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Expert Opinion on Therapeutic Targets Volume 19, 2015 - Issue 12
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Original Research

Endothelial dysfunction markers as a therapeutic target for Sildenafil treatment and effects on metabolic control in type 2 diabetes

Elisabetta MandosiSapienza University of Rome, Policlinico Umberto I, Department of Experimental Medicine, Viale del Policlinico 155, 00161, Rome, Italy+390 649 978 381; +390 649 978 381; [email protected]
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Elisa GiannettaSapienza University of Rome, Policlinico Umberto I, Department of Experimental Medicine, Viale del Policlinico 155, 00161, Rome, Italy+390 649 978 381; +390 649 978 381; [email protected]
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Tiziana FilardiSapienza University of Rome, Policlinico Umberto I, Department of Experimental Medicine, Viale del Policlinico 155, 00161, Rome, Italy+390 649 978 381; +390 649 978 381; [email protected]
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Manuela LococoSapienza University of Rome, Policlinico Umberto I, Department of Experimental Medicine, Viale del Policlinico 155, 00161, Rome, Italy+390 649 978 381; +390 649 978 381; [email protected]
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Camilla BertoliniSapienza University of Rome, Policlinico Umberto I, Department of Experimental Medicine, Viale del Policlinico 155, 00161, Rome, Italy+390 649 978 381; +390 649 978 381; [email protected]
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Mara FallarinoSapienza University of Rome, Policlinico Umberto I, Department of Experimental Medicine, Viale del Policlinico 155, 00161, Rome, Italy+390 649 978 381; +390 649 978 381; [email protected]
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Daniele GianfrilliSapienza University of Rome, Policlinico Umberto I, Department of Experimental Medicine, Viale del Policlinico 155, 00161, Rome, Italy+390 649 978 381; +390 649 978 381; [email protected]
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Mary Anna VenneriSapienza University, Departement of Histology and Embryology, Rome, Italy
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Luisa LentiSapienza University of Rome, Policlinico Umberto I, Department of Experimental Medicine, Viale del Policlinico 155, 00161, Rome, Italy+390 649 978 381; +390 649 978 381; [email protected]
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Andrea LenziSapienza University of Rome, Policlinico Umberto I, Department of Experimental Medicine, Viale del Policlinico 155, 00161, Rome, Italy+390 649 978 381; +390 649 978 381; [email protected]
&
Susanna MoranoSapienza University of Rome, Policlinico Umberto I, Department of Experimental Medicine, Viale del Policlinico 155, 00161, Rome, Italy+390 649 978 381; +390 649 978 381; [email protected]
 show all
Pages 1617-1622 | Published online: 15 Jul 2015

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Gabriela Elisa Hirsch & Thiago Gomes Heck. (2022) Inflammation, oxidative stress and altered heat shock response in type 2 diabetes: the basis for new pharmacological and non-pharmacological interventions. Archives of Physiology and Biochemistry 128:2, pages 411-425.
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Articles from other publishers (36)

Priyanka Kalyani, Sara M. Lippa, J. Kent Werner, Franck Amyot, Carol B. Moore, Kimbra Kenney & Ramon Diaz-Arrastia. (2023) Phosphodiesterase-5 (PDE-5) Inhibitors as Therapy for Cerebrovascular Dysfunction in Chronic Traumatic Brain Injury. Neurotherapeutics 20:6, pages 1629-1640.
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Dimitar Monov & Olga Pashanova. (2023) Experimental Substantiation of the Use of Phenibut Combinations with Salicylic, Nicotinic, and Glutamic Acids in Cerebral Ischemia. Neurocritical Care.
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Rakesh C. Kukreja, Rui Wang, Saisudha Koka, Anindita Das, Arun Samidurai & Lei Xi. (2022) Treating diabetes with combination of phosphodiesterase 5 inhibitors and hydroxychloroquine—a possible prevention strategy for COVID-19?. Molecular and Cellular Biochemistry 478:3, pages 679-696.
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Paola Caruso, Maria Ida Maiorino, Lorenzo Scappaticcio, Chiara Porcellini, Rita Matrone, Paolo Cirillo, Margherita Macera, Maurizio Gicchino, Maria Teresa Vietri, Giuseppe Bellastella, Nicola Coppola & Katherine Esposito. (2022) Biochemical predictors of diabetic foot osteomyelitis: A potential diagnostic role for parathormone. Diabetes/Metabolism Research and Reviews 39:1.
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T. Schmitz, E. Harmel, M. Heier, A. Peters, J. Linseisen & C. Meisinger. (2022) Inflammatory plasma proteins predict short-term mortality in patients with an acute myocardial infarction. Journal of Translational Medicine 20:1.
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Xuelin Yao, Ying Wang, Li Wang, Mingfeng Cao, Aifang Chen & Xinhuan Zhang. (2022) Expression patterns of serum MicroRNAs related to endothelial dysfunction in patients with subclinical hypothyroidism. Frontiers in Endocrinology 13.
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Shu-yi Li, Si Chen, Xiao-ting Lu, Ai-ping Fang, Yu-ming Chen, Rong-zhu Huang, Xin-lei Lin, Zi-hui Huang, Jing-fei Ma, Bi-xia Huang & Hui-lian Zhu. (2022) Serum trimethylamine-N-oxide is associated with incident type 2 diabetes in middle-aged and older adults: a prospective cohort study. Journal of Translational Medicine 20:1.
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Alexandra Petraina, Cristian Nogales, Thomas Krahn, Hermann Mucke, Thomas F Lüscher, Rodolphe Fischmeister, David A Kass, John C BurnettJrJr, Adrian J Hobbs & Harald H H W Schmidt. (2022) Cyclic GMP modulating drugs in cardiovascular diseases: mechanism-based network pharmacology. Cardiovascular Research 118:9, pages 2085-2102.
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Andreas Ouranidis, Anastasia Tsiaxerli, Elisavet Vardaka, Catherine K. Markopoulou, Constantinos K. Zacharis, Ioannis Nicolaou, Dimitris Hatzichristou, Anna-Bettina Haidich, Nikolaos Kostomitsopoulos & Kyriakos Kachrimanis. (2021) Sildenafil 4.0—Integrated Synthetic Chemistry, Formulation and Analytical Strategies Effecting Immense Therapeutic and Societal Impact in the Fourth Industrial Era. Pharmaceuticals 14:4, pages 365.
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Moein Ala, Razieh Mohammad Jafari & Ahmad Reza Dehpour. (2020) Sildenafil beyond erectile dysfunction and pulmonary arterial hypertension: Thinking about new indications. Fundamental & Clinical Pharmacology 35:2, pages 235-259.
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Lili Wang, Qielan Wu, Jiwei Liu, Huimin Zhang & Li Bai. (2021) Lactic acid inhibits iNKT cell functions via a phosphodiesterase-5 dependent pathway. Biochemical and Biophysical Research Communications 547, pages 9-14.
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Andrea M. Isidori, Elisa Giannetta, Riccardo Pofi, Mary A. Venneri, Daniele Gianfrilli, Federica Campolo, Claudio M. Mastroianni, Andrea Lenzi & Gabriella d’Ettorre. (2020) Targeting the NO‐cGMP‐PDE5 pathway in COVID‐19 infection. The DEDALO project. Andrology 9:1, pages 33-38.
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Agnieszka Kilanowska & Agnieszka Ziółkowska. (2020) Role of Phosphodiesterase in the Biology and Pathology of Diabetes. International Journal of Molecular Sciences 21:21, pages 8244.
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Federica Barbagallo, Federica Campolo, Edoardo Franceschini, Elena Crecca, Riccardo Pofi, Andrea M. Isidori & Mary Anna Venneri. (2020) PDE5 Inhibitors in Type 2 Diabetes Cardiovascular Complications. Endocrines 1:2, pages 90-101.
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David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortíz Herrera, Armando Valenzuela Peraza, Gerardo Barragán Mejía, Hugo Juárez Olguín & Francisca Trujillo Jiménez. (2020) Sildenafil alters biogenic amines and increases oxidative damage in brain regions of insulin-hypoglycemic rats. Acta Pharmaceutica 70:1, pages 121-127.
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E. A. Ismail, S. E. Younis, I. Y. Ismail, Y. M. El‐Wazir & A. I. El‐Sakka. (2019) Early administration of phosphodiesterase 5 inhibitors after induction of diabetes in a rat model may prevent erectile dysfunction. Andrology 8:1, pages 241-248.
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George S. Baillie, Gonzalo S. Tejeda & Michy P. Kelly. (2019) Therapeutic targeting of 3′,5′-cyclic nucleotide phosphodiesterases: inhibition and beyond. Nature Reviews Drug Discovery 18:10, pages 770-796.
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Tiziana Filardi, Barbara Ghinassi, Angela Di Baldassarre, Gaetano Tanzilli, Susanna Morano, Andrea Lenzi, Stefania Basili & Clara Crescioli. (2019) Cardiomyopathy Associated with Diabetes: The Central Role of the Cardiomyocyte. International Journal of Molecular Sciences 20:13, pages 3299.
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S. Giannattasio, C. Corinaldesi, M. Colletti, L. Di Luigi, C. Antinozzi, T. Filardi, S. Scolletta, S. Basili, A. Lenzi, S. Morano & C. Crescioli. (2018) The phosphodiesterase 5 inhibitor sildenafil decreases the proinflammatory chemokine IL-8 in diabetic cardiomyopathy: in vivo and in vitro evidence. Journal of Endocrinological Investigation 42:6, pages 715-725.
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Toru Hiyoshi, Mutsunori Fujiwara & Zemin Yao. (2019) Postprandial hyperglycemia and postprandial hypertriglyceridemia in type 2 diabetes. The Journal of Biomedical Research 33:1, pages 1.
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Daniela Fiore, Daniele Gianfrilli, Silvia Cardarelli, Fabio Naro, Andrea Lenzi, Andrea M. Isidori & Mary A. Venneri. (2018) Chronic phosphodiesterase type 5 inhibition has beneficial effects on subcutaneous adipose tissue plasticity in type 2 diabetic mice. Journal of Cellular Physiology 233:11, pages 8411-8417.
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Yousuke Imai, Taro Kariya, Masaki Iwakiri, Yoshitsugu Yamada & Eiki Takimoto. (2018) Sildenafil ameliorates right ventricular early molecular derangement during left ventricular pressure overload. PLOS ONE 13:4, pages e0195528.
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Kimbra Kenney, Franck Amyot, Carol Moore, Margalit Haber, L. Christine Turtzo, Christian Shenouda, Erika Silverman, Yunhua Gong, Bao‐ Xi Qu, Leah Harburg, Eric M. Wassermann, Hanzhang Lu & Ramon Diaz‐Arrastia. (2018) Phosphodiesterase‐5 inhibition potentiates cerebrovascular reactivity in chronic traumatic brain injury. Annals of Clinical and Translational Neurology 5:4, pages 418-428.
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. (2018) UNIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA AS A POTENTIAL PREDICTOR OF ARTERIAL HYPERTENSION DEVELOPMENT IN PATIENTS WITH TYPE 2 DIABETES MELLITUS. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine":36.
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Fatima Iqbal, Wendy S Baker, Madiha I Khan, Shwetha Thukuntla, Kevin H McKinney, Nicola Abate & Demidmaa Tuvdendorj. (2017) Current and future therapies for addressing the effects of inflammation on HDL cholesterol metabolism. British Journal of Pharmacology 174:22, pages 3986-4006.
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Z. Zhang, Z. Xu, Y. Dai & Y. Chen. (2017) Elevated serum homocysteine level as an independent risk factor for erectile dysfunction: a prospective pilot case-control study. Andrologia 49:6, pages e12684.
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Taymour Mostafa. (2017) Non-Sexual Implications of Phosphodiesterase Type 5 Inhibitors. Sexual Medicine Reviews 5:2, pages 170-199.
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Riccardo Pofi, Daniela Fiore, Rita De Gaetano, Giuseppe Panio, Daniele Gianfrilli, Carlotta Pozza, Federica Barbagallo, Yang Kevin Xiang, Konstantinos Giannakakis, Susanna Morano, Andrea Lenzi, Fabio Naro, Andrea M. Isidori & Mary Anna Venneri. (2017) Phosphodiesterase-5 inhibition preserves renal hemodynamics and function in mice with diabetic kidney disease by modulating miR-22 and BMP7. Scientific Reports 7:1.
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Arnold Melman, Barry Mason, Albert C. Leung & Michael E. DiSanto. 2017. Principles of Diabetes Mellitus. Principles of Diabetes Mellitus 491 512 .
Licette C.Y. Liu, Yoran M. Hummel, Peter van der Meer, Rolf M.F. Berger, Kevin Damman, Dirk J. van Veldhuisen, Adriaan A. Voors & Elke S. Hoendermis. (2016) Effects of sildenafil on cardiac structure and function, cardiopulmonary exercise testing and health‐related quality of life measures in heart failure patients with preserved ejection fraction and pulmonary hypertension. European Journal of Heart Failure 19:1, pages 116-125.
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Canan G. Nebigil. (2016) Updates on Endothelial Functions of Proangiogenic Prokineticin. Hypertension 68:5, pages 1091-1097.
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A. M. Isidori, M. A. Venneri & D. Fiore. (2016) Angiopoietin-1 and Angiopoietin-2 in metabolic disorders: therapeutic strategies to restore the highs and lows of angiogenesis in diabetes. Journal of Endocrinological Investigation 39:11, pages 1235-1246.
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Thiago Pereira, Fabio Pimenta, Marcella Porto, Marcelo Baldo, Bianca Campagnaro, Agata Gava, Silvana Meyrelles & Elisardo Vasquez. (2016) Coadjuvants in the Diabetic Complications: Nutraceuticals and Drugs with Pleiotropic Effects. International Journal of Molecular Sciences 17:8, pages 1273.
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Arnold Melman, Barry Mason, Albert C. Leung & Michael E. DiSanto. 2016. Principles of Diabetes Mellitus. Principles of Diabetes Mellitus 1 22 .
Christina Alves Peixoto, Ana Karolina Santana Nunes & Ana Garcia-Osta. (2015) Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition. Mediators of Inflammation 2015, pages 1-17.
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