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Expert Opinion on Therapeutic Targets Volume 20, 2016 - Issue 9
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Review

Mir-221/222 are promising targets for innovative anticancer therapy

Maria Teresa Di MartinoDepartment of Experimental and Clinical Medicine, Magna Graecia University, Salvatore Venuta University Campus, Catanzaro, ItalyCorrespondence[email protected]
,
Marco RossiDepartment of Experimental and Clinical Medicine, Magna Graecia University, Salvatore Venuta University Campus, Catanzaro, Italy
,
Daniele CaraccioloDepartment of Experimental and Clinical Medicine, Magna Graecia University, Salvatore Venuta University Campus, Catanzaro, Italy
,
Annamaria GullàDepartment of Experimental and Clinical Medicine, Magna Graecia University, Salvatore Venuta University Campus, Catanzaro, Italy
,
Pierosandro TagliaferriDepartment of Experimental and Clinical Medicine, Magna Graecia University, Salvatore Venuta University Campus, Catanzaro, Italy
&
Pierfrancesco TassoneDepartment of Experimental and Clinical Medicine, Magna Graecia University, Salvatore Venuta University Campus, Catanzaro, Italy;Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USACorrespondence[email protected]
Pages 1099-1108 | Received 03 Dec 2015, Accepted 02 Mar 2016, Published online: 21 Mar 2016

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Sara Carpi, Beatrice Polini, Stefano Fogli, Adriano Podestà, Erkko Ylösmäki, Vincenzo Cerullo, Antonella Romanini & Paola Nieri. (2020) Circulating microRNAs as biomarkers for early diagnosis of cutaneous melanoma. Expert Review of Molecular Diagnostics 20:1, pages 19-30.
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Daniele Caracciolo, Martina Montesano, Emanuela Altomare, Francesca Scionti, Maria Teresa Di Martino, Pierosandro Tagliaferri & Pierfrancesco Tassone. (2018) The potential role of miRNAs in multiple myeloma therapy. Expert Review of Hematology 11:10, pages 793-803.
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Articles from other publishers (37)

Himali Gujrati, Siyoung Ha & Bi-Dar Wang. (2023) Deregulated microRNAs Involved in Prostate Cancer Aggressiveness and Treatment Resistance Mechanisms. Cancers 15:12, pages 3140.
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Mohammad Javad Kamali, Mohammad Salehi, Somayeh Fatemi, Fereshteh Moradi, Azin Khoshghiafeh & Mohamadreza Ahmadifard. (2023) Locked nucleic acid (LNA): A modern approach to cancer diagnosis and treatment. Experimental Cell Research 423:1, pages 113442.
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Jie Yang, Zi-Xuan Wang, Lei Fang, Tu-Shuai Li, Zhi-Hong Liu, Ying Pan & Ling-Dong Kong. (2023) Atractylodes lancea and Magnolia officinalis combination protects against high fructose-impaired insulin signaling in glomerular podocytes through upregulating Sirt1 to inhibit p53-driven miR-221. Journal of Ethnopharmacology 300, pages 115688.
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Hao Zhang, Yu-Han Cai, Yajie Ding, Guiyuan Zhang, Yufeng Liu, Jie Sun, Yuchen Yang, Zhen Zhan, Anton Iliuk, Zhongze Gu, Yanhong Gu & W. Andy Tao. (2022) Proteomics, Phosphoproteomics and Mirna Analysis of Circulating Extracellular Vesicles through Automated and High-Throughput Isolation. Cells 11:13, pages 2070.
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Julia Ramírez-Moya, León Wert-Lamas, Adrián Acuña-Ruíz, Alice Fletcher, Carlos Wert-Carvajal, Christopher J. McCabe, Pilar Santisteban & Garcilaso Riesco-Eizaguirre. (2022) Identification of an interactome network between lncRNAs and miRNAs in thyroid cancer reveals SPTY2D1-AS1 as a new tumor suppressor. Scientific Reports 12:1.
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Yusheng Guo, Guohui Wu, Junrong Yi, Qin Yang, Wengong Jiang, Shaoqiang Lin, Xiaorong Yang, Xiangsheng Cai & Liufeng Mao. (2022) Anti-Hepatocellular Carcinoma Effect and Molecular Mechanism of the Estrogen Signaling Pathway. Frontiers in Oncology 11.
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Michael Nabil Said, Shaden Muawia, Amany Helal, Amal Fawzy, Rasha Mahmoud Allam & Nevine F. Shafik. (2021) Regulation of CDK inhibitor p27 by microRNA 222 in breast cancer patients. Experimental and Molecular Pathology 123, pages 104718.
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Eusebio Chiefari, Maria Mirabelli, Sandro La Vignera, Sinan Tanyolaç, Daniela Patrizia Foti, Antonio Aversa & Antonio Brunetti. (2021) Insulin Resistance and Cancer: In Search for a Causal Link. International Journal of Molecular Sciences 22:20, pages 11137.
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Maria Teresa Di Martino, Caterina Riillo, Francesca Scionti, Katia Grillone, Nicoletta Polerà, Daniele Caracciolo, Mariamena Arbitrio, Pierosandro Tagliaferri & Pierfrancesco Tassone. (2021) miRNAs and lncRNAs as Novel Therapeutic Targets to Improve Cancer Immunotherapy. Cancers 13:7, pages 1587.
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Giulia Romano, Mario Acunzo & Patrick Nana-Sinkam. (2021) microRNAs as Novel Therapeutics in Cancer. Cancers 13:7, pages 1526.
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Amro M. Soliman, Teoh Seong Lin, Pasuk Mahakkanukrauh & Srijit Das. (2020) Role of microRNAs in Diagnosis, Prognosis and Management of Multiple Myeloma. International Journal of Molecular Sciences 21:20, pages 7539.
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Yanze Chen, Yunan Gao, Ying Lian, Chengkun Li, Chen Qu & Xiaowen Jiang. (2020) Overexpression of miR-221 stimulates proliferation of rat neural stem cell with activating Phosphatase and tensin homolog/protein kinase B signaling pathway. NeuroReport 31:14, pages 1015-1023.
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Samantha Franzoni, Lisa Morbioli, Antonio Turtoro, Lara Solazzo, Alessandro Greco, Mariamena Arbitrio, Pierosandro Tagliaferri, Pierfrancesco Tassone, Maria Teresa Di Martino & Massimo Breda. (2020) Development and validation of bioanalytical methods for LNA-i-miR-221 quantification in human plasma and urine by LC-MS/MS. Journal of Pharmaceutical and Biomedical Analysis 188, pages 113451.
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Hao Shen, Zaikai Lin, Haiyan Shi, Lingling Wu, Baojin Ma, Hong Li, Baobing Yin, Jun Tang, Hongjin Yu & Xiaoxing Yin. (2020) MiR-221/222 promote migration and invasion, and inhibit autophagy and apoptosis by modulating ATG10 in aggressive papillary thyroid carcinoma. 3 Biotech 10:8.
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Maria Teresa Di Martino, Mariamena Arbitrio, Daniele Caracciolo, Francesca Scionti, Pierosandro Tagliaferri & Pierfrancesco Tassone. (2020) Dose-Finding Study and Pharmacokinetics Profile of the Novel 13-Mer Antisense miR-221 Inhibitor in Sprague-Dawley Rats. Molecular Therapy - Nucleic Acids 20, pages 73-85.
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Padacherri Vethil Jishnu, Pradyumna Jayaram, Vaibhav Shukla, Vinay Koshy Varghese, Deeksha Pandey, Krishna Sharan, Sanjiban Chakrabarty, Kapaettu Satyamoorthy & Shama Prasada Kabekkodu. (2019) Prognostic role of 14q32.31 miRNA cluster in various carcinomas: a systematic review and meta-analysis. Clinical & Experimental Metastasis 37:1, pages 31-46.
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Lilian Quero, André N. Tiaden, Edveena Hanser, Julien Roux, Artur Laski, Jonathan Hall & Diego Kyburz. (2020) miR-221-3p Drives the Shift of M2-Macrophages to a Pro-Inflammatory Function by Suppressing JAK3/STAT3 Activation. Frontiers in Immunology 10.
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Qian Song, Quanlin An, Bing Niu, Xiaoling Lu, Ning Zhang & Xin Cao. (2019) Role of miR-221/222 in Tumor Development and the Underlying Mechanism. Journal of Oncology 2019, pages 1-15.
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Maria Teresa Di Martino, Mariamena Arbitrio, Massimiliano Fonsi, Claudio Alberto Erratico, Francesca Scionti, Daniele Caracciolo, Pierosandro Tagliaferri & Pierfrancesco Tassone. (2019) Allometric Scaling Approaches for Predicting Human Pharmacokinetic of a Locked Nucleic Acid Oligonucleotide Targeting Cancer-Associated miR-221. Cancers 12:1, pages 27.
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Kangkang Liu, Lining Wang & Erlin Sun. (2019) Prognostic value of miR-221 in human malignancy: evidence from 3041 subjects. BMC Cancer 19:1.
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Silvia Catuogno, Maria Teresa Di Martino, Silvia Nuzzo, Carla Lucia Esposito, Pierfrancesco Tassone & Vittorio de Franciscis. (2019) An Anti-BCMA RNA Aptamer for miRNA Intracellular Delivery. Molecular Therapy - Nucleic Acids 18, pages 981-990.
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Beatrice Polini, Sara Carpi, Antonella Romanini, Maria Cristina Breschi, Paola Nieri & Adriano Podestà. (2019) Circulating cell‐free micro RNA s in cutaneous melanoma staging and recurrence or survival prognosis . Pigment Cell & Melanoma Research 32:4, pages 486-499.
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Jian Xu, Yan Su, Aoshuang Xu, Fengjuan Fan, Shidai Mu, Lei Chen, Zhangbo Chu, Bo Zhang, Haifan Huang, Jiasi Zhang, Jun Deng, Lisha Ai, Chunyan Sun & Yu Hu. (2019) miR-221/222-Mediated Inhibition of Autophagy Promotes Dexamethasone Resistance in Multiple Myeloma. Molecular Therapy 27:3, pages 559-570.
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Nicola Amodio, Maria Gallo Cantafio, Cirino Botta, Valter Agosti, Cinzia Federico, Daniele Caracciolo, Domenica Ronchetti, Marco Rossi, Christoph Driessen, Antonino Neri, Pierosandro Tagliaferri & Pierfrancesco Tassone. (2019) Replacement of miR-155 Elicits Tumor Suppressive Activity and Antagonizes Bortezomib Resistance in Multiple Myeloma. Cancers 11:2, pages 236.
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Maria T. Di Martino & Pietro H. Guzzi. 2019. Encyclopedia of Bioinformatics and Computational Biology. Encyclopedia of Bioinformatics and Computational Biology 1099 1103 .
Thomas Moehler, Dirk Hose, Mindaugas Andrulis, Anja Seckinger & Hartmut Goldschmidt. 2019. Tumor Angiogenesis. Tumor Angiogenesis 639 658 .
Nicola Amodio, Lavinia Raimondi, Giada Juli, Maria Angelica Stamato, Daniele Caracciolo, Pierosandro Tagliaferri & Pierfrancesco Tassone. (2018) MALAT1: a druggable long non-coding RNA for targeted anti-cancer approaches. Journal of Hematology & Oncology 11:1.
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Yu Kakimoto, Masayuki Tanaka, Hideki Hayashi, Keiko Yokoyama & Motoki Osawa. (2018) Overexpression of miR-221 in sudden death with cardiac hypertrophy patients. Heliyon 4:6, pages e00639.
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Santiago Grijalvo, Adele Alagia, Andreia Jorge & Ramon Eritja. (2018) Covalent Strategies for Targeting Messenger and Non-Coding RNAs: An Updated Review on siRNA, miRNA and antimiR Conjugates. Genes 9:2, pages 74.
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S. Franzoni, A. Vezzelli, A. Turtoro, L. Solazzo, A. Greco, P. Tassone, M.T. Di Martino & M. Breda. (2018) Development and validation of a bioanalytical method for quantification of LNA-i-miR-221, a 13-mer oligonucleotide, in rat plasma using LC–MS/MS. Journal of Pharmaceutical and Biomedical Analysis 150, pages 300-307.
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Maria Angelica Stamato, Giada Juli, Enrica Romeo, Domenica Ronchetti, Mariamena Arbitrio, Daniele Caracciolo, Antonino Neri, Pierosandro Tagliaferri, Pierfrancesco Tassone & Nicola Amodio. (2017) Inhibition of EZH2 triggers the tumor suppressive miR-29b network in multiple myeloma. Oncotarget 8:63, pages 106527-106537.
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Shanrong Zhao, William Gordon, Sarah Du, Chi Zhang, Wen He, Li Xi, Sachin Mathur, Michael Agostino, Theresa Paradis, David von Schack, Michael Vincent & Baohong Zhang. (2017) QuickMIRSeq: a pipeline for quick and accurate quantification of both known miRNAs and isomiRs by jointly processing multiple samples from microRNA sequencing. BMC Bioinformatics 18:1.
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Zijun Yin, Meng Xu & Ping Li. (2017) miRNA-221 acts as an oncogenic role by directly targeting TIMP2 in non-small-cell lung carcinoma. Gene 620, pages 46-53.
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Pierosandro Tagliaferri, Mariamena Arbitrio, Antonella Ierardi, Domenico Ciliberto, Maria Teresa Di Martino & Pierfrancesco Tassone. 2017. Liquid Biopsy in Cancer Patients. Liquid Biopsy in Cancer Patients 7 26 .
Thomas Moehler, Dirk Hose, Mindaugas Andrulis, Anja Seckinger & Hartmut Goldschmidt. 2017. Tumor Angiogenesis. Tumor Angiogenesis 1 19 .
Domenica Ronchetti, Martina Manzoni, Katia Todoerti, Antonino Neri & Luca Agnelli. (2016) In Silico Characterization of miRNA and Long Non-Coding RNA Interplay in Multiple Myeloma. Genes 7:12, pages 107.
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