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Molecular targeting of the GK-GKRP pathway in diabetes

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Yixin Ren, Li Li, Li Wan, Yan Huang & Shuang Cao. (2022) Glucokinase as an emerging anti-diabetes target and recent progress in the development of its agonists. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 606-615.
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Articles from other publishers (16)

Ziqi Zhang, Guang Ji & Meng Li. (2023) Glucokinase regulatory protein: a balancing act between glucose and lipid metabolism in NAFLD. Frontiers in Endocrinology 14.
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R. Mata, L. Flores-Bocanegra, B. Ovalle-Magallanes & M. Figueroa. (2023) Natural products from plants targeting key enzymes for the future development of antidiabetic agents. Natural Product Reports 40:7, pages 1198-1249.
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Masaki Kimura, Takuma Iguchi, Kentaro Iwasawa, Andrew Dunn, Wendy L. Thompson, Yosuke Yoneyama, Praneet Chaturvedi, Aaron M. Zorn, Michelle Wintzinger, Mattia Quattrocelli, Miki Watanabe-Chailland, Gaohui Zhu, Masanobu Fujimoto, Meenasri Kumbaji, Asuka Kodaka, Yevgeniy Gindin, Chuhan Chung, Robert P. Myers, G. Mani Subramanian, Vivian Hwa & Takanori Takebe. (2022) En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH. Cell 185:22, pages 4216-4232.e16.
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Hilla Mills, Ronald Acquah, Nova Tang, Luke Cheung, Susanne Klenk, Ronald Glassen, Magali Pirson, Alain Albert, Duong Trinh Hoang & Thang Nguyen Van. (2022) Type 2 Diabetes Mellitus (T2DM) and Carbohydrate Metabolism in Relation to T2DM from Endocrinology, Neurophysiology, Molecular Biology, and Biochemistry Perspectives. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-11.
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Ximing Liu, Ying Bai, Ran Cui, Shuaihan He, Xingbo Zhao, Keliang Wu & Meiying Fang. (2022) Sus_circPAPPA2 Regulates Fat Deposition in Castrated Pigs through the miR-2366/GK Pathway. Biomolecules 12:6, pages 753.
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Dan Li, Sen Yang, Hai-yan Ding, Hong-ping Chen, You-ping Liu & Yuan Hu. (2021) Hypoglycemic and Hepatoprotective Effects of Dried and Rice-Fried Psidium guajava Leaves in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-9.
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Akinobu Nakamura, Kazuno Omori & Yasuo Terauchi. (2021) Glucokinase activation or inactivation: Which will lead to the treatment of type 2 diabetes?. Diabetes, Obesity and Metabolism 23:10, pages 2199-2206.
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Klara R. Klein, Jennifer L.R. Freeman, Imogene Dunn, Chris Dvergsten, M. Sue Kirkman, John B. Buse, Carmen Valcarce, John B. Buse, Klara R. Klein, M. Sue Kirkman, Katherine A. Bergamo, Elizabeth H. Harris, Jean M. Dostou, Laura A. Young, Sriram Machineni, Alex M. Kass, Jamie C. Diner, Milana Dezube, Virginia C. Purrington, Julie M. Uehling, Rachael M. Fraser, Katherine R. Schuch, Jennifer V. Rowell, Ali Qamar, K. Jean Lucas, Luke Snedaker, Stephanie Hoover, Justin Smith, Paul Becton, Jeffrey Hainsworth, Timothy S. Bailey, Juan Pablo Garcia-Naranjo, Niki Nguyen, Bruce W. Bode, Jennifer M. Boyd, Betsy Childs, Pablo Mora, Allison Camacho, Carl D. Vance, Karen Lugo, Anuj Bhargava, Kirstie Stifel, Lisa B. Connery, Birjis Khan, Simone D. Smith, John Parker, Kathryn Zweier, Emily Kronenfeld, Brittany Savoca, Viral N. Shah, Prakriti Joshee, Shivani Dixit, Hal Joseph, Halis Kaan Akturk, Subbulaxami Trikudanathan, Dori Khakpour, Julia Chang, Anne Peters, Pejman Cohan, Mark Harmel & Wendy S . Lane. (2021) The SimpliciT1 Study: A Randomized, Double-Blind, Placebo-Controlled Phase 1b/2 Adaptive Study of TTP399, a Hepatoselective Glucokinase Activator, for Adjunctive Treatment of Type 1 Diabetes. Diabetes Care 44:4, pages 960-968.
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Meng Li, Yanqi Dang, Qiong Li, Wenjun Zhou, Jianping Zuo, Zemin Yao, Li Zhang & Guang Ji. (2019) Berberine alleviates hyperglycemia by targeting hepatic glucokinase in diabetic db/db mice. Scientific Reports 9:1.
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Adrian Vella, Jennifer L. R. FreemanImogene DunnKit KellerJohn B. BuseCarmen Valcarce. (2019) Targeting hepatic glucokinase to treat diabetes with TTP399, a hepatoselective glucokinase activator. Science Translational Medicine 11:475.
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Angel Gutierrez-Nogués, Carmen-María García-Herrero, Josep Oriola, Olivier Vincent & María-Angeles Navas. (2018) Functional characterization of MODY2 mutations in the nuclear export signal of glucokinase. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:7, pages 2385-2394.
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Zhengyu Wang, Xiaofan Shi, Huan Zhang, Liang Yu, Yanhua Cheng, Hefeng Zhang, Huibin Zhang, Jinpei Zhou, Jing Chen, Xu Shen & Wenhu Duan. (2017) Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation. European Journal of Medicinal Chemistry 139, pages 128-152.
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Jiayi Xu, Songnian Lin, Robert W. Myers, Maria E. Trujillo, Michele J. Pachanski, Sunita Malkani, Hsuan-shen Chen, Zhesheng Chen, Brian Campbell, George J. Eiermann, Nadine Elowe, Brian T. Farrer, Wen Feng, Qinghong Fu, Roman Kats-Kagan, Michael Kavana, Daniel R. McMasters, Kaushik Mitra, Xinchun Tong, Libo Xu, Fengqi Zhang, Rui Zhang, George H. Addona, Joel P. Berger, Bei Zhang & Emma R. Parmee. (2017) Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus. Bioorganic & Medicinal Chemistry Letters 27:9, pages 2063-2068.
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Nynke Simons, Jacqueline M. Dekker, Marleen M.J. van Greevenbroek, Giel Nijpels, Leen M. ’t Hart, Carla J.H. van der Kallen, Casper G. Schalkwijk, Nicolaas C. Schaper, Coen D.A. Stehouwer & Martijn C.G.J. Brouwers. (2016) A Common Gene Variant in Glucokinase Regulatory Protein Interacts With Glucose Metabolism on Diabetic Dyslipidemia: the Combined CODAM and Hoorn Studies. Diabetes Care 39:10, pages 1811-1817.
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Hao He, Wan-Guo Yu, Jun-peng Yang, Sheng Ge & Yan-Hua Lu. (2015) Multiple Comparisons of Glucokinase Activation Mechanisms of Five Mulberry Bioactive Ingredients in Hepatocyte. Journal of Agricultural and Food Chemistry 64:12, pages 2475-2484.
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P. M. Rubtsov, E. L. Igudin & A. N. Tiulpakov. (2015) Glucokinase and glucokinase regulatory proteins as molecular targets for novel antidiabetic drugs. Molecular Biology 49:4, pages 494-499.
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