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Expert Opinion on Therapeutic Targets Volume 12, 2008 - Issue 8
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Review

DNA methylation: A promising target for the twenty-first century

Paula A Abreu Federal Fluminense University, Biology Institute, Department of Celular and Molecular Biology, CEP 24020-150 Niterói, Rio de Janeiro, Brazil +55 21 26292294; +55 21 26292284; [email protected]; Federal Fluminense University, Biology Institute, Neuroimmunology Postgraduate course, CEP 24020-150 Niterói, Rio de Janeiro, Brazil
,
Gisela Dellamora-Ortiz Federal University of Rio de Janeiro, Faculty of Pharmacy, CEP 21941-590, Rio de Janeiro, RJ, Brazil
,
Luiz R Leão-Ferreira Federal Fluminense University, Biology Institute, Department of Celular and Molecular Biology, CEP 24020-150 Niterói, Rio de Janeiro, Brazil +55 21 26292294; +55 21 26292284; [email protected]
,
Maria Gouveia Federal Fluminense University, Biology Institute, Neuroimmunology Postgraduate course, CEP 24020-150 Niterói, Rio de Janeiro, Brazil
,
Esteban Braggio National Institute of Cancer, Marrow Bone Transplant Center, CEP 21941-590, Rio de Janeiro, RJ, Brazil
,
Ilana Zalcberg National Institute of Cancer, Marrow Bone Transplant Center, CEP 21941-590, Rio de Janeiro, RJ, Brazil
,
Dilvani O Santos Federal Fluminense University, Biology Institute, Department of Celular and Molecular Biology, CEP 24020-150 Niterói, Rio de Janeiro, Brazil +55 21 26292294; +55 21 26292284; [email protected]
,
Saulo Bourguinhon Federal Fluminense University, Biology Institute, Department of Celular and Molecular Biology, CEP 24020-150 Niterói, Rio de Janeiro, Brazil +55 21 26292294; +55 21 26292284; [email protected]
,
Lucio M Cabral Federal University of Rio de Janeiro, Faculty of Pharmacy, CEP 21941-590, Rio de Janeiro, RJ, Brazil
,
Carlos R Rodrigues Federal University of Rio de Janeiro, Faculty of Pharmacy, CEP 21941-590, Rio de Janeiro, RJ, Brazil
&
Helena C Castro Federal Fluminense University, Biology Institute, Department of Celular and Molecular Biology, CEP 24020-150 Niterói, Rio de Janeiro, Brazil +55 21 26292294; +55 21 26292284; [email protected]; Federal Fluminense University, Biology Institute, Neuroimmunology Postgraduate course, CEP 24020-150 Niterói, Rio de Janeiro, Brazil
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Pages 1035-1047 | Published online: 12 Jul 2008

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Teni Boulikas. (2009) Clinical overview on Lipoplatin™: a successful liposomal formulation of cisplatin. Expert Opinion on Investigational Drugs 18:8, pages 1197-1218.
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Bruna Mascaro-Cordeiro, Indhira Dias Oliveira, Francine Tesser-Gamba, Lorena Favaro Pavon, Nasjla Saba-Silva, Sergio Cavalheiro, Patrícia Dastoli & Silvia Regina Caminada Toledo. (2018) Valproic acid treatment response in vitro is determined by TP53 status in medulloblastoma. Child's Nervous System 34:8, pages 1497-1509.
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Yong Ling, Jiao Feng, Lin Luo, Jing Guo, Yanfu Peng, Tingting Wang, Xiang Ge, Qibing Xu, Xinyang Wang, Hong Dai & Yanan Zhang. (2017) Design and Synthesis of C3-Substituted β-Carboline-Based Histone Deacetylase Inhibitors with Potent Antitumor Activities. ChemMedChem 12:9, pages 646-651.
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Yong Zhu, Xin Chen, Zeng Wu, Yixuan Zheng, Yadong Chen, Weifang Tang & Tao Lu. (2012) Synthesis and antitumor activity of novel diaryl ether hydroxamic acids derivatives as potential HDAC inhibitors. Archives of Pharmacal Research 35:10, pages 1723-1732.
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Da Pang, Yashuang Zhao, Weinan Xue, Ming Shan, Yanbo Chen, Youxue Zhang, Guoqiang Zhang, Feng Liu, Dalin Li & Yanmei Yang. (2011) Methylation profiles of the BRCA1 promoter in hereditary and sporadic breast cancer among Han Chinese. Medical Oncology 29:3, pages 1561-1568.
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Amancio Carnero & Matilde E. LLeonart. (2011) Epigenetic mechanisms in senescence, immortalisation and cancer. Biological Reviews 86:2, pages 443-455.
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Paola Conti, Lucia Tamborini, Andrea Pinto, Laura Sola, Roberta Ettari, Ciro Mercurio & Carlo De Micheli. (2010) Design and synthesis of novel isoxazole-based HDAC inhibitors. European Journal of Medicinal Chemistry 45:9, pages 4331-4338.
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J.-H. Lee, M. L. Choy, L. Ngo, S. S. Foster & Paul A. Marks. (2010) Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair. Proceedings of the National Academy of Sciences 107:33, pages 14639-14644.
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Yu Ye & James T. Stivers. (2010) Fluorescence-based high-throughput assay for human DNA (cytosine-5)-methyltransferase 1. Analytical Biochemistry 401:1, pages 168-172.
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Subhasish Tapadar, Rong He, Doris N. Luchini, Daniel D. Billadeau & Alan P. Kozikowski. (2009) Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: Effects on HDAC biology and antiproliferative activity. Bioorganic & Medicinal Chemistry Letters 19:11, pages 3023-3026.
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