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Potential targets for the treatment of preeclampsia

, BMedSci (Hons) MB ChB Dip OMG (Clinical Research Fellow) (Clinical Research Fellow) (Clinical Research Fellow) (Clinical Research Fellow) , , PhD (Postdoctoral Research fellow) (Postdoctoral Research fellow) (Postdoctoral Research fellow) (Postdoctoral Research fellow) & , BMedSci BM BS DM FRCOG FRANZCOG FMedSci

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Rulin Deniz, Yakup Baykus, Sefer Ustebay, Kader Ugur, Şeyda Yavuzkir & Suleyman Aydin. (2019) Evaluation of elabela, apelin and nitric oxide findings in maternal blood of normal pregnant women, pregnant women with pre-eclampsia, severe pre-eclampsia and umbilical arteries and venules of newborns. Journal of Obstetrics and Gynaecology 39:7, pages 907-912.
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Anouk Pels, Wessel Ganzevoort, Louise C Kenny, Philip N Baker, Peter von Dadelszen, Christian Gluud, Chirag T Kariya, Aleid G Leemhuis, Katie M Groom, Andrew N Sharp, Laura A Magee, Janus C Jakobsen, Ben Willem J Mol & Aris T Papageorghiou. (2023) Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy. Cochrane Database of Systematic Reviews 2023:7.
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Ellen Menkhorst, Leilani L. Santos, Wei Zhou, Guannan Yang, Amy L. Winship, Katarzyna E. Rainczuk, Philana Nguyen, Jian-Guo Zhang, Paddy Moore, Michelle Williams, Kim-Anh Lê Cao, Ashley Mansell & Evdokia Dimitriadis. (2023) IL11 activates the placental inflammasome to drive preeclampsia. Frontiers in Immunology 14.
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Jinjuan Guo, Weiqiao Bian & Huadong Jiang. (2021) Puerarin attenuates preeclampsia‐induced trophoblast mobility loss and inflammation by modulating miR‐181b‐5p/RBAK axis. American Journal of Reproductive Immunology 87:2.
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Eun Hui Joo, Young Ran Kim, Nari Kim, Jae Eun Jung, Seon Ha Han & Hee Young Cho. (2021) Effect of Endogenic and Exogenic Oxidative Stress Triggers on Adverse Pregnancy Outcomes: Preeclampsia, Fetal Growth Restriction, Gestational Diabetes Mellitus and Preterm Birth. International Journal of Molecular Sciences 22:18, pages 10122.
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Reham Hamza, Abdel Diab, Mansour Zahra, Mai Attia, Suzan Moursi & Najah Al-Baqami. (2021) A Potential Role of Apelin-13 against Hepatic Injury and Metabolic Disorders in Preeclampsia Induced by L-NAME. Coatings 11:4, pages 391.
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Qing Zuo, Yanfeng Zou, Shiyun Huang, Tianjun Wang, Yetao Xu, Tingting Zhang, Min Zhang, Zhiping Ge & Ziyan Jiang. (2021) Aspirin reduces sFlt-1-mediated apoptosis of trophoblast cells in preeclampsia. Molecular Human Reproduction 27:1.
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Ellen MenkhorstWei ZhouLeilani L. SantosSarah DelforceTeresa SoKate RainczukHannah Loke, Argyro SyngelakiSwati Varshney, Nicholas Williamson, Kirsty PringleMorag J. Young, Kypros H. NicolaidesYves St-PierreEvdokia Dimitriadis. (2020) Galectin-7 Impairs Placentation and Causes Preeclampsia Features in Mice. Hypertension 76:4, pages 1185-1194.
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Solwayo Ngwenya, Brian Jones, Desmond Mwembe, Hausitoe Nare & Alexander Heazell. (2020) The predictive value of signs and symptoms in predicting adverse maternal and perinatal outcomes in severe preeclampsia in a low-resource setting, findings from a cross-sectional study at Mpilo Central Hospital, Bulawayo, Zimbabwe. Pregnancy Hypertension 21, pages 77-83.
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Delia I. Chiarello, Cilia Abad, Deliana Rojas, Fernando Toledo, Carmen M. Vázquez, Alfonso Mate, Luis Sobrevia & Reinaldo Marín. (2020) Oxidative stress: Normal pregnancy versus preeclampsia. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866:2, pages 165354.
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Lu Zhang, Fei Zhao, Cuncun Yang, Qian Tang, Ru Zhang, Jing Li, Aiping Chen, Lin Hou & Shiguo Liu. (2020) Hypomethylation of CTGF Promoter in Placenta and Peripheral Blood of Pre-eclampsia Women. Reproductive Sciences 27:2, pages 468-476.
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Solwayo Ngwenya, Brian Jones, Alexander Edward Patrick Heazell & Desmond Mwembe. (2019) Statistical risk prediction models for adverse maternal and neonatal outcomes in severe preeclampsia in a low-resource setting: proposal for a single-centre cross-sectional study at Mpilo Central Hospital, Bulawayo, Zimbabwe. BMC Research Notes 12:1.
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Solwayo Ngwenya, Brian Jones & Desmond Mwembe. (2019) Determinants of adverse maternal and perinatal outcomes in severe preeclampsia and eclampsia in a low-resource setting, Mpilo Central Hospital, Bulawayo, Zimbabwe. BMC Research Notes 12:1.
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N.S. Das, S.T. Dheen, E.A. Ling, B.H. Bay & D.K. Srinivasan. (2019) Therapeutic Prospects in Preeclampsia - A Mini-Review. Current Medicinal Chemistry 26:25, pages 4786-4798.
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J.M. Wat, M.C. Audette & J.C. Kingdom. (2018) Molecular actions of heparin and their implications in preventing pre‐eclampsia. Journal of Thrombosis and Haemostasis 16:8, pages 1510-1522.
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Sarah A. Marshall, Natalie J. Hannan, Maria Jelinic, Thy P.H. Nguyen, Jane E. Girling & Laura J. Parry. (2018) Animal models of preeclampsia: translational failings and why. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 314:4, pages R499-R508.
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A. Pels, L. C. Kenny, Z. Alfirevic, P. N. Baker, Peter von Dadelszen, C. Gluud, C. T. Kariya, B. W. Mol, A. T. Papageorghiou, A. G. van Wassenaer-Leemhuis, W. Ganzevoort & K. M. Groom. (2017) STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): an international consortium of randomised placebo-controlled trials. BMC Pregnancy and Childbirth 17:1.
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Nina D. PaauwFieke TerstappenWessel GanzevoortJaap A. JolesHendrik GremmelsA. Titia Lely. (2017) Sildenafil During Pregnancy. Hypertension 70:5, pages 998-1006.
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Chengshu Wang, Xiaoli Liu, Desheng Kong, Xijing Qin, Yanqing Li, Xu Teng & Xianghua Huang. (2017) Apelin as a novel drug for treating preeclampsia. Experimental and Therapeutic Medicine.
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Paulina B. Szklanna, Kieran Wynne, Marie Nolan, Karl Egan, Fionnuala Ní Áinle & Patricia B. Maguire. (2017) Comparative proteomic analysis of trophoblast cell models reveals their differential phenotypes, potential uses, and limitations. PROTEOMICS 17:10, pages 1700037.
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Marcelo R Luizon, Ana CT Palei, Ricardo C Cavalli & Valeria C Sandrim. (2017) Pharmacogenetics in the treatment of pre-eclampsia: current findings, challenges and perspectives. Pharmacogenomics 18:6, pages 571-583.
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SARA ORNAGHI & MICHAEL J. PAIDAS. (2017) Novel Therapy for the Treatment of Early-Onset Preeclampsia. Clinical Obstetrics & Gynecology 60:1, pages 169-182.
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