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Targeting 5-lipoxygenase-activating protein in asthma and chronic obstructive pulmonary disease

, MD PhD

Keep up to date with the latest research on this topic with citation updates for this article.

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Oliver Werz, Jana Gerstmeier & Ulrike Garscha. (2017) Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents. Expert Opinion on Therapeutic Patents 27:5, pages 607-620.
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Hock Tay, Peter A. B. Wark & Nathan W. Bartlett. (2016) Advances in the treatment of virus-induced asthma. Expert Review of Respiratory Medicine 10:6, pages 629-641.
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Articles from other publishers (10)

Hafiza Aliza Khan & Ishrat Jabeen. (2022) Combined Machine Learning and GRID-Independent Molecular Descriptor (GRIND) Models to Probe the Activity Profiles of 5-Lipoxygenase Activating Protein Inhibitors. Frontiers in Pharmacology 13.
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Guiping Tu, Zijian Qin, Donghui Huo, Shengde Zhang & Aixia Yan. (2020) Fingerprint‐based computational models of 5‐lipo‐oxygenase activating protein inhibitors: Activity prediction and structure clustering. Chemical Biology & Drug Design 96:3, pages 931-947.
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Madhuranayaki Thulasingam & Jesper Z. Haeggström. (2020) Integral Membrane Enzymes in Eicosanoid Metabolism: Structures, Mechanisms and Inhibitor Design. Journal of Molecular Biology 432:18, pages 4999-5022.
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Abdurrahman Olgac, Andrea Carotti, Christian Kretzer, Stephanie Zergiebel, Andreas Seeling, Ulrike Garscha, Oliver Werz, Antonio Macchiarulo & Erden Banoglu. (2020) Discovery of Novel 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors by Exploiting a Multistep Virtual Screening Protocol. Journal of Chemical Information and Modeling 60:3, pages 1737-1748.
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Tapan Dey, Jatin Kalita, Sinéad Weldon & Clifford Taggart. (2018) Proteases and Their Inhibitors in Chronic Obstructive Pulmonary Disease. Journal of Clinical Medicine 7:9, pages 244.
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Zehra Tuğçe Gür, Burcu Çalışkan & Erden Banoglu. (2018) Drug discovery approaches targeting 5-lipoxygenase-activating protein (FLAP) for inhibition of cellular leukotriene biosynthesis. European Journal of Medicinal Chemistry 153, pages 34-48.
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Yi Xu, Xi Su, Xiaodan Zhang, Shunbo Li & Li Chen. (2018) Suppression activity analysis of 5- lipoxygenase from Chinese herbal extracts by designed 3D array microfluidic chip. Suppression activity analysis of 5- lipoxygenase from Chinese herbal extracts by designed 3D array microfluidic chip.
Otylia Kowal-Bielecka, Sylwia Chwiesko-Minarowska, Pawel L. Bernatowicz, Yannick Allanore, Timothy Radstake, Marco Matucci-Cerinic, Jasper Broen, Roger Hesselstrand, Dorota Krasowska, Gabriella Riemekasten, Madelon Vonk, Oksana Kowalczuk, Marek Bielecki, Robert Milewski, Lech Chyczewski, Jacek Niklinski & Krzysztof Kowal. (2017) The arachidonate 5-lipoxygenase activating protein gene polymorphism is associated with the risk of scleroderma-related interstitial lung disease: a multicentre European Scleroderma Trials and Research group (EUSTAR) study. Rheumatology 56:5, pages 844-852.
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Ben A. Chindo, Helmut Schröder, Andreas Koeberle, Oliver Werz & Axel Becker. (2016) Analgesic potential of standardized methanol stem bark extract of Ficus platyphylla in mice: Mechanisms of action. Journal of Ethnopharmacology 184, pages 101-106.
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Daniel Pettersen, Öjvind Davidsson & Carl Whatling. (2015) Recent advances for FLAP inhibitors. Bioorganic & Medicinal Chemistry Letters 25:13, pages 2607-2612.
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