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Expert Opinion on Therapeutic Targets Volume 12, 2008 - Issue 8
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Review

PPAR-γ signaling pathway in placental development and function: A potential therapeutic target in the treatment of gestational diseases

Costas Giaginis University of Athens, Department of Forensic Medicine and Toxicology, Medical School, 75, M. Asias street, Goudi, Athens, GR11527, Greece +30 210 7462413; +30 210 7716098; [email protected]
,
Evangelia Spanopoulou University of Athens, Department of Forensic Medicine and Toxicology, Medical School, 75, M. Asias street, Goudi, Athens, GR11527, Greece +30 210 7462413; +30 210 7716098; [email protected]
&
Stamatios Theocharis University of Athens, Department of Forensic Medicine and Toxicology, Medical School, 75, M. Asias street, Goudi, Athens, GR11527, Greece +30 210 7462413; +30 210 7716098; [email protected]
, MD PhD
Pages 1049-1063 | Published online: 12 Jul 2008

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Jamie Klein, Ron Charach & Eyal Sheiner. (2015) Treating diabetes during pregnancy. Expert Opinion on Pharmacotherapy 16:3, pages 357-368.
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Articles from other publishers (17)

Xi-Zi Zhu, Zhi-Min Deng, Fang-Fang Dai, Hua Liu & Yan-Xiang Cheng. (2023) The impact of early pregnancy metabolic disorders on pregnancy outcome and the specific mechanism. European Journal of Medical Research 28:1.
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Yi Jiang, Yuting Chen, Lijie Wei, Huiting Zhang, Jingyi Zhang, Xuan Zhou, Shenglan Zhu, Yuanyuan Du, Rui Su, Chenyun Fang, Wencheng Ding & Ling Feng. (2023) DHA supplementation and pregnancy complications. Journal of Translational Medicine 21:1.
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Yushu Qin, Donalyn Bily, Makayla Aguirre, Ke Zhang & Linglin Xie. (2023) Understanding PPARγ and Its Agonists on Trophoblast Differentiation and Invasion: Potential Therapeutic Targets for Gestational Diabetes Mellitus and Preeclampsia. Nutrients 15:11, pages 2459.
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Iason Psilopatis, Kleio Vrettou, Florian Nima Fleckenstein & Stamatios Theocharis. (2023) The Role of Peroxisome Proliferator-Activated Receptors in Preeclampsia. Cells 12:4, pages 647.
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Yifei Ma, Shan Xu, Juan Meng & Lu Li. (2022) Protective effect of nimbolide against streptozotocin induced gestational diabetes mellitus in rats via alteration of inflammatory reaction, oxidative stress, and gut microbiota. Environmental Toxicology 37:6, pages 1382-1393.
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Jing Li, Xiaojie Quan, Saifei Lei, Zhenyao Huang, Qi Wang & Pengfei Xu. (2021) PFOS Inhibited Normal Functional Development of Placenta Cells via PPARγ Signaling. Biomedicines 9:6, pages 677.
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Zhenyao Huang, Hao Yu, Guizhen Du, Li Han, Xiaomin Huang, Dan Wu, Xiumei Han, Yankai Xia, Xinru Wang & Chuncheng Lu. (2021) Enhancer RNA lnc-CES1-1 inhibits decidual cell migration by interacting with RNA-binding protein FUS and activating PPARγ in URPL. Molecular Therapy - Nucleic Acids 24, pages 104-112.
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W. Permadi, K. I. Mantilidewi, A. F. Khairani, U. A. Lantika, A. R. Ronosulistyo & H. Bayuaji. (2020) Differences in expression of Peroxisome Proliferator-activated Receptor-γ in early-onset preeclampsia and late-onset preeclampsia. BMC Research Notes 13:1.
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Thomas R. Magee, Michael G. Ross, Lauren Wedekind, Mina Desai, Siri Kjos & Louiza Belkacemi. (2014) Gestational diabetes mellitus alters apoptotic and inflammatory gene expression of trophobasts from human term placenta. Journal of Diabetes and its Complications 28:4, pages 448-459.
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P. Murthi, B. Kalionis, M. Cocquebert, G. Rajaraman, A. Chui, R.J. Keogh, D. Evain-Brion & T. Fournier. (2013) Homeobox genes and down-stream transcription factor PPARγ in normal and pathological human placental development. Placenta 34:4, pages 299-309.
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Costantinos Giaginis, Ekaterini Politi, Paraskevi Alexandrou, John Sfiniadakis, Gregory Kouraklis & Stamatios Theocharis. (2012) Expression of Peroxisome Proliferator Activated Receptor-Gamma (PPAR-γ) in Human Non-small Cell Lung Carcinoma: Correlation with Clinicopathological Parameters, Proliferation and Apoptosis Related Molecules and Patients’ Survival. Pathology & Oncology Research 18:4, pages 875-883.
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Thierry Fournier, Jean Guibourdenche, Karen Handschuh, Vassilis Tsatsaris, Benjamin Rauwel, Christian Davrinche & Danièle Evain-Brion. (2011) PPARγ and human trophoblast differentiation. Journal of Reproductive Immunology 90:1, pages 41-49.
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Constantinos Giaginis, Christos Klonaris, Athanassios Katsargyris, Gregorios Kouraklis, Chara Spiliopoulou & Stamatios Theocharis. (2011) Correlation of Peroxisome Proliferator-Activated Receptor-gamma (PPAR-gamma) and Retinoid X Receptor-alpha (RXR-alpha) expression with clinical risk factors in patients with advanced carotid atherosclerosis. Medical Science Monitor 17:7, pages CR381-CR391.
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Martha Lappas, Amberlee Mitton, Ratana Lim, Gillian Barker, Clyde Riley & Michael Permezel. (2011) SIRT1 Is a Novel Regulator of Key Pathways of Human Labor1. Biology of Reproduction 84:1, pages 167-178.
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Petra Arck, Bettina Toth, Aurelia Pestka & Udo Jeschke. (2010) Nuclear Receptors of the Peroxisome Proliferator-Activated Receptor (PPAR) Family in Gestational Diabetes: From Animal Models to Clinical Trials1. Biology of Reproduction 83:2, pages 168-176.
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J. L. Fernández-Morera, S. Rodríguez-Rodero, E. Menéndez-Torre & M. F. Fraga. (2010) The Possible Role of Epigenetics in Gestational Diabetes: Cause, Consequence, or Both. Obstetrics and Gynecology International 2010, pages 1-7.
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M. Lappas & G.E. Rice. (2009) Transcriptional Regulation of the Processes of Human Labour and Delivery. Placenta 30, pages 90-95.
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