Citations (50)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (1)
Ashok Kumar & Julie D Saba. (2009) Lyase to live by: Sphingosine phosphate lyase as a therapeutic target. Expert Opinion on Therapeutic Targets 13:8, pages 1013-1025.
Read now
Read now
Articles from other publishers (49)
Kyu Min Kim, Eun Jin Shin, Ji Hye Yang & Sung Hwan Ki. (2023) Integrative roles of sphingosine kinase in liver pathophysiology. Toxicological Research.
Crossref
Crossref
Yanhong Bu, Hong Wu, Ran Deng & Yan Wang. (2021) Therapeutic Potential of SphK1 Inhibitors Based on Abnormal Expression of SphK1 in Inflammatory Immune Related-Diseases. Frontiers in Pharmacology 12.
Crossref
Crossref
Nina Grytten, Kjell-Morten Myhr, Elisabeth G. Celius, Espen Benjaminsen, Margitta T. Kampman, Rune Midgard, Anita Vatne, Jan H. Aarseth, Trond Riise & Øivind Torkildsen. (2021) Incidence of cancer in multiple sclerosis before and after the treatment era– a registry- based cohort study. Multiple Sclerosis and Related Disorders 55, pages 103209.
Crossref
Crossref
Lian Fang, Jiangtao Hou, Yihui Cao, Jia-Jie Shan & Jie Zhao. (2021) Spinster homolog 2 in cancers, its functions and mechanisms. Cellular Signalling 77, pages 109821.
Crossref
Crossref
Esther Melamed & Michael William Lee. (2020) Multiple Sclerosis and Cancer: The Ying-Yang Effect of Disease Modifying Therapies. Frontiers in Immunology 10.
Crossref
Crossref
Xianwang Wang, Yong Sun, Xiaochun Peng, Syed Manzar Abbas Shah Naqvi, Yue Yang, Jing Zhang, Meiwen Chen, Yuan Chen, Hongyue Chen, Huizi Yan, Guangliang Wei, Peng Hong & Yingying Lu. (2020) The Tumorigenic Effect of Sphingosine Kinase 1 and Its Potential Therapeutic Target. Cancer Control 27:1, pages 107327482097666.
Crossref
Crossref
Alaeddine El Jamal, Carole Bougault, Saida Mebarek, David Magne, Olivier Cuvillier & Leyre Brizuela. (2020) The role of sphingosine 1-phosphate metabolism in bone and joint pathologies and ectopic calcification. Bone 130, pages 115087.
Crossref
Crossref
Mariam Gachechiladze, Tom�š Tich�, V�tězslav Kolek, Ivona Gryg�rkov�, Jiř� Klein, Giorgi Mgebrishvili, Gvantsa Kharaishvili, M�ria Jan�kov�, Petra Smičkov�, Lucia Cierna, Stuart Pitson, Marie‑Lise Maddelein, Olivier Cuvillier & Jozef Škarda. (2019) Sphingosine kinase‑1 predicts overall survival outcomes in non‑small cell lung cancer patients treated with carboplatin and navelbine. Oncology Letters.
Crossref
Crossref
Heba Alshaker, Shyam Srivats, Danielle Monteil, Qi Wang, Caroline M. R. Low & Dmitri Pchejetski. (2018) Field template-based design and biological evaluation of new sphingosine kinase 1 inhibitors. Breast Cancer Research and Treatment 172:1, pages 33-43.
Crossref
Crossref
Mateo Jelovica, Petra Grbčić, Martina Mušković, Mirela Sedić, Sandra Kraljević Pavelić, Martin Lončarić & Nela Malatesti. (2018) In Vitro Photodynamic Activity of N‐Methylated and N‐Oxidised Tripyridyl Porphyrins with Long Alkyl Chains and Their Inhibitory Activity in Sphingolipid Metabolism. ChemMedChem 13:4, pages 360-372.
Crossref
Crossref
Olivier Cuvillier & Anastassia Hatzoglou. (2018) La sphingosine 1-phosphate, un nouveau régulateur de la mitose. médecine/sciences 34:2, pages 112-114.
Crossref
Crossref
吟絮 刘. (2018) Advances in Research of Metabolomics in Lung Cancer. Advances in Clinical Medicine 08:02, pages 135-140.
Crossref
Crossref
Seon-Ok Lee, Joo-Seok Kim, Myoung-Sun Lee & Hyo-Jeong Lee. (2016) Anti-cancer effect of pristimerin by inhibition of HIF-1α involves the SPHK-1 pathway in hypoxic prostate cancer cells. BMC Cancer 16:1.
Crossref
Crossref
Cécile Gstalder, Isabelle Ader & Olivier Cuvillier. (2016) FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model. Molecular Cancer Therapeutics 15:10, pages 2465-2474.
Crossref
Crossref
Christopher White, Heba Alshaker, Colin Cooper, Matthias Winkler & Dmitri Pchejetski. (2016) The emerging role of FTY720 (Fingolimod) in cancer treatment. Oncotarget 7:17, pages 23106-23127.
Crossref
Crossref
P Bouquerel, C Gstalder, D Müller, J Laurent, L Brizuela, R A Sabbadini, B Malavaud, S Pyronnet, Y Martineau, I Ader & O Cuvillier. (2016) Essential role for SphK1/S1P signaling to regulate hypoxia-inducible factor 2α expression and activity in cancer. Oncogenesis 5:3, pages e209-e209.
Crossref
Crossref
Kohsuke Tani, Keiji Tabuchi & Akira Hara. (2015) Hair Cell Loss Induced by Sphingosine and a Sphingosine Kinase Inhibitor in the Rat Cochlea. Neurotoxicity Research 29:1, pages 35-46.
Crossref
Crossref
Isabelle Ader, Cécile Gstalder, Pierre Bouquerel, Muriel Golzio, Guillaume Andrieu, Santiago Zalvidea, Sylvain Richard, Roger A. Sabbadini, Bernard Malavaud & Olivier Cuvillier. (2015) Neutralizing S1P inhibits intratumoral hypoxia, induces vascular remodelling and sensitizes to chemotherapy in prostate cancer. Oncotarget 6:15, pages 13803-13821.
Crossref
Crossref
S. Riedel, S. Abel, S. Swanevelder & W.C.A. Gelderblom. (2015) Induction of an altered lipid phenotype by two cancer promoting treatments in rat liver. Food and Chemical Toxicology 78, pages 96-104.
Crossref
Crossref
Kwang Hong Tay, Xiaoying Liu, Mengna Chi, Lei Jin, Chen Chen Jiang, Su Tang Guo, Nicole M. Verrills, Hsin-Yi Tseng & Xu Dong Zhang. (2015)
Involvement of vacuolar H
+
-ATPase in killing of human melanoma cells by the sphingosine kinase analogue FTY720
. Pigment Cell & Melanoma Research 28:2, pages 171-183.
Crossref
Crossref
Pei-Hua Li, Jin-Xia Wu, Jun-Nian Zheng & Dong-Sheng Pei. (2015) A Sphingosine Kinase-1 Inhibitor, SKI-II, Induces Growth Inhibition and Apoptosis in Human Gastric Cancer Cells. Asian Pacific Journal of Cancer Prevention 15:23, pages 10381-10385.
Crossref
Crossref
Yingrong Chen, Zhihong Ma, Lishan Min, Hongwei Li, Bin Wang, Jing Zhong & Licheng Dai. (2015) Biomarker Identification and Pathway Analysis by Serum Metabolomics of Lung Cancer. BioMed Research International 2015, pages 1-9.
Crossref
Crossref
Johnatan Ceccom, Najat Loukh, Valérie Lauwers-Cances, Christian Touriol, Yvan Nicaise, Catherine Gentil, Emmanuelle Uro-Coste, Stuart Pitson, Claude Alain Maurage, Charles Duyckaerts, Olivier Cuvillier & Marie-Bernadette Delisle. (2014) Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer’s disease. Acta Neuropathologica Communications 2:1.
Crossref
Crossref
Eric Bradley, Somsankar Dasgupta, Xue Jiang, Xiaying Zhao, Gu Zhu, Qian He, Michael Dinkins, Erhard Bieberich & Guanghu Wang. (2014) Critical Role of Spns2, a Sphingosine-1-Phosphate Transporter, in Lung Cancer Cell Survival and Migration. PLoS ONE 9:10, pages e110119.
Crossref
Crossref
Leyre Brizuela, Claire Martin, Pauline Jeannot, Isabelle Ader, Cécile Gstalder, Guillaume Andrieu, Magalie Bocquet, Jean-Michel Laffosse, Anne Gomez-Brouchet, Bernard Malavaud, Roger A. Sabbadini & Olivier Cuvillier. (2014) Osteoblast‐derived sphingosine 1‐phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis‐derived prostate cancer cells. Molecular Oncology 8:7, pages 1181-1195.
Crossref
Crossref
Hongxia Yuan, Pingting Yang, Dun Zhou, Wei Gao, Zhenyu Qiu, Fang Fang, Shuang Ding & Weiguo Xiao. (2014) Knockdown of sphingosine kinase 1 inhibits the migration and invasion of human rheumatoid arthritis fibroblast-like synoviocytes by down-regulating the PI3K/AKT activation and MMP-2/9 production in vitro. Molecular Biology Reports 41:8, pages 5157-5165.
Crossref
Crossref
Olivier Cuvillier. 2014. Molecular Mechanisms of Angiogenesis. Molecular Mechanisms of Angiogenesis
199
217
.
Sandip B. Bharate, Sanghapal D. Sawant, Parvinder Pal Singh & Ram A. Vishwakarma. (2013) Kinase Inhibitors of Marine Origin. Chemical Reviews 113:8, pages 6761-6815.
Crossref
Crossref
Brian M. Barth, Sriram S. Shanmugavelandy, James M. Kaiser, Christopher McGovern, Erhan İ. Altınoğlu, Jeremy K. Haakenson, Jeremy A. Hengst, Evan L. Gilius, Sarah A. Knupp, Todd E. Fox, Jill P. Smith, Timothy M. Ritty, James H. Adair & Mark Kester. (2013) PhotoImmunoNanoTherapy Reveals an Anticancer Role for Sphingosine Kinase 2 and Dihydrosphingosine-1-Phosphate. ACS Nano 7:3, pages 2132-2144.
Crossref
Crossref
Linda A. Heffernan-Stroud & Lina M. Obeid. 2013. The Role of Sphingolipids in Cancer Development and Therapy. The Role of Sphingolipids in Cancer Development and Therapy
201
235
.
Heba Alshaker, Lysann Sauer, Danielle Monteil, Silvia Ottaviani, Shyam Srivats, Torsten Böhler & Dmitri Pchejetski. 2013. The Role of Sphingolipids in Cancer Development and Therapy. The Role of Sphingolipids in Cancer Development and Therapy
143
200
.
Leyre Brizuela, Isabelle Ader, Catherine Mazerolles, Magalie Bocquet, Bernard Malavaud & Olivier Cuvillier. (2012) First Evidence of Sphingosine 1-Phosphate Lyase Protein Expression and Activity Downregulation in Human Neoplasm: Implication for Resistance to Therapeutics in Prostate Cancer. Molecular Cancer Therapeutics 11:9, pages 1841-1851.
Crossref
Crossref
A. Estrada-Bernal, K. Palanichamy, A. Ray Chaudhury & J. R. Van Brocklyn. (2012) Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma. Neuro-Oncology 14:4, pages 405-415.
Crossref
Crossref
Zu-An Zhu, Zheng-Qiu Zhu, Hong-Xing Cai & Ying Liu. (2012) Reversion of Multidrug Resistance by SKI-II in SGC7901/DDP Cells and Exploration of Underlying Mechanisms. Asian Pacific Journal of Cancer Prevention 13:2, pages 625-631.
Crossref
Crossref
D. James Morré & Dorothy M. MorréD. James Morré & Dorothy M. Morré. 2013. ECTO-NOX Proteins. ECTO-NOX Proteins
345
417
.
Sung-Yun Cho, Hyo-Jeong Lee, Soo-Jin Jeong, Hyo-Jung Lee, Hyun-Seok Kim, Chang Yan Chen, Eun-Ok Lee & Sung-Hoon Kim. (2011) Sphingosine kinase 1 pathway is involved in melatonin-induced HIF-1α inactivation in hypoxic PC-3 prostate cancer cells. Journal of Pineal Research 51:1, pages 87-93.
Crossref
Crossref
Gabriella Marfe, Carla Di Stefano, Alessandra Gambacurta, Tiziana Ottone, Valentina Martini, Elisabetta Abruzzese, Luca Mologni, Paola Sinibaldi-Salimei, Paolo de Fabritis, Carlo Gambacorti-Passerini, Sergio Amadori & Raymond B. Birge. (2011) Sphingosine kinase 1 overexpression is regulated by signaling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia cells. Experimental Hematology 39:6, pages 653-665.e6.
Crossref
Crossref
Adriana Estrada-Bernal, Sean E. Lawler, Michal O. Nowicki, Abhik Ray Chaudhury & James R. Van Brocklyn. (2010) The role of sphingosine kinase-1 in EGFRvIII-regulated growth and survival of glioblastoma cells. Journal of Neuro-Oncology 102:3, pages 353-366.
Crossref
Crossref
Stuart M. Pitson. (2011) Regulation of sphingosine kinase and sphingolipid signaling. Trends in Biochemical Sciences 36:2, pages 97-107.
Crossref
Crossref
Uttam K. Sinha, Victor J. Schorn, Christian Hochstim, Steven B. Chinn, Sutao Zhu & Rizwan Masood. (2011) Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition. Head & Neck 33:2, pages 178-188.
Crossref
Crossref
T M Leclercq, P A B Moretti & S M Pitson. (2010) Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis. Oncogene 30:3, pages 372-378.
Crossref
Crossref
Syed M. Qadri, Julia Bauer, Christine Zelenak, Hasan Mahmud, Yuliya Kucherenko, Seung Hun Lee, Klaus Ferlinz & Florian Lang. (2011) Sphingosine but not Sphingosine-1-phosphate Stimulates Suicidal Erythrocyte Death. Cellular Physiology and Biochemistry 28:2, pages 339-346.
Crossref
Crossref
Bernard Malavaud, Dimitri Pchejetski, Catherine Mazerolles, Geisilène Russano de Paiva, Cyril Calvet, Nicolas Doumerc, Stuart Pitson, Pascal Rischmann & Olivier Cuvillier. (2010) Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens. European Journal of Cancer 46:18, pages 3417-3424.
Crossref
Crossref
James R Van Brocklyn. (2010) Regulation of cancer cell migration and invasion by sphingosine-1-phosphate. World Journal of Biological Chemistry 1:10, pages 307.
Crossref
Crossref
Olga Sukocheva, Lijun Wang, Emily Verrier, Mathew A. Vadas & Pu Xia. (2009) Restoring Endocrine Response in Breast Cancer Cells by Inhibition of the Sphingosine Kinase-1 Signaling Pathway. Endocrinology 150:10, pages 4484-4492.
Crossref
Crossref
M. Khodadadian, M.E. Leroux, E. Auzenne, S.C. Ghosh, D. Farquhar, R. Evans, W. Spohn, Y. Zou & J. Klostergaard. (2009) MRP- and BCL-2-mediated drug resistance in human SCLC: Effects of apoptotic sphingolipids in vitro. Lung Cancer 66:1, pages 48-57.
Crossref
Crossref
Dmitri Kapitonov, Jeremy C. Allegood, Clint Mitchell, Nitai C. Hait, Jorge A. Almenara, Jeffrey K. Adams, Robert E. Zipkin, Paul Dent, Tomasz Kordula, Sheldon Milstien & Sarah Spiegel. (2009) Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts. Cancer Research 69:17, pages 6915-6923.
Crossref
Crossref
Isabelle Ader, Bernard Malavaud & Olivier Cuvillier. (2009) When the Sphingosine Kinase 1/Sphingosine 1-Phosphate Pathway Meets Hypoxia Signaling: New Targets for Cancer Therapy. Cancer Research 69:9, pages 3723-3726.
Crossref
Crossref
Thomas De Luca, Dorothy M. Morré, Elena Bosneaga & D. James Morré. (2009) Downstream targets of altered sphingolipid metabolism in response to inhibition of ENOX2 by phenoxodiol. BioFactors 34:3, pages 253-260.
Crossref
Crossref