1,237
Views
187
CrossRef citations to date
0
Altmetric
Reviews

Targeting the Bcl-2 family for cancer therapy

, , , , , , , , , , & show all
Pages 61-75 | Published online: 22 Nov 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Bayanika Manunu, Antonio M. Serafin & John M. Akudugu. (2023) BAG1, MGMT, FOXO1, and DNAJA1 as potential drug targets for radiosensitizing cancer cell lines. International Journal of Radiation Biology 99:2, pages 292-307.
Read now
Pratik Pal, Peiyi Zhang, Saikat K. Poddar & Guangrong Zheng. (2022) Patent landscape of inhibitors and PROTACs of the anti-apoptotic BCL-2 family proteins. Expert Opinion on Therapeutic Patents 32:9, pages 1003-1026.
Read now
Jin-Ping Wang, Ji-Ping Yan, Jing Xu, Ting-Hui Yin, Rong-Qin Zheng & Wei Wang. (2019) Paclitaxel-loaded nanobubble targeted to pro-gastrin-releasing peptide inhibits the growth of small cell lung cancer. Cancer Management and Research 11, pages 6637-6649.
Read now
Tao Li, Yinglu Cui & Bian Wu. (2019) Molecular dynamics investigations of structural and functional changes in Bcl-2 induced by the novel antagonist BDA-366. Journal of Biomolecular Structure and Dynamics 37:10, pages 2527-2537.
Read now
Roghayeh Rastegar, Hamid Akbari Javar, Mehdi Khoobi, Poua Dehghan Kelishadi, Gholam Hossein Yousefi, Mahmoud Doosti, Mohammad Hossien Ghahremani, Ahmad Shariftabrizi, Fatemeh Imanparast, Elham Gholibeglu & Mahdi Gholami. (2018) Evaluation of a novel biocompatible magnetic nanomedicine based on beta-cyclodextrin, loaded doxorubicin-curcumin for overcoming chemoresistance in breast cancer. Artificial Cells, Nanomedicine, and Biotechnology 46:sup2, pages 207-216.
Read now
Li Qin, Lei Wu, Shanshan Jiang, Dandan Yang, Huiyang He, Fang Zhang & Peng Zhang. (2018) Multifunctional micelle delivery system for overcoming multidrug resistance of doxorubicin. Journal of Drug Targeting 26:4, pages 289-295.
Read now
Wanli Yang, Jiaojiao Ma, Wei Zhou, Xin Zhou, Bo Cao, Hongwei Zhang, Qingchuan Zhao, Daiming Fan & Liu Hong. (2017) Molecular mechanisms and clinical implications of miRNAs in drug resistance of esophageal cancer. Expert Review of Gastroenterology & Hepatology 11:12, pages 1151-1163.
Read now
Shadia Zaman, Rui Wang & Varsha Gandhi. (2014) Targeting the apoptosis pathway in hematologic malignancies. Leukemia & Lymphoma 55:9, pages 1980-1992.
Read now
Shilpa Bhatia, Luni Emdad, Swadesh K Das, Hossein Hamed, Paul Dent, Devanand Sarkar & Paul B Fisher. (2014) Non-BRAF targeted therapies for melanoma: protein kinase inhibitors in Phase II clinical trials. Expert Opinion on Investigational Drugs 23:4, pages 489-500.
Read now
Kang-Ni Wu, Yan-Min Zhao, Ying He, Bin-Sheng Wang, Kai-Li Du, Shan Fu, Kai-Min Hu, Li-Fei Zhang, Li-Zhen Liu, Yong-Xian Hu, Ying-Jia Wang & He Huang. (2014) Rapamycin interacts synergistically with idarubicin to induce T-leukemia cell apoptosis in vitro and in a mesenchymal stem cell simulated drug-resistant microenvironment via Akt/mammalian target of rapamycin and extracellular signal-related kinase signaling pathways. Leukemia & Lymphoma 55:3, pages 668-676.
Read now

Articles from other publishers (177)

Indy BuiStavroula BaritakiMassimo LibraApostolos ZaravinosBenjamin Bonavida. (2023) Cancer Resistance Is Mediated by the Upregulation of Several Anti-Apoptotic Gene Products via the Inducible Nitric Oxide Synthase/Nitric Oxide Pathway: Therapeutic Implications . Antioxidants & Redox Signaling 39:13-15, pages 853-889.
Crossref
Abd El-Fattah B. M. El-Beltagy, Samaa M. Bakr, Samah S. G. Mekhaimer, Noura F. Ghanem & Amany Attaallah. (2023) Zinc-nanoparticles alleviate the ovarian damage induced by bacterial lipopolysaccharide (LPS) in pregnant rats and their fetuses. Histochemistry and Cell Biology 160:5, pages 453-475.
Crossref
Blake R. Rushing. (2023) Multi-Omics Analysis of NCI-60 Cell Line Data Reveals Novel Metabolic Processes Linked with Resistance to Alkylating Anti-Cancer Agents. International Journal of Molecular Sciences 24:17, pages 13242.
Crossref
Christopher A. Lucchesi, Demitria M. Vasilatis, Saisamkalpa Mantrala, Thenappan Chandrasekar, Maria Mudryj & Paramita M. Ghosh. (2023) Pesticides and Bladder Cancer: Mechanisms Leading to Anti-Cancer Drug Chemoresistance and New Chemosensitization Strategies. International Journal of Molecular Sciences 24:14, pages 11395.
Crossref
Eluri Pavitra, Jyothsna Kancharla, Vivek Kumar Gupta, Kiran Prasad, Ju Yong Sung, Jigyeong Kim, Mandava Bhuvan Tej, Rino Choi, Jeong-Hwan Lee, Young-Kyu Han, Ganji Seeta Rama Raju, LVKS Bhaskar & Yun Suk Huh. (2023) The role of NF-κB in breast cancer initiation, growth, metastasis, and resistance to chemotherapy. Biomedicine & Pharmacotherapy 163, pages 114822.
Crossref
Yihua Lin, Yiling Zhao, Minggui Chen, Zishuo Li, Qiao Liu, Jian Chen, Yi Ding, Chunyong Ding, Ye Ding, Cuiling Qi, Lingyun Zheng, Jiangchao Li, Rongxin Zhang, Jia Zhou, Lijing Wang & Qian-Qian Zhang. (2023) CYD0281, a Bcl-2 BH4 domain antagonist, inhibits tumor angiogenesis and breast cancer tumor growth. BMC Cancer 23:1.
Crossref
Nuwayo Ishimwe Sincere, Krishnan Anand, Sumel Ashique, Jing Yang & Chongge You. (2023) PROTACs: Emerging Targeted Protein Degradation Approaches for Advanced Druggable Strategies. Molecules 28:10, pages 4014.
Crossref
Seyed Mojtaba Mousavi, Saereh Hosseindoost, Seyed Mohammad Amin Mahdian, Nasim Vousooghi, Ali Rajabi, Ameneh Jafari, Amirreza Ostadian, Michael R. Hamblin, MahmoudReza Hadjighassem & Hamed Mirzaei. (2023) Exosomes released from U87 glioma cells treated with curcumin and/or temozolomide produce apoptosis in naive U87 cells. Pathology - Research and Practice 245, pages 154427.
Crossref
Vilma Petrikaite, Nicola D'Avanzo, Christian Celia & Massimo Fresta. (2023) Nanocarriers overcoming biological barriers induced by multidrug resistance of chemotherapeutics in 2D and 3D cancer models. Drug Resistance Updates 68, pages 100956.
Crossref
Sepideh Ebrahimi, Mohammad Soukhtanloo & Zohreh Mostafavi-Pour. (2023) Anti-tumor effects of Auraptene through induction of apoptosis and oxidative stress in a mouse model of colorectal cancer. Tissue and Cell 81, pages 102004.
Crossref
Indra Wahyu Nufroha, Adri Nora & Henny Saraswati. (2023) Primer characterization of in-house real time PCR (RT-PCR) for BCL2 gene using saliva sample. Asia Pacific Journal of Molecular Biology and Biotechnology, pages 39-44.
Crossref
Hossam Saadawy, Esraa M. Fathi, Islam Elsayed, Janset S. Anzour, Ahmed Zaki, Mohamed El Shaer & Marwan Emara. (2023) Treatment of hepatocellular carcinoma with in situ generated plasma‐activated air‐driven water mist. Plasma Processes and Polymers.
Crossref
Viktar Abashkin, Elżbieta Pędziwiatr-Werbicka, Katarzyna Horodecka, Victoriya Zhogla, Egor Ulashchik, Vadim Shmanai, Dzmitry Shcharbin & Maria Bryszewska. (2023) Silver Nanoparticles Modified by Carbosilane Dendrons and PEG as Delivery Vectors of Small Interfering RNA. International Journal of Molecular Sciences 24:1, pages 840.
Crossref
Neha Mehrotra, Mohd Anees, Sachchidanand Tiwari, Surender Kharbanda & Harpal Singh. (2023) Polylactic acid based polymeric nanoparticle mediated co-delivery of navitoclax and decitabine for cancer therapy. Nanomedicine: Nanotechnology, Biology and Medicine 47, pages 102627.
Crossref
Adéla Tiffner, Valentina Hopl & Isabella Derler. (2022) CRAC and SK Channels: Their Molecular Mechanisms Associated with Cancer Cell Development. Cancers 15:1, pages 101.
Crossref
Peter Wolfrum, Agnes Fietz, Sven Schnichels & José Hurst. (2022) The function of p53 and its role in Alzheimer’s and Parkinson’s disease compared to age-related macular degeneration. Frontiers in Neuroscience 16.
Crossref
Jeffrey A. Moscow, Shannon K. Hughes, Kenneth H. Cowan & Branimir I. Sikic. 2017. Holland‐Frei Cancer Medicine. Holland‐Frei Cancer Medicine 1 7 .
Yuehua Qi, Chunjing Zhang, Di Wu, Yue Zhang, Yunfeng Zhao & Wenjuan Li. (2022) Indole-3-Carbinol Stabilizes p53 to Induce miR-34a, Which Targets LDHA to Block Aerobic Glycolysis in Liver Cancer Cells. Pharmaceuticals 15:10, pages 1257.
Crossref
Sameer Ullah Khan, Kaneez Fatima & Fayaz Malik. (2022) Understanding the cell survival mechanism of anoikis-resistant cancer cells during different steps of metastasis. Clinical & Experimental Metastasis 39:5, pages 715-726.
Crossref
Adnin Ashrafi, Zakia Akter, Pouya Modareszadeh, Parsa Modareszadeh, Eranda Berisha, Parinaz Sadat Alemi, Maria del Carmen Chacon Castro, Alexander R. Deese & Li Zhang. (2022) Current Landscape of Therapeutic Resistance in Lung Cancer and Promising Strategies to Overcome Resistance. Cancers 14:19, pages 4562.
Crossref
Chunlong Zhao & Frank J. Dekker. (2022) Novel Design Strategies to Enhance the Efficiency of Proteolysis Targeting Chimeras. ACS Pharmacology & Translational Science 5:9, pages 710-723.
Crossref
Susanta Kumar Rout, Vishnu Priya, Aseem Setia, Abhishesh Kumar Mehata, Syam Mohan, Mohammed Albratty, Asim Najmi, Abdulkarim M. Meraya, Hafiz A. Makeen, Murtaza M. Tambuwala & Madaswamy S. Muthu. (2022) Mitochondrial targeting theranostic nanomedicine and molecular biomarkers for efficient cancer diagnosis and therapy. Biomedicine & Pharmacotherapy 153, pages 113451.
Crossref
Abdelrahman Abaza, Advait M Vasavada, Akhil Sadhu, Carla Valencia, Hameeda Fatima, Ijeoma Nwankwo, Mahvish Anam, Shrinkhala Maharjan, Zainab Amjad & Safeera Khan. (2022) A Systematic Review of Apoptosis in Correlation With Cancer: Should Apoptosis Be the Ultimate Target for Cancer Treatment?. Cureus.
Crossref
Wei Cheng, Dan Liu, Min Guo, Honglei Li & Qiang Wang. (2022) Sophoraflavanone G suppresses the progression of triple‐negative breast cancer via the inactivation of EGFR–PI3K–AKT signaling. Drug Development Research 83:5, pages 1138-1151.
Crossref
Jiaojiao Yang, Juanli Zhang, Xiaoli Gao, Ruirui Luo, Kaihui Xie, Wei Wang, Jie Li, Qiaoli Yang, Xiaoyu Huang, Zunqiang Yan, Pengfei Wang & Shuangbao Gun. (2022) FTO Regulates Apoptosis in CPB2-Treated IPEC-J2 Cells by Targeting Caspase 3 Apoptotic Protein. Animals 12:13, pages 1644.
Crossref
Erwin R. BoghaertMegan C. Cox & Kedar S. Vaidya. (2022) Pathophysiologic and Pharmacologic Considerations to Improve the Design and Application of Antibody–Drug Conjugates. Cancer Research 82:10, pages 1858-1869.
Crossref
Linzhang Li, Chengwu Han, Xueying Yu, Jun Shen & Yongtong Cao. (2022) Targeting AraC-Resistant Acute Myeloid Leukemia by Dual Inhibition of CDK9 and Bcl-2: A Systematic Review and Meta-Analysis. Journal of Healthcare Engineering 2022, pages 1-7.
Crossref
Hiren Nath, Pranay Sharma, Antonio Frontera, Miquel Barcelo-Oliver, Akalesh K. Verma, Jumi Das & Manjit K. Bhattacharyya. (2022) Phenanthroline-based Ni(II) coordination compounds involving unconventional discrete fumarate-water-nitrate clusters and energetically significant cooperative ternary π-stacked assemblies: Antiproliferative evaluation and theoretical studies. Journal of Molecular Structure 1248, pages 131424.
Crossref
Marinela Bostan, Gabriela Ion, Mirela Mihaila, Viviana Roman, Carolina Constantin & Monica Teodora Neagu. 2022.
Nirali Pandya, Sonali R. Bhagwat & Amit Kumar. (2021) Regulatory role of Non-canonical DNA Polymorphisms in human genome and their relevance in Cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1876:2, pages 188594.
Crossref
Dongwen Lv, Pratik Pal, Xingui Liu, Yannan Jia, Dinesh Thummuri, Peiyi Zhang, Wanyi Hu, Jing Pei, Qi Zhang, Shuo Zhou, Sajid Khan, Xuan Zhang, Nan Hua, Qingping Yang, Sebastian Arango, Weizhou Zhang, Digant Nayak, Shaun K. Olsen, Susan T. Weintraub, Robert Hromas, Marina Konopleva, Yaxia Yuan, Guangrong Zheng & Daohong Zhou. (2021) Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity,. Nature Communications 12:1.
Crossref
Kamalakannan Vijayan, Ling Wei, Elizabeth K. K. Glennon, Christa Mattocks, Natasha Bourgeois, Bart Staker & Alexis Kaushansky. (2021) Host-targeted Interventions as an Exciting Opportunity to Combat Malaria. Chemical Reviews 121:17, pages 10452-10468.
Crossref
Christiana M. Neophytou, Ioannis P. Trougakos, Nuray Erin & Panagiotis Papageorgis. (2021) Apoptosis Deregulation and the Development of Cancer Multi-Drug Resistance. Cancers 13:17, pages 4363.
Crossref
Agata Bikiewicz, Maciej Banach, Stephan von Haehling, Marek Maciejewski & Agata Bielecka‐Dabrowa. (2021) Adjuvant breast cancer treatments cardiotoxicity and modern methods of detection and prevention of cardiac complications. ESC Heart Failure 8:4, pages 2397-2418.
Crossref
Amal Das, Pranay Sharma, Antonio Frontera, Miquel Barcelo-Oliver, Akalesh K. Verma, Ruksana Sultana Ahmed, Sahid Hussain & Manjit K. Bhattacharyya. (2021) Supramolecular assemblies involving biologically relevant antiparallel π-stacking and unconventional solvent driven structural topology in maleato and fumarato bridged Zn( ii ) coordination polymers: antiproliferative evaluation and theoretical studies . New Journal of Chemistry 45:29, pages 13040-13055.
Crossref
Luke Soliman, Andre De Souza, Praveen Srinivasan, Matthew Danish, Paul Bertone, Wafik S. El-Deiry & Benedito A. Carneiro. (2021) The Role of BCL-2 Proteins in the Development of Castration-resistant Prostate Cancer and Emerging Therapeutic Strategies. American Journal of Clinical Oncology 44:7, pages 374-382.
Crossref
Guo-dong Huang, Ping Cui, Guo-Xu Ma, Fan-fan Chen, Ze-bin Chen, Xue-juan Li, Zi-jun Liao, Wei-ping Li, Zong-yang Li & Lei Chen. (2021) Phragmunis a suppresses glioblastoma through the regulation of MCL1-FBXW7 by blocking ELK1-SRF complex-dependent transcription. Neurochemistry International 147, pages 105051.
Crossref
Devendra Choudhary, Hanmant Goykar, Tukaram Karanwad, Suraj Kannaujia, Vedant Gadekar & Manju Misra. (2021) An understanding of mitochondria and its role in targeting nanocarriers for diagnosis and treatment of cancer. Asian Journal of Pharmaceutical Sciences 16:4, pages 397-418.
Crossref
Lei Zhong, Yueshan Li, Liang Xiong, Wenjing Wang, Ming Wu, Ting Yuan, Wei Yang, Chenyu Tian, Zhuang Miao, Tianqi Wang & Shengyong Yang. (2021) Small molecules in targeted cancer therapy: advances, challenges, and future perspectives. Signal Transduction and Targeted Therapy 6:1.
Crossref
Baranya Murugan & Uma Maheswari Krishnan. (2021) Differently sized drug-loaded mesoporous silica nanoparticles elicit differential gene expression in MCF-7 cancer cells. Nanomedicine 16:12, pages 1017-1034.
Crossref
Sevgi Uğur MUTLUAY & Leyla Didem KOZACI. (2021) Hücre İçi Sinyal Yolaklarını Hedefleyen Kemoterapötik AjanlarChemotherapeutic Agents Targeting Intracellular Signaling Pathways. Black Sea Journal of Health Science 4:2, pages 175-184.
Crossref
Basel A. Abdel-Wahab, Ismail A. Walbi, Hassan A. Albarqi, Fares E.M. Ali & Emad H.M. Hassanein. (2021) Roflumilast protects from cisplatin-induced testicular toxicity in male rats and enhances its cytotoxicity in prostate cancer cell line. Role of NF-κB-p65, cAMP/PKA and Nrf2/HO-1, NQO1 signaling. Food and Chemical Toxicology 151, pages 112133.
Crossref
Saeed Mehrzadi, Mohammad Hossein Pourhanifeh, Alireza Mirzaei, Farid Moradian & Azam Hosseinzadeh. (2021) An updated review of mechanistic potentials of melatonin against cancer: pivotal roles in angiogenesis, apoptosis, autophagy, endoplasmic reticulum stress and oxidative stress. Cancer Cell International 21:1.
Crossref
Sundaram Vickram, Karunakaran Rohini, Subramanian Srinivasan, David Nancy Veenakumari, Kumar Archana, Krishnan Anbarasu, Palanivelu Jeyanthi, Sundaram Thanigaivel, Govindarajan Gulothungan, Nanmaran Rajendiran & Padmalayam Sadanandan Srikumar. (2021) Role of Zinc (Zn) in Human Reproduction: A Journey from Initial Spermatogenesis to Childbirth. International Journal of Molecular Sciences 22:4, pages 2188.
Crossref
Manar I. Nagy, Khaled M. Darwish, Safaa M. Kishk, Mohamed A. Tantawy, Ali M. Nasr, Mona Qushawy, Shady A. Swidan, Samia M. Mostafa & Ismail Salama. (2021) Design, Synthesis, Anticancer Activity, and Solid Lipid Nanoparticle Formulation of Indole- and Benzimidazole-Based Compounds as Pro-Apoptotic Agents Targeting Bcl-2 Protein. Pharmaceuticals 14:2, pages 113.
Crossref
Shilpi Singh, Abha Meena & Suaib Luqman. (2021) Baicalin mediated regulation of key signaling pathways in cancer. Pharmacological Research 164, pages 105387.
Crossref
Ronay Cetin, Eva Quandt & Manuel Kaulich. (2021) Functional Genomics Approaches to Elucidate Vulnerabilities of Intrinsic and Acquired Chemotherapy Resistance. Cells 10:2, pages 260.
Crossref
Juhee SonMi-Jeong KimJi Su LeeJi Young KimEunyoung ChunKi-Young Lee. (2021) Hepatitis B virus X Protein Promotes Liver Cancer Progression through Autophagy Induction in Response to TLR4 Stimulation. Immune Network 21:5.
Crossref
Changyu Li, Haonan Ran, Shaojun Song, Weisong Liu, Wenhui Zou, Bei Jiang, Hongmei Zhao & Bin Shao. (2020) Overexpression of RPN2 suppresses radiosensitivity of glioma cells by activating STAT3 signal transduction. Molecular Medicine 26:1.
Crossref
Parthiban Marimuthu, Jamoliddin Razzokov & Gofur Eshonqulov. (2020) Disruption of conserved polar interactions causes a sequential release of Bim mutants from the canonical binding groove of Mcl1. International Journal of Biological Macromolecules 158, pages 364-374.
Crossref
Peiyi Zhang, Xuan Zhang, Xingui Liu, Sajid Khan, Daohong Zhou & Guangrong Zheng. (2020) PROTACs are effective in addressing the platelet toxicity associated with BCL-XL inhibitors. Exploration of Targeted Anti-tumor Therapy 1:4, pages 259-272.
Crossref
Bushra Hafeez Kiani, Waqas Khan Kayani, Asma Umer Khayam, Erum Dilshad, Hammad Ismail & Bushra Mirza. (2020) Artemisinin and its derivatives: a promising cancer therapy. Molecular Biology Reports 47:8, pages 6321-6336.
Crossref
Siew Ching Ngai. (2020) Curcumin Sensitizes Cancers Towards TRAIL-induced Apoptosis via Extrinsic and Intrinsic Apoptotic Pathways. Current Drug Targets 21:9, pages 849-854.
Crossref
Benedito A. Carneiro & Wafik S. El-Deiry. (2020) Targeting apoptosis in cancer therapy. Nature Reviews Clinical Oncology 17:7, pages 395-417.
Crossref
Souneek Chakraborty, Khalid Bashir Mir, Nathan D. Seligson, Debasis Nayak, Rakesh Kumar & Anindya Goswami. (2020) Integration of EMT and cellular survival instincts in reprogramming of programmed cell death to anastasis. Cancer and Metastasis Reviews 39:2, pages 553-566.
Crossref
Wael A.A. Fadaly, Yaseen A.M.M. Elshaier, Emad H.M. Hassanein & Khaled R.A. Abdellatif. (2020) New 1,2,4-triazole/pyrazole hybrids linked to oxime moiety as nitric oxide donor celecoxib analogs: Synthesis, cyclooxygenase inhibition anti-inflammatory, ulcerogenicity, anti-proliferative activities, apoptosis, molecular modeling and nitric oxide release studies. Bioorganic Chemistry 98, pages 103752.
Crossref
Korrakod Petsri, Masashi Yokoya, Sucharat Tungsukruthai, Thanyada Rungrotmongkol, Bodee Nutho, Chanida Vinayanuwattikun, Naoki Saito, Takehiro Matsubara, Ryo Sato & Pithi Chanvorachote. (2020) Structure–Activity Relationships and Molecular Docking Analysis of Mcl-1 Targeting Renieramycin T Analogues in Patient-derived Lung Cancer Cells. Cancers 12:4, pages 875.
Crossref
Cui Li, Yuchun Song & Pan Li. (2019) MCL1 regulates cell death, tumor growth and chemosensitivity to sabutoclax in ovarian adenocarcinoma. Cell and Tissue Research 379:3, pages 625-633.
Crossref
Xuan Zhang, Dinesh Thummuri, Yonghan He, Xingui Liu, Peiyi Zhang, Daohong Zhou & Guangrong Zheng. (2019) Utilizing PROTAC technology to address the on-target platelet toxicity associated with inhibition of BCL-X L . Chemical Communications 55:98, pages 14765-14768.
Crossref
Veenita Khare, Shaheda Tabassum, Uttara Chatterjee, Sandip Chatterjee & Mrinal K. Ghosh. (2019) RNA helicase p68 deploys β-catenin in regulating RelA/p65 gene expression: implications in colon cancer. Journal of Experimental & Clinical Cancer Research 38:1.
Crossref
Sajid Khan, Xuan Zhang, Dongwen Lv, Qi Zhang, Yonghan He, Peiyi Zhang, Xingui Liu, Dinesh Thummuri, Yaxia Yuan, Janet S. Wiegand, Jing Pei, Weizhou Zhang, Abhisheak Sharma, Christopher R. McCurdy, Vinitha M. Kuruvilla, Natalia Baran, Adolfo A. Ferrando, Yong-mi Kim, Anna Rogojina, Peter J. Houghton, Guangcun Huang, Robert Hromas, Marina Konopleva, Guangrong Zheng & Daohong Zhou. (2019) A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Nature Medicine 25:12, pages 1938-1947.
Crossref
Xiaoxiao Gao, Hongzhi Yao, Yu Mu, Peipei Guan, Guiding Li, Bin Lin, Yi Jiang, Li Han, Xueshi Huang & Chenglin Jiang. (2019) The antiproliferative effect of spectinabilins from Streptomyces spectabilis on hepatocellular carcinoma cells in vitro and in vivo. Bioorganic Chemistry 93, pages 103311.
Crossref
Sonia How Ming Wong, Wei Yang Kong, Chee-Mun Fang, Hwei-San Loh, Lay-Hong Chuah, Syahril Abdullah & Siew Ching Ngai. (2019) The TRAIL to cancer therapy: Hindrances and potential solutions. Critical Reviews in Oncology/Hematology 143, pages 81-94.
Crossref
Kuan-Lin Kuo, Shing-Hwa Liu, Wei-Chou Lin, Po-Ming Chow, Yu-Wei Chang, Shao-Ping Yang, Chung-Sheng Shi, Chen-Hsun Hsu, Shih-Ming Liao, Hong-Chiang Chang & Kuo-How Huang. (2019) The Deubiquitinating Enzyme Inhibitor PR-619 Enhances the Cytotoxicity of Cisplatin via the Suppression of Anti-Apoptotic Bcl-2 Protein: In Vitro and In Vivo Study. Cells 8:10, pages 1268.
Crossref
Hang-wei Fu, Xia Lin, Yuan-xin Zhu, Xiang Lan, Yi Kuang, Yu-zhou Wang, Zhi-gang Ke, Tao Yuan & Ping Chen. (2019) Circ-IGF1R has pro-proliferative and anti-apoptotic effects in HCC by activating the PI3K/AKT pathway. Gene 716, pages 144031.
Crossref
Roya Mahdizadeh, Masoud Homayouni‐Tabrizi, Ali Neamati, Seyed Mohammad Reza Seyedi & Haleh Sadat Tavakkol Afshari. (2019) Green synthesized‐zinc oxide nanoparticles, the strong apoptosis inducer as an exclusive antitumor agent in murine breast tumor model and human breast cancer cell lines (MCF7). Journal of Cellular Biochemistry 120:10, pages 17984-17993.
Crossref
Anjali Lathwal, Chakit Arora & Gajendra P. S. Raghava. (2019) Prediction of risk scores for colorectal cancer patients from the concentration of proteins involved in mitochondrial apoptotic pathway. PLOS ONE 14:9, pages e0217527.
Crossref
Myoung-Schook Yoou, Sungjoon Cho & Youngjin Choi. (2019) Molecular Docking-assisted Protein Chip Screening of Inhibitors for Bcl-2 Family Protein-protein Interaction to Discover Anticancer Agents by Fragment-based Approach. BioChip Journal 13:3, pages 260-268.
Crossref
Fengju Li, Dingran Si, Xuejun Guo, Ningru Guo, Dandan Li, Liujing Zhang, Xianan Jian & Jiasheng Ma. (2019) Aberrant expression of miR‑130a‑3p in ankylosing spondylitis and its role in regulating T‑cell survival. Molecular Medicine Reports.
Crossref
Yu-kai Su, Oluwaseun Adebayo Bamodu, Yew-Min Tzeng, Michael Hsiao, Chi-Tai Yeh & Chien-Min Lin. (2019) Ovatodiolide inhibits the oncogenicity and cancer stem cell-like phenotype of glioblastoma cells, as well as potentiate the anticancer effect of temozolomide. Phytomedicine 61, pages 152840.
Crossref
Kuan-Lin Kuo, Shing-Hwa Liu, Wei-Chou Lin, Fu-Shun Hsu, Po-Ming Chow, Yu-Wei Chang, Shao-Ping Yang, Chung-Sheng Shi, Chen-Hsun Hsu, Shih-Ming Liao, Hong-Chiang Chang & Kuo-How Huang. (2019) Trifluoperazine, an Antipsychotic Drug, Effectively Reduces Drug Resistance in Cisplatin-Resistant Urothelial Carcinoma Cells via Suppressing Bcl-xL: An In Vitro and In Vivo Study. International Journal of Molecular Sciences 20:13, pages 3218.
Crossref
Rehmat Jan & Gul-e-Saba Chaudhry. (2019) Understanding Apoptosis and Apoptotic Pathways Targeted Cancer Therapeutics. Advanced Pharmaceutical Bulletin 9:2, pages 205-218.
Crossref
Véronique Vendrely, Samuel Amintas, Cécile Noel, Isabelle Moranvillier, Isabelle Lamrissi, Benoit Rousseau, Soulé Coulibaly, Aurélie Bedel, François Moreau-Gaudry, Etienne Buscail, Laurence Chiche, Geneviève Belleannée, Charles Dupin & Sandrine Dabernat. (2019) Combination treatment of resveratrol and capsaicin radiosensitizes pancreatic tumor cells by unbalancing DNA repair response to radiotherapy towards cell death. Cancer Letters 451, pages 1-10.
Crossref
Korrakod Petsri, Supakarn Chamni, Khanit Suwanborirux, Naoki Saito & Pithi Chanvorachote. (2019) Renieramycin T Induces Lung Cancer Cell Apoptosis by Targeting Mcl-1 Degradation: A New Insight in the Mechanism of Action. Marine Drugs 17:5, pages 301.
Crossref
Qingguo Mo, Lin Liu, Guanghe Bao & Tongfei Li. (2019) Effects of melanoma differentiation associated gene-7 (MDA-7/IL-24) on apoptosis of liver cancer cells via regulating the expression of B-cell lymphoma-2. Oncology Letters.
Crossref
Santanu Maji, Omprakash Shriwas, Sabindra K Samal, Manashi Priyadarshini, Rachna Rath, Sanjay Panda, Saroj Kumar Das Majumdar, Dillip Kumar Muduly & Rupesh Dash. (2019) STAT3- and GSK3β-mediated Mcl-1 regulation modulates TPF resistance in oral squamous cell carcinoma. Carcinogenesis 40:1, pages 173-183.
Crossref
Qiu Xiang, Juan Tang, Qin Luo, Jinfeng Xue, Yexing Tao, Honghui Jiang, Jing Tian & Caiwen Fan. (2019) In vitro study of anti-ER positive breast cancer effect and mechanism of 1,2,3,4-6-pentyl-O-galloyl-beta-d-glucose (PGG). Biomedicine & Pharmacotherapy 111, pages 813-820.
Crossref
Fan Jiang, Hong‐S. Xing, Wei‐Y. Chen, Jie Du, Yue‐l. Ruan, An‐Y. Lin & Chi‐Z. Zhou. (2018) Itraconazole inhibits proliferation of pancreatic cancer cells through activation of Bak‐1. Journal of Cellular Biochemistry 120:3, pages 4333-4341.
Crossref
Hong Li, Huogang Wang, Ke Deng, Wei Han, Bo Hong & Wenchu Lin. (2019) The ratio of Bcl-2/Bim as a predictor of cisplatin response provides a rational combination of ABT-263 with cisplatin or radiation in small cell lung cancer. Cancer Biomarkers 24:1, pages 51-59.
Crossref
Kojo S. J. Elenitoba-Johnson. (2019) Functional profiling to improve therapy in TCL. Blood 133:6, pages 504-506.
Crossref
Xuebo Xu, Yueyang Lai & Zi-Chun Hua. (2019) Apoptosis and apoptotic body: disease message and therapeutic target potentials. Bioscience Reports 39:1.
Crossref
Marilina García-Aranda, Elisabet Pérez-Ruiz & Maximino Redondo. (2018) Bcl-2 Inhibition to Overcome Resistance to Chemo- and Immunotherapy. International Journal of Molecular Sciences 19:12, pages 3950.
Crossref
Haihong Yuan, Hui Li, Ping Yu, Qichen Fan, Xuan Zhang, Wei Huang, Junyi Shen, Yongyao Cui & Wei Zhou. (2018) Involvement of HDAC6 in ischaemia and reperfusion-induced rat retinal injury. BMC Ophthalmology 18:1.
Crossref
Pouria Samadi, Sahar Saki, Fatemeh Karimi Dermani, Mona Pourjafar & Massoud Saidijam. (2018) Emerging ways to treat breast cancer: will promises be met?. Cellular Oncology 41:6, pages 605-621.
Crossref
Jingfei Chen, Juchang Zhong, Yeying Liu, Yuan Huang, Fei Luo, Yingjun Zhou, Xi Pan, Shousong Cao, Lingling Zhang, Yingjie Zhang & Jiangang Wang. (2018) Purified vitexin compound 1, a new neolignan isolated compound, promotes PUMA‐dependent apoptosis in colorectal cancer. Cancer Medicine 7:12, pages 6158-6169.
Crossref
Kush Patel, Zainab SO Ahmed, Xuemei Huang, Qianqian Yang, Elmira Ekinci, Christine M Neslund-Dudas, Bharati Mitra, Fawzy AEM Elnady, Young-Hoon Ahn, Huanjie Yang, Jinbao Liu & Qing Ping Dou. (2018) Discovering proteasomal deubiquitinating enzyme inhibitors for cancer therapy: lessons from rational design, nature and old drug reposition. Future Medicinal Chemistry 10:17, pages 2087-2108.
Crossref
Clara R. L. Oudenaarden, Robert A. H. van de Ven & Patrick W. B. Derksen. (2018) Re-inforcing the cell death army in the fight against breast cancer. Journal of Cell Science 131:16.
Crossref
Hoi Man Leung, Miu Shan Chan, Ling Sum Liu, Sze Wing Wong, Tsz Wan Lo, Cia-Hin Lau, Chung Tin & Pik Kwan Lo. (2018) Dual-Function, Cationic, Peptide-Coated Nanodiamond Systems: Facilitating Nuclear-Targeting Delivery for Enhanced Gene Therapy Applications. ACS Sustainable Chemistry & Engineering 6:8, pages 9671-9681.
Crossref
Anis Irmawati, Nadira Jasmin & Sidarningsih. (2018) The effect of moderate exercise on the elevation of Bax/Bcl-2 ratio in oral squamous epithelial cells induced by benzopyrene. Veterinary World 11:2, pages 177-180.
Crossref
Santanu Maji, Sanjay Panda, Sabindra K. Samal, Omprakash Shriwas, Rachna Rath, Maurizio Pellecchia, Luni Emdad, Swadesh K. Das, Paul B. Fisher & Rupesh Dash. 2018. 37 75 .
Tracy Murray-Stewart & Robert Casero. (2017) Regulation of Polyamine Metabolism by Curcumin for Cancer Prevention and Therapy. Medical Sciences 5:4, pages 38.
Crossref
Qiang Kang, Hao Zou, Xuan Yang, Jia‑Bin Cai, Li‑Xin Liu, Nan Xie, Lian‑Min Wang, Yue‑Hua Li & Xiao‑Wen Zhang. (2017) Characterization and prognostic significance of mortalin, Bcl‑2 and Bax in intrahepatic cholangiocarcinoma. Oncology Letters.
Crossref
Mei-lin Cui, Huan-yi Yang & Guo-qing He. (2017) Apoptosis induction of colorectal cancer cells HTL-9 in vitro by the transformed products of soybean isoflavones by Ganoderma lucidum灵芝菌生物转化大豆异黄酮及其产物对结直肠癌细胞HTL-9 的体外凋亡诱导研究. Journal of Zhejiang University-SCIENCE B 18:12, pages 1101-1112.
Crossref
Feng Jin, Guang Zhu, Dan Li, Tengyang Ni, Xiaojun Dai, Haibo Wang, Jun Feng, Yayun Qian, Lin Yang, Shiyu Guo, Tadashi Hisamitsu & Yanqing Liu. (2017) Celastrus�orbiculatus extracts induce cell cycle arrest and apoptosis in human esophageal squamous carcinoma ECA-109 cells in�vitro via the PI3K/AKT/mTOR signaling pathway. Oncology Letters.
Crossref
Aubert Ribaucourt, Christopher Towers, Laia Josa‐Culleré, Frances Willenbrock, Amber L. Thompson & David M. Hodgson. (2017) Aruncin B: Synthetic Studies, Structural Reassignment and Biological Evaluation. Chemistry – A European Journal 23:65, pages 16525-16534.
Crossref
Sang-Woo Kim, Yeon Kyung Lee, Jong Yeon Lee, Jeong Hee Hong & Dongwoo Khang. (2017) PEGylated anticancer-carbon nanotubes complex targeting mitochondria of lung cancer cells. Nanotechnology 28:46, pages 465102.
Crossref
Lei Qiao, Xiangyu Liu, Yichao Tang, Zheng Zhao, Jilong Zhang & Yong Feng. (2017) Down regulation of the long non-coding RNA PCAT-1 induced growth arrest and apoptosis of colorectal cancer cells. Life Sciences 188, pages 37-44.
Crossref
Benjamin Onyeagucha, Panneerdoss Subbarayalu, Nourhan Abdelfattah, Subapriya Rajamanickam, Santosh Timilsina, Rosa Guzman, Carla Zeballos, Vijay Eedunuri, Sanjay Bansal, Tabrez Mohammad, Yidong Chen, Ratna K. Vadlamudi & Manjeet K. Rao. (2017) Novel post-transcriptional and post-translational regulation of pro-apoptotic protein BOK and anti-apoptotic protein Mcl-1 determine the fate of breast cancer cells to survive or die. Oncotarget 8:49, pages 85984-85996.
Crossref
Florence Lefranc, Nurhayat Tabanca & Robert Kiss. (2017) Assessing the anticancer effects associated with food products and/or nutraceuticals using in vitro and in vivo preclinical development-related pharmacological tests. Seminars in Cancer Biology 46, pages 14-32.
Crossref
Zhen Wang, You-Min Ying, Kai-Qiang Li, Yu Zhang, Bing-Yu Chen, Jing-Jing Zeng, Xu-Jun He, Meng-Meng Jiang, Bo-Xu Chen, Ying Wang, Xiao-Dong Xu, Ke Hao, Meng-Hua Zhu & Wei Zhang. (2017) Marsdeniae tenacissima extract-induced growth inhibition and apoptosis in hepatoma carcinoma cells is mediated through the p53/nuclear factor-κB signaling pathway. Experimental and Therapeutic Medicine 14:3, pages 2477-2484.
Crossref
Vishnupriya Kanakaveti, Ramasamy Sakthivel, S. K. Rayala & M. Michael Gromiha. (2017) Importance of functional groups in predicting the activity of small molecule inhibitors for Bcl-2 and Bcl-xL. Chemical Biology & Drug Design 90:2, pages 308-316.
Crossref
Pallabi Sengupta, Samit Chattopadhyay & Subhrangsu Chatterjee. (2017) G-Quadruplex surveillance in BCL-2 gene: a promising therapeutic intervention in cancer treatment. Drug Discovery Today 22:8, pages 1165-1186.
Crossref
Gudapureddy Radha & Sathees C. Raghavan. (2017) BCL2: A promising cancer therapeutic target. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1868:1, pages 309-314.
Crossref
Yang Nan, Liyun Guo, Yunpeng Song, Le Wang, Kai Yu, Qiang Huang & Yue Zhong. (2017) Combinatorial therapy with adenoviral-mediated PTEN and a PI3K inhibitor suppresses malignant glioma cell growth in vitro and in vivo by regulating the PI3K/AKT signaling pathway. Journal of Cancer Research and Clinical Oncology 143:8, pages 1477-1487.
Crossref
Nabanita Mukherjee, Yan Lu, Adam Almeida, Karoline Lambert, Chung-Wai Shiau, Jung-Chen Su, Yuchun Luo, Mayumi Fujita, William A. Robinson, Steven E. Robinson, David A. Norris & Yiqun G. Shellman. (2016) Use of a MCL-1 inhibitor alone to de-bulk melanoma and in combination to kill melanoma initiating cells. Oncotarget 8:29, pages 46801-46817.
Crossref
Ying Chen & Lei Zhang. (2017) Members of the microRNA-200 family are promising therapeutic targets in cancer. Experimental and Therapeutic Medicine 14:1, pages 10-17.
Crossref
Kobra Velaei, Nasser Samadi, Sina Soltani, Balal Barazvan & Jafar Soleimani Rad. (2016) NFκBP65 transcription factor modulates resistance to doxorubicin through ABC transporters in breast cancer. Breast Cancer 24:4, pages 552-561.
Crossref
Sai Wu, Yan Zhou, Gaoxiang Yang, Hua Tian, Yang Geng, Yabin Hu, Kai Lin & Wei Wu. (2017) Sulforaphane-cysteine induces apoptosis by sustained activation of ERK1/2 and caspase 3 in human glioblastoma U373MG and U87MG cells. Oncology Reports 37:5, pages 2829-2838.
Crossref
Mingfei Li, Yuan Yang, Yu Kuang, Xianfeng Gan, Wei Zeng, Yuping Liu & Hua Guan. (2017) miR-365 induces hepatocellular carcinoma cell apoptosis through targeting Bcl-2. Experimental and Therapeutic Medicine 13:5, pages 2279-2285.
Crossref
Leônidas João de MelloJrJr, Gabriela Regina Rosa Souza, Evelyn Winter, Adny Henrique Silva, Frederico Pittella & Tânia Beatriz Creczynski-Pasa. (2017) Knockdown of antiapoptotic genes in breast cancer cells by siRNA loaded into hybrid nanoparticles. Nanotechnology 28:17, pages 175101.
Crossref
Jeffrey A. Moscow, Kenneth H. Cowan & Branimir I. Sikic. 2016. Holland‐Frei Cancer Medicine. Holland‐Frei Cancer Medicine 1 7 .
Jiaxuan Zhang, Xiaofei Zhi, Shiyu Shi, Ran Tao, Peisheng Chen, Shiyu Sun, Longjun Bian, Zhangyan Xu & Lilin Ma. (2017) SPOCK1 is up-regulated and promotes tumor growth via the PI3K/AKT signaling pathway in colorectal cancer. Biochemical and Biophysical Research Communications 482:4, pages 870-876.
Crossref
Fatemeh Atyabi, Forouhe Zahir, Fatemeh Khonsari, Akram Shafiee & Fatemeh Mottaghitalab. 2017. Nanostructures for Cancer Therapy. Nanostructures for Cancer Therapy 541 561 .
Tianli Fan, Jing Chen, Lirong Zhang, Pan Gao, Yiran Hui, Peirong Xu, Xiaqing Zhang & Hongtao Liu. (2016) Bit1 knockdown contributes to growth suppression as well as the decreases of migration and invasion abilities in esophageal squamous cell carcinoma via suppressing FAK-paxillin pathway. Molecular Cancer 15:1.
Crossref
Ming Li, Li Xue, Haifeng Sun & Suochun Xu. (2016) Myocardial Protective Effects of L-Carnitine on Ischemia-Reperfusion Injury in Patients With Rheumatic Valvular Heart Disease Undergoing Cardiac Surgery. Journal of Cardiothoracic and Vascular Anesthesia 30:6, pages 1485-1493.
Crossref
XinGang Lu, HongFu Qiu, Liu Yang, JieYing Zhang, ShuJie Ma & Lan Zhen. (2016) Anti-proliferation effects, efficacy of cyasterone in vitro and in vivo and its mechanism. Biomedicine & Pharmacotherapy 84, pages 330-339.
Crossref
Eva Vidomanova, Peter Racay, Ivana Pilchova, Erika Halasova & Jozef Hatok. (2016) Microfluidic profiling of apoptosis-related genes after treatment with BH3-mimetic agents in astrocyte and glioblastoma cell lines. Oncology Reports 36:6, pages 3188-3196.
Crossref
Xingang Lu, Jianxia Ma, Hongfu Qiu, Liu Yang, Lei Cao & Jie Shen. (2016) Anti-proliferation effects of trifolirhizin on MKN45 cells and possible mechanism. Oncology Reports 36:5, pages 2785-2792.
Crossref
Lin Yang, Yanqing Liu, Mei Wang, Yayun Qian, Xiaojun Dai, Yaodong Zhu, Jue Chen, Shiyu Guo & Tadashi Hisamitsu. (2016) Celastrus orbiculatus extract triggers apoptosis and autophagy via PI3K/Akt/mTOR inhibition in human colorectal cancer cells. Oncology Letters 12:5, pages 3771-3778.
Crossref
Lin Yang, Yanqing Liu, Mei Wang, Yayun Qian, Xiaoyun Dong, Hao Gu, Haibo Wang, Shiyu Guo & Tadashi Hisamitsu. (2016) Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis. Molecular Medicine Reports 14:5, pages 4559-4566.
Crossref
Katarína Koňariková, Georgios A. Perdikaris, Helena Gbelcová, Lucia Andrezálová, Martin Švéda, Tomáš Ruml, Lucia Laubertová & Ingrid Žitňanová. (2016) Effect of Schiff base Cu(II) complexes on signaling pathways in HT-29 cells. Molecular Medicine Reports 14:5, pages 4436-4444.
Crossref
Brad Rybinski & Kyuson Yun. (2016) Addressing intra-tumoral heterogeneity and therapy resistance. Oncotarget 7:44, pages 72322-72342.
Crossref
L Jones, H Carol, K Evans, J Richmond, P J Houghton, M A Smith & R B Lock. (2016) A review of new agents evaluated against pediatric acute lymphoblastic leukemia by the Pediatric Preclinical Testing Program. Leukemia 30:11, pages 2133-2141.
Crossref
S. Harrow, G.G. Hanna, C. Faivre-Finn, F. McDonald & A.J. Chalmers. (2016) The Challenges Faced in Developing Novel Drug Radiation Combinations in Non-small Cell Lung Cancer. Clinical Oncology 28:11, pages 720-725.
Crossref
Jian-guo Sun, Feng Ruan, Xue-li Zeng, Jun Xiang, Xia Li, Ping Wu, Kwok Pui Fung & Fei-yan Liu. (2016) Clitocine potentiates TRAIL-mediated apoptosis in human colon cancer cells by promoting Mcl-1 degradation. Apoptosis 21:10, pages 1144-1157.
Crossref
Abdul Shukkur Ebrahim, Hussam Sabbagh, Allison Liddane, Ali Raufi, Mustapha Kandouz & Ayad Al-Katib. (2016) Hematologic malignancies: newer strategies to counter the BCL-2 protein. Journal of Cancer Research and Clinical Oncology 142:9, pages 2013-2022.
Crossref
Shuhei Osaki, Hiroshi Tazawa, Joe Hasei, Yasuaki Yamakawa, Toshinori Omori, Kazuhisa Sugiu, Tadashi Komatsubara, Tomohiro Fujiwara, Tsuyoshi Sasaki, Toshiyuki Kunisada, Aki Yoshida, Yasuo Urata, Shunsuke Kagawa, Toshifumi Ozaki & Toshiyoshi Fujiwara. (2016) Ablation of MCL1 expression by virally induced microRNA-29 reverses chemoresistance in human osteosarcomas. Scientific Reports 6:1.
Crossref
Zhiqing Liu, Christopher Wild, Ye Ding, Na Ye, Haiying Chen, Eric A. Wold & Jia Zhou. (2016) BH4 domain of Bcl-2 as a novel target for cancer therapy. Drug Discovery Today 21:6, pages 989-996.
Crossref
Mart Bittremieux, Jan B. Parys, Paolo Pinton & Geert Bultynck. (2016) ER functions of oncogenes and tumor suppressors: Modulators of intracellular Ca2+ signaling. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1863:6, pages 1364-1378.
Crossref
RUITAO ZHANG, HUIRONG SHI, FANG REN, XIA LI, MINGHUI ZHANG, WEI FENG & YANYAN JIA. (2016) Knockdown of MACC1 expression increases cisplatin sensitivity in cisplatin-resistant epithelial ovarian cancer cells. Oncology Reports 35:4, pages 2466-2472.
Crossref
Uddhav Timilsina & Ritu Gaur. (2016) Modulation of apoptosis and viral latency – an axis to be well understood for successful cure of human immunodeficiency virus. Journal of General Virology 97:4, pages 813-824.
Crossref
Yogesh M. Kulkarni, Vivek Kaushik, Neelam Azad, Clayton Wright, Yon Rojanasakul, George O'Doherty & Anand Krishnan V. Iyer. (2016) Autophagy-Induced Apoptosis in Lung Cancer Cells by a Novel Digitoxin Analog. Journal of Cellular Physiology 231:4, pages 817-828.
Crossref
Zhiqing Liu, Ye Ding, Na Ye, Christopher Wild, Haiying Chen & Jia Zhou. (2016) Direct Activation of Bax Protein for Cancer Therapy. Medicinal Research Reviews 36:2, pages 313-341.
Crossref
Manoj Pandey, Sahdeo Prasad, Amit Tyagi, Lokesh Deb, Jiamin Huang, Deepkamal Karelia, Shantu Amin & Bharat Aggarwal. (2016) Targeting Cell Survival Proteins for Cancer Cell Death. Pharmaceuticals 9:1, pages 11.
Crossref
S Baig, I Seevasant, J Mohamad, A Mukheem, H Z Huri & T Kamarul. (2016) Potential of apoptotic pathway-targeted cancer therapeutic research: Where do we stand?. Cell Death & Disease 7:1, pages e2058-e2058.
Crossref
Jing Ren, Gang Li, Wen Zhao, Ling Lin & Tao Ye. (2016) Norcantharidin combined with ABT-737 for hepatocellular carcinoma: Therapeutic effects and molecular mechanisms. World Journal of Gastroenterology 22:15, pages 3962.
Crossref
XinGang Lu, Liu Yang, ChengHua Lu, ZhenYu Xu, HongFu Qiu, JiaJia Wu, JingWen Wang, JiaFeng Tong, Yin Zhu & Jie Shen. (2016) Molecular Role of EGFR-MAPK Pathway in Patchouli Alcohol-Induced Apoptosis and Cell Cycle Arrest on A549 Cells In Vitro and In Vivo . BioMed Research International 2016, pages 1-12.
Crossref
Joyce Liu, Xuejun Zhu, Seong Jong Kim & Wenjun Zhang. (2016) Antimycin-type depsipeptides: discovery, biosynthesis, chemical synthesis, and bioactivities. Natural Product Reports 33:10, pages 1146-1165.
Crossref
Duong Nhu, Guillaume Lessene, David C. S. Huang & Christopher J. Burns. (2016) Small molecules targeting Mcl-1: the search for a silver bullet in cancer therapy. MedChemComm 7:5, pages 778-787.
Crossref
Eva Blahovcová, Henrieta Škovierová, Ján Strnádel, Dušan Mištuna & Erika Halašová. 2016. Information Technologies in Medicine. Information Technologies in Medicine 207 213 .
EVA BLAHOVCOVA, ROMANA RICHTEROVA, BRANISLAV KOLAROVSZKI, DUSAN DOBROTA, PETER RACAY & JOZEF HATOK. (2015) Apoptosis-related gene expression in tumor tissue samples obtained from patients diagnosed with glioblastoma multiforme. International Journal of Molecular Medicine 36:6, pages 1677-1684.
Crossref
Y He, D Chen & W Zheng. (2015) An enhanced functional interrogation/manipulation of intracellular signaling pathways with the peptide ‘stapling’ technology. Oncogene 34:46, pages 5685-5698.
Crossref
Xin Li, Xiao Miao, Hongshen Wang, Zhixiang Xu & Bin Li. (2015) The tissue dependent interactions between p53 and Bcl-2 in vivo . Oncotarget 6:34, pages 35699-35709.
Crossref
Nina Bionda & Rudi Fasan. 2015. Small Molecule Medicinal Chemistry. Small Molecule Medicinal Chemistry 431 464 .
QUNCHUAN ZHUANG, JING LI, YOUQIN CHEN, JIUMAO LIN, FAZE LAI, XUZHENG CHEN, XINDENG LIN & JUN PENG. (2015) Ethyl acetate extract of Hypericum japonicum induces apoptosis via the mitochondria-dependent pathway in vivo and in vitro. Molecular Medicine Reports 12:4, pages 4851-4858.
Crossref
Bo Peng, Suthakar Ganapathy, Ling Shen, Junchi Huang, Bo Yi, Xiaodong Zhou, Wei Dai & Changyan Chen. (2015) Targeting Bcl-2 stability to sensitize cells harboring oncogenic ras . Oncotarget 6:26, pages 22328-22337.
Crossref
Nabanita Mukherjee, Josianna V. Schwan, Mayumi Fujita, David A. Norris & Yiqun G. Shellman. (2015) Alternative Treatments For Melanoma: Targeting BCL-2 Family Members to De-Bulk and Kill Cancer Stem Cells. Journal of Investigative Dermatology 135:9, pages 2155-2161.
Crossref
Samaher Besbes, Massoud Mirshahi, Marc Pocard & Christian Billard. (2015) Strategies targeting apoptosis proteins to improve therapy of chronic lymphocytic leukemia. Blood Reviews 29:5, pages 345-350.
Crossref
ZHOU-JING JI, JIAN-LI WANG & LI CHEN. (2015) Inhibition of skin squamous cell carcinoma proliferation and promote apoptosis by dual silencing of NET-1 and survivin. Oncology Reports 34:2, pages 811-822.
Crossref
Samaher Besbes, Massoud Mirshahi, Marc Pocard & Christian Billard. (2015) New dimension in therapeutic targeting of BCL-2 family proteins. Oncotarget 6:15, pages 12862-12871.
Crossref
Geoffrey Y Berguig, Anthony J Convertine, Shani Frayo, Hanna B Kern, Erik Procko, Debashish Roy, Selvi Srinivasan, Daciana H Margineantu, Garrett Booth, Maria Corinna Palanca-Wessels, David Baker, David Hockenbery, Oliver W Press & Patrick S Stayton. (2015) Intracellular Delivery System for Antibody–Peptide Drug Conjugates. Molecular Therapy 23:5, pages 907-917.
Crossref
Nabanita Mukherjee, Steven N. Reuland, Yan Lu, Yuchun Luo, Karoline Lambert, Mayumi Fujita, William A. Robinson, Steven E. Robinson, David A. Norris & Yiqun G. Shellman. (2015) Combining a BCL2 Inhibitor with the Retinoid Derivative Fenretinide Targets Melanoma Cells Including Melanoma Initiating Cells. Journal of Investigative Dermatology 135:3, pages 842-850.
Crossref
Yu Fujita, Shigehiro Yagishita, Fumitaka Takeshita, Yusuke Yamamoto, Kazuyoshi Kuwano & Takahiro Ochiya. (2015) Prognostic and therapeutic impact of RPN2-mediated tumor malignancy in non-small-cell lung cancer. Oncotarget 6:5, pages 3335-3345.
Crossref
XIAOLI MA, HUA DUAN, JIA LIU, QINGQING MO, CHENGJUAN SUN, DING MA & JIANDONG WANG. (2015) Effect of LIV1 on the sensitivity of ovarian cancer cells to trichostatin A. Oncology Reports 33:2, pages 893-898.
Crossref
Bridget A. Quinn, Nathaniel A. Lee, Timothy P. Kegelman, Praveen Bhoopathi, Luni Emdad, Swadesh K. Das, Maurizio Pellecchia, Devanand Sarkar & Paul B. Fisher. 2015. 283 306 .
Viralkumar Patel, Kumudha Balakrishnan & Varsha Gandhi. 2015. Multi-Targeted Approach to Treatment of Cancer. Multi-Targeted Approach to Treatment of Cancer 73 98 .
Jian-guo Sun, Jun Xiang, Xue-li Zeng, Xia Li, Ping Wu, Kwok Pui Fung & Fei-yan Liu. (2014) Clitocine induces apoptosis and enhances the lethality of ABT-737 in human colon cancer cells by disrupting the interaction of Mcl-1 and Bak. Cancer Letters 355:2, pages 253-263.
Crossref
D Schmid, G E Jarvis, F Fay, D M Small, M K Greene, J Majkut, S Spence, K M McLaughlin, K D McCloskey, P G Johnston, A Kissenpfennig, D B Longley & C J Scott. (2014) Nanoencapsulation of ABT-737 and camptothecin enhances their clinical potential through synergistic antitumor effects and reduction of systemic toxicity. Cell Death & Disease 5:10, pages e1454-e1454.
Crossref
JI HOON JANG, YOON CHUL CHO, KI HO KIM, KYUNG SEOP LEE, JINHO LEE, DONG EUN KIM, JUN-SOO PARK, BYEONG-CHURL JANG, SHIN KIM, TAEG KYU KWON & JONG-WOOK PARK. (2014) BAI, a novel Cdk inhibitor, enhances farnesyltransferase inhibitor LB42708-mediated apoptosis in renal carcinoma cells through the downregulation of Bcl-2 and c-FLIP (L). International Journal of Oncology 45:4, pages 1680-1690.
Crossref
Shanna K. Nifoussi, Nora R. Ratcliffe, Deborah L. Ornstein, Gary Kasof, Stefan Strack & Ruth W. Craig. (2014) Inhibition of Protein Phosphatase 2A (PP2A) Prevents Mcl-1 Protein Dephosphorylation at the Thr-163/Ser-159 Phosphodegron, Dramatically Reducing Expression in Mcl-1-amplified Lymphoma Cells. Journal of Biological Chemistry 289:32, pages 21950-21959.
Crossref
Wendi V. Rodrigueza, Michael J. Woolliscroft, Abdul-Shukkur Ebrahim, Robert Forgey, Patrick J. McGovren, Gerold Endert, Andreas Wagner, Danielle Holewa, Amro Aboukameel, Richard D. Gill, Charles L. Bisgaier, Richard A. Messmann, Christopher E. Whitehead, Elzbieta Izbicka, Robert Streeper, Michael C. Wick, Gabriela Stiegler, C. A. Stein, David Monsma, Craig Webb, Mina P. Sooch, Steffen Panzner, Ramzi Mohammad, Neal C. Goodwin & Ayad Al-Katib. (2014) Development and antitumor activity of a BCL-2 targeted single-stranded DNA oligonucleotide. Cancer Chemotherapy and Pharmacology 74:1, pages 151-166.
Crossref
Christian Billard. (2014) Targeting antiapoptotic and proapoptotic proteins for novel chronic lymphocytic leukemia therapeutics. International Journal of Hematologic Oncology 3:3, pages 233-241.
Crossref
Timothy G. Whitsett, Ian T. Mathews, Michael H. Cardone, Ryan J. Lena, William E. Pierceall, Michael Bittner, Chao Sima, Janine LoBello, Glen J. Weiss & Nhan L. Tran. (2014) Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response. Molecular Cancer Research 12:4, pages 550-559.
Crossref
Wanxing Eugene Ho, Hong Yong Peh, Tze Khee Chan & W.S. Fred Wong. (2014) Artemisinins: Pharmacological actions beyond anti-malarial. Pharmacology & Therapeutics 142:1, pages 126-139.
Crossref
Barry D LiboironLawrence D Mayer. (2014) Nanoscale particulate systems for multidrug delivery: towards improved combination chemotherapy. Therapeutic Delivery 5:2, pages 149-171.
Crossref
Jan Akervall, Sirisha Nandalur, Jacob Zhang, Chao-Nan Qian, Neal Goldstein, Paulina Gyllerup, Ylva Gardinger, Jens Alm, Katarina Lorenc, Karolina Nilsson, James Resau, George Wilson & Bin Teh. (2014) A novel panel of biomarkers predicts radioresistance in patients with squamous cell carcinoma of the head and neck. European Journal of Cancer 50:3, pages 570-581.
Crossref
Christian Billard. (2013) Apoptosis inducers in chronic lymphocytic leukemia. Oncotarget 5:2, pages 309-325.
Crossref
Ellen Preuss, Manuela Hugle, Romy Reimann, Marcel Schlecht & Simone Fulda. (2013) Pan-Mammalian Target of Rapamycin (mTOR) Inhibitor AZD8055 Primes Rhabdomyosarcoma Cells for ABT-737-induced Apoptosis by Down-regulating Mcl-1 Protein. Journal of Biological Chemistry 288:49, pages 35287-35296.
Crossref
Ryan F Seipke & Matthew I Hutchings. (2013) The regulation and biosynthesis of antimycins. Beilstein Journal of Organic Chemistry 9, pages 2556-2563.
Crossref
Joanna Bidzinska, Graziella Cimino-Reale, Nadia Zaffaroni & Marco Folini. (2013) G-Quadruplex Structures in the Human Genome as Novel Therapeutic Targets. Molecules 18:10, pages 12368-12395.
Crossref
Giovanna ZinzallaAlex W WhiteJitka SoukupováAndrew D Westwell. 2013. Understanding and Exploiting Protein–Protein Interactions as Drug Targets. Understanding and Exploiting Protein–Protein Interactions as Drug Targets 6 17 .
CHENG CHANG, SHAO-PING LIU, CHUN-HUA FANG, REN-SHENG HE, ZHEN WANG, YOU-QING ZHU & SHAO-WEI JIANG. (2013) Effects of matrine on the proliferation of HT29 human colon cancer cells and its antitumor mechanism. Oncology Letters 6:3, pages 699-704.
Crossref
Andrew Stone, Mark J. Cowley, Fatima Valdes-Mora, Rachael A. McCloy, C. Marcelo Sergio, David Gallego-Ortega, C. Elizabeth Caldon, Christopher J. Ormandy, Andrew V. Biankin, Julia M.W. Gee, Robert I. Nicholson, Cristin G. Print, Susan J. Clark & Elizabeth A. Musgrove. (2013) BCL-2 Hypermethylation Is a Potential Biomarker of Sensitivity to Antimitotic Chemotherapy in Endocrine-Resistant Breast Cancer. Molecular Cancer Therapeutics 12:9, pages 1874-1885.
Crossref
Clémentine Aguirre, Tim ten Brink, Olivier Walker, Florence Guillière, Dany Davesne & Isabelle Krimm. (2013) BcL-xL Conformational Changes upon Fragment Binding Revealed by NMR. PLoS ONE 8:5, pages e64400.
Crossref
Franziska Ertel, Mai Nguyen, Anne Roulston & Gordon C Shore. (2013) Programming cancer cells for high expression levels of Mcl1. EMBO reports 14:4, pages 328-336.
Crossref
Selma Olsson Åkefeldt, Mohamad Bachar Ismail, Hélène Valentin, Maurizio Aricò, Jan-Inge Henter & Christine Delprat. (2013) Targeting BCL2 Family in Human Myeloid Dendritic Cells: A Challenge to Cure Diseases with Chronic Inflammations Associated with Bone Loss. Clinical and Developmental Immunology 2013, pages 1-11.
Crossref
William Garland, Robert Benezra & Jaideep Chaudhary. 2013. 227 245 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.