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The emerging roles of liver X receptors and their ligands in cancer

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Oriana Lo Re, Julien Douet, Marcus Buschbeck, Caterina Fusilli, Valerio Pazienza, Concetta Panebianco, Carlo Castruccio Castracani, Tommaso Mazza, Giovanni Li Volti & Manlio Vinciguerra. (2018) Histone variant macroH2A1 rewires carbohydrate and lipid metabolism of hepatocellular carcinoma cells towards cancer stem cells. Epigenetics 13:8, pages 829-845.
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Xiao-yu He, Meng-meng Zhu, Juan Zheng, Cheng-yi Wang, Xiao-kang Zhao, Bao-tong Zhang, Da-chen Zhou, Shuang Zhang, Xiao-xiao Yang, Ya-jun Duan, Ji-hong Han & Yuan-li Chen. (2022) Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing REPS2 expression. Acta Pharmacologica Sinica 44:3, pages 635-646.
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Asitha Premaratne, Charles Ho, Shinjini Basu, Ashfia Fatima Khan, Tasneem Bawa-Khalfe & Chin-Yo Lin. (2023) Liver X Receptor Inverse Agonist GAC0001E5 Impedes Glutaminolysis and Disrupts Redox Homeostasis in Breast Cancer Cells. Biomolecules 13:2, pages 345.
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Scott Widmann, Shivangi Srivastava & Chin-Yo Lin. (2023) A Novel Liver X Receptor Inverse Agonist Impairs Cholesterol and Phospholipid Metabolism and Induces Apoptosis and Necroptosis in Pancreatic Ductal Adenocarcinoma Cells. Receptors 2:1, pages 34-46.
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Diego Gómez-Coronado, Miguel A. Lasunción, Javier Martínez-Botas & María E. Fernández-Suárez. (2021) Role of cholesterol metabolism in the anticancer pharmacology of selective estrogen receptor modulators. Seminars in Cancer Biology 73, pages 101-115.
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Qiang Wang, Jing Wang, Jiayou Wang & Heng Zhang. (2021) Molecular mechanism of liver X receptors in cancer therapeutics. Life Sciences 273, pages 119287.
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Rosa Vona, Elisabetta Iessi & Paola Matarrese. (2021) Role of Cholesterol and Lipid Rafts in Cancer Signaling: A Promising Therapeutic Opportunity?. Frontiers in Cell and Developmental Biology 9.
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Shivangi Srivastava, Scott Widmann, Charles Ho, Donovan Nguyen, Alexis Nguyen, Asitha Premaratne, Jan-Åke Gustafsson & Chin-Yo Lin. (2020) Novel Liver X Receptor Ligand GAC0001E5 Disrupts Glutamine Metabolism and Induces Oxidative Stress in Pancreatic Cancer Cells. International Journal of Molecular Sciences 21:24, pages 9622.
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Céline Ben Hassen, Jorge L. Gutierrez-Pajares, Cyrille Guimaraes, Roseline Guibon, Michelle Pinault, Gaëlle Fromont & Philippe G. Frank. (2020) Apolipoprotein-mediated regulation of lipid metabolism induces distinctive effects in different types of breast cancer cells. Breast Cancer Research 22:1.
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Husna Karaboga, Wentao Huang, Shivangi Srivastava, Scott Widmann, Sridevi Addanki, Kasuni Thawalama Gamage, Zahra Mazhar, Jerry O. Ebalunode, James M. Briggs, Jan-Åke Gustafsson, Carly S. Filgueira, Scott R. Gilbertson & Chin-Yo Lin. (2020) Screening of Focused Compound Library Targeting Liver X Receptors in Pancreatic Cancer Identified Ligands with Inverse Agonist and Degrader Activity. ACS Chemical Biology 15:11, pages 2916-2928.
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Maud Voisin, Matthew C Gage, Natalia Becares, Elina Shrestha, Edward A Fisher, Ines Pineda-Torra & Michael J Garabedian. (2020) LXRα Phosphorylation in Cardiometabolic Disease: Insight From Mouse Models. Endocrinology 161:7.
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Lautaro D. Alvarez, María V. Dansey, María F. Ogara, Carina I. Peña, René Houtman, Adriana S. Veleiro, Adali Pecci & Gerardo Burton. (2020) Cholestenoic acid analogues as inverse agonists of the liver X receptors. The Journal of Steroid Biochemistry and Molecular Biology 199, pages 105585.
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Venkat Krishnan Sundaram, Charbel Massaad & Julien Grenier. (2019) Liver X Receptors and Their Implications in the Physiology and Pathology of the Peripheral Nervous System. International Journal of Molecular Sciences 20:17, pages 4192.
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Leonore Wigger, Cristina Casals-Casas, Michaël Baruchet, Khanh B. Trang, Sylvain Pradervand, Aurélien Naldi & Béatrice Desvergne. (2019) System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells. PLOS ONE 14:8, pages e0220894.
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Talita Helen Bombardelli Gomig, Iglenir João Cavalli, Ricardo Lehtonen Rodrigues de Souza, Evelyn Vieira, Aline Castro Rodrigues Lucena, Michel Batista, Kelly Cavalcanti Machado, Fabricio Klerynton Marchini, Fabio Albuquerque Marchi, Rubens Silveira Lima, Cícero de Andrade Urban, Luciane Regina Cavalli & Enilze Maria de Souza Fonseca Ribeiro. (2019) Quantitative label-free mass spectrometry using contralateral and adjacent breast tissues reveal differentially expressed proteins and their predicted impacts on pathways and cellular functions in breast cancer. Journal of Proteomics 199, pages 1-14.
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Weijun Wan, Yongying Hou, Ke Wang, Yue Cheng, Xia Pu & Xiufeng Ye. (2019) The LXR-623-induced long non-coding RNA LINC01125 suppresses the proliferation of breast cancer cells via PTEN/AKT/p53 signaling pathway. Cell Death & Disease 10:3.
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Qiang Wang, Fan Feng, Jiayou Wang, Meijia Ren, Zhonggang Shi, Xiang Mao, Heng Zhang & Xiaoli Ju. (2019) Liver X receptor activation reduces gastric cancer cell proliferation by suppressing Wnt signalling via LXRβ relocalization. Journal of Cellular and Molecular Medicine 23:2, pages 789-797.
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P. Holy, A. Kloudova & P. Soucek. (2018) Importance of genetic background of oxysterol signaling in cancer. Biochimie 153, pages 109-138.
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Fenghua Guo, Wenting Hong, Mingjie Yang, Dongke Xu, Qianming Bai, Xiaobo Li & Zongyou Chen. (2018) Upregulation of 24(R/S),25-epoxycholesterol and 27-hydroxycholesterol suppresses the proliferation and migration of gastric cancer cells. Biochemical and Biophysical Research Communications 504:4, pages 892-898.
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Sandrine Silvente-Poirot, Florence Dalenc & Marc Poirot. (2018) The Effects of Cholesterol-Derived Oncometabolites on Nuclear Receptor Function in Cancer. Cancer Research 78:17, pages 4803-4808.
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Qiang Wang, Meijia Ren, Fan Feng, Keping Chen & Xiaoli Ju. (2018) Treatment of colon cancer with liver X receptor agonists induces immunogenic cell death. Molecular Carcinogenesis 57:7, pages 903-910.
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Martin Perreault, René Maltais, Lucie Carolle Kenmogne, Danny Létourneau, Jean-Guy LeHoux, Stéphane Gobeil & Donald Poirier. (2018) Implication of STARD5 and cholesterol homeostasis disturbance in the endoplasmic reticulum stress-related response induced by pro-apoptotic aminosteroid RM-133. Pharmacological Research 128, pages 52-60.
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Albert Stuart Reece & Gary Kenneth Hulse. (2018) What are the characteristics of vitamin D metabolism in opioid dependence? An exploratory longitudinal study in Australian primary care. BMJ Open 8:1, pages e016806.
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Michael B. Fessler. (2018) The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease. Pharmacology & Therapeutics 181, pages 1-12.
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Gregory Segala, Marion David, Philippe de Medina, Mathias C. Poirot, Nizar Serhan, François Vergez, Aurelie Mougel, Estelle Saland, Kevin Carayon, Julie Leignadier, Nicolas Caron, Maud Voisin, Julia Cherier, Laetitia Ligat, Frederic Lopez, Emmanuel Noguer, Arnaud Rives, Bruno Payré, Talal al Saati, Antonin Lamaziere, Gaëtan Despres, Jean-Marc Lobaccaro, Silvere Baron, Cecile Demur, Fabienne de Toni, Clément Larrue, Helena Boutzen, Fabienne Thomas, Jean-Emmanuel Sarry, Marie Tosolini, Didier Picard, Michel Record, Christian Récher, Marc Poirot & Sandrine Silvente-Poirot. (2017) Dendrogenin A drives LXR to trigger lethal autophagy in cancers. Nature Communications 8:1.
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Gurdeep Marwarha, Shaneabbas Raza, Kimberly Hammer & Othman Ghribi. (2017) 27-hydroxycholesterol: A novel player in molecular carcinogenesis of breast and prostate cancer. Chemistry and Physics of Lipids 207, pages 108-126.
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Haojun Xiong, Yan Zhang, Shan Chen, Zhenhong Ni, Jintao He, Xinzhe Li, Bo Li, Kai Zhao, Fan Yang, Yijun Zeng, Bingbo Chen & Fengtian He. (2017) Induction of SOCS3 by liver X receptor suppresses the proliferation of hepatocellular carcinoma cells. Oncotarget 8:38, pages 64083-64094.
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Yong Hu, Jialan Zang, Haixia Cao, Ying Wu, Dali Yan, Xiaobing Qin, Leilei Zhou, Fan Fan, Jie Ni, Xiaoyue Xu, Huanhuan Sha, Siwen Liu, Shaorong Yu, Zhuo Wang, Rong Ma, Jianzhong Wu & Jifeng Feng. (2017) Liver X receptors agonist GW3965 re-sensitizes gefitinib-resistant human non-small cell lung cancer cell to gefitinib treatment by inhibiting NF-κB in vitro . Oncotarget 8:9, pages 15802-15814.
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Haixia Cao, Shaorong Yu, Dan Chen, Changwen Jing, Zhuo Wang, Rong Ma, Siwen Liu, Jie Ni, Jifeng Feng & Jianzhong Wu. (2017) Liver X receptor agonist T0901317 reverses resistance of A549 human lung cancer cells to EGFR-TKI treatment. FEBS Open Bio 7:1, pages 35-43.
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