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Expert Opinion on Therapeutic Targets Volume 19, 2015 - Issue 5
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Review

Targeting the 5′-AMP-activated protein kinase and related metabolic pathways for the treatment of prostate cancer

Petra PopovicsVeterans Affairs Medical Center and South Florida Veterans Affairs Foundation for Research and Education, Research (151) 2A127, 1201 NW 16th St, Miami, FL 33125, USA+1 305 5753477; +1 305 5753126; [email protected];University of Miami, Miller School of Medicine, Division of Cardiovascular Diseases, Department of Medicine, Miami, FL 33136, USA;Department of Medicine III, Medical Faculty Carl Gustav Carus, D-01307 TU Dresden, Germany
,
Daniel E FrigoUniversity of Houston, Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, Houston, TX 77204, USA;Houston Methodist Research Institute, Genomic Medicine Program, Houston, TX 77030, USA
,
Andrew V SchallyVeterans Affairs Medical Center and South Florida Veterans Affairs Foundation for Research and Education, Research (151) 2A127, 1201 NW 16th St, Miami, FL 33125, USA+1 305 5753477; +1 305 5753126; [email protected];University of Miami, Miller School of Medicine, Division of Hematology/Oncology, Department of Medicine, Miami, FL 33136, USA;University of Miami, Miller School of Medicine, Division of Endocrinology, Department of Medicine, Miami, FL 33136, USA
&
Ferenc G RickVeterans Affairs Medical Center and South Florida Veterans Affairs Foundation for Research and Education, Research (151) 2A127, 1201 NW 16th St, Miami, FL 33125, USA+1 305 5753477; +1 305 5753126; [email protected];Florida International University, Herbert Wertheim College of Medicine, Department of Urology, Miami, FL 33199, USA
, MD PhD
Pages 617-632 | Published online: 20 Jan 2015

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Rakesh Kumar, Ranjana Maurya & Shweta Saran. (2019) Introducing a simple model system for binding studies of known and novel inhibitors of AMPK: a therapeutic target for prostate cancer. Journal of Biomolecular Structure and Dynamics 37:3, pages 781-795.
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Yashmin Choudhury, Ian P Salt & Hing Y Leung. (2015) AMPK—friend or foe for targeted therapy?. Cell Cycle 14:12, pages 1761-1762.
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Articles from other publishers (22)

Kun Zheng, Suzhen Chen & Xiaoyong Hu. (2022) Peroxisome Proliferator-activated Receptor Gamma Coactivator-1 Alpha: A Double-edged Sword in Prostate Cancer. Current Cancer Drug Targets 22:7, pages 541-559.
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Soghra Bagheri, Mahdie Rahban, Fatemeh Bostanian, Fatemeh Esmaeilzadeh, Arash Bagherabadi, Samaneh Zolghadri & Agata Stanek. (2022) Targeting Protein Kinases and Epigenetic Control as Combinatorial Therapy Options for Advanced Prostate Cancer Treatment. Pharmaceutics 14:3, pages 515.
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Clara Lemos, Volker K. Schulze, Simon J. Baumgart, Ekaterina Nevedomskaya, Tobias Heinrich, Julien Lefranc, Benjamin Bader, Clara D. Christ, Hans Briem, Lara P. Kuhnke, Simon J. Holton, Ulf Bömer, Philip Lienau, Franz von Nussbaum, Carl F. Nising, Marcus Bauser, Andrea Hägebarth, Dominik Mumberg & Bernard Haendler. (2021) The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models. Cellular Oncology 44:3, pages 581-594.
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Antonio Villalobo & Martin W. Berchtold. (2020) The Role of Calmodulin in Tumor Cell Migration, Invasiveness, and Metastasis. International Journal of Molecular Sciences 21:3, pages 765.
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Zhenwei Tang, Wenrui Ye, Haotian Chen, Xinwei Kuang, Jia Guo, Minmin Xiang, Cong Peng, Xiang Chen & Hong Liu. (2019) Role of purines in regulation of metabolic reprogramming. Purinergic Signalling 15:4, pages 423-438.
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Kevin Gonthier, Raghavendra Tejo Karthik Poluri, Cindy Weidmann, Maude Tadros & Étienne Audet-Walsh. (2019) Reprogramming of Isocitrate Dehydrogenases Expression and Activity by the Androgen Receptor in Prostate Cancer. Molecular Cancer Research 17:8, pages 1699-1709.
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Toby A. Dite, Christopher G. Langendorf, Ashfaqul Hoque, Sandra Galic, Richard J. Rebello, Ashley J. Ovens, Lisa M. Lindqvist, Kevin R.W. Ngoei, Naomi X.Y. Ling, Luc Furic, Bruce E. Kemp, John W. Scott & Jonathan S. Oakhill. (2018) AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965. Journal of Biological Chemistry 293:23, pages 8874-8885.
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Alicia Bort, Sergio Quesada, Ágata Ramos-Torres, Marta Gargantilla, Eva María Priego, Sophie Raynal, Franck Lepifre, Jose M. Gasalla, Nieves Rodriguez-Henche, Ana Castro & Inés Díaz-Laviada. (2018) Identification of a novel 2-oxindole fluorinated derivative as in vivo antitumor agent for prostate cancer acting via AMPK activation. Scientific Reports 8:1.
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T Monteverde, J Tait-Mulder, A Hedley, J R Knight, O J Sansom & D J Murphy. (2017) Calcium signalling links MYC to NUAK1. Oncogene 37:8, pages 982-992.
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Ali Razaghi, Kirsten Heimann, Patrick M. Schaeffer & Spencer B. Gibson. (2018) Negative regulators of cell death pathways in cancer: perspective on biomarkers and targeted therapies. Apoptosis 23:2, pages 93-112.
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Mohamed A. Abu el Maaty, Hamed Alborzinia, Shehryar J. Khan, Michael Büttner & Stefan Wölfl. (2017) 1,25(OH)2D3 disrupts glucose metabolism in prostate cancer cells leading to a truncation of the TCA cycle and inhibition of TXNIP expression. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864:10, pages 1618-1630.
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Meihong Wong, Kohei Funasaka, Tomohiko Obayashi, Ryoji Miyahara, Yoshiki Hirooka, Michinari Hamaguchi, Hidemi Goto & Takeshi Senga. (2017) AMPD3 is associated with the malignant characteristics of gastrointestinal stromal tumors. Oncology Letters 13:3, pages 1281-1287.
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Ayesha S. Khan & Daniel E. Frigo. (2017) A spatiotemporal hypothesis for the regulation, role, and targeting of AMPK in prostate cancer. Nature Reviews Urology 14:3, pages 164-180.
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Huier Yuan, Yaqiu Hu, Yuzhang Zhu, Yongneng Zhang, Chaohuan Luo, Zhi Li, Tengfei Wen, Wanling Zhuang, Jinfang Zou, Liangli Hong, Xin Zhang, Ichiro Hisatome, Tetsuya Yamamoto & Jidong Cheng. (2017) Metformin ameliorates high uric acid-induced insulin resistance in skeletal muscle cells. Molecular and Cellular Endocrinology 443, pages 138-145.
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Claire Tonry, John Armstrong & Stephen Pennington. (2017) Probing the prostate tumour microenvironment II: Impact of hypoxia on a cell model of prostate cancer progression. Oncotarget 8:9, pages 15307-15337.
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Rohit A. SinhaBrijesh K. SinghPaul M. Yen. (2017) Reciprocal Crosstalk Between Autophagic and Endocrine Signaling in Metabolic Homeostasis. Endocrine Reviews 38:1, pages 69-102.
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Vishalakshi Nanjappa, Gajanan J. Sathe, Ankit P. Jain, Pavithra Rajagopalan, Remya Raja, Tejaswini Subbannayya, Arun H. Patil, Prashant Kumar, T. S. Keshava Prasad, Premendu Prakash Mathur, David Sidransky, Harsha Gowda & Aditi Chatterjee. (2017) Investigation of curcumin-mediated signalling pathways in head and neck squamous cell carcinoma. Translational Research in Oral Oncology 2, pages 2057178X1774314.
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Tim A. D. Smith, Su M. Phyu, Kholoud S. Alzyoud & Chih-Chung Tseng. (2017) Response Detection of Castrate-Resistant Prostate Cancer to Clinically Utilised and Novel Treatments by Monitoring Phospholipid Metabolism. BioMed Research International 2017, pages 1-7.
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SongTao Xiang, QiuHong Zhang, Qing Tang, Fang Zheng, JingJing Wu, LiJun Yang & Swei Sunny Hann. (2016) Activation of AMPKα mediates additive effects of solamargine and metformin on suppressing MUC1 expression in castration-resistant prostate cancer cells. Scientific Reports 6:1.
Crossref
Tao Huan, Dean A. Troyer & Liang Li. (2016) Metabolite Analysis and Histology on the Exact Same Tissue: Comprehensive Metabolomic Profiling and Metabolic Classification of Prostate Cancer. Scientific Reports 6:1.
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Da-Ming Liu, Hong-Jun Wang, Bo Han, Xiang-Qi Meng, Ming-Hui Chen, Dong-Bo Yang, Ying Sun, Yong-Li Li & Chuan-Lu Jiang. (2016) CAMKK2, Regulated by Promoter Methylation, is a Prognostic Marker in Diffuse Gliomas. CNS Neuroscience & Therapeutics 22:6, pages 518-524.
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Tiziana Monteverde, Nathiya Muthalagu, Jennifer Port & Daniel J. Murphy. (2015) Evidence of cancer-promoting roles for AMPK and related kinases. FEBS Journal 282:24, pages 4658-4671.
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