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Emerging Therapeutic Targets Volume 4, 2000 - Issue 4
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Review

Nucleoside transporter proteins: emerging targets for drug discovery

Mark F Vickers Molecular Biology of Membranes Group and Membrane Transport Research Group, Departments of Biochemistry, Oncology and Physiology Department of Oncology, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta T6G 1Z2, Canada.
,
James D Young Molecular Biology of Membranes Group and Membrane Transport Research Group, Departments of Biochemistry and Physiology, University of Alberta, Alberta, Canada.
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Stephen A Baldwin School of Biochemistry and Molecular Biology, University of Leeds, Leeds, UK.
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John R Mackey Department of Physiology and Oncology, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta T6G 1Z2, Canada.
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Carol E Cass Molecular Biology of Membranes Group and Membrane Transport Research Group, Departments of Biochemistry, Oncology, University of Alberta, Alberta, Canada, Department of Oncology, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta T6G 1Z2, Canada. [email protected]
Pages 515-539 | Published online: 25 Feb 2005

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Mark F. Vickers , Jing Zhang , Frank Visser, Tracey Tackaberry, Morris J. Robins, Lars P. C. Nielsen, Ireneusz Nowak, Stephen A. Baldwin, James D. Young & Carol E. Cass. (2004) Uridine Recognition Motifs of Human Equilibrative Nucleoside Transporters 1 and 2 Produced in Saccharomyces cerevisiae . Nucleosides, Nucleotides & Nucleic Acids 23:1-2, pages 361-373.
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Mark F. Vickers, James D. Young, Stephen A. Baldwin, Michael J. Ellison & Carol E. Cass. (2001) Functional production of mammalian concentrative nucleoside transporters in Saccharomyces cerevisiae. Molecular Membrane Biology 18:1, pages 73-79.
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Articles from other publishers (11)

Simone H. Stahl, Katherine S. Fenner, M. Raymond V. Finlay, Ravindra V. Alluri, Beth Williamson, Johan X. Johansson & Jason Kettle. 2021. The Medicinal Chemist's Guide to Solving ADMET Challenges. The Medicinal Chemist's Guide to Solving ADMET Challenges 62 108 .
Rebba C. Boswell-Casteel, Jennifer M. Johnson, Kelli D. Duggan, Zygy Roe-Žurž, Hannah Schmitz, Carter Burleson & Franklin A. Hays. (2014) FUN26 (Function Unknown Now 26) Protein from Saccharomyces cerevisiae Is a Broad Selectivity, High Affinity, Nucleoside and Nucleobase Transporter. Journal of Biological Chemistry 289:35, pages 24440-24451.
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Robert J. Paproski, Frank Visser, Jing Zhang, Tracey Tackaberry, Vijaya Damaraju, Stephen A. BaldwinJames D. Young & Carol E. Cass. (2008) Mutation of Trp29 of human equilibrative nucleoside transporter 1 alters affinity for coronary vasodilator drugs and nucleoside selectivity. Biochemical Journal 414:2, pages 291-300.
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Jing Zhang, Frank Visser, Karen M. King, Stephen A. Baldwin, James D. Young & Carol E. Cass. (2007) The role of nucleoside transporters in cancer chemotherapy with nucleoside drugs. Cancer and Metastasis Reviews 26:1, pages 85-110.
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Jing Zhang, Kyla M. Smith, Tracey Tackaberry, Xuejun Sun, Pat Carpenter, Melissa D. Slugoski, Morris J. Robins, Lars P.C. Nielsen, Ireneusz Nowak, Stephen A. Baldwin, James D. Young & Carol E. Cass. (2006) Characterization of the Transport Mechanism and Permeant Binding Profile of the Uridine Permease Fui1p of Saccharomyces cerevisiae. Journal of Biological Chemistry 281:38, pages 28210-28221.
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Frank Visser, Stephen A. Baldwin, R. Elwyn Isaac, James D. Young & Carol E. Cass. (2005) Identification and Mutational Analysis of Amino Acid Residues Involved in Dipyridamole Interactions with Human and Caenorhabditis elegans Equilibrative Nucleoside Transporters. Journal of Biological Chemistry 280:12, pages 11025-11034.
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Vijaya L Damaraju, Sambasivarao Damaraju, James D Young, Stephen A Baldwin, John Mackey, Michael B Sawyer & Carol E Cass. (2003) Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy. Oncogene 22:47, pages 7524-7536.
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Miguel A Cabrita, Stephen A Baldwin, James D Young & Carol E Cass. (2002) Molecular biology and regulation of nucleoside and nucleobase transporter proteins in eukaryotes and prokaryotes. Biochemistry and Cell Biology 80:5, pages 623-638.
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Mark F Vickers, Rakesh Kumar, Frank Visser, Jing Zhang, Jahangir Charania, R Taylor Raborn, Stephen A Baldwin, James D Young & Carol E Cass. (2002) Comparison of the interaction of uridine, cytidine, and other pyrimidine nucleoside analogues with recombinant human equilibrative nucleoside transporter 2 (hENT2) produced in Saccharomyces cerevisiae . Biochemistry and Cell Biology 80:5, pages 639-644.
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Frank Visser, Mark F. Vickers, Amy M.L. Ng, Stephen A. Baldwin, James D. Young & Carol E. Cass. (2002) Mutation of Residue 33 of Human Equilibrative Nucleoside Transporters 1 and 2 Alters Sensitivity to Inhibition of Transport by Dilazep and Dipyridamole. Journal of Biological Chemistry 277:1, pages 395-401.
Crossref
Marilyn L. Clarke, John R. Mackey, Stephen A. Baldwin, James D. Young & Carol E. Cass. 2002. Clinically Relevant Resistance in Cancer Chemotherapy. Clinically Relevant Resistance in Cancer Chemotherapy 27 47 .

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