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Expert Opinion on Therapeutic Targets Volume 18, 2014 - Issue 9
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Eukaryotic translation initiation factor 4E as a novel therapeutic target in hematological malignancies and beyond

Filippa PetterssonMcGill University, Lady Davis Institute for Medical Research, Jewish General Hospital, Segal Cancer Centre, Montreal, Quebec H3T 1E2, Canada+1 514 340 8222, Ext. 4365; +1 514 340 8717; [email protected]
, PhD,
Sonia V del RinconMcGill University, Lady Davis Institute for Medical Research, Jewish General Hospital, Segal Cancer Centre, Montreal, Quebec H3T 1E2, Canada+1 514 340 8222, Ext. 4365; +1 514 340 8717; [email protected]
, PhD &
Wilson H Miller Jr
, MD PhD
Pages 1035-1048 | Published online: 08 Jul 2014

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Sara Mongiorgi, Carlo Finelli, Yong Ryoul Yang, Cristina Clissa, James A. McCubrey, Anna Maria Billi, Lucia Manzoli, Pann-Ghill Suh, Lucio Cocco & Matilde Y. Follo. (2016) Inositide-dependent signaling pathways as new therapeutic targets in myelodysplastic syndromes. Expert Opinion on Therapeutic Targets 20:6, pages 677-687.
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Suyin Ge, Qingqing Zhang, Yonglin Chen, Yizhen Tian, Ruiying Yang, Xu Chen, Fang Li & Baolai Zhang. (2021) Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation. Toxicology and Applied Pharmacology 415, pages 115450.
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Peiqi Hao, Jiaojiao Yu, Richard Ward, Yin Liu, Qiao Hao, Su An & Tianrui Xu. (2020) Eukaryotic translation initiation factors as promising targets in cancer therapy. Cell Communication and Signaling 18:1.
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Laiquan Huang, Zhongling Wei, Xiangxiang Chang, Xinyuan Zheng, Jiawei Yan, Jun Huang, Jun Zhang & Lili Sheng. (2020) eIF3b regulates the cell proliferation and apoptosis processes in chronic myelogenous leukemia cell lines via regulating the expression of C3G. Biotechnology Letters 42:7, pages 1275-1286.
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Andrew J. Link, Xinnan Niu, Connie M. Weaver, Jennifer L. Jennings, Dexter T. Duncan, K. Jill McAfee, Morgan Sammons, Vince R. Gerbasi, Adam R. Farley, Tracey C. Fleischer, Christopher M. Browne, Parimal Samir, Allison Galassie & Braden Boone. (2020) Targeted Identification of Protein Interactions in Eukaryotic mRNA Translation. PROTEOMICS 20:7, pages 1900177.
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Xuan Zhang, Chengfeng Bi, Ting Lu, Weiwei Zhang, Ting Yue, Cheng Wang, Tian Tian, Xiaoyan Zhang, Yuhua Huang, Matthew Lunning, Xinbao Hao, Lauren E. Brown, William G. Devine, Julie Vose, John A. PorcoJr.Jr. & Kai Fu. (2019) Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas. Leukemia 34:1, pages 138-150.
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Benjin Cao, Meng Duan, Yang Xing, Chanjuan Liu, Fan Yang, Yinan Li, Tianxiao Yang, Yuanyan Wei, Qiang Gao & Jianhai Jiang. (2019) O‐GlcNAc transferase activates stem‐like cell potential in hepatocarcinoma through O‐GlcNAcylation of eukaryotic initiation factor 4E. Journal of Cellular and Molecular Medicine 23:4, pages 2384-2398.
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Senthilmurugan Ramalingam, Vidya Ramamurthy, Lalji Gediya, Francis Murigi, Puranik Purushottamachar, Weiliang Huang, Eun Choi, Yuji Zhang, Tadas Vasaitis, Maureen Kane, Rena Lapidus & Vincent Njar. (2019) The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis. Cancers 11:3, pages 299.
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F Volpin, J Casaos, J Sesen, A Mangraviti, J Choi, N Gorelick, J Frikeche, T Lott, R Felder, S J Scotland, T S K Eisinger-Mathason, H Brem, B Tyler & N Skuli. (2016) Use of an anti-viral drug, Ribavirin, as an anti-glioblastoma therapeutic. Oncogene 36:21, pages 3037-3047.
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Yongxiang Zhao, Mingyu Yan, Ye Yun, Jianguo Zhang, Ruimin Zhang, Yan Li, Xiangming Wu, Qiang Liu, Wei Miao & Haishan Jiang. (2017) MicroRNA-455-3p functions as a tumor suppressor by targeting eIF4E in prostate cancer. Oncology Reports.
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Y. J. Choi, Y. S. Lee, H. W. Lee, D. M. Shim & S. W. Seo. (2017) Silencing of translation initiation factor eIF3b promotes apoptosis in osteosarcoma cells. Bone & Joint Research 6:3, pages 186-193.
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Xue-Mei Jiang, Xiang-Nan Yu, Ren-Zheng Huang, Hai-Rong Zhu, Xiao-Peng Chen, Ju Xiong, Zheng-Yi Chen, Xiao-Xi Huang, Xi-Zhong Shen & Ji-Min Zhu. (2016) Prognostic significance of eukaryotic initiation factor 4E in hepatocellular carcinoma. Journal of Cancer Research and Clinical Oncology 142:11, pages 2309-2317.
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Bing Chen, Jin Zhao, Shengbin Zhang, Yonggang Zhang & Zonghai Huang. (2016) HPIP promotes gastric cancer cell proliferation through activation of cap-dependent translation. Oncology Reports.
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S Diamanti, N Nikitakis, G Rassidakis, I Doulis & A Sklavounou. (2016) Immunohistochemical evaluation of the mTOR pathway in intra-oral minor salivary gland neoplasms. Oral Diseases 22:7, pages 620-629.
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Elena Martínez‐Sáez, Vicente Peg, Arantxa Ortega‐Aznar, Francisco Martínez‐Ricarte, Jessica Camacho, Javier Hernández‐Losa, Joan Carles Ferreres Piñas & Santiago Ramón y Cajal. (2016) peIF4E as an independent prognostic factor and a potential therapeutic target in diffuse infiltrating astrocytomas. Cancer Medicine 5:9, pages 2501-2512.
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Emilie Horvilleur, Lindsay A. Wilson, Amandine Bastide, David Piñeiro, Tuija A. A. Pöyry & Anne E. Willis. (2015) Cap-Independent Translation in Hematological Malignancies. Frontiers in Oncology 5.
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Sougat Misra, Marita Wallenberg, Ola Brodin & Mikael Björnstedt. 2015. Diversity of Selenium Functions in Health and Disease. Diversity of Selenium Functions in Health and Disease 109 136 .

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