656
Views
66
CrossRef citations to date
0
Altmetric
Reviews

Targeting liver X receptors in human health: deadlock or promising trail?

, , , , , , , , & show all
Pages 219-232 | Published online: 05 Jan 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Temidayo O. Adigun, Ammar U. Danazumi, Haruna I. Umar, Asiat Na’Allah, Mutiu A. Alabi, Wisdom O. Joel, Adepeju Aberuagba, Omokolade O. Alejolowo, Joy O. Bamidele, Olakunle S. Omotayo & Oluwatobi A. Medayedupin. (2023) In silico molecular modeling and simulations of black tea theaflavins revealed theaflavin-3’-gallate as putative liver X receptor-beta agonist. Journal of Biomolecular Structure and Dynamics 41:22, pages 13015-13028.
Read now
Anthony Alioui, Olivier Celhay, Silvère Baron & Jean-Marc A Lobaccaro. (2014) Lipids and prostate cancer adenocarcinoma. Clinical Lipidology 9:6, pages 643-655.
Read now
Michael France, Jonathan Schofield, See Kwok & Handrean Soran. (2014) Treatment of homozygous familial hypercholesterolemia. Clinical Lipidology 9:1, pages 101-118.
Read now
Hugues De Boussac, Anthony Alioui, Emilie Viennois, Julie Dufour, Amalia Trousson, Aurélie Vega, Laurent Guy, David H Volle, Jean-Marc A. Lobaccaro & Silvère Baron. (2013) Oxysterol receptors and their therapeutic applications in cancer conditions. Expert Opinion on Therapeutic Targets 17:9, pages 1029-1038.
Read now
Jean-Marc A. Lobaccaro, Florence Brugnon, David H. Volle & Silvère Baron. (2012) Lipid metabolism and infertility: is there a link?. Clinical Lipidology 7:5, pages 485-488.
Read now

Articles from other publishers (61)

Mohamed Ksila, Imen Ghzaiel, Khouloud Sassi, Amira Zarrouk, Valerio Leoni, Giuseppe Poli, Leila Rezig, Vivien Pires, Smail Meziane, Atanas G. Atanasov, Sonia Hammami, Mohamed Hammami, Olfa Masmoudi-Kouki, Oumaima Hamdi, Pierre Jouanny, Mohammad Samadi, Anne Vejux, Taoufik Ghrairi & Gérard Lizard. 2024. Implication of Oxysterols and Phytosterols in Aging and Human Diseases. Implication of Oxysterols and Phytosterols in Aging and Human Diseases 379 400 .
Tong-Mei Yang, Miao Miao, Wen-Qian Yu, Xue Wang, Fang-Jie Xia, Yan-Jie Li & Shou-Dong Guo. (2023) Targeting macrophages in atherosclerosis using nanocarriers loaded with liver X receptor agonists: A narrow review. Frontiers in Molecular Biosciences 10.
Crossref
Tian-tian Zhao, Ying Zhang, Cheng-qin Zhang, Ya-fei Chang, Mei-rong Cui, Yue Sun, Wen-qian Hao, Yu-meng Yan, Shuo Gu, Yao Xie & Bin-bin Wei. (2023) Combined with UPLC-Triple-TOF/MS-based plasma lipidomics and molecular pharmacology reveals the mechanisms of schisandrin against Alzheimer’s disease. Chinese Medicine 18:1.
Crossref
Zdeněk Dvořák, Hao Li & Sridhar Mani. (2023) Microbial Metabolites as Ligands to Xenobiotic Receptors: Chemical Mimicry as Potential Drugs of the Future. Drug Metabolism and Disposition 51:2, pages 219-227.
Crossref
Gérard Lizard, John J. Mackrill & Tim Willinger. (2023) Implication of Oxysterols in Infectious and Non-Communicable Inflammatory Diseases. Cells 12:2, pages 241.
Crossref
Julio Buñay, Allan Fouache, Amalia Trousson, Cyrille Joussineau, Erwan Bouchareb, Zhekun Zhu, Ayhan Kocer, Laurent Morel, Silvere Baron & Jean‐Marc A. Lobaccaro. (2020) Screening for liver X receptor modulators: Where are we and for what use?. British Journal of Pharmacology 178:16, pages 3277-3293.
Crossref
Qiang Wang, Jing Wang, Jiayou Wang & Heng Zhang. (2021) Molecular mechanism of liver X receptors in cancer therapeutics. Life Sciences 273, pages 119287.
Crossref
Divya Goel & Divya Vohora. (2021) Liver X receptors and skeleton: Current state-of-knowledge. Bone 144, pages 115807.
Crossref
Lili Chen, Dan Song, Beibei Chen, Xuemei Yang & Oumei Cheng. (2019) Activation of liver X receptor promotes hippocampal neurogenesis and improves long‐term cognitive function recovery in acute cerebral ischemia‐reperfusion mice. Journal of Neurochemistry 154:2, pages 205-217.
Crossref
Deolinda Santinha, Anna Klopot, Igor Marques, Ewa Ellis, Carl Jorns, Helene Johansson, Tânia Melo, Per Antonson, Tomas Jakobsson, Vítor Félix, Jan-Åke Gustafsson, Maria Rosário Domingues, Agneta Mode & Luisa A. Helguero. (2020) Lipidomic analysis of human primary hepatocytes following LXR activation with GW3965 identifies AGXT2L1 as a main target associated to changes in phosphatidylethanolamine. The Journal of Steroid Biochemistry and Molecular Biology 198, pages 105558.
Crossref
Xiaoyu Hu, Naisheng Zhang & Yunhe Fu. (2018) Role of Liver X Receptor in Mastitis Therapy and Regulation of Milk Fat Synthesis. Journal of Mammary Gland Biology and Neoplasia 24:1, pages 73-83.
Crossref
Laura Bousset, Amandine Rambur, Allan Fouache, Julio Bunay, Laurent Morel, Jean-Marc Lobaccaro, Silvère Baron, Amalia Trousson & Cyrille de Joussineau. (2018) New Insights in Prostate Cancer Development and Tumor Therapy: Modulation of Nuclear Receptors and the Specific Role of Liver X Receptors. International Journal of Molecular Sciences 19:9, pages 2545.
Crossref
Marc Poirot & Sandrine Silvente-Poirot. (2018) The tumor-suppressor cholesterol metabolite, dendrogenin A, is a new class of LXR modulator activating lethal autophagy in cancers. Biochemical Pharmacology 153, pages 75-81.
Crossref
Zhengwu Peng, Bin Deng, Ji Jia, Wugang Hou, Sheng Hu, Jiao Deng, Wei Lin, Lichao Hou & Hanfei Sang. (2018) Liver X receptor β in the hippocampus: A potential novel target for the treatment of major depressive disorder?. Neuropharmacology 135, pages 514-528.
Crossref
Tali Czarnowicki, Anders B. Dohlman, Kunal Malik, Diane Antonini, Robert Bissonnette, Tom C. Chan, Lisa Zhou, Huei-Chi Wen, Yeriel Estrada, Hui Xu, Catherine Bryson, Jie Shen, Deepak Lala, Avi Ma'ayan, Gerard McGeehan, Richard Gregg & Emma Guttman-Yassky. (2018) Effect of short-term liver X receptor activation on epidermal barrier features in mild to moderate atopic dermatitis. Annals of Allergy, Asthma & Immunology 120:6, pages 631-640.e11.
Crossref
Marica Cariello, Simon Ducheix, Salwan Maqdasy, Silvère Baron, Antonio Moschetta & Jean-Marc A. Lobaccaro. (2018) LXRs, SHP, and FXR in Prostate Cancer: Enemies or Ménage à Quatre With AR? . Nuclear Receptor Signaling 15, pages 155076291880107.
Crossref
Dimitrios Gkikas, Matina Tsampoula & Panagiotis K. Politis. (2017) Nuclear receptors in neural stem/progenitor cell homeostasis. Cellular and Molecular Life Sciences 74:22, pages 4097-4120.
Crossref
Xiaoli Ju, Pan Huang, Miao Chen & Qiang Wang. (2017) Liver X receptors as potential targets for cancer therapeutics (Review). Oncology Letters.
Crossref
Zangbéwendé Guy Ouedraogo, Allan Fouache, Amalia Trousson, Silvère Baron & Jean-Marc A. Lobaccaro. (2017) Role of the liver X receptors in skin physiology: Putative pharmacological targets in human diseases. Chemistry and Physics of Lipids 207, pages 59-68.
Crossref
Ming Gu, Yu Zhang, Chuhe Liu, Dongshan Wang, Li Feng, Shengjie Fan, Baican Yang, Qingchun Tong, Guang Ji & Cheng Huang. (2017) Morin, a novel liver X receptor α/β dual antagonist, has potent therapeutic efficacy for nonalcoholic fatty liver diseases. British Journal of Pharmacology 174:18, pages 3032-3044.
Crossref
Elvar Örn Viktorsson, Mari Gabrielsen, Nugalya Kumarachandran, Ingebrigt Sylte, Pål Rongved, Ove Alexander Høgmoen Åstrand & Eili Tranheim Kase. (2017) Regulation of liver X receptor target genes by 22-functionalized oxysterols. Synthesis, in silico and in vitro evaluations. Steroids 118, pages 119-127.
Crossref
Ove Alexander Høgmoen Åstrand, Elvar Örn Viktorsson, Aleksander Lim Kristensen, Dag Ekeberg, Hanne Røberg-Larsen, Steven Ray Wilson, Mari Gabrielsen, Ingebrigt Sylte, Arild Christian Rustan, G. Hege Thoresen, Pål Rongved & Eili Tranheim Kase. (2017) Synthesis, in vitro and in vivo biological evaluation of new oxysterols as modulators of the liver X receptors. The Journal of Steroid Biochemistry and Molecular Biology 165, pages 323-330.
Crossref
A. J. Unsworth, A. P. Bye & J. M. Gibbins. 2017. Platelets in Thrombotic and Non-Thrombotic Disorders. Platelets in Thrombotic and Non-Thrombotic Disorders 541 556 .
Jing Wang, Xing Dong, Hong-yan Wu, Nan Wu, Xue-jun Zhang, Xin Wang & Li-xin Shang. (2016) Relationship of Liver X Receptors α and Endoglin Levels in Serum and Placenta with Preeclampsia. PLOS ONE 11:10, pages e0163742.
Crossref
Salwan Maqdasy, Amalia Trousson, Igor Tauveron, David H. Volle, Silvère Baron & Jean-Marc A. Lobaccaro. (2016) Once and for all, LXRα and LXRβ are gatekeepers of the endocrine system. Molecular Aspects of Medicine 49, pages 31-46.
Crossref
Megan V. Cannon, Wiek H. van Gilst & Rudolf A. de Boer. (2015) Emerging role of liver X receptors in cardiac pathophysiology and heart failure. Basic Research in Cardiology 111:1.
Crossref
Mayur Choudhary & Goldis Malek. 2016. Retinal Degenerative Diseases. Retinal Degenerative Diseases 45 51 .
Jean-Marc A. Lobaccaro, Claude Beaudoin, Bagora Bayala, Silvère Baron & Amalia Trousson. 2016. The Nuclear Receptor Superfamily. The Nuclear Receptor Superfamily 13 19 .
Ying Wu, Dan-dan Yu, Yong Hu, Hai-xia Cao, Shao-rong Yu, Si-wen Liu & Ji-feng Feng. (2015) LXR ligands sensitize EGFR-TKI-resistant human lung cancer cells in vitro by inhibiting Akt activation. Biochemical and Biophysical Research Communications 467:4, pages 900-905.
Crossref
Mengyang Liu, Yuanli Chen, Ling Zhang, Qixue Wang, Xingzhe Ma, Xiaoju Li, Rong Xiang, Yan Zhu, Shucun Qin, Yang Yu, Xian-cheng Jiang, Yajun Duan & Jihong Han. (2015) Regulation of Hepatic Cholesteryl Ester Transfer Protein Expression and Reverse Cholesterol Transport by Inhibition of DNA Topoisomerase II. Journal of Biological Chemistry 290:23, pages 14418-14429.
Crossref
Elvar Ørn Viktorsson, Ove Alexander Høgmoen Åstrand, Rasha Sabah Haseeb, Carl Henrik Görbitz & Pål Rongved. (2015) Crystal structure of ( S )-2-[(3 S ,8 S ,9 S ,10 R ,13 S ,14 S ,17 R )-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1 H -cyclopenta[ a ]phenanthren-17-yl]- N -methoxy- N -methylpropanamide (Fernholz Weinreb amide) . Acta Crystallographica Section E Crystallographic Communications 71:3, pages 275-277.
Crossref
Sang Bong Ahn, Kiseok Jang, Dae Won Jun, Byung Hoon Lee & Kye Jung Shin. (2014) Expression of Liver X Receptor Correlates with Intrahepatic Inflammation and Fibrosis in Patients with Nonalcoholic Fatty Liver Disease. Digestive Diseases and Sciences 59:12, pages 2975-2982.
Crossref
Ting Bai, You-li Yao, Xue-Jun Jin, Li-hua Lian, Qian Li, Ning Yang, Quan Jin, Yan-ling Wu & Ji-xing Nan. (2014) Acanthoic acid, a diterpene in Acanthopanax koreanum, ameliorates the development of liver fibrosis via LXRs signals. Chemico-Biological Interactions 218, pages 63-70.
Crossref
Rupinder K. Sodhi & Nirmal Singh. (2014) Liver X receptor agonist T0901317 reduces neuropathological changes and improves memory in mouse models of experimental dementia. European Journal of Pharmacology 732, pages 50-59.
Crossref
Qixue Wang, Xingzhe Ma, Yuanli Chen, Ling Zhang, Meixiu Jiang, Xiaoju Li, Rong Xiang, Robert MiaoDavid P. HajjarYajun Duan & Jihong Han. (2014) Identification of interferon-γ as a new molecular target of liver X receptor. Biochemical Journal 459:2, pages 345-354.
Crossref
Abdelkader Oumeddour, Emilie Viennois, Françoise Caira, Clélia Decourbey, Salwan Maqdasy, Abdelkrim Tahraoui, Silvère Baron, David H. Volle & Jean-Marc A. Lobaccaro. (2014) Liver X receptors interfere with the deleterious effect of diethylstilbestrol on testicular physiology. Biochemical and Biophysical Research Communications 446:3, pages 656-662.
Crossref
Cheng Huang. (2014) Natural modulators of liver X receptors. Journal of Integrative Medicine 12:2, pages 76-85.
Crossref
O. Alexander H. Åstrand, Marcel Sandberg, Ingebrigt Sylte, Carl Henrik Görbitz, G. Hege Thoresen, Eili T. Kase & Pål Rongved. (2014) Synthesis and initial biological evaluation of new mimics of the LXR-modulator 22(S)-hydroxycholesterol. Bioorganic & Medicinal Chemistry 22:1, pages 643-650.
Crossref
Yongxia Cheng, Yukuan Feng, Min Zhu, Bin Yan, Songbin Fu, Jin Guo, Jing Hu, Xiandong Song, Sufen Guo & Guibo Liu. (2014) Synthetic liver X receptor agonist T0901317 attenuates high glucose-induced oxidative stress, mitochondrial damage and apoptosis in cardiomyocytes. Acta Histochemica 116:1, pages 214-221.
Crossref
Pei Xu, Dabing Li, Xiaotong Tang, Xiaohang Bao, Jing Huang, Yongping Tang, Yang Yang, Haiwei Xu & Xiaotang Fan. (2013) LXR Agonists: New Potential Therapeutic Drug for Neurodegenerative Diseases. Molecular Neurobiology 48:3, pages 715-728.
Crossref
Jean-Joseph Hoang, Silvère Baron, David H. Volle, Jean-Marc A. Lobaccaro & Amalia Trousson. (2013) Lipids, LXRs and prostate cancer: Are HDACs a new link?. Biochemical Pharmacology 86:1, pages 168-174.
Crossref
Simon Ducheix, Alexandra Montagner, Vassilia Theodorou, Laurent Ferrier & Hervé Guillou. (2013) The liver X receptor: A master regulator of the gut–liver axis and a target for non alcoholic fatty liver disease. Biochemical Pharmacology 86:1, pages 96-105.
Crossref
Rupinder K. Sodhi & Nirmal Singh. (2013) Liver X receptors: Emerging therapeutic targets for Alzheimer's disease. Pharmacological Research 72, pages 45-51.
Crossref
Ling Zhang, Meixiu Jiang, Yongsheng Shui, Yuanli Chen, Qixue Wang, Wenquan Hu, Xingzhe Ma, Xiaoju Li, Xin Liu, Xingyue Cao, Mengyang Liu, Yajun Duan & Jihong Han. (2013) DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux—An LXR-dependent mechanism. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1831:6, pages 1134-1145.
Crossref
Aurélien J. C. Pommier, Julie Dufour, Georges Alves, Emilie Viennois, Hugues De Boussac, Amalia Trousson, David H. Volle, Françoise Caira, Pierre Val, Philippe Arnaud, Jean-Marc A. Lobaccaro & Silvère Baron. (2013) Liver X Receptors Protect from Development of Prostatic Intra-Epithelial Neoplasia in Mice. PLoS Genetics 9:5, pages e1003483.
Crossref
Salwan Maqdasy, Marine Baptissart, Aurélie Vega, Silvère Baron, Jean-Marc A. Lobaccaro & David H. Volle. (2013) Cholesterol and male fertility: What about orphans and adopted?. Molecular and Cellular Endocrinology 368:1-2, pages 30-46.
Crossref
Kevin Mouzat, Silvère Baron, Geoffroy Marceau, Françoise Caira, Vincent Sapin, David H. Volle, Serge Lumbroso & Jean-Marc Lobaccaro. (2013) Emerging roles for LXRs and LRH-1 in female reproduction. Molecular and Cellular Endocrinology 368:1-2, pages 47-58.
Crossref
Julie Dufour, Aurélien Pommier, Georges Alves, Hugues De Boussac, Corinne Lours-Calet, David H. Volle, Jean-Marc A. Lobaccaro & Silvère Baron. (2013) Lack of Liver X Receptors Leads to Cell Proliferation in a Model of Mouse Dorsal Prostate Epithelial Cell. PLoS ONE 8:3, pages e58876.
Crossref
Simon Ducheix, Normand Podechard, Frédéric Lasserre, Arnaud Polizzi, Aurélien Pommier, Stefania Murzilli, Chiara Di Lisio, Simona D’Amore, Justine Bertrand-Michel, Alexandra Montagner, Thierry Pineau, Nicolas Loiseau, Jean-Marc Lobaccaro, Pascal G.P. Martin & Hervé Guillou. (2013) A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARα. Biochimie 95:3, pages 556-567.
Crossref
Marc Poirot & Sandrine Silvente-Poirot. (2013) Cholesterol-5,6-epoxides: Chemistry, biochemistry, metabolic fate and cancer. Biochimie 95:3, pages 622-631.
Crossref
Spyridon Theofilopoulos, Yuqin Wang, Satish Srinivas Kitambi, Paola Sacchetti, Kyle M Sousa, Karl Bodin, Jayne Kirk, Carmen Saltó, Magnus Gustafsson, Enrique M Toledo, Kersti Karu, Jan-Åke Gustafsson, Knut R Steffensen, Patrik Ernfors, Jan Sjövall, William J Griffiths & Ernest Arenas. (2012) Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. Nature Chemical Biology 9:2, pages 126-133.
Crossref
J Laurencikiene & M Rydén. (2012) Liver X receptors and fat cell metabolism. International Journal of Obesity 36:12, pages 1494-1502.
Crossref
Julie Dufour, Emilie Viennois, Hugues De Boussac, Silvère Baron & Jean-Marc Lobaccaro. (2012) Oxysterol receptors, AKT and prostate cancer. Current Opinion in Pharmacology 12:6, pages 724-728.
Crossref
Vincent Muczynski, Charlotte Lecureuil, Sébastien Messiaen, Marie-Justine Guerquin, Thierry N’Tumba-Byn, Delphine Moison, Wassim Hodroj, Hinde Benjelloun, Jan Baijer, Gabriel Livera, René Frydman, Alexandra Benachi, René Habert & Virginie Rouiller-Fabre. (2012) Cellular and Molecular Effect of MEHP Involving LXRα in Human Fetal Testis and Ovary. PLoS ONE 7:10, pages e48266.
Crossref
XianYun Jiao, David J. Kopecky, Ben Fisher, Derek E. Piper, Marc Labelle, Sharon McKendry, Martin Harrison, Stuart Jones, Juan Jaen, Andrew K. Shiau, Patrick Escaron, Jean Danao, Anne Chai, Peter Coward & Frank Kayser. (2012) Discovery and optimization of a series of liver X receptor antagonists. Bioorganic & Medicinal Chemistry Letters 22:18, pages 5966-5970.
Crossref
Emilie Viennois, Kevin Mouzat, Julie Dufour, Laurent Morel, Jean-Marc Lobaccaro & Silvère Baron. (2012) Selective liver X receptor modulators (SLiMs): What use in human health?. Molecular and Cellular Endocrinology 351:2, pages 129-141.
Crossref
A. K. Croft, W. Groenewald & M. S. Tierney. 2012. Marine Bioactive Compounds. Marine Bioactive Compounds 173 206 .
Kevin Mouzat, Eric Mercier, Anne Polge, Alexandre Evrard, Silvère Baron, Jean-Pierre Balducchi, Jean-Paul Brouillet, Serge Lumbroso & Jean-Christophe Gris. (2011) A common polymorphism in NR1H2 (LXRbeta) is associated with preeclampsia. BMC Medical Genetics 12:1.
Crossref
Ariane Mallat & Sophie Lotersztajn. (2011) The liver X receptor in hepatic stellate cells: A novel antifibrogenic target?. Journal of Hepatology 55:6, pages 1452-1454.
Crossref
S. Ducheix, J.M.A. Lobaccaro, P.G. Martin & H. Guillou. (2011) Liver X Receptor: an oxysterol sensor and a major player in the control of lipogenesis. Chemistry and Physics of Lipids 164:6, pages 500-514.
Crossref
Fatim-Zorah El-Hajjaji, Abdelkader Oumeddour, Aurélien J.C. Pommier, Aurélia Ouvrier, Emilie Viennois, Julie Dufour, Françoise Caira, Joël R. Drevet, David H. Volle, Silvère Baron, Fabrice Saez & Jean-Marc A. Lobaccaro. (2011) Liver X receptors, lipids and their reproductive secrets in the male. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1812:8, pages 974-981.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.