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The prolactin receptor as a therapeutic target in human diseases: browsing new potential indications

& (Professor at University Pierre et Marie Curie, Head of the Adult Endocrinology Department at Hôpital Pitié Salpêtrière)

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Ying Jiang, Huyan Chen, Jinran Lin, Jiewen Pan, Yanyun Shen & Qiao Li. (2023) Anti‐prolactin treatment alleviates lupus conditions by regulating the JAK2 – STAT3 pathway . Clinical and Experimental Pharmacology and Physiology 50:12, pages 936-943.
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Laia Cuesta-Casanovas, Jennifer Delgado-Martínez, Josep M. Cornet-Masana, José M. Carbó, Antònia Banús-Mulet, Francesca Guijarro, Jordi Esteve & Ruth M. Risueño. (2023) Prolactin receptor signaling induces acquisition of chemoresistance and reduces clonogenicity in acute myeloid leukemia. Cancer Cell International 23:1.
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E. A. Sukhareva & A. N. Somov. (2023) Dispensary group of women with benign diseases of the mammary glands: a school of prevention, observation, examination, treatment. Meditsinskiy sovet = Medical Council:5, pages 43-49.
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Rosa Maria Paragliola, Nadine Binart & Roberto Salvatori. 2022. The Pituitary. The Pituitary 131 172 .
Olga Ya. Leshchenko. (2021) Hyperprolactinemia in the postmenopause: versions and contraversions. Terapevticheskii arkhiv 93:10, pages 1234-1239.
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Hua Feng, Huifang Zhou, Jianxia Lu, Qing Zhang, Xingran Tang & Yujie Shang. (2021) Bu-Shen-Zhu-Yun decoction induces PRLR deubiquitination and JAK2/STAT5 activation via CSN5 in vitro. Aging 13:16, pages 20418-20437.
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Dana C. Borcherding, Eric R. Hugo, Sejal R. Fox, Eric M. Jacobson, Brian G. Hunt, Edward J. Merino & Nira Ben-Jonathan. (2021) Suppression of Breast Cancer by Small Molecules That Block the Prolactin Receptor. Cancers 13:11, pages 2662.
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Xin Chen, Di Wu, Yan Zheng, Xingxing Liu & Jianmeng Wang. (2020) Preparation of a Growth Hormone Receptor/Prolactin Receptor Bispecific Antibody Antagonist Which Exhibited Anti-Cancer Activity. Frontiers in Pharmacology 11.
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Aneta Ostróżka-Cieślik, Barbara Dolińska & Florian Ryszka. (2020) Therapeutic Potential of Selenium as a Component of Preservation Solutions for Kidney Transplantation. Molecules 25:16, pages 3592.
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P. A. Abramicheva, T. A. Balakina, I. A. Morozov, T. A. Schelkunova & O. V. Smirnova. (2019) Prolactin Signaling Pathways Determining Its Direct Effects on Kidneys in the Cholestasis of Pregnancy Model. Biochemistry (Moscow) 84:10, pages 1204-1212.
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Ibrahim Y. Hachim, Vanessa M. López-Ozuna, Mahmood Y. Hachim, Jean-Jacques Lebrun & Suhad Ali. (2019) Prolactin hormone exerts anti-tumorigenic effects in HER-2 overexpressing breast cancer cells through regulation of stemness. Stem Cell Research 40, pages 101538.
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Shengze Yu, Amira Alkharusi, Gunnar Norstedt & Torbjörn Gräslund. (2019) An in vivo half-life extended prolactin receptor antagonist can prevent STAT5 phosphorylation. PLOS ONE 14:5, pages e0215831.
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Rüdiger Nave, Stefan Jodl, Anja Hoffmann, Isabella Gashaw, Frank Zollmann, Matthias Berse, Joachim Höchel, Jörn Krätzschmar & Beate Rohde. (2019) Monoclonal Antibody Against Prolactin Receptor: A Randomized Placebo-Controlled Study Evaluating Safety, Tolerability, and Pharmacokinetics of Repeated Subcutaneous Administrations in Postmenopausal Women. Reproductive Sciences 26:4, pages 523-531.
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P. A. Abramicheva & O. V. Smirnova. (2019) Prolactin Receptor Isoforms as the Basis of Tissue-Specific Action of Prolactin in the Norm and Pathology. Biochemistry (Moscow) 84:4, pages 329-345.
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Nataly de Dios, Santiago Orrillo, Martín Irizarri, María Susana Theas, Florence Boutillon, Marianela Candolfi, Adriana Seilicovich, Vincent Goffin, Daniel Pisera & Jimena Ferraris. (2019) JAK2/STAT5 Pathway Mediates Prolactin-Induced Apoptosis of Lactotropes. Neuroendocrinology 108:2, pages 84-97.
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Sandra Pekić, Milica Medic Stojanoska & Vera Popovic. (2019) Hyperprolactinemia/Prolactinomas in the Postmenopausal Period: Challenges in Diagnosis and Management. Neuroendocrinology 109:1, pages 28-33.
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Alexander Faje, Marcus A. Zachariah & Brooke Swearingen. 2019. Prolactin Disorders. Prolactin Disorders 137 159 .
Naresh Goli, Pradeep Kumar Bolla & Venu Talla. (2018) Antibody-drug conjugates (ADCs): Potent biopharmaceuticals to target solid and hematological cancers- an overview. Journal of Drug Delivery Science and Technology 48, pages 106-117.
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E. A. Langan, T. Fink & R. Paus. (2018) Is prolactin a negative neuroendocrine regulator of human skin re-epithelisation after wounding?. Archives of Dermatological Research 310:10, pages 833-841.
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Sarah M. Cheal, Shutian Ruan, Darren R. Veach, Valerie A. Longo, Blesida J. Punzalan, Jiong Wu, Edward K. Fung, Marcus P. Kelly, Jessica R. Kirshner, Jason T. Giurleo, George Ehrlich, Amy Q. Han, Gavin Thurston, William C. Olson, Pat B. Zanzonico, Steven M. Larson & Jorge A. Carrasquillo. (2018) ImmunoPET Imaging of Endogenous and Transfected Prolactin Receptor Tumor Xenografts. Molecular Pharmaceutics 15:6, pages 2133-2141.
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Ewa Ocłoń, Gili Solomon, Zvi Hayouka, Tomer Meir Salame, Vincent Goffin & Arieh Gertler. (2018) Novel reagents for human prolactin research: large-scale preparation and characterization of prolactin receptor extracellular domain, non-pegylated and pegylated prolactin and prolactin receptor antagonist. Protein Engineering, Design and Selection 31:1, pages 7-16.
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Vincent Goffin. (2017) Prolactin receptor targeting in breast and prostate cancers: New insights into an old challenge. Pharmacology & Therapeutics 179, pages 111-126.
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Maria M. Pineyro, Gabriela Sosa, Maria R. Finozzi, Natalia Stecker, Raul Pisabarro & Maria C. Belzarena. (2017) Chronic cluster-like headache in a patient with a macroprolactinoma presenting with falsely low prolactin levels: bromocriptine versus cabergoline?. Clinical Case Reports 5:11, pages 1868-1873.
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Marcus P. Kelly, Carlos Hickey, Sosina Makonnen, Sandra Coetzee, Sumreen Jalal, Yu Wang, Frank Delfino, Jing Shan, Terra B. Potocky, Ishita Chatterjee, Julian Andreev, Arthur Kunz, Christopher D'Souza, Jason T. Giurleo, Thomas Nittoli, Pamela A. Trail, Gavin Thurston & Jessica R. Kirshner. (2017) Preclinical Activity of the Novel Anti-Prolactin Receptor (PRLR) Antibody–Drug Conjugate REGN2878-DM1 in PRLR-Positive Breast Cancers. Molecular Cancer Therapeutics 16:7, pages 1299-1311.
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Najat Binothman, Ibrahim Y. Hachim, Jean-Jacques Lebrun & Suhad Ali. (2017) CPSF6 is a Clinically Relevant Breast Cancer Vulnerability Target. EBioMedicine 21, pages 65-78.
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Lynn N. Thomas, Emily R. Chedrawe, Penelope J. Barnes & Catherine K. L. Too. (2017) Prolactin/androgen-inducible carboxypeptidase-D increases with nitrotyrosine and Ki67 for breast cancer progression in vivo, and upregulates progression markers VEGF-C and Runx2 in vitro. Breast Cancer Research and Treatment 164:1, pages 27-40.
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Felicitas Lopez Vicchi & Damasia Becu-Villalobos. (2017) Prolactin: The Bright and the Dark Side. Endocrinology 158:6, pages 1556-1559.
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Lilian Fedra Castillo, Ezequiel M. Rivero, Vincent Goffin & Isabel Alicia Lüthy. (2017) Alpha2-adrenoceptor agonists trigger prolactin signaling in breast cancer cells. Cellular Signalling 34, pages 76-85.
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Julian Andreev, Nithya Thambi, Andres E. Perez Bay, Frank Delfino, Joel Martin, Marcus P. Kelly, Jessica R. Kirshner, Ashique Rafique, Arthur Kunz, Thomas Nittoli, Douglas MacDonald, Christopher Daly, William Olson & Gavin Thurston. (2017) Bispecific Antibodies and Antibody–Drug Conjugates (ADCs) Bridging HER2 and Prolactin Receptor Improve Efficacy of HER2 ADCs. Molecular Cancer Therapeutics 16:4, pages 681-693.
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Nicola RomanòAnne GuillouDavid J. Hodson, Agnès O MartinPatrice Mollard. (2017) Multiple-scale neuroendocrine signals connect brain and pituitary hormone rhythms. Proceedings of the National Academy of Sciences 114:9, pages 2379-2382.
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J. Espada & J. Martín-Pérez. 2017. 83 122 .
David R. Grattan. (2016) The Eyes Have it! Protective Role of Prolactin in the Retina. EBioMedicine 8, pages 26-27.
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Ciara C. O’Sullivan & Susan E. Bates. (2016) Targeting Prolactin Receptor (PRLR) Signaling in PRLR-Positive Breast and Prostate Cancer. The Oncologist 21:5, pages 523-526.
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