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Therapeutic targeting of osteoclast function and pathways

, BSc(Med) MBBS(Hons), , MBBS, , PhD, , MBBS MD FRACS FAOrthA & , BAppSc MAppSc PhD(Medicine)
Pages 169-181 | Published online: 05 Jan 2011

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Seong Hwan Kim & Seong-Hee Moon. (2013) Osteoclast differentiation inhibitors: a patent review (2008 – 2012). Expert Opinion on Therapeutic Patents 23:12, pages 1591-1610.
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Xiangying Kong, Wenbin Wu, Yue Yang, Hongye Wan, Xiaomin Li, Michun Zhong, Hongyan Zhao, Xiaohui Su, Shiwei Jia, Dahong Ju & Na Lin. (2015) Total saponin from Anemone flaccida Fr. Schmidt abrogates osteoclast differentiation and bone resorption via the inhibition of RANKL-induced NF-κB, JNK and p38 MAPKs activation. Journal of Translational Medicine 13:1.
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Parnian Kalbasi Anaraki, Margret Patecki, Sergey Tkachuk, Yulia Kiyan, Hermann Haller & Inna Dumler. (2015) Urokinase Receptor Mediates Osteoclastogenesis via M-CSF Release From Osteoblasts and the c-Fms/PI3K/Akt/NF-κB Pathway in Osteoclasts. Journal of Bone and Mineral Research 30:2, pages 379-388.
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Madhuri Newa, Michael Lam, Krishna Hari Bhandari, Biwen Xu & Michael R. Doschak. (2013) Expression, Characterization, and Evaluation of a RANK-Binding Single Chain Fraction Variable: An Osteoclast Targeting Drug Delivery Strategy. Molecular Pharmaceutics 11:1, pages 81-89.
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Yanqing Gu, Weimin Fan & Guoyong Yin. (2014) The Study of Mechanisms of Protective Effect of Rg1 against Arthritis by Inhibiting Osteoclast Differentiation and Maturation in CIA Mice. Mediators of Inflammation 2014, pages 1-14.
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Zhi-feng Wei, Bei Tong, Yu-feng Xia, Qian Lu, Gui-xin Chou, Zheng-tao Wang & Yue Dai. (2013) Norisoboldine Suppresses Osteoclast Differentiation through Preventing the Accumulation of TRAF6-TAK1 Complexes and Activation of MAPKs/NF-κB/c-Fos/NFATc1 Pathways. PLoS ONE 8:3, pages e59171.
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Zhi-feng Wei, Xiao-lan Jiao, Ting Wang, Qian Lu, Yu-feng Xia, Zheng-tao Wang, Qing-long Guo, Gui-xin Chou & Yue Dai. (2013) Norisoboldine alleviates joint destruction in rats with adjuvant-induced arthritis by reducing RANKL, IL-6, PGE2, and MMP-13 expression. Acta Pharmacologica Sinica 34:3, pages 403-413.
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A. Qin, T.S. Cheng, N.J. Pavlos, Z. Lin, K.R. Dai & M.H. Zheng. (2012) V-ATPases in osteoclasts: Structure, function and potential inhibitors of bone resorption. The International Journal of Biochemistry & Cell Biology 44:9, pages 1422-1435.
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Roberto A. Garcia, Carrie Y. Inwards & Krishnan K. Unni. (2011) Benign bone tumors—recent developments. Seminars in Diagnostic Pathology 28:1, pages 73-85.
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