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New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease

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Davide Seripa, Vincenzo Solfrizzi, Bruno P. Imbimbo, Antonio Daniele, Andrea Santamato, Madia Lozupone, Giovanni Zuliani, Antonio Greco, Giancarlo Logroscino & Francesco Panza. (2016) Tau-directed approaches for the treatment of Alzheimer’s disease: focus on leuco-methylthioninium. Expert Review of Neurotherapeutics 16:3, pages 259-277.
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Miguel Medina & Jesús Avila. (2015) Further understanding of tau phosphorylation: implications for therapy. Expert Review of Neurotherapeutics 15:1, pages 115-122.
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Alena V. Savonenko, Philip C. Wong & Tong Li. 2023. Neurobiology of Brain Disorders. Neurobiology of Brain Disorders 313 336 .
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Abdalla M. Albeely, Olivia O. F. Williams & Melissa L. Perreault. (2021) GSK-3β Disrupts Neuronal Oscillatory Function to Inhibit Learning and Memory in Male Rats. Cellular and Molecular Neurobiology 42:5, pages 1341-1353.
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Ryszard Pluta & Marzena Ulamek-Koziol. 2020. Alzheimer’s Disease: Drug Discovery. Alzheimer’s Disease: Drug Discovery 69 82 .
Liping Chen, Hanbo Pan, Yujing Bai, Huiqin Li, Wen Yang, Zhi-Xiu Lin, Wei Cui & Yan-Fang Xian. (2020) Gelsemine, a natural alkaloid extracted from Gelsemium elegans Benth. alleviates neuroinflammation and cognitive impairments in Aβ oligomer-treated mice. Psychopharmacology 237:7, pages 2111-2124.
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Li Lin, Sarmad Sheraz Jadoon, Shang-Zhi Liu, Ru-Yi Zhang, Fan Li, Mei-Ya Zhang, Tan Ai-Hua, Qiu-Yun You & Ping Wang. (2019) Tanshinone IIA Ameliorates Spatial Learning and Memory Deficits by Inhibiting the Activity of ERK and GSK-3β. Journal of Geriatric Psychiatry and Neurology 32:3, pages 152-163.
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Mu-N Liu, Chi-Ieong Lau & Ching-Po Lin. (2019) Precision Medicine for Frontotemporal Dementia. Frontiers in Psychiatry 10.
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Andrea Gamir-Morralla, Sandra Sacristán, Miguel Medina & Teresa Iglesias. (2019) Effects of Thioflavin T and GSK-3 Inhibition on Lifespan and Motility in a Caenorhabditis elegans Model of Tauopathy. Journal of Alzheimer's Disease Reports 3:1, pages 47-57.
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Jordan Rowlands, Julian Heng, Philip Newsholme & Rodrigo Carlessi. (2018) Pleiotropic Effects of GLP-1 and Analogs on Cell Signaling, Metabolism, and Function. Frontiers in Endocrinology 9.
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Li Lin, Jie Cao, Shu‐Sheng Yang, Zheng‐Qi Fu, Peng Zeng, Jiang Chu, Lin‐Na Ning, Teng Zhang, Yan Shi, Qing Tian, Xin‐Wen Zhou & Jian‐Zhi Wang. (2018) Endoplasmic reticulum stress induces spatial memory deficits by activating GSK ‐3 . Journal of Cellular and Molecular Medicine 22:7, pages 3489-3502.
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Anthony Flamier, Jida El Hajjar, James Adjaye, Karl J. Fernandes, Mohamed Abdouh & Gilbert Bernier. (2018) Modeling Late-Onset Sporadic Alzheimer’s Disease through BMI1 Deficiency. Cell Reports 23:9, pages 2653-2666.
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Miguel Medina. (2018) An Overview on the Clinical Development of Tau-Based Therapeutics. International Journal of Molecular Sciences 19:4, pages 1160.
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Yali Zhang, Jiahui Zhang, Enhao Wang, Wei Qian, Yan Fan, Ying Feng, Haimeng Yin, Yang Li, Yuning Wang & Tianli Yuan. (2018) Microcystin-Leucine-Arginine Induces Tau Pathology Through Bα Degradation via Protein Phosphatase 2A Demethylation and Associated Glycogen Synthase Kinase-3β Phosphorylation. Toxicological Sciences 162:2, pages 475-487.
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Zhi-Peng Xu, Guo-Sheng Gan, Yu-Min Liu, Jin-Song Xiao, Han-Xing Liu, Bin Mei & Jun-Jian Zhang. (2017) Adiponectin Attenuates Streptozotocin-Induced Tau Hyperphosphorylation and Cognitive Deficits by Rescuing PI3K/Akt/GSK-3β Pathway. Neurochemical Research 43:2, pages 316-323.
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Hans Zempel, Frank J.A. Dennissen, Yatender Kumar, Julia Luedtke, Jacek Biernat, Eva-Maria Mandelkow & Eckhard Mandelkow. (2017) Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture. Journal of Biological Chemistry 292:29, pages 12192-12207.
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Sufang Zhao, Jingyu Zhu, Lei Xu & Jian Jin. (2017) Theoretical studies on the selective mechanisms of GSK3? and CDK2 by molecular dynamics simulations and free energy calculations. Chemical Biology & Drug Design 89:6, pages 846-855.
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Isabel Gameiro, Patrycja Michalska, Giammarco Tenti, Ángel Cores, Izaskun Buendia, Ana I. Rojo, Nikolaos D. Georgakopoulos, Jesús M. Hernández-Guijo, María Teresa Ramos, Geoffrey Wells, Manuela G. López, Antonio Cuadrado, J. Carlos Menéndez & Rafael León. (2017) Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer’s disease. Scientific Reports 7:1.
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Anne E. Harasta & Lars M. Ittner. 2017. Neurodegenerative Diseases. Neurodegenerative Diseases 3 29 .
Yijun Shen, Yiling Xia, Shiquan Meng, Nastasia K.H. Lim, Wenan Wang & Fude Huang. (2016) SH2B1 is Involved in the Accumulation of Amyloid-β42 in Alzheimer’s Disease. Journal of Alzheimer's Disease 55:2, pages 835-847.
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Reginald C. Adiele & Chiedukam A. Adiele. (2016) Mitochondrial Regulatory Pathways in the Pathogenesis of Alzheimer’s Disease. Journal of Alzheimer's Disease 53:4, pages 1257-1270.
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Chih-Hsin Lin, Yu-Shao Hsieh, Yih-Ru Wu, Chia-Jen Hsu, Hsuan-Chiang Chen, Wun-Han Huang, Kuo-Hsuan Chang, Hsiu Mei Hsieh-Li, Ming-Tsan Su, Ying-Chieh Sun, Guan-Chiun Lee & Guey-Jen Lee-Chen. (2016) Identifying GSK-3β kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays. European Journal of Pharmaceutical Sciences 89, pages 11-19.
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Dilan Athauda & Thomas Foltynie. (2016) The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action. Drug Discovery Today 21:5, pages 802-818.
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Illana Gozes & Yanina Ivashko-Pachima. (2015) ADNP: in search for molecular mechanisms and innovative therapeutic strategies for frontotemporal degeneration. Frontiers in Aging Neuroscience 7.
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Gao-feng ZengShao-hui ZongZhi-yong ZhangSong-wen FuKe-ke LiYe FangLi LuDe-qiang Xiao. (2015) The Role of 6-Gingerol on Inhibiting Amyloid β Protein-Induced Apoptosis in PC12 Cells. Rejuvenation Research 18:5, pages 413-421.
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T T Quach, J Honnorat, P E Kolattukudy, R Khanna & A M Duchemin. (2015) CRMPs: critical molecules for neurite morphogenesis and neuropsychiatric diseases. Molecular Psychiatry 20:9, pages 1037-1045.
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N. Nuray Ulusu. (2015) Glucose-6-phosphate dehydrogenase deficiency and Alzheimer’s disease: Partners in crime? The hypothesis. Medical Hypotheses 85:2, pages 219-223.
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Cristina Tintori, Giuseppina La Sala, Giulia Vignaroli, Lorenzo Botta, Anna Lucia Fallacara, Federico Falchi, Marco Radi, Claudio Zamperini, Elena Dreassi, Lucia Dello Iacono, Donata Orioli, Giuseppe Biamonti, Mirko Garbelli, Andrea Lossani, Francesca Gasparrini, Tiziano Tuccinardi, Ilaria Laurenzana, Adriano Angelucci, Giovanni Maga, Silvia Schenone, Chiara Brullo, Francesca Musumeci, Andrea Desogus, Emmanuele Crespan & Maurizio Botta. (2015) Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors. Journal of Medicinal Chemistry 58:11, pages 4590-4609.
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Kathlyn J. Gan, Takashi Morihara & Michael A. Silverman. (2015) Atlas stumbled : Kinesin light chain-1 variant E triggers a vicious cycle of axonal transport disruption and amyloid-β generation in Alzheimer's disease . BioEssays 37:2, pages 131-141.
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Yixuan Wang, Riyun Yang, Jianlan Gu, Xiaomin Yin, Nana Jin, Shutao Xie, Yifan Wang, Huanhuan Chang, Wei Qian, Jianhua Shi, Khalid Iqbal, Cheng-Xin Gong, Chun Cheng & Fei Liu. (2015) Cross talk between PI3K-AKT-GSK-3? and PP2A pathways determines tau hyperphosphorylation. Neurobiology of Aging 36:1, pages 188-200.
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Kazuhiko Namekata, Atsuko Kimura, Kazuto Kawamura, Chikako Harada & Takayuki Harada. (2014) Dock GEFs and their therapeutic potential: Neuroprotection and axon regeneration. Progress in Retinal and Eye Research 43, pages 1-16.
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Zhi-Peng Xu, Li Li, Jian Bao, Zhi-Hao Wang, Juan Zeng, En-Jie Liu, Xiao-Guang Li, Rong-Xi Huang, Di Gao, Meng-Zhu Li, Yao Zhang, Gong-Ping Liu & Jian-Zhi Wang. (2014) Magnesium Protects Cognitive Functions and Synaptic Plasticity in Streptozotocin-Induced Sporadic Alzheimer?s Model. PLoS ONE 9:9, pages e108645.
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Gang Fu, Prasanna Sivaprakasam, Olivia R. Dale, Susan P. Manly, Stephen J. Cutler & Robert J. Doerksen. (2014) Pharmacophore Modeling, Ensemble Docking, Virtual Screening, and Biological Evaluation on Glycogen Synthase Kinase‐3β. Molecular Informatics 33:9, pages 610-626.
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Sandra Tenreiro, Katrin Eckermann & Tiago F. Outeiro. (2014) Protein phosphorylation in neurodegeneration: friend or foe?. Frontiers in Molecular Neuroscience 7.
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Jean-Marie Sontag & Estelle Sontag. (2014) Protein phosphatase 2A dysfunction in Alzheimer’s disease. Frontiers in Molecular Neuroscience 7.
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