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Targeting liver X receptors in inflammation

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Pages 977-990 | Published online: 06 Jun 2013

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Lorenzo Pontini & Maura Marinozzi. (2021) Novel Synthetic Access to 24a-Homochol-5-en-24a-oate Scaffold from Stigmasterol. Organic Preparations and Procedures International 53:6, pages 571-577.
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Ichiro Takada & Makoto Makishima. (2020) Peroxisome proliferator-activated receptor agonists and antagonists: a patent review (2014-present). Expert Opinion on Therapeutic Patents 30:1, pages 1-13.
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Lucie Popineau, Lucille Morzyglod, Nadège Carré, Michèle Caüzac, Pascale Bossard, Carina Prip-Buus, Véronique Lenoir, Bruno Ragazzon, Véronique Fauveau, Lorenne Robert, Sandra Guilmeau, Catherine Postic, Masaaki Komatsu, François Canonne-Hergaux, Hervé Guillou & Anne-Françoise Burnol. (2016) Novel Grb14-Mediated Cross Talk between Insulin and p62/Nrf2 Pathways Regulates Liver Lipogenesis and Selective Insulin Resistance. Molecular and Cellular Biology 36:16, pages 2168-2181.
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Chin-Yo Lin, Lise-Lotte Vedin & Knut R Steffensen. (2016) The emerging roles of liver X receptors and their ligands in cancer. Expert Opinion on Therapeutic Targets 20:1, pages 61-71.
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Articles from other publishers (46)

Xiaoyu Song, Wanfu Wu, Yubing Dai, Margaret Warner, Ivan Nalvarte, Per Antonson, Mukesh Varshney & Jan-Åke Gustafsson. (2023) Loss of ERβ in Aging LXRαβ Knockout Mice Leads to Colitis. International Journal of Molecular Sciences 24:15, pages 12461.
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Yang Yang, Wangrui Lei, Lu Qian, Shaofei Zhang, Wenwen Yang, Chenxi Lu, Yanbin Song, Zhenxing Liang, Chao Deng, Ying Chen, Ye Tian & Huadong Zhao. (2023) Activation of NR1H3 signaling pathways by psoralidin attenuates septic myocardial injury. Free Radical Biology and Medicine 204, pages 8-19.
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Tao Wang & Hongmei Jia. (2023) The Sigma Receptors in Alzheimer’s Disease: New Potential Targets for Diagnosis and Therapy. International Journal of Molecular Sciences 24:15, pages 12025.
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Tong-Mei Yang, Miao Miao, Wen-Qian Yu, Xue Wang, Fang-Jie Xia, Yan-Jie Li & Shou-Dong Guo. (2023) Targeting macrophages in atherosclerosis using nanocarriers loaded with liver X receptor agonists: A narrow review. Frontiers in Molecular Biosciences 10.
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Ni Li, Yan Li, Xiaowan Han, Jing Zhang, Jiangxue Han, Xinhai Jiang, Weizhi Wang, Yang Xu, Yanni Xu, Yu Fu & Shuyi Si. (2022) LXR agonist inhibits inflammation through regulating MyD88 mRNA alternative splicing. Frontiers in Pharmacology 13.
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Meng Sun, Huadong Zhao, Zhenxiao Jin, Wangrui Lei, Chao Deng, Wenwen Yang, Chenxi Lu, Yuxuan Hou, Yan Zhang, Ran Tang, Lin Zhao, Shaofei Zhang & Yang Yang. (2022) Silibinin protects against sepsis and septic myocardial injury in an NR1H3-dependent pathway. Free Radical Biology and Medicine 187, pages 141-157.
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José Miranda-Bautista, Juan A Rodríguez-Feo, Marta Puerto, Beatriz López-Cauce, José M Lara, Raquel González-Novo, David Martín-Hernández, Rocío Ferreiro-Iglesias, Rafael Bañares & Luis Menchén. (2021) Liver X Receptor Exerts Anti-Inflammatory Effects in Colonic Epithelial Cells via ABCA1 and Its Expression Is Decreased in Human and Experimental Inflammatory Bowel Disease . Inflammatory Bowel Diseases 27:10, pages 1661-1673.
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Adil Rasheed & Katey J Rayner. (2021) Macrophage Responses to Environmental Stimuli During Homeostasis and Disease. Endocrine Reviews 42:4, pages 407-435.
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José M. Carbó, Theresa E. León, Joan Font-Díaz, Juan Vladimir De la Rosa, Antonio Castrillo, Felix R. Picard, Daniel Staudenraus, Magdalena Huber, Lídia Cedó, Joan Carles Escolà-Gil, Lucía Campos, Latifa Bakiri, Erwin F. Wagner, Carme Caelles, Thomas Stratmann, Jo A. Van Ginderachter & Annabel F. Valledor. (2021) Pharmacologic Activation of LXR Alters the Expression Profile of Tumor-Associated Macrophages and the Abundance of Regulatory T Cells in the Tumor Microenvironment. Cancer Research 81:4, pages 968-985.
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Mireille Alhouayek, Hafsa Ameraoui & Giulio G. Muccioli. (2021) Bioactive lipids in inflammatory bowel diseases – From pathophysiological alterations to therapeutic opportunities. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1866:2, pages 158854.
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Kai Yang, Cheng Zeng, Changcai Wang, Meng Sun, Dan Yin & Taolei Sun. (2020) Sigma-2 Receptor—A Potential Target for Cancer/Alzheimer’s Disease Treatment via Its Regulation of Cholesterol Homeostasis. Molecules 25:22, pages 5439.
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Sadia Rahman, Karlo Wittine, Mirela Sedić & Elitza P. Markova-Car. (2020) Small Molecules Targeting Biological Clock; A Novel Prospective for Anti-Cancer Drugs. Molecules 25:21, pages 4937.
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Bright Asare-Bediako, Sunil Noothi, Sergio Li Calzi, Baskaran Athmanathan, Cristiano Vieira, Yvonne Adu-Agyeiwaah, Mariana Dupont, Bryce Jones, Xiaoxin Wang, Dibyendu Chakraborty, Moshe Levi, Prabhakara Nagareddy & Maria Grant. (2020) Characterizing the Retinal Phenotype in the High-Fat Diet and Western Diet Mouse Models of Prediabetes. Cells 9:2, pages 464.
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Tamhida Masi, Ramesh K. Goyal & Bhoomika M. Patel. 2020. Biochemistry of Cardiovascular Dysfunction in Obesity. Biochemistry of Cardiovascular Dysfunction in Obesity 77 96 .
Enyuan Cao, Anna Lindgren, Sofia Martinsson, Luojuan Hu, Lennart Lindfors, Kalle Sigfridsson, Urban Skantze, Erik Michaëlsson, Natalie L. Trevaskis & Christopher J.H. Porter. (2019) Promoting intestinal lymphatic transport targets a liver-X receptor (LXR) agonist (WAY-252,623) to lymphocytes and enhances immunomodulation. Journal of Controlled Release 296, pages 29-39.
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Shakti Prasad Pattanayak, Pritha Bose, Priyashree Sunita, Mohd Usman Mohd Siddique & Antonio Lapenna. (2018) Bergapten inhibits liver carcinogenesis by modulating LXR/PI3K/Akt and IDOL/LDLR pathways. Biomedicine & Pharmacotherapy 108, pages 297-308.
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Adil Rasheed & Carolyn Cummins. (2018) Beyond the Foam Cell: The Role of LXRs in Preventing Atherogenesis. International Journal of Molecular Sciences 19:8, pages 2307.
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Hirozumi Toyama, Hitoshi Shirakawa, Michio Komai, Yuichi Hashimoto & Shinya Fujii. (2018) Development of novel silanol-based human pregnane X receptor (PXR) agonists with improved receptor selectivity. Bioorganic & Medicinal Chemistry 26:15, pages 4493-4501.
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Soumaya Kouidhi & Marie-Stéphanie Clerget-Froidevaux. (2018) Integrating Thyroid Hormone Signaling in Hypothalamic Control of Metabolism: Crosstalk Between Nuclear Receptors. International Journal of Molecular Sciences 19:7, pages 2017.
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Zhengwu Peng, Bin Deng, Ji Jia, Wugang Hou, Sheng Hu, Jiao Deng, Wei Lin, Lichao Hou & Hanfei Sang. (2018) Liver X receptor β in the hippocampus: A potential novel target for the treatment of major depressive disorder?. Neuropharmacology 135, pages 514-528.
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Anthony Mukwaya, Anton Lennikov, Maria Xeroudaki, Pierfrancesco Mirabelli, Mieszko Lachota, Lasse Jensen, Beatrice Peebo & Neil Lagali. (2018) Time-dependent LXR/RXR pathway modulation characterizes capillary remodeling in inflammatory corneal neovascularization. Angiogenesis 21:2, pages 395-413.
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Pengfei Xu, Yonggong Zhai & Jing Wang. (2018) The Role of PPAR and Its Cross-Talk with CAR and LXR in Obesity and Atherosclerosis. International Journal of Molecular Sciences 19:4, pages 1260.
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Michael B. Fessler. (2018) The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease. Pharmacology & Therapeutics 181, pages 1-12.
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George A. Robinson, Kirsty E. Waddington, Ines Pineda-Torra & Elizabeth C. Jury. (2017) Transcriptional Regulation of T-Cell Lipid Metabolism: Implications for Plasma Membrane Lipid Rafts and T-Cell Function. Frontiers in Immunology 8.
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Mariola Kurowska-Stolarska, Manhl K. Hasoo, David J. Welsh, Lynn Stewart, Donna McIntyre, Brian E. Morton, Steven Johnstone, Ashley M. Miller, Darren L. Asquith, Neal L. Millar, Ann B. Millar, Carol A. Feghali-Bostwick, Nikhil Hirani, Peter J. Crick, Yuqin Wang, William J. Griffiths, Iain B. McInnes & Charles McSharry. (2017) The role of microRNA-155/liver X receptor pathway in experimental and idiopathic pulmonary fibrosis. Journal of Allergy and Clinical Immunology 139:6, pages 1946-1956.
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Jessica Walls, Linda Sinclair & David Finlay. (2016) Nutrient sensing, signal transduction and immune responses. Seminars in Immunology 28:5, pages 396-407.
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Kevin Mouzat, Cédric Raoul, Anne Polge, Jovana Kantar, William Camu & Serge Lumbroso. (2016) Liver X receptors: from cholesterol regulation to neuroprotection—a new barrier against neurodegeneration in amyotrophic lateral sclerosis?. Cellular and Molecular Life Sciences 73:20, pages 3801-3808.
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Mingxin Zuo, Asif Rashid, Ying Wang, Apurva Jain, Donghui Li, Anu Behari, Vinay Kumar Kapoor, Eugene J. Koay, Ping Chang, Jean Nicholas Vauthey, Yanan Li, Jaime A. Espinoza, Juan Carlos Roa & Milind Javle. (2016) RNA sequencing-based analysis of gallbladder cancer reveals the importance of the liver X receptor and lipid metabolism in gallbladder cancer. Oncotarget 7:23, pages 35302-35312.
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Chun-mu Miao, Kun He, Pei-zhi Li, Zuo-jin Liu, Xi-wen Zhu, Zhi-bing Ou, Xiong-zhong Ruan, Jian-ping Gong & Chang-an Liu. (2016) LXRα represses LPS-induced inflammatory responses by competing with IRF3 for GRIP1 in Kupffer cells. International Immunopharmacology 35, pages 272-279.
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Benoit Pourcet, Matthew C. Gage, Theresa E. León, Kirsty E. Waddington, Oscar M. Pello, Knut R. Steffensen, Antonio Castrillo, Annabel F. Valledor & Inés Pineda-Torra. (2016) The nuclear receptor LXR modulates interleukin-18 levels in macrophages through multiple mechanisms. Scientific Reports 6:1.
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Michael B. Fessler & Ross S. Summer. (2016) Surfactant Lipids at the Host–Environment Interface. Metabolic Sensors, Suppressors, and Effectors of Inflammatory Lung Disease. American Journal of Respiratory Cell and Molecular Biology 54:5, pages 624-635.
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Jaime A. Espinoza, Carolina Bizama, Patricia García, Catterina Ferreccio, Milind Javle, Juan F. Miquel, Jill Koshiol & Juan C. Roa. (2016) The inflammatory inception of gallbladder cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1865:2, pages 245-254.
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Birgit Waltenberger, Atanas G. Atanasov, Elke H. Heiss, David Bernhard, Judith M. Rollinger, Johannes M. Breuss, Daniela Schuster, Rudolf Bauer, Brigitte Kopp, Chlodwig Franz, Valery Bochkov, Marko D. Mihovilovic, Verena M. Dirsch & Hermann Stuppner. (2016) Drugs from nature targeting inflammation (DNTI): a successful Austrian interdisciplinary network project. Monatshefte für Chemie - Chemical Monthly 147:3, pages 479-491.
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Caroline Lucia Pinto, Sharanya Maanasi Kalasekar, Catherine W. McCollum, Anne Riu, Philip Jonsson, Justin Lopez, Eric C. Swindell, Abdel Bouhlatouf, Patrick Balaguer, Maria Bondesson & Jan-Åke Gustafsson. (2016) Lxr regulates lipid metabolic and visual perception pathways during zebrafish development. Molecular and Cellular Endocrinology 419, pages 29-43.
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Nicolas Venteclef, Tomas Jakobsson & Eckardt Treuter. 2016. Compendium of Inflammatory Diseases. Compendium of Inflammatory Diseases 994 1016 .
Adrián Sandoval-Hernández, María José Contreras, Jenny Jaramillo & Gonzalo Arboleda. 2016. Glial Cells in Health and Disease of the CNS. Glial Cells in Health and Disease of the CNS 287 310 .
Luisa Ercolani, Alessio Ferrari, Claudia De Mei, Chiara Parodi, Mark Wade & Benedetto Grimaldi. (2015) Circadian clock: Time for novel anticancer strategies?. Pharmacological Research 100, pages 288-295.
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Paloma Guillem-Llobat & Miguel A. Íñiguez. (2015) Inhibition of lipopolysaccharide-induced gene expression by liver X receptor ligands in macrophages involves interference with early growth response factor 1. Prostaglandins, Leukotrienes and Essential Fatty Acids 96, pages 37-49.
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Ying Dong, Guirong Gao, Hongyan Fan, Shengxian Li, Xuhang Li & Wei Liu. (2015) Activation of the Liver X Receptor by Agonist TO901317 Improves Hepatic Insulin Resistance via Suppressing Reactive Oxygen Species and JNK Pathway. PLOS ONE 10:4, pages e0124778.
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Brigitte Malgrange, Isabel Varela-Nieto, Philippe de Medina & Michael R. Paillasse. (2015) Targeting Cholesterol Homeostasis to Fight Hearing Loss: A New Perspective. Frontiers in Aging Neuroscience 7.
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Treska S. Hassan, Aida Paniccia, Vincenzo Russo & Knut R. Steffensen. (2015) LXR Inhibits Proliferation of Human Breast Cancer Cells through the PI3K-Akt Pathway. Nuclear Receptor Research 2.
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Yabin WangChunhong LiKang ChengRan ZhangKazim NarsinhShuang LiXiujuan LiXing QinRongqing ZhangCongye LiTao SuJiangwei ChenFeng Cao. (2014) Activation of Liver X Receptor Improves Viability of Adipose-Derived Mesenchymal Stem Cells to Attenuate Myocardial Ischemia Injury Through TLR4/NF-κB and Keap-1/Nrf-2 Signaling Pathways. Antioxidants & Redox Signaling 21:18, pages 2543-2557.
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T Jakobsson, L-L Vedin, T Hassan, N Venteclef, D Greco, M D'Amato, E Treuter, J-Å Gustafsson & K R Steffensen. (2014) The oxysterol receptor LXRβ protects against DSS- and TNBS-induced colitis in mice. Mucosal Immunology 7:6, pages 1416-1428.
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Rizwan Haq & Keith Flaherty. (2014) The melanoma metastasis X-factor. Pigment Cell & Melanoma Research 27:5, pages 698-698.
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Gabriella Testa, Paola Gamba, Ulya Badilli, Simona Gargiulo, Marco Maina, Tina Guina, Simone Calfapietra, Fiorella Biasi, Roberta Cavalli, Giuseppe Poli & Gabriella Leonarduzzi. (2014) Loading into Nanoparticles Improves Quercetin's Efficacy in Preventing Neuroinflammation Induced by Oxysterols. PLoS ONE 9:5, pages e96795.
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Nicolas Venteclef, Tomas Jakobsson & Eckardt Treuter. 2015. Encyclopedia of Inflammatory Diseases. Encyclopedia of Inflammatory Diseases 1 24 .

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