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Bombesin receptor subtype 3 as a potential target for obesity and diabetes

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Paola Moreno, Irene Ramos-Álvarez, Terry W. Moody & Robert T. Jensen. (2016) Bombesin related peptides/receptors and their promising therapeutic roles in cancer imaging, targeting and treatment. Expert Opinion on Therapeutic Targets 20:9, pages 1055-1073.
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Cody A. Boyle & Saobo Lei. (2023) Neuromedin B excites central lateral amygdala neurons and reduces cardiovascular output and fear‐potentiated startle. Journal of Cellular Physiology 238:6, pages 1381-1404.
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Irene Ramos-Alvarez, Tatiana Iordanskaia, Samuel A. Mantey & Robert T. Jensen. (2022) The Nonpeptide Agonist MK-5046 Functions As an Allosteric Agonist for the Bombesin Receptor Subtype-3. Journal of Pharmacology and Experimental Therapeutics 382:2, pages 66-78.
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P. Castleman, G. Szwabowski, D. Bowman, J. Cole, A.L. Parrill & D.L. Baker. (2022) Ligand-based G Protein Coupled Receptor pharmacophore modeling: Assessing the role of ligand function in model development. Journal of Molecular Graphics and Modelling 111, pages 108107.
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Ryan A. Lafferty, Finbarr P.M. O’Harte, Nigel Irwin, Peter R. Flatt & Victor A. Gault. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 301 343 .
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Eric A. Wilson, Hui Sun, Zhenzhong Cui, Marshal T. Jahnke, Mritunjay Pandey, Peter Metzger, Oksana Gavrilova, Min Chen & Lee S. Weinstein. (2021) G q α/G 11 α deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity . American Journal of Physiology-Endocrinology and Metabolism 320:2, pages E270-E280.
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P. Korol & O. Shcherbina. (2021) Diagnostic role of gastrin-releasing peptide receptors in oncology. Radiation Diagnostics, Radiation Therapy 12:1, pages 21-34.
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Bahareh Rasaeifar, Patricia Gomez-Gutierrez & Juan J. Perez. (2020) New Insights into the Stereochemical Requirements of the Bombesin BB1 Receptor Antagonists Binding. Pharmaceuticals 13:8, pages 197.
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Lucia Baratto, Heying Duan, Helmut Mäcke & Andrei Iagaru. (2020) Imaging the Distribution of Gastrin-Releasing Peptide Receptors in Cancer. Journal of Nuclear Medicine 61:6, pages 792-798.
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Lijie Dong, Baohui Zhang, Lehao Wu, Zhi Shang, Sha Liu, Xiaoteng Jiang, Huiyu Wang, Liuyin Fan, Yan Zhang & Hua Xiao. (2020) Proteomics Analysis of Cellular BRS3 Receptor Activation Reveals Potential Mechanism for Signal Transduction and Cell Proliferation. Journal of Proteome Research 19:4, pages 1513-1521.
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Maja Kesić, Petra Baković, Marina Horvatiček, Bastien Lucien Jean Proust, Jasminka Štefulj & Lipa Čičin-Šain. (2020) Constitutionally High Serotonin Tone Favors Obesity: Study on Rat Sublines With Altered Serotonin Homeostasis. Frontiers in Neuroscience 14.
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Mei Li, Peng Liang, Di Liu, Fang Yuan, Guo-Chun Chen, Lei Zhang, Yu Liu & Hong Liu. (2019) Bombesin Receptor Subtype-3 in Human Diseases. Archives of Medical Research 50:7, pages 463-467.
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Irene Ramos-Alvarez, Lingaku Lee, Samuel A. Mantey & Robert T. Jensen. (2019) Development and Characterization of a Novel, High-Affinity, Specific, Radiolabeled Ligand for BRS-3 Receptors. Journal of Pharmacology and Experimental Therapeutics 369:3, pages 454-465.
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Huihao Tang, Chuanjun Shu, Haidi Chen, Xiaojing Zhang, Zhuqing Zang & Cheng Deng. (2019) Constitutively active BRS3 is a genuinely orphan GPCR in placental mammals. PLOS Biology 17:3, pages e3000175.
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Zaida Moreno-Villegas, Antonio Martín-Duce, César Aparicio, Sergio Portal-Núñez, Raúl Sanz, Samuel A. Mantey, Robert T. Jensen, Oscar Lorenzo, Jesús Egido & Nieves González. (2018) Activation of bombesin receptor Subtype-3 by [D-Tyr6,β-Ala11,Phe13,Nle14]bombesin6-14 increased glucose uptake and lipogenesis in human and rat adipocytes. Molecular and Cellular Endocrinology 474, pages 10-19.
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Donald E. Greydanus, Marisha Agana, Manmohan K. Kamboj, Saad Shebrain, Neelkamal Soares, Ransome Eke & Dilip R. Patel. (2018) Pediatric obesity: Current concepts. Disease-a-Month 64:4, pages 98-156.
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Paola Moreno, Samuel A. Mantey, Suk H. Lee, Irene Ramos-Álvarez, Terry W. Moody & Robert T. Jensen. (2018) A possible new target in lung-cancer cells: The orphan receptor, bombesin receptor subtype-3. Peptides 101, pages 213-226.
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Cuiying Xiao, Ramón A. Piñol, Jesse Lea Carlin, Cuiling Li, Chuxia Deng, Oksana Gavrilova & Marc L. Reitman. (2017) Bombesin-like receptor 3 ( Brs3 ) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism. Molecular Metabolism 6:11, pages 1540-1550.
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Chunheng Mo, Long Huang, Lin Cui, Can Lv, Dongliang Lin, Liang Song, Guoqiang Zhu, Juan Li & Yajun Wang. (2017) Characterization of NMB, GRP and their receptors (BRS3, NMBR and GRPR) in chickens. Journal of Molecular Endocrinology 59:1, pages 61-79.
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Cuiying Xiao & Marc L. Reitman. (2016) Bombesin-Like Receptor 3: Physiology of a Functional Orphan. Trends in Endocrinology & Metabolism 27:9, pages 603-605.
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Taichi Nakamura, Irene Ramos-Álvarez, Tatiana Iordanskaia, Paola Moreno, Samuel A. Mantey & R.T. Jensen. (2016) Molecular basis for high affinity and selectivity of peptide antagonist, Bantag-1, for the orphan BB3 receptor. Biochemical Pharmacology 115, pages 64-76.
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Irene Ramos-Álvarez, Taichi Nakamura, Samuel A. Mantey, Paola Moreno, Bernardo Nuche-Berenguer & Robert T. Jensen. (2016) Novel chiral-diazepines function as specific, selective receptor agonists with variable coupling and species variability in human, mouse and rat BRS-3 receptor cells. Peptides 75, pages 8-17.
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