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Editorial

Poly(ADP-ribose) polymerase inhibitor therapeutic effect: are we just scratching the surface?

, DVM PhD (Professor)

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Penelope D. Ruiz, Gregory A. Hamilton, Jong Woo Park & Matthew J. Gamble. (2020) MacroH2A1 Regulation of Poly(ADP-Ribose) Synthesis and Stability Prevents Necrosis and Promotes DNA Repair. Molecular and Cellular Biology 40:1.
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Articles from other publishers (13)

Peter Schraml, Fabio Aimi, Martin Zoche, Domingo Aguilera‐Garcia, Fabian Arnold, Holger Moch & Michael O Hottiger. (2023) Altered cytoplasmic and nuclear ADP ‐ribosylation levels analyzed with an improved ADP ‐ribose binder are a prognostic factor in renal cell carcinoma . The Journal of Pathology: Clinical Research 9:4, pages 273-284.
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Fabio Aimi, Holger Moch, Peter Schraml & Michael O. Hottiger. (2021) Cytoplasmic ADP-ribosylation levels correlate with markers of patient outcome in distinct human cancers. Modern Pathology 34:8, pages 1468-1477.
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Chun-Song Yang, Kasey Jividen, Teddy Kamata, Natalia Dworak, Luke Oostdyk, Bartlomiej Remlein, Yasin Pourfarjam, In-Kwon Kim, Kang-Ping Du, Tarek Abbas, Nicholas E. Sherman, David Wotton & Bryce M. Paschal. (2021) Androgen signaling uses a writer and a reader of ADP-ribosylation to regulate protein complex assembly. Nature Communications 12:1.
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Peter M. Gehrig, Kathrin Nowak, Christian Panse, Mario Leutert, Jonas Grossmann, Ralph Schlapbach & Michael O. Hottiger. (2020) Gas-Phase Fragmentation of ADP-Ribosylated Peptides: Arginine-Specific Side-Chain Losses and Their Implication in Database Searches. Journal of the American Society for Mass Spectrometry 32:1, pages 157-168.
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Andrea K. Watters, Emily S. Seltzer, Danny MacKenzieJr.Jr., Melody Young, Jonathan Muratori, Rama Hussein, Andrej M. Sodoma, Julie To, Manrose Singh & Dong Zhang. (2020) The Effects of Genetic and Epigenetic Alterations of BARD1 on the Development of Non-Breast and Non-Gynecological Cancers. Genes 11:7, pages 829.
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Ling Tao, Xiyan Wang & Qi Zhou. (2019) Long noncoding RNA SNHG16 promotes the tumorigenicity of cervical cancer cells by recruiting transcriptional factor SPI1 to upregulate PARP9. Cell Biology International 44:3, pages 773-784.
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Hanaa H. Gaballah, Heba B. Ghanem, Nahid M. Tahoon, Darin A. Mohamed & Abla M. Ebeid. (2018) Hesperidin promotes lysosomal biogenesis in chronically ethanol‐induced cardiotoxicity in rats: A proposed mechanisms of protection. Journal of Biochemical and Molecular Toxicology 33:3.
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Friedrich A. Kunze & Michael O. Hottiger. (2019) Regulating Immunity via ADP-Ribosylation: Therapeutic Implications and Beyond. Trends in Immunology 40:2, pages 159-173.
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András Vida, Judit Márton, Edit Mikó & Péter Bai. (2017) Metabolic roles of poly(ADP-ribose) polymerases. Seminars in Cell & Developmental Biology 63, pages 135-143.
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Carina de Lima Buzzo, Tiago Medina, Laura M. Branco, Silvia L. Lage, Luís Carlos de Souza Ferreira, Gustavo P. Amarante-Mendes, Michael O. Hottiger, Daniel D. De Carvalho & Karina R. Bortoluci. (2017) Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage. Scientific Reports 7:1.
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Slava Rom, Viviana Zuluaga-Ramirez, Nancy L. Reichenbach, Holly Dykstra, Sachin Gajghate, Pal Pacher & Yuri Persidsky. (2016) PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier. Journal of Neuroinflammation 13:1.
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Rebecca A. Jackson & Ee Sin Chen. (2016) Synthetic lethal approaches for assessing combinatorial efficacy of chemotherapeutic drugs. Pharmacology & Therapeutics 162, pages 69-85.
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Federico Teloni & Matthias Altmeyer. (2016) Readers of poly(ADP-ribose): designed to be fit for purpose. Nucleic Acids Research 44:3, pages 993-1006.
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