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Peripheral metabotropic glutamate receptors as drug targets for pain relief

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Pages 349-361 | Published online: 25 Feb 2005

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Perumal Yogeeswari, Arvind Semwal, Ramkumar Mishra & Dharmarajan Sriram. (2009) Current approaches with the glutamatergic system as targets in the treatment of neuropathic pain. Expert Opinion on Therapeutic Targets 13:8, pages 925-943.
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Sonia Kartha, Prabesh Ghimire & Beth A Winkelstein. (2021) Inhibiting spinal secretory phospholipase A 2 after painful nerve root injury attenuates established pain and spinal neuronal hyperexcitability by altering spinal glutamatergic signaling . Molecular Pain 17, pages 174480692110662.
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Mariacristina Mazzitelli & Volker Neugebauer. (2019) Amygdala group II mGluRs mediate the inhibitory effects of systemic group II mGluR activation on behavior and spinal neurons in a rat model of arthritis pain. Neuropharmacology 158, pages 107706.
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Amna Khan, Salman Khan & Yeong Shik Kim. (2019) Insight into Pain Modulation: Nociceptors Sensitization and Therapeutic Targets. Current Drug Targets 20:7, pages 775-788.
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Steve Davidson, Judith P. Golden, Bryan A. Copits, Pradipta R. Ray, Sherri K. Vogt, Manouela V. Valtcheva, Robert E. Schmidt, Andrea GhettiTheodore J. Price & Robert W. Gereau. (2016) Group II mGluRs suppress hyperexcitability in mouse and human nociceptors. Pain 157:9, pages 2081-2088.
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Xiong Gan, Jing Wu, Cuixia Ren, Chun-Yu Qiu, Yan-Kun Li & Wang-Ping Hu. (2016) Potentiation of acid-sensing ion channel activity by peripheral group I metabotropic glutamate receptor signaling. Pharmacological Research 107, pages 19-26.
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Jae Wan Jang, Nam‐Chul Cho, Sun‐Joon Min, Yong Seo Cho, Ki Duk Park, Seon Hee Seo, Kyoung Tai No & Ae Nim Pae. (2015) Novel Scaffold Identification of mG lu1 Receptor Negative Allosteric Modulators Using a Hierarchical Virtual Screening Approach . Chemical Biology & Drug Design 87:2, pages 239-256.
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Takaki Kiritoshi & Volker Neugebauer. (2015) Group II mGluRs modulate baseline and arthritis pain-related synaptic transmission in the rat medial prefrontal cortex. Neuropharmacology 95, pages 388-394.
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Miau-Hwa Ko, Yu-Lin Hsieh, Sung-Tsang Hsieh & To-Jung Tseng. (2015) Nerve Demyelination Increases Metabotropic Glutamate Receptor Subtype 5 Expression in Peripheral Painful Mononeuropathy. International Journal of Molecular Sciences 16:3, pages 4642-4665.
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Mohammad Zarei, Saeed Mohammadi, Nasreen Abolhassani & Mahtab Asgari Nematian. (2015) The Antinociceptive Effects of Hydroalcoholic Extract of Bryonia dioica in Male Rats. Avicenna Journal of Neuro Psych Physiology 2:1.
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Rachel D. Moloney, Anna V. Golubeva, Richard M. O'Connor, Mikhail Kalinichev, Timothy G. Dinan & John F. Cryan. (2015) Negative allosteric modulation of the mGlu7 receptor reduces visceral hypersensitivity in a stress-sensitive rat strain. Neurobiology of Stress 2, pages 28-33.
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Susan M. Carlton. (2014) Nociceptive primary afferents: they have a mind of their own. The Journal of Physiology 592:16, pages 3403-3411.
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Catarine M. Nishijima, Ellen G. Ganev, Leidiane Mazzardo-Martins, Daniel F. Martins, Lúcia R.M. Rocha, Adair R.S. Santos & Clelia A. Hiruma-Lima. (2014) Citral: A monoterpene with prophylactic and therapeutic anti-nociceptive effects in experimental models of acute and chronic pain. European Journal of Pharmacology 736, pages 16-25.
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B.F. Kania & D. Wrońska. (2014) Supraspinal basis of analgesic and clinical effects of the metabotropic glutamate mGluR1 antagonist during colonic distension in sheep. Small Ruminant Research 117:1, pages 84-93.
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Enza Palazzo, Ida Marabese, Vito de Novellis, Francesco Rossi & Sabatino Maione. (2014) Supraspinal metabotropic glutamate receptors: a target for pain relief and beyond. European Journal of Neuroscience 39:3, pages 444-454.
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Dany Arsenault, Aijun Zhu, Chunyu Gong, Kun-Eek Kil, Sreekanth Kura, Ji-Kyung Choi & Anna-Liisa Brownell. (2014) Hypo-Anxious Phenotype of Adolescent Offspring Prenatally Exposed to LPS Is Associated with Reduced mGluR5 Expression in Hippocampus. Open Journal of Medical Psychology 03:03, pages 202-211.
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Ming-Gang Liu & Min Zhuo. (2014) Loss of Long-Term Depression in the Insular Cortex after Tail Amputation in Adult Mice. Molecular Pain 10, pages 1744-8069-10-1.
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Maria Osikowicz, Joanna Mika & Barbara Przewlocka. (2013) The glutamatergic system as a target for neuropathic pain relief. Experimental Physiology 98:2, pages 372-384.
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Tiago G. Santos, Flavio H. Beraldo, Glaucia N. M. Hajj, Marilene H. Lopes, Martin Roffe, Fernanda C. S. Lupinacci, Valeriy G. Ostapchenko, Vania F. Prado, Marco A. M. Prado & Vilma R. Martins. (2012) Laminin‐γ1 chain and stress inducible protein 1 synergistically mediate Pr P C ‐dependent axonal growth via Ca 2+ mobilization in dorsal root ganglia neurons . Journal of Neurochemistry 124:2, pages 210-223.
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R.M. Govea, S. Zhou & S.M. Carlton. (2012) Group III metabotropic glutamate receptors and transient receptor potential vanilloid 1 co-localize and interact on nociceptors. Neuroscience 217, pages 130-139.
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Klára Hlouchová, Cyril BaŘinka & Jan Konvalinka. 2011. Proteinases as Drug Targets. Proteinases as Drug Targets 62 95 .
Soo Suk Jung, Ki Woon Sung, Seo Eun Lee & Hong Kee Shin. (2011) Capsaicin prevents the hyperalgesia induced by peripheral group I mGluRs activation. Neuroscience Letters 500:3, pages 197-201.
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Sonia Maria Figueredo, Francisney Pinto do Nascimento, Cristina Setim Freitas, Cristiane Hatsuko Baggio, Cristian Soldi, Moacir Geraldo Pizzolatti, Maria del Carmen Chellion de Ibarrola, Rosa Luisa Degen de Arrua & Adair Roberto Soares Santos. (2011) Antinociceptive and gastroprotective actions of ethanolic extract from Pluchea sagittalis (Lam.) Cabrera. Journal of Ethnopharmacology 135:3, pages 603-609.
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William R. Lariviere, Paolo Fiorenzani, Ilaria Ceccarelli, Cosimo Massafra, Giuseppina Sorda, Clara Di Canio & Anna Maria Aloisi. (2011) Central CRH administration changes formalin pain responses in male and female rats. Brain Research 1383, pages 128-134.
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Marcela Julio-Pieper, Peter J. Flor, Timothy G. Dinan & John F. Cryan. (2011) Exciting Times beyond the Brain: Metabotropic Glutamate Receptors in Peripheral and Non-Neural Tissues. Pharmacological Reviews 63:1, pages 35-58.
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Janelle Drouin-Ouellet, Anna-Liisa Brownell, Martine Saint-Pierre, Caroline Fasano, Vincent Emond, Louis-Eric Trudeau, Daniel Lévesque & Francesca Cicchetti. (2011) Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions. Glia 59:2, pages 188-199.
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H. Nie & H. R. Weng. (2010) Impaired Glial Glutamate Uptake Induces Extrasynaptic Glutamate Spillover in the Spinal Sensory Synapses of Neuropathic Rats. Journal of Neurophysiology 103:5, pages 2570-2580.
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Cyril Goudet, Valerio Magnaghi, Marc Landry, Fr?d?ric Nagy, Robert W. GereauIVIV & Jean-Philippe Pin. (2009) Metabotropic receptors for glutamate and GABA in pain. Brain Research Reviews 60:1, pages 43-56.
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Christine Favre-Guilmard, Hamida Zeroual-Hider, Chantal Soulard, Caroline Touvay, Pierre-Etienne Chabrier, Grégoire Prevost & Michel Auguet. (2008) The novel inhibitor of the heterotrimeric G-protein complex, BIM-46187, elicits anti-hyperalgesic properties and synergizes with morphine. European Journal of Pharmacology 594:1-3, pages 70-76.
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P. Brumovsky, M. Watanabe & T. Hökfelt. (2007) Expression of the vesicular glutamate transporters-1 and -2 in adult mouse dorsal root ganglia and spinal cord and their regulation by nerve injury. Neuroscience 147:2, pages 469-490.
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Susan M. Carlton & Gregory L. Hargett. (2007) Colocalization of metabotropic glutamate receptors in rat dorsal root ganglion cells. Journal of Comparative Neurology 501:5, pages 780-789.
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J.-S. Lee & J.Y. Ro. (2007) Peripheral metabotropic glutamate receptor 5 mediates mechanical hypersensitivity in craniofacial muscle via protein kinase C dependent mechanisms. Neuroscience 146:1, pages 375-383.
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Kyu Sang Lee, Junesun Kim, Young Wook Yoon, Min-Goo Lee, Seung Kil Hong & Hee Chul Han. (2007) The peripheral role of group I metabotropic glutamate receptors on nociceptive behaviors in rats with knee joint inflammation. Neuroscience Letters 416:2, pages 123-127.
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Weidong Li & Volker Neugebauer. (2006) Differential Changes of Group II and Group III mGluR Function in Central Amygdala Neurons in a Model of Arthritic Pain. Journal of Neurophysiology 96:4, pages 1803-1815.
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Jeong S Han, Yu Fu, Gary C Bird & Volker Neugebauer. (2006) Enhanced Group II mGluR-Mediated Inhibition of Pain-Related Synaptic Plasticity in the Amygdala. Molecular Pain 2, pages 1744-8069-2-18.
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J. Du, S. Zhou & S.M. Carlton. (2006) Kainate-induced excitation and sensitization of nociceptors in normal and inflamed rat glabrous skin. Neuroscience 137:3, pages 999-1013.
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Guo Zhu Zheng, Pramila Bhatia, Jerome Daanen, Teodozyj Kolasa, Meena Patel, Steven Latshaw, Odile F. El Kouhen, Renjie Chang, Marie E. Uchic, Loan Miller, Masaki Nakane, Sonya G. Lehto, Marie P. Honore, Robert B. Moreland, Jorge D. Brioni & Andrew O. Stewart. (2005) Structure−Activity Relationship of Triazafluorenone Derivatives as Potent and Selective mGluR1 Antagonists. Journal of Medicinal Chemistry 48:23, pages 7374-7388.
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Young Seob Gwak & Claire E. Hulsebosch. (2005) Upregulation of Group I metabotropic glutamate receptors in neurons and astrocytes in the dorsal horn following spinal cord injury. Experimental Neurology 195:1, pages 236-243.
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Gary C. Bird, L. Leanne Lash, Jeong S. Han, Xiaoju Zou, William D. Willis & Volker Neugebauer. (2005) Protein kinase A-dependent enhanced NMDA receptor function in pain-related synaptic plasticity in rat amygdala neurones. The Journal of Physiology 564:3, pages 907-921.
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Chang Z. Zhu, Gin Hsieh, Odile EI-Kouhen, Sonya G. Wilson, Joe P. Mikusa, Peter R. Hollingsworth, Renjie Chang, Robert B. Moreland, Jorge Brioni, Michael W. Decker & Prisca Honore. (2005) Role of central and peripheral mGluR5 receptors in post-operative pain in rats. Pain 114:1, pages 195-202.
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Jeong Seok Han & Volker Neugebauer. (2005) mGluR1 and mGluR5 antagonists in the amygdala inhibit different components of audible and ultrasonic vocalizations in a model of arthritic pain. Pain 113:1, pages 211-222.
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Weidong Li & Volker Neugebauer. (2004) Differential Roles of mGluR1 and mGluR5 in Brief and Prolonged Nociceptive Processing in Central Amygdala Neurons. Journal of Neurophysiology 91:1, pages 13-24.
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