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Identification of MFG-E8 as a novel therapeutic target for diseases

, , & , MD
Pages 1275-1285 | Published online: 23 Aug 2013

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Vijay Kumar. (2020) Phagocytosis: Phenotypically Simple Yet a Mechanistically Complex Process. International Reviews of Immunology 39:3, pages 118-150.
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Weijuan Lou, Wenhui Li, Ming Yang, Chong Yuan, Rui Jing, Shunjie Chen & Cheng Fang. (2023) In-depth exploration of the shared genetic signature and molecular mechanisms between end-stage renal disease and osteoporosis. Frontiers in Genetics 14.
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Jinwu Bai, Weijun Zhang, Chenwei Zhou, Guangfeng Zhao, Huiming Zhong, Kai Hang, Jianxiang Xu, Wei Zhang, Erman Chen, Jiaqi Wu, Ling Liu & Deting Xue. (2023) MFG‐E8 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells through GSK3β/β‐catenin signaling pathway. The FASEB Journal 37:6.
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Brian A. Perrino, Justin Malogan, Caroline A. Cobine & Kent C. Sasse. (2023) Mfge8 is expressed by pericytes in gastric antrum submucosa from patients with obesity. American Journal of Physiology-Cell Physiology 324:5, pages C992-C1006.
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Jeffrey T. Bagdanoff, Thomas M. Smith, Martin Allan, Peter O’Donnell, Zachary Nguyen, Elizabeth A. Moore, Jason Baird, Shuangxi Wang, Vanitha Subramanian, Bruno Tigani, David O. Nettleton, Lauren G. Monovich, Ian Lewis, Alec N. Flyer, Brian Granda, John W. Blankenship, David Barnes-Seeman & Kevin B. Clairmont. (2023) Clearance of plasma PCSK9 via the asialoglycoprotein receptor mediated by heterobifunctional ligands. Cell Chemical Biology 30:1, pages 97-109.e9.
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Orhan KARAYİĞİT, Serdar Gökhan NURKOÇ & Funda BAŞYIĞIT. (2022) Association between serum MFG-E8 levels and coronary severity index in patients with acute coronary syndromeAkut koroner sendrom hastalarında koroner arter hastalığı ciddiyeti ile serum MFG-E8 düzeyleri arasındaki ilişki. Turkish Journal of Clinics and Laboratory 13:4, pages 463-469.
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Yun Xiao, Ying Tang, Xiao Shu, Jinshuo Zhu, Xinan Wu & Yuan Zhang. (2022) Milk fat-globule epidermal growth factor 8: A potential Regulator of Cutaneous Wound Healing. Molecular Biology Reports 49:9, pages 8883-8893.
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Teodor Svedung Wettervik, Dick Folkvaljon, Torsten Gordh, Eva Freyhult, Kim Kultima, Hans Ericson & Sami Abu Hamdeh. (2022) Cerebrospinal Fluid in Classical Trigeminal Neuralgia: An Exploratory Study on Candidate Biomarkers. Biomedicines 10:5, pages 998.
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Desirae Chandran, Alexandra ConfairKaitlyn Warren, Yuka Imamura KawasawaSteven D. Hicks. (2022) Maternal Variants in the MFGE8 Gene are Associated with Perceived Breast Milk Supply . Breastfeeding Medicine 17:4, pages 331-340.
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Lin Yuan, Mengjie Li, Zhishuai Zhang, Wanli Li, Wei Jin & Mingfa Wang. (2021) Camostat mesilate inhibits pro-inflammatory cytokine secretion and improves cell viability by regulating MFGE8 and HMGN1 in lipopolysaccharide-stimulated DF-1 chicken embryo fibroblasts. PeerJ 9, pages e12053.
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Wen Li, Ashley Olseen, Yeming Xie, Cristina Alexandru, Andrew Outland, Angela F. Herrera, Andrew J. Syder, Jill Wykosky & Brian A. Perrino. (2021) Mfge8 attenuates human gastric antrum smooth muscle contractions. Journal of Muscle Research and Cell Motility.
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Victor Delprat & Carine Michiels. (2021) A bi-directional dialog between vascular cells and monocytes/macrophages regulates tumor progression. Cancer and Metastasis Reviews 40:2, pages 477-500.
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Ritwik Datta, Carlos O. LizamaAmin K. Soltani, William MckleroyMichael J. PodolskyChristopher D. Yang, Tony L. Huynh, Kelly M. CautivoBiao Wang, Suneil K. KoliwadNada A. Abumrad & Kamran Atabai. (2021) Autoregulation of insulin receptor signaling through MFGE8 and the αvβ5 integrin. Proceedings of the National Academy of Sciences 118:18.
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Yifan Ren, Wuming Liu, Lin zhang, Jia Zhang, Jianbin Bi, Tao Wang, Mengzhou Wang, Zhaoqing Du, Yawen Wang, Lin zhang, Zheng Wu, Yi Lv, Lingzhong Meng & Rongqian Wu. (2021) Milk fat globule EGF factor 8 restores mitochondrial function via integrin‐medicated activation of the FAK‐STAT3 signaling pathway in acute pancreatitis. Clinical and Translational Medicine 11:2.
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Yunxiang Zhou, Yihan Yao, Yongchuan Deng & Anwen Shao. (2020) Regulation of efferocytosis as a novel cancer therapy. Cell Communication and Signaling 18:1.
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Wei Huang, Jinyu Jiao, Ju Liu, Meng Huang, Yanyan Hu, Wenzhuo Ran, Li Yan, Yin Xiong, Mei Li, Ziyao Quan, Yahua Rao, Jiayi Chen, Yan Huang & Dongxin Zhang. (2020) MFG-E8 accelerates wound healing in diabetes by regulating “NLRP3 inflammasome-neutrophil extracellular traps” axis. Cell Death Discovery 6:1.
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Emilio Boada-Romero, Jennifer Martinez, Bradlee L. Heckmann & Douglas R. Green. (2020) The clearance of dead cells by efferocytosis. Nature Reviews Molecular Cell Biology 21:7, pages 398-414.
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Duck Sung Ko, Su Hyun Kim, Ji Young Park, Gyunggyu Lee, Hyo Jin Kim, Gyeongmin Kim, Kyun You Chi, Ilsoo Kim, Jinseok Lee, Kyu-Yeoun Won, Jiyou Han, Jeongsang Son, Dong-Hun Woo, Choongseong Han & Jong-Hoon Kim. (2020) Milk Fat Globule-EGF Factor 8 Contributes to Progression of Hepatocellular Carcinoma. Cancers 12:2, pages 403.
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Feihu Chen, Hao Liu, Jie Xia, Xiaomin Ding, Jianbo Fan, Xinhui Zhu, Shengyu Cui, Hong Yi, Rufeng Gao & Wei Liu. (2019) Synovial fluid and plasma levels of milk fat globule–epidermal growth factor 8 are inversely correlated with radiographic severity of knee osteoarthritis. Journal of International Medical Research 47:9, pages 4422-4430.
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Cletus Cheyuo, Monowar Aziz & Ping Wang. (2019) Neurogenesis in Neurodegenerative Diseases: Role of MFG-E8. Frontiers in Neuroscience 13.
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Lifeng Yu, Lin Zhao, Zhen Jia, Jia Bi, Qian Wei, Xinyue Song, Longyang Jiang, Shu Lin & Minjie Wei. (2019) MFG-E8 overexpression is associated with poor prognosis in breast cancer patients. Pathology - Research and Practice 215:3, pages 490-498.
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Leilei Liu, Cheng Cheng, Dongdong Zhang, Ruiyuan Zhang, Yu Liu, Xizhuo Sun, Zhaoxia Yin, Honghui Li, Yang Zhao, Bingyuan Wang, Yongcheng Ren, Xuejiao Liu, Dechen Liu, Feiyan Liu, Xu Chen, Qionggui Zhou, Yihan Xiong, Qihuan Xu, Jiali Liu, Shihao Hong, Ziyang You, Dongsheng Hu & Ming Zhang. (2018) MFGE8 polymorphisms are significantly associated with metabolism-related indicators rather than metabolic syndrome in Chinese people: A nested case–control study. Gene 677, pages 176-181.
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Yueqin Wang, Guangwei Luo, Jie Chen, Rui Jiang, Jianhua Zhu, Na Hu, Wei Huang, Guilian Cheng, Min Jia, Bingtao Su, Nian Zhang & Tianpen Cui. (2017) Cigarette smoke attenuates phagocytic ability of macrophages through down-regulating Milk fat globule-EGF factor 8 (MFG-E8) expressions. Scientific Reports 7:1.
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Amitava Das, Subhadip Ghatak, Mithun Sinha, Scott Chaffee, Noha S. Ahmed, Narasimham L. Parinandi, Eric S. Wohleb, John F. Sheridan, Chandan K. Sen & Sashwati Roy. (2016) Correction of MFG-E8 Resolves Inflammation and Promotes Cutaneous Wound Healing in Diabetes. The Journal of Immunology 196:12, pages 5089-5100.
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Fei Liu, Yujie Chen, Qin Hu, Bo Li, Junjia Tang, Yue He, Zongduo Guo, Hua Feng, Jiping Tang & John H. Zhang. (2015) MFGE8/Integrin ?3 pathway alleviates apoptosis and inflammation in early brain injury after subarachnoid hemorrhage in rats. Experimental Neurology 272, pages 120-127.
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Jinwu Bai, Weijun Zhang, Kai Hang, Guangfeng Zhao, Huiming Zhong, Chenwei Zhou, Jianxiang Xu, Wei Zhang, Erman Chen, Jiaqi Wu, Ling Liu & Deting Xue. (2021) MFG-E8, a Novel Target of Promoting Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells. SSRN Electronic Journal.
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