846
Views
75
CrossRef citations to date
0
Altmetric
Reviews

The multiple faces of RAGE – opportunities for therapeutic intervention in aging and chronic disease

, &

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Nitish Jangde, Rashmi Ray & Vivek Rai. (2020) RAGE and its ligands: from pathogenesis to therapeutics. Critical Reviews in Biochemistry and Molecular Biology 55:6, pages 555-575.
Read now
Thomas Langer, Carsten Corvey, Katja Kroll, Oliver Boscheinen, Thomas Wendrich & Werner Dittrich. (2017) Expression and purification of the extracellular domains of human glycoprotein VI (GPVI) and the receptor for advanced glycation end products (RAGE) from Rattus norvegicus in Leishmania tarentolae. Preparative Biochemistry & Biotechnology 47:10, pages 1008-1015.
Read now

Articles from other publishers (73)

Ryan K. Perkins, Edwin R. Miranda, Pallavi Varshney, Sarah S. Farabi, Lauretta T. Quinn & Jacob M. Haus. (2023) Effects of acute aerobic exercise on circulating sTLR and sRAGE profiles in normal‐ and abnormal ‐ glucose‐tolerant individuals . Physiological Reports 11:22.
Crossref
Kenneth D. Carr, Sydney P. Weiner, Carolina Vasquez & Ann Marie Schmidt. (2023) Involvement of the Receptor for Advanced Glycation End Products (RAGE) in high fat-high sugar diet-induced anhedonia in rats. Physiology & Behavior 271, pages 114337.
Crossref
Yao Xiao & Robert J. Woods. (2023) Protein–Ligand CH−π Interactions: Structural Informatics, Energy Function Development, and Docking Implementation. Journal of Chemical Theory and Computation 19:16, pages 5503-5515.
Crossref
Joshua Nicholas Farr. (2023) Skeletal Senescence with Aging and Type 2 Diabetes. Endocrinology and Metabolism 38:3, pages 295-301.
Crossref
Emad Manni, Nicola Jeffery, David Chambers, Luke Slade, Timothy Etheridge & Lorna W. Harries. (2023) An evaluation of the role of miR-361-5p in senescence and systemic ageing. Experimental Gerontology 174, pages 112127.
Crossref
Kamila Zglejc‐Waszak, Ann Marie Schmidt & Judyta K. Juranek. (2022) The receptor for advanced glycation end products and its ligands’ expression in OVE26 diabetic sciatic nerve during the development of length‐dependent neuropathy . Neuropathology 43:1, pages 84-94.
Crossref
Hayder M. Al‐Kuraishy, Ali I. Al‐Gareeb, Ali A Mohammed, Athanasios Alexiou, Marios Papadakis & Gaber El‐Saber Batiha. (2022) The potential link between Covid‐19 and multiple myeloma: A new saga. Immunity, Inflammation and Disease 10:12.
Crossref
Wenge Zheng, Huijuan Li, Yuyo Go, Xi Hui (Felicia) Chan, Qing Huang & Jianxin Wu. (2022) Research Advances on the Damage Mechanism of Skin Glycation and Related Inhibitors. Nutrients 14:21, pages 4588.
Crossref
Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Walaa A. Negm, Athanasios Alexiou & Gaber El-Saber Batiha. (2022) Ursolic acid and SARS-CoV-2 infection: a new horizon and perspective. Inflammopharmacology 30:5, pages 1493-1501.
Crossref
Japneet Kaur, Sundeep Khosla & Joshua N. Farr. (2022) Effects of diabetes on osteocytes. Current Opinion in Endocrinology, Diabetes & Obesity 29:4, pages 310-317.
Crossref
Charles N. S. Allen, Maryline Santerre, Sterling P. Arjona, Lea J. Ghaleb, Muna Herzi, Megan D. Llewellyn, Natalia Shcherbik & Bassel E. Sawaya. (2022) SARS-CoV-2 Causes Lung Inflammation through Metabolic Reprogramming and RAGE. Viruses 14:5, pages 983.
Crossref
Monika Zaręba-Kozioł, Michał Burdukiewicz & Aleksandra Wysłouch-Cieszyńska. (2022) Intracellular Protein S-Nitrosylation—A Cells Response to Extracellular S100B and RAGE Receptor. Biomolecules 12:5, pages 613.
Crossref
Saba Khan, Divya Mishra, Roshan Alam, Mohammad Kaleem Ahmed, Pulak Raj & Mustafa Khan. (2022) RAGE and Serum Copeptin Act as a Potential Biomarker for Chronic Kidney Disease with and without Type 2 Diabetes Mellitus. Indian Journal of Medical Biochemistry 25:3, pages 131-134.
Crossref
Theresa H Page, Derick Chiappo, Francesca Brunini, Josep Garnica, Jack Blackburn, Fayaz Dudhiya, Maria Prendecki, Stephen P McAdoo & Charles D Pusey. (2022) Danger-associated molecular pattern molecules and the receptor for advanced glycation end products enhance ANCA-induced responses. Rheumatology 61:2, pages 834-845.
Crossref
Sundeep Khosla, Joshua N. Farr & David G. Monroe. (2022) Cellular senescence and the skeleton: pathophysiology and therapeutic implications. Journal of Clinical Investigation 132:3.
Crossref
Sundeep Khosla, David G. Monroe & Joshua N. Farr. 2022. Cellular Senescence in Disease. Cellular Senescence in Disease 335 361 .
Bao Q. Lam, Rashmi Srivastava, Jason Morvant, Sharmila Shankar & Rakesh K. Srivastava. (2021) Association of Diabetes Mellitus and Alcohol Abuse with Cancer: Molecular Mechanisms and Clinical Significance. Cells 10:11, pages 3077.
Crossref
Sundeep Khosla, Parinya Samakkarnthai, David G. Monroe & Joshua N. Farr. (2021) Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus. Nature Reviews Endocrinology 17:11, pages 685-697.
Crossref
Kamila Zglejc‐Waszak, Konark Mukherjee & Judyta Karolina Juranek. (2021) The cross‐talk between RAGE and DIAPH1 in neurological complications of diabetes: A review. European Journal of Neuroscience 54:6, pages 5982-5999.
Crossref
Gautham Yepuri, Alexander Shekhtman, Ann Marie Schmidt & Ravichandran Ramasamy. (2021) Heme & RAGE: A new opportunistic relationship?. The FEBS Journal 288:11, pages 3424-3427.
Crossref
Armando Rojas, Cristian Lindner, Ileana Gonzàlez & Miguel Angel Morales. (2021) Advanced-glycation end-products axis: A contributor to the risk of severe illness from COVID-19 in diabetes patients. World Journal of Diabetes 12:5, pages 590-602.
Crossref
Gur Serap. (2021) Potential therapeutic applications of mesenchymal stem cells for erectile dysfunction in diabetes mellitus: From preclinical/clinical perspectives. Studies on Stem Cells Research and Therapy, pages 001-011.
Crossref
Sravya Jannapureddy, Mira Sharma, Gautham Yepuri, Ann Marie Schmidt & Ravichandran Ramasamy. (2021) Aldose Reductase: An Emerging Target for Development of Interventions for Diabetic Cardiovascular Complications. Frontiers in Endocrinology 12.
Crossref
Danilo Milardi, Ehud Gazit, Sheena E. Radford, Yong Xu, Rodrigo U. Gallardo, Amedeo Caflisch, Gunilla T. Westermark, Per Westermark, Carmelo La Rosa & Ayyalusamy Ramamoorthy. (2021) Proteostasis of Islet Amyloid Polypeptide: A Molecular Perspective of Risk Factors and Protective Strategies for Type II Diabetes. Chemical Reviews 121:3, pages 1845-1893.
Crossref
D. Recabarren-Leiva, C.F. Burgos, B. Hernández, F.J. Garcïa-García, R.I. Castro, L. Guzman, E. Fuentes, I. Palomo & M. Alarcón. (2021) Effects of the age/rage axis in the platelet activation. International Journal of Biological Macromolecules 166, pages 1149-1161.
Crossref
Wei Li, Chunyi Luo, Xiaoping Xie, Yongjian Xiao, Feijun Zhao, Jialun Cai, Xiangping Zhou, Tiebing Zeng, Bo Fu, Yimou Wu, Xinhua Xiao & Shuangquan Liu. (2020) Identification of key genes and pathways in syphilis combined with diabetes: a bioinformatics study. AMB Express 10:1.
Crossref
M. E. Garay-Sevilla, M. S. Beeri, M. P. de la Maza, A. Rojas, S. Salazar-Villanea & J. Uribarri. (2020) The potential role of dietary advanced glycation endproducts in the development of chronic non-infectious diseases: a narrative review. Nutrition Research Reviews 33:2, pages 298-311.
Crossref
Mohsen Kerkeni & Jawhar Gharbi. (2020) RAGE receptor: May be a potential inflammatory mediator for SARS-COV-2 infection?. Medical Hypotheses 144, pages 109950.
Crossref
Adriana Machado-Lima, Raquel López-Díez, Rodrigo Tallada Iborra, Raphael de Souza Pinto, Gurdip Daffu, Xiaoping Shen, Edna Regina Nakandakare, Ubiratan Fabres Machado, Maria Lucia Cardillo Corrêa-Giannella, Ann Marie Schmidt & Marisa Passarelli. (2020) RAGE Mediates Cholesterol Efflux Impairment in Macrophages Caused by Human Advanced Glycated Albumin. International Journal of Molecular Sciences 21:19, pages 7265.
Crossref
Fritz Line Velayoudom-CephiseMariola Cano-SanchezSylvie BercionFrédéric TessierYichi YuEric BoulangerRemi Neviere. (2020) Receptor for advanced glycation end products modulates oxidative stress and mitochondrial function in the soleus muscle of mice fed a high-fat diet. Applied Physiology, Nutrition, and Metabolism 45:10, pages 1107-1117.
Crossref
Michael Lawes, Adi Pinkas, Bailey A. Frohlich, Joy D. Iroegbu, Omamuyovwi M. Ijomone & Michael Aschner. (2020) Metal-induced neurotoxicity in a RAGE-expressing C. elegans model. NeuroToxicology 80, pages 71-75.
Crossref
A. V. Morgun, E. D. Osipova, E. B. Boitsova, O. L. Lopatina, Ya. V. Gorina, E. A. Pozhilenkova & A. B. Salmina. (2020) Vascular Component of Neuroinflammation in Experimental Alzheimer’s Disease in Mice. Cell and Tissue Biology 14:4, pages 256-262.
Crossref
Katja Zunkel, Andreas Simm & Babett Bartling. (2020) Long-term intake of the reactive metabolite methylglyoxal is not toxic in mice. Food and Chemical Toxicology 141, pages 111333.
Crossref
Serap Gur & Wayne J.G. Hellstrom. (2020) Harnessing Stem Cell Potential for the Treatment of Erectile Function in Men with Diabetes Mellitus: From Preclinical/Clinical Perspectives to Penile Tissue Engineering. Current Stem Cell Research & Therapy 15:4, pages 308-320.
Crossref
María Constanza Potilinski, Valeria Lorenc, Sofía Perisset & Juan Eduardo Gallo. (2020) Mechanisms behind Retinal Ganglion Cell Loss in Diabetes and Therapeutic Approach. International Journal of Molecular Sciences 21:7, pages 2351.
Crossref
Massimo De Martinis, Lia Ginaldi, Maria Maddalena Sirufo, Giovanni Pioggia, Gioacchino Calapai, Sebastiano Gangemi & Carmen Mannucci. (2020) Alarmins in Osteoporosis, RAGE, IL-1, and IL-33 Pathways: A Literature Review. Medicina 56:3, pages 138.
Crossref
Lander Egaña-Gorroño, Raquel López-Díez, Gautham Yepuri, Lisa S. Ramirez, Sergey Reverdatto, Paul F. Gugger, Alexander Shekhtman, Ravichandran Ramasamy & Ann Marie Schmidt. (2020) Receptor for Advanced Glycation End Products (RAGE) and Mechanisms and Therapeutic Opportunities in Diabetes and Cardiovascular Disease: Insights From Human Subjects and Animal Models. Frontiers in Cardiovascular Medicine 7.
Crossref
Efthalia Angelopoulou, Yam Nath Paudel & Christina Piperi. (2020) Unraveling the Role of Receptor for Advanced Glycation End Products (RAGE) and Its Ligands in Myasthenia Gravis. ACS Chemical Neuroscience 11:5, pages 663-673.
Crossref
Venkata S.K. IndurthiJaime L. JensenEstelle LeclercSangita SinhaChristopher L. ColbertStefan W. Vetter. (2020) The Trp triad within the V-domain of the receptor for advanced glycation end products modulates folding, stability and ligand binding. Bioscience Reports 40:1.
Crossref
Zhanyun Ren, Xiaotian Chen, Wuzhuang Tang, Jie Li, Song Yang, Yanchun Chen, Xianghai Zhao, Huihua Zong, Chunlan Liu & Chong Shen. (2020) Association of DIAPH1 gene polymorphisms with ischemic stroke. Aging 12:1, pages 416-435.
Crossref
Babett Bartling, Katja Zunkel, Samiya Al-Robaiy, Faramarz Dehghani & Andreas Simm. (2020) Gene doubling increases glyoxalase 1 expression in RAGE knockout mice. Biochimica et Biophysica Acta (BBA) - General Subjects 1864:1, pages 129438.
Crossref
Francesca Riuzzi, Sara Chiappalupi, Cataldo Arcuri, Ileana Giambanco, Guglielmo Sorci & Rosario Donato. (2019) S100 proteins in obesity: liaisons dangereuses. Cellular and Molecular Life Sciences 77:1, pages 129-147.
Crossref
Nobuhiro TaharaRuchia KojimaRisa YoshidaMunehisa BekkiYoichi SugiyamaAtsuko TaharaShoko MaedaAkihiro HondaSachiyo IgataTomohisa NakamuraJiahui SunTakanori MatsuiYoshihiro FukumotoToshiro MatsuiSho-Ichi Yamagishi. (2019) Serum Levels of Protein-Bound Methylglyoxal-Derived Hydroimidazolone-1 are Independently Correlated with Asymmetric Dimethylarginine. Rejuvenation Research 22:5, pages 431-438.
Crossref
Cristina Luceri, Elisabetta Bigagli, Sara Agostiniani, Francesco Giudici, Daniela Zambonin, Stefano Scaringi, Ferdinando Ficari, Maura Lodovici & Cecilia Malentacchi. (2019) Analysis of Oxidative Stress-Related Markers in Crohn’s Disease Patients at Surgery and Correlations with Clinical Findings. Antioxidants 8:9, pages 378.
Crossref
Seon-Heui Cha, Yongha Hwang, Soo-Jin Heo & Hee-Sook Jun. (2019) Indole-4-carboxaldehyde Isolated from Seaweed, Sargassum thunbergii, Attenuates Methylglyoxal-Induced Hepatic Inflammation. Marine Drugs 17:9, pages 486.
Crossref
Olvera-Montaño Cecilia, Castellanos-González José Alberto, Navarro-Partida José, Cardona-Muñoz Ernesto Germán, López-Contreras Ana Karen, Roman-Pintos Luis Miguel, Robles-Rivera Ricardo Raúl & Rodríguez-Carrizalez Adolfo Daniel. (2019) Oxidative Stress as the Main Target in Diabetic Retinopathy Pathophysiology. Journal of Diabetes Research 2019, pages 1-21.
Crossref
O.P. Mintser & V.Z. Zaliskyi. (2019) СИСТЕМНА БІОЛОГІЯ СТАРІННЯ: МОДЕЛЮВАННЯ МОЛЕКУЛЯРНИХ МЕХАНІЗМІВ РОЗВИТКУ ВІКОВИХ ЗАХВОРЮВАНЬ. КОНЦЕПТУАЛЬНИЙ АНАЛІТИЧНИЙ ОГЛЯД. Medical Informatics and Engineering:2, pages 4-24.
Crossref
Hannah M. Davis, Alyson L. Essex, Sinai Valdez, Padmini J. Deosthale, Mohammad W. Aref, Matthew R. Allen, Andrea Bonetto & Lilian I. Plotkin. (2019) Short-term pharmacologic RAGE inhibition differentially affects bone and skeletal muscle in middle-aged mice. Bone 124, pages 89-102.
Crossref
Claus W. Heizmann. (2019) S100 proteins: Diagnostic and prognostic biomarkers in laboratory medicine. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1866:7, pages 1197-1206.
Crossref
Laurent Detzen, Bin Cheng, Ching-Yuan Chen, Panos N. Papapanou & Evanthia Lalla. (2019) Soluble Forms of the Receptor for Advanced Glycation Endproducts (RAGE) in Periodontitis. Scientific Reports 9:1.
Crossref
Michael MacLean, Julia Derk, Henry H. Ruiz, Judyta K. Juranek, Ravichandran Ramasamy & Ann Marie Schmidt. (2019) The Receptor for Advanced Glycation End Products (RAGE) and DIAPH1: Implications for vascular and neuroinflammatory dysfunction in disorders of the central nervous system. Neurochemistry International 126, pages 154-164.
Crossref
Abdishakur Abdulle, Claire K. Inman, Abdelkarim Saleh, Mohamed Noshi, Divya Galani, Laila Abdelwareth, Habiba Alsafar, Abubaker Elfatih, Hefsa Al Shamsi, Raghib Ali, Huilin Li, Ravichandran Ramasamy, Ann Marie Schmidt, Mahmoud M. Benbarka & Mohamed H. Hassan. (2019) Metabolic dysfunction in Emirati subjects in Abu Dhabi: Relationship to levels of soluble RAGEs. Journal of Clinical & Translational Endocrinology 16, pages 100192.
Crossref
Jamillah Zamoon, Dhanya Madhu & Ikhlas Ahmed. (2019) Dynamic oligomerization of hRAGE's transmembrane and cytoplasmic domains within SDS micelles. International Journal of Biological Macromolecules 130, pages 10-18.
Crossref
Thibault Teissier, Valentine Quersin, Viviane Gnemmi, Maité Daroux, Mike Howsam, Florian Delguste, Cécile Lemoine, Chantal Fradin, Ann‐Marie Schmidt, Christelle Cauffiez, Thierry Brousseau, François Glowacki, Frédéric J. Tessier, Eric Boulanger & Marie Frimat. (2019) Knockout of receptor for advanced glycation end‐products attenuates age‐related renal lesions. Aging Cell 18:2.
Crossref
M. Body-Malapel, M. Djouina, C. Waxin, A. Langlois, C. Gower-Rousseau, P. Zerbib, A.-M. Schmidt, P. Desreumaux, E. Boulanger & C. Vignal. (2019) The RAGE signaling pathway is involved in intestinal inflammation and represents a promising therapeutic target for Inflammatory Bowel Diseases. Mucosal Immunology 12:2, pages 468-478.
Crossref
Lilian I. Plotkin, Alyson L. Essex & Hannah M. Davis. (2019) RAGE Signaling in Skeletal Biology. Current Osteoporosis Reports 17:1, pages 16-25.
Crossref
Adi Pinkas, Kun He Lee, Pan Chen & Michael Aschner. (2018) A C. elegans Model for the Study of RAGE-Related Neurodegeneration. Neurotoxicity Research 35:1, pages 19-28.
Crossref
Masako Toda, Michael Hellwig, Thomas Henle & Stefan Vieths. (2019) Influence of the Maillard Reaction on the Allergenicity of Food Proteins and the Development of Allergic Inflammation. Current Allergy and Asthma Reports 19:1.
Crossref
Mónica De la Fuente. 2019. Handbook of Immunosenescence. Handbook of Immunosenescence 1425 1455 .
Margarita Díaz-Flores & Luis Arturo Baiza-Gutman. 2019. The Diabetes Textbook. The Diabetes Textbook 695 707 .
Claus W. Heizmann. 2019. Calcium-Binding Proteins of the EF-Hand Superfamily. Calcium-Binding Proteins of the EF-Hand Superfamily 157 186 .
Safa Lotfi & Marzieh Dehghan Shahsaltane. (2018) In silico investigation of extracellular domain of RAGE receptor interaction with A-box and B-box of HMGB1 protein. Acta Biologica Slovenica 61:2, pages 3-13.
Crossref
Sheldon Rowan, Eloy Bejarano & Allen Taylor. (2018) Mechanistic targeting of advanced glycation end-products in age-related diseases. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:12, pages 3631-3643.
Crossref
Wioletta Olejarz, Dominika Łacheta, Alicja Głuszko, Ewa Migacz, Wojciech Kukwa, Mirosław J. Szczepański, Piotr Tomaszewski & Grażyna Nowicka. (2018) RAGE and TLRs as Key Targets for Antiatherosclerotic Therapy. BioMed Research International 2018, pages 1-10.
Crossref
Camila Tiefensee Ribeiro, Juciano Gasparotto, Alexsander Alves Teixeira, Luis Valmor Cruz Portela, Viviane Noll Louzada Flores, José Claudio Fonseca Moreira & Daniel Pens Gelain. (2018) Immune neutralization of the receptor for advanced glycation end products reduce liver oxidative damage induced by an acute systemic injection of lipopolysaccharide. The Journal of Biochemistry 163:6, pages 515-523.
Crossref
Sho-ichi Yamagishi. 2018. Diabetes and Aging-related Complications. Diabetes and Aging-related Complications 201 212 .
Mónica De la Fuente. 2018. Handbook of Immunosenescence. Handbook of Immunosenescence 1 31 .
Aron S. BuchmanSue E. LeurgansSukriti NagVeronique G.J.M. VanderHorstAlifiya KapasiJulie A. SchneiderDavid A. Bennett. (2017) Spinal Arteriolosclerosis Is Common in Older Adults and Associated With Parkinsonism. Stroke 48:10, pages 2792-2798.
Crossref
Yu-Ju Wen & Mei-Chin Yin. (2017) The anti-inflammatory and anti-glycative effects of rosmarinic acid in the livers of type 1 diabetic mice. BioMedicine 7:3, pages 19.
Crossref
Mari van de Vyver. (2017) Intrinsic Mesenchymal Stem Cell Dysfunction in Diabetes Mellitus: Implications for Autologous Cell Therapy. Stem Cells and Development 26:14, pages 1042-1053.
Crossref
A. A. Moskalev, E. N. Proshkina, A. A. Belyi & I. A. Solovyev. (2017) Genetics of aging and longevity. Russian Journal of Genetics: Applied Research 7:4, pages 369-384.
Crossref
Cristiane L. de la Hoz, Chu Cheng, Paul Fernyhough & Douglas W. Zochodne. (2017) A model of chronic diabetic polyneuropathy: benefits from intranasal insulin are modified by sex and RAGE deletion. American Journal of Physiology-Endocrinology and Metabolism 312:5, pages E407-E419.
Crossref
Genny Degani, Alessandra A. Altomare, Mara Colzani, Caterina Martino, Angelica Mazzolari, Guenter Fritz, Giulio Vistoli, Laura Popolo & Giancarlo Aldini. (2017) A capture method based on the VC1 domain reveals new binding properties of the human receptor for advanced glycation end products (RAGE). Redox Biology 11, pages 275-285.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.