sheau-Pey Wang, Shigeru Iwata, Shingo Nakayamada, Hiroaki Niiro, Siamak Jabbarzadeh-Tabrizi, Masahiro Kondo, Satoshi Kubo, Maiko Yoshikawa & Yoshiya Tanaka. (2015) Amplification of IL-21 signalling pathway through Bruton’s tyrosine kinase in human B cell activation. Rheumatology 54:8, pages 1488-1497.
Crossref
Ellen R. Laird. 2015. Antitargets and Drug Safety. Antitargets and Drug Safety 413 434 .
Wendy B. Young, James Barbosa, Peter Blomgren, Meire C. Bremer, James J. Crawford, Donna Dambach, Steve Gallion, Sarah G. Hymowitz, Jeffrey E. Kropf, Seung H. Lee, Lichuan Liu, Joseph W. Lubach, Jen Macaluso, Pat Maciejewski, Brigitte Maurer, Scott A. Mitchell, Daniel F. Ortwine, Julie Di Paolo, Karin Reif, Heleen Scheerens, Aaron Schmitt, C. Gregory Sowell, Xiaojing Wang, Harvey Wong, Jin-Ming Xiong, Jianjun Xu, Zhongdong Zhao & Kevin S. Currie. (2015) Potent and selective Bruton’s tyrosine kinase inhibitors: Discovery of GDC-0834. Bioorganic & Medicinal Chemistry Letters 25:6, pages 1333-1337.
Crossref
Shingo Nakayamada, Shigeru Iwata & Yoshiya Tanaka. (2015) Relevance of lymphocyte subsets to B cell-targeted therapy in systemic lupus erythematosus. International Journal of Rheumatic Diseases 18:2, pages 208-218.
Crossref
James J.-W. Duan, Zhonghui Lu, Bin Jiang, Bingwei V. Yang, Lidia M. Doweyko, David S. Nirschl, Lauren E. Haque, Shuqun Lin, Gregory Brown, John HynesJr.Jr., John S. Tokarski, John S. Sack, Javed Khan, Jonathan S. Lippy, Rosemary F. Zhang, Sidney Pitt, Guoxiang Shen, William J. Pitts, Percy H. Carter, Joel C. Barrish, Steven G. Nadler, Luisa M. Salter-Cid, Murray McKinnon, Aberra Fura, Gary L. Schieven & Stephen T. Wrobleski. (2014) Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors. Bioorganic & Medicinal Chemistry Letters 24:24, pages 5721-5726.
Crossref
Richard B. Silverman & Mark W. Holladay. 2014. The Organic Chemistry of Drug Design and Drug Action. The Organic Chemistry of Drug Design and Drug Action 207 274 .
Sana Siddiqui, Naresh Singh Redhu, Oluwaseun O. Ojo, Bo Liu, Nneka Irechukwu, Charlotte Billington, Luke Janssen & Lyn M. Moir. (2013) Emerging airway smooth muscle targets to treat asthma. Pulmonary Pharmacology & Therapeutics 26:1, pages 132-144.
Crossref
Olga S. Safronova. (2013) Post-translational modifications of proteins in gene regulation under hypoxic conditions. Inflammation and Regeneration 33:4, pages 203-216.
Crossref
MICHAEL SKYNNER, PHIL JEFFREY, MICHAEL BINKS & MICHAEL WOODROW. 2012. Anti-Inflammatory Drug Discovery. Anti-Inflammatory Drug Discovery 211 254 .
Yan Lou, Timothy D. Owens, Andreas Kuglstatter, Rama K. Kondru & David M. Goldstein. (2012) Bruton’s Tyrosine Kinase Inhibitors: Approaches to Potent and Selective Inhibition, Preclinical and Clinical Evaluation for Inflammatory Diseases and B Cell Malignancies. Journal of Medicinal Chemistry 55:10, pages 4539-4550.
Crossref
Joseph A. DiDonato, Frank Mercurio & Michael Karin. (2012) NF‐κB and the link between inflammation and cancer. Immunological Reviews 246:1, pages 379-400.
Crossref
Michael H. Ieong & Harrison W. Farber. 2011. Textbook of Pulmonary Vascular Disease. Textbook of Pulmonary Vascular Disease 1033 1041 .
Tamsin M. Lindstrom & William H. Robinson. (2010) A Multitude of Kinases—Which are the Best Targets in Treating Rheumatoid Arthritis?. Rheumatic Disease Clinics of North America 36:2, pages 367-383.
Crossref
Richard Morphy. (2009) Selectively Nonselective Kinase Inhibition: Striking the Right Balance. Journal of Medicinal Chemistry 53:4, pages 1413-1437.
Crossref
Steven I. Sherman. (2009) Tyrosine kinase inhibitors and the thyroid. Best Practice & Research Clinical Endocrinology & Metabolism 23:6, pages 713-722.
Crossref
Alan S. Bass, Mark E. Cartwright, Craig Mahon, Richard Morrison, Ronald Snyder, Paul McNamara, Prudence Bradley, Ying-Ying Zhou & John Hunter. (2009) Exploratory drug safety: A discovery strategy to reduce attrition in development. Journal of Pharmacological and Toxicological Methods 60:1, pages 69-78.
Crossref
João Carlos da Silva Bizario, Daniel Giuliano Cerri, Lilian Cataldi Rodrigues, Gislane L.V. Oliveira, Auro Nomizo, Daniela Dover de Araujo, Paula Sakemi Fukuhara, Juliana Caldas Ribeiro, Fabíola Attié de Castro & Maria Cristina Ramos Costa. (2009) Imatinib mesylate ameliorates the dystrophic phenotype in exercised mdx mice. Journal of Neuroimmunology 212:1-2, pages 93-101.
Crossref
Christina D'Aura Swanson, Ricardo T. Paniagua, Tamsin M. Lindstrom & William H. Robinson. (2009) Tyrosine kinases as targets for the treatment of rheumatoid arthritis. Nature Reviews Rheumatology 5:6, pages 317-324.
Crossref
Allison L. Miller, Chao Zhang, Kevan M. Shokat & Clifford A. Lowell. (2009) Generation of a Novel System for Studying Spleen Tyrosine Kinase Function in Macrophages and B Cells. The Journal of Immunology 182:2, pages 988-998.
Crossref
Stephen T. Wrobleski & William J. Pitts. 2009. Annual Reports in Medicinal Chemistry Volume 44. Annual Reports in Medicinal Chemistry Volume 44 247 264 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.