Citations (58)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (2)
Maria Gabriella Matera, Luigino Calzetta, Andrea Segreti & Mario Cazzola. (2012) Emerging drugs for chronic obstructive pulmonary disease. Expert Opinion on Emerging Drugs 17:1, pages 61-82.
Read now
Read now
Michael J Fischer, Eva-Maria Strasser & Renate J Scheibe. (2011) Going in deeper and deeper: signal transduction pathways in myofacial trigger points – A narrative review. International Musculoskeletal Medicine 33:2, pages 64-74.
Read now
Read now
Articles from other publishers (56)
Payal Ganguly, Tom Macleod, Chi Wong, Mark Harland & Dennis McGonagle. (2023) Revisiting p38 Mitogen-Activated Protein Kinases (MAPK) in Inflammatory Arthritis: A Narrative of the Emergence of MAPK-Activated Protein Kinase Inhibitors (MK2i). Pharmaceuticals 16:9, pages 1286.
Crossref
Crossref
Quy T.N. Tran, Phyllis X.L. Gan, Wupeng Liao, Yu Keung Mok, Christina L.L. Chai & W.S. Fred Wong. (2023) Degradation of MK2 with natural compound andrographolide: A new modality for anti-inflammatory therapy. Pharmacological Research 194, pages 106861.
Crossref
Crossref
Qi Chen, Chengchuan Che, Shanshan Yang, Pingping Ding, Meiru Si & Ge Yang. (2022) Anti-inflammatory effects of extracellular vesicles from Morchella on LPS-stimulated RAW264.7 cells via the ROS-mediated p38 MAPK signaling pathway. Molecular and Cellular Biochemistry 478:2, pages 317-327.
Crossref
Crossref
Mohamad Bittar & Philip Mease. (2022) Novel therapies in axial spondyloarthritis. Best Practice & Research Clinical Rheumatology 36:4, pages 101811.
Crossref
Crossref
Amy F.T. Arnsten, Elizabeth Woo, Shengtao Yang, Min Wang & Dibyadeep Datta. (2022) Unusual Molecular Regulation of Dorsolateral Prefrontal Cortex Layer III Synapses Increases Vulnerability to Genetic and Environmental Insults in Schizophrenia. Biological Psychiatry 92:6, pages 480-490.
Crossref
Crossref
C.K. Matthew Heng, Nechama Gilad, Ilona Darlyuk-Saadon, W.S. Fred Wong & David Engelberg. (2022) Targeting the p38α pathway in chronic inflammatory diseases: Could activation, not inhibition, be the appropriate therapeutic strategy?. Pharmacology & Therapeutics 235, pages 108153.
Crossref
Crossref
Lucia Suarez-Lopez, Bing Shui, Douglas K. Brubaker, Marza Hill, Alexander Bergendorf, Paul S. Changelian, Aisha Laguna, Alina Starchenko, Douglas A. Lauffenburger & Kevin M. Haigis. (2021) Cross-species transcriptomic signatures predict response to MK2 inhibition in mouse models of chronic inflammation. iScience 24:12, pages 103406.
Crossref
Crossref
Anamika Sharma, Narendra Vijay Tirpude, Monika Kumari & Yogendra Padwad. (2021)
Rutin prevents inflammation-associated colon damage
via
inhibiting the p38/MAPKAPK2 and PI3K/Akt/GSK3β/NF-κB signalling axes and enhancing splenic Tregs in DSS-induced murine chronic colitis
. Food & Function 12:18, pages 8492-8506.
Crossref
Crossref
Mohammad Shafiq, Kumaravelu JagaveluHina IqbalPankaj YadavDebabrata Chanda, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias GaestelKashif Hanif. (2021) Inhibition of Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase 2 (MK2) is Protective in Pulmonary Hypertension. Hypertension 77:4, pages 1248-1259.
Crossref
Crossref
Lucia Suarez-Lopez, Yi Wen Kong, Ganapathy Sriram, Jesse C. Patterson, Samantha Rosenberg, Sandra Morandell, Kevin M. Haigis & Michael B. Yaffe. (2021) MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer. Frontiers in Immunology 11.
Crossref
Crossref
Ulf Hedström, Monica Norberg, Emma Evertsson, Sarah R. Lever, Magnus Munck af Rosenschöld, Hans Lönn, Peter Bold, Helena Käck, Pia Berntsson, Johanna Vinblad, Jianming Liu, Anette Welinder, Johan Karlsson, Arjan Snijder, Katerina Pardali, Ulf Andersson, Andrew M. Davis & Mickael Mogemark. (2019) An Angle on MK2 Inhibition—Optimization and Evaluation of Prevention of Activation Inhibitors. ChemMedChem 14:19, pages 1701-1709.
Crossref
Crossref
Dipti TripathiBharti BiswasAmit ManhasAbhinav SinghDipika GoyalMatthias GaestelKumaravelu Jagavelu. (2019) Proinflammatory Effect of Endothelial Microparticles Is Mitochondria Mediated and Modulated Through MAPKAPK2 (MAPK-Activated Protein Kinase 2) Leading to Attenuation of Cardiac Hypertrophy. Arteriosclerosis, Thrombosis, and Vascular Biology 39:6, pages 1100-1112.
Crossref
Crossref
Rakesh Kumar Singh & Abul Kalam Najmi. (2019) Novel Therapeutic Potential of Mitogen-Activated Protein Kinase Activated Protein Kinase 2 (MK2) in Chronic Airway Inflammatory Disorders. Current Drug Targets 20:4, pages 367-379.
Crossref
Crossref
Yu Li, Depeng Zhang, Kaikai Yu, Yudong Hu, Qiong Wu, Feng Qian & Zishu Wang. (2018) CMPD1 inhibited human gastric cancer cell proliferation by inducing apoptosis and G2/M cell cycle arrest. Biological Research 51:1.
Crossref
Crossref
Yaxian Wu, Huiqiong He, Yunhe Ding, Sirui Liu, Depeng Zhang, Jun Wang, Hongchao Jiang, Dan Zhang, Lei Sun, Richard D. Ye & Feng Qian. (2018)
MK2 mediates macrophage activation and acute lung injury by regulating
let-7e
miRNA
. American Journal of Physiology-Lung Cellular and Molecular Physiology 315:3, pages L371-L381.
Crossref
Crossref
Nan Wang, Zhiping Feng, Wei Zhao, Zhiqiang Zhang & Lixin Zhang. (2018) Ultrashortwave radiation promotes the recovery of spinal cord injury by inhibiting inflammation via suppression of the MK2/TNF‑α pathway. International Journal of Molecular Medicine.
Crossref
Crossref
RK Singh, M Diwan, SG Dastidar & AK Najmi. (2017) Differential effect of p38 and MK2 kinase inhibitors on the inflammatory and toxicity biomarkers in vitro. Human & Experimental Toxicology 37:5, pages 521-531.
Crossref
Crossref
Lucia Suarez-Lopez, Ganapathy SriramYi Wen KongSandra MorandellKarl A. MerrickYuliana HernandezKevin M. HaigisMichael B. Yaffe. (2018) MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis. Proceedings of the National Academy of Sciences 115:18.
Crossref
Crossref
Matthieu Ruiz, Lise Coderre, Bruce Gordon Allen & Christine Des Rosiers. (2018) Protecting the heart through MK2 modulation, toward a role in diabetic cardiomyopathy and lipid metabolism. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:5, pages 1914-1922.
Crossref
Crossref
Panlai ShiLin ZhangMingliang ZhangWenlong YangKemin WangJunfeng ZhangKinya OtsuGonghua HuangXuemei FanJunling Liu. (2017) Platelet-Specific p38α Deficiency Improved Cardiac Function After Myocardial Infarction in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology 37:12.
Crossref
Crossref
Rakesh Kumar Singh, Abul Kalam Najmi & Sunanda Ghosh Dastidar. (2017) Biological functions and role of mitogen-activated protein kinase activated protein kinase 2 (MK2) in inflammatory diseases. Pharmacological Reports 69:4, pages 746-756.
Crossref
Crossref
Isabel Jaco, Alessandro Annibaldi, Najoua Lalaoui, Rebecca Wilson, Tencho Tenev, Lucie Laurien, Chun Kim, Kunzah Jamal, Sidonie Wicky John, Gianmaria Liccardi, Diep Chau, James M. Murphy, Gabriela Brumatti, Rebecca Feltham, Manolis Pasparakis, John Silke & Pascal Meier. (2017) MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death. Molecular Cell 66:5, pages 698-710.e5.
Crossref
Crossref
Kirsty F. HouslayFrank ChristianRuth MacLeodDavid R. AdamsMiles D. HouslayGeorge S. Baillie. (2017) Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners. Biochemical Journal 474:4, pages 597-609.
Crossref
Crossref
Ye Dao Xiong, Lu Xing Rong & Chi Pan. (2016) Regulation of Postoperative Ileus by Lentivirus-Mediated HuR RNA Interference via the p38/MK2 Signaling Pathway. Journal of Gastrointestinal Surgery 21:2, pages 389-397.
Crossref
Crossref
Thomas M. Sanderson, Ellen L. Hogg, Graham L. Collingridge & Sonia A. L. Corrêa. (2016) Hippocampal metabotropic glutamate receptor long‐term depression in health and disease: focus on mitogen‐activated protein kinase pathways. Journal of Neurochemistry 139:S2, pages 200-214.
Crossref
Crossref
Yanfeng Chen, Wenzhao Yang, Xiaobo Zhang, Shu Yang, Gao Peng, Ting Wu, Yueping Zhou, Caihong Huang, Peter S. Reinach, Wei Li & Zuguo Liu. (2016) MK2 inhibitor reduces alkali burn-induced inflammation in rat cornea. Scientific Reports 6:1.
Crossref
Crossref
Dauren Alimbetov, Terence Davis, Amy J. C. Brook, Lynne S. Cox, Richard G. A. Faragher, Talgat Nurgozhin, Zhaxybay Zhumadilov & David Kipling. (2015) Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2. Biogerontology 17:2, pages 305-315.
Crossref
Crossref
Lale Ozcan, Xiaoming Xu, Shi-Xian Deng, Devram S. Ghorpade, Tiffany Thomas, Serge Cremers, Brian Hubbard, Michael H. Serrano-Wu, Matthias Gaestel, Donald W. Landry & Ira Tabas. (2015) Treatment of Obese Insulin-Resistant Mice With an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity. Diabetes 64:10, pages 3396-3405.
Crossref
Crossref
Mark Bagley, Mohammed Baashen, Irina Chuckowree, Jessica Dwyer, David Kipling & Terence Davis. (2015) Microwave-Assisted Synthesis of a MK2 Inhibitor by Suzuki-Miyaura Coupling for Study in Werner Syndrome Cells. Pharmaceuticals 8:2, pages 257-276.
Crossref
Crossref
Ravikanth Velagapudi, Mutallib Aderogba & Olumayokun A. Olajide. (2014) Tiliroside, a dietary glycosidic flavonoid, inhibits TRAF-6/NF-κB/p38-mediated neuroinflammation in activated BV2 microglia. Biochimica et Biophysica Acta (BBA) - General Subjects 1840:12, pages 3311-3319.
Crossref
Crossref
John Spencer & Mark C BagleyMark C BagleyMohammed Baashen, Jessica Dwyer, Pierre Milbeo, David Kipling & Terence Davis. 2014. Microwaves in Drug Discovery and Development: Recent Advances. Microwaves in Drug Discovery and Development: Recent Advances
86
104
.
Dong Xiao, Xiaohong Zhu, Michael Sofolarides, Sylvia Degrado, Ning Shao, Ashwin Rao, Xiao Chen, Robert Aslanian, James Fossetta, Fang Tian, Prashant Trivedi, Daniel Lundell & Anandan Palani. (2014) Discovery of a novel series of potent MK2 non-ATP competitive inhibitors using 1,2-substituted azoles as cis-amide isosteres. Bioorganic & Medicinal Chemistry Letters 24:15, pages 3609-3613.
Crossref
Crossref
Olumayokun A. Olajide, Ravikanth Velagapudi, Uchechukwu P. Okorji, Satyajit D. Sarker & Bernd L. Fiebich. (2014) Picralima nitida seeds suppress PGE2 production by interfering with multiple signalling pathways in IL-1β-stimulated SK-N-SH neuronal cells. Journal of Ethnopharmacology 152:2, pages 377-383.
Crossref
Crossref
José M. C. Ribeiro, Fernando A. Genta, Marcos H. F. Sorgine, Raquel Logullo, Rafael D. Mesquita, Gabriela O. Paiva-Silva, David Majerowicz, Marcelo Medeiros, Leonardo Koerich, Walter R. Terra, Clélia Ferreira, André C. Pimentel, Paulo M. Bisch, Daniel C. Leite, Michelle M. P. Diniz, João Lídio da S. G. V. Junior, Manuela L. Da Silva, Ricardo N. Araujo, Ana Caroline P. Gandara, Sébastien Brosson, Didier Salmon, Sabrina Bousbata, Natalia González-Caballero, Ariel Mariano Silber, Michele Alves-Bezerra, Katia C. Gondim, Mário Alberto C. Silva-Neto, Georgia C. Atella, Helena Araujo, Felipe A. Dias, Carla Polycarpo, Raquel J. Vionette-Amaral, Patrícia Fampa, Ana Claudia A. Melo, Aparecida S. Tanaka, Carsten Balczun, José Henrique M. Oliveira, Renata L. S. Gonçalves, Cristiano Lazoski, Rolando Rivera-Pomar, Luis Diambra, Günter A. Schaub, Elói S. Garcia, Patrícia Azambuja, Glória R. C. Braz & Pedro L. Oliveira. (2014) An Insight into the Transcriptome of the Digestive Tract of the Bloodsucking Bug, Rhodnius prolixus. PLoS Neglected Tropical Diseases 8:1, pages e2594.
Crossref
Crossref
Xiaodong Liu, Ting Wu & Pan Chi. (2013) Inhibition of MK2 shows promise for preventing postoperative ileus in mice. Journal of Surgical Research 185:1, pages 102-112.
Crossref
Crossref
Dong Xiao, Anandan Palani, Xianhai Huang, Michael Sofolarides, Wei Zhou, Xiao Chen, Robert Aslanian, Zhuyan Guo, James Fossetta, Fang Tian, Prashant Trivedi, Peter Spacciapoli, Charles E. Whitehurst & Daniel Lundell. (2013) Conformation constraint of anilides enabling the discovery of tricyclic lactams as potent MK2 non-ATP competitive inhibitors. Bioorganic & Medicinal Chemistry Letters 23:11, pages 3262-3266.
Crossref
Crossref
Linda D. Bobo, Rana E. El Feghaly, Yee-Shiuan Chen, Erik R. Dubberke, Zhuolin Han, Alexandra H. Baker, Jinmei Li, Carey-Ann D. Burnham & David B. Haslam. (2013) MAPK-Activated Protein Kinase 2 Contributes to Clostridium difficile-Associated Inflammation. Infection and Immunity 81:3, pages 713-722.
Crossref
Crossref
Athanasios Mavropoulos, Timoklia Orfanidou, Christos Liaskos, Daniel S. Smyk, Charalambos Billinis, Miri Blank, Eirini I. Rigopoulou & Dimitrios P. Bogdanos. (2013) p38 mitogen-activated protein kinase (p38 MAPK)-mediated autoimmunity: Lessons to learn from ANCA vasculitis and pemphigus vulgaris. Autoimmunity Reviews 12:5, pages 580-590.
Crossref
Crossref
Athanasios Mavropoulos, Eirini I. Rigopoulou, Christos Liaskos, Dimitrios P. Bogdanos & Lazaros I. Sakkas. (2013) The Role of p38 MAPK in the Aetiopathogenesis of Psoriasis and Psoriatic Arthritis. Clinical and Developmental Immunology 2013, pages 1-8.
Crossref
Crossref
Olumayokun A. Olajide, Harsharan S. Bhatia, Antonio C. P. de Oliveira, Colin W. Wright & Bernd L. Fiebich. (2013) Inhibition of Neuroinflammation in LPS-Activated Microglia by Cryptolepine. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-10.
Crossref
Crossref
JEREMY J. EDMUNDS & ROBERT V. TALANIAN. 2012. Anti-Inflammatory Drug Discovery. Anti-Inflammatory Drug Discovery
158
180
.
Senthil Natesan, Rajesh Subramaniam, Charles Bergeron & Stefan Balaz. (2012) Binding Affinity Prediction for Ligands and Receptors Forming Tautomers and Ionization Species: Inhibition of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2). Journal of Medicinal Chemistry 55:5, pages 2035-2047.
Crossref
Crossref
Jun Qin, Pawan Dhondi, Xianhai Huang, Robert Aslanian, James Fossetta, Fang Tian, Daniel Lundell & Anandan Palani. (2011) Discovery of a Potent Dihydrooxadiazole Series of Non-ATP-Competitive MK2 (MAPKAPK2) Inhibitors. ACS Medicinal Chemistry Letters 3:2, pages 100-105.
Crossref
Crossref
Ying Yang, Huanxiang Liu & Xiaojun Yao. (2012) Understanding the molecular basis of MK2–p38α signaling complex assembly: insights into protein–protein interaction by molecular dynamics and free energy studies. Molecular BioSystems 8:8, pages 2106.
Crossref
Crossref
Ashwin U. Rao, Dong Xiao, Xianhai Huang, Wei Zhou, James Fossetta, Dan Lundell, Fang Tian, Prashant Trivedi, Robert Aslanian & Anandan Palani. (2012) Facile synthesis of tetracyclic azepine and oxazocine derivatives and their potential as MAPKAP-K2 (MK2) inhibitors. Bioorganic & Medicinal Chemistry Letters 22:2, pages 1068-1072.
Crossref
Crossref
Kieran P. O'Dea, Justina O. Dokpesi, Kate C. Tatham, Michael R. Wilson & Masao Takata. (2011) Regulation of monocyte subset proinflammatory responses within the lung microvasculature by the p38 MAPK/MK2 pathway. American Journal of Physiology-Lung Cellular and Molecular Physiology 301:5, pages L812-L821.
Crossref
Crossref
Ya Jing FENG & Yong Yu LI. (2011) The role of p38 mitogen-activated protein kinase in the pathogenesis of inflammatory bowel disease. Journal of Digestive Diseases 12:5, pages 327-332.
Crossref
Crossref
Xiaohua Huang, Gerald W. ShippsJr.Jr., Cliff C. Cheng, Peter Spacciapoli, Xingmin Zhang, Mark A. McCoy, Daniel F. Wyss, Xianshu Yang, Abdelghani Achab, Kyle Soucy, Donna K. Montavon, Denise M. Murphy & Charles E. Whitehurst. (2011) Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors. ACS Medicinal Chemistry Letters 2:8, pages 632-637.
Crossref
Crossref
Kirsty F. MacKenzieDerek A. WallaceElaine V. HillDiana F. AnthonyDavid J. P. HendersonDaniel M. HouslayJ. Simon C. ArthurGeorge S. BaillieMiles D. Houslay. (2011) Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation. Biochemical Journal 435:3, pages 755-769.
Crossref
Crossref
Bart S Hendriks, Kelly M Seidl & Jeffrey R Chabot. (2010) Two additive mechanisms impair the differentiation of 'substrate-selective' p38 inhibitors from classical p38 inhibitors in vitro. BMC Systems Biology 4:1.
Crossref
Crossref
Mark C. Bagley, Terence Davis, Paola G. S. Murziani, Caroline S. Widdowson & David Kipling. (2010) Use of p38 MAPK Inhibitors for the Treatment of Werner Syndrome. Pharmaceuticals 3:6, pages 1842-1872.
Crossref
Crossref
Arndt J. Schottelius, Ulrich Zügel, Wolf-Dietrich Döcke, Thomas M. Zollner, Lars Röse, Anne Mengel, Bernd Buchmann, Andreas Becker, Gerald Grütz, Sandra Naundorf, Anke Friedrich, Matthias Gaestel & Khusru Asadullah. (2010) The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in the p38/TNF-α Pathway of Systemic and Cutaneous Inflammation. Journal of Investigative Dermatology 130:2, pages 481-491.
Crossref
Crossref
Juraj Velcicky, Roland Feifel, Stuart Hawtin, Richard Heng, Christine Huppertz, Guido Koch, Markus Kroemer, Henrik Moebitz, Laszlo Revesz, Clemens Scheufler & Achim Schlapbach. (2010) Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy. Bioorganic & Medicinal Chemistry Letters 20:3, pages 1293-1297.
Crossref
Crossref
Achim Schlapbach & Christine Huppertz. (2009) Low-molecular-weight MK2 inhibitors: a tough nut to crack!. Future Medicinal Chemistry 1:7, pages 1243-1257.
Crossref
Crossref
Cristina Balagué, Steven L. Kunkel & Núria Godessart. (2009) Understanding autoimmune disease: new targets for drug discovery. Drug Discovery Today 14:19-20, pages 926-934.
Crossref
Crossref
Robert Cheng, Brunella Felicetti, Shilpa Palan, Ian Toogood-Johnson, Christoph Scheich, John Barker, Mark Whittaker & Thomas Hesterkamp. (2009) High-resolution crystal structure of human Mapkap kinase 3 in complex with a high affinity ligand. Protein Science, pages n/a-n/a.
Crossref
Crossref